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Fusion gene ID: 30489 |
FusionGeneSummary for RARB_FAM19A4 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: RARB_FAM19A4 | Fusion gene ID: 30489 | Hgene | Tgene | Gene symbol | RARB | FAM19A4 | Gene ID | 5915 | 151647 |
| Gene name | retinoic acid receptor beta | family with sequence similarity 19 member A4, C-C motif chemokine like | |
| Synonyms | HAP|MCOPS12|NR1B2|RARbeta1|RRB2 | TAFA-4|TAFA4 | |
| Cytomap | 3p24.2 | 3p14.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | retinoic acid receptor betaHBV-activated proteinRAR-betaRAR-epsilonhepatitis B virus activated proteinnuclear receptor subfamily 1 group B member 2retinoic acid receptor, beta polypeptide | protein FAM19A4chemokine-like protein TAFA-4family with sequence similarity 19 (chemokine (C-C motif)-like), member A4 | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | P10826 | Q96LR4 | |
| Ensembl transtripts involved in fusion gene | ENST00000404969, ENST00000437042, ENST00000330688, ENST00000462272, ENST00000458646, | ENST00000295569, | |
| Fusion gene scores | * DoF score | 3 X 2 X 3=18 | 2 X 2 X 2=8 |
| # samples | 3 | 2 | |
| ** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: RARB [Title/Abstract] AND FAM19A4 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Oncogene involved fusion gene, in-frame and retained their domain. Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. Transcription factor involved fusion gene, inframe and retained DNA-binding domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | PRAD | TCGA-EJ-5501-01A | RARB | chr3 | 25542814 | + | FAM19A4 | chr3 | 68802169 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000404969 | ENST00000295569 | RARB | chr3 | 25542814 | + | FAM19A4 | chr3 | 68802169 | - |
| In-frame | ENST00000437042 | ENST00000295569 | RARB | chr3 | 25542814 | + | FAM19A4 | chr3 | 68802169 | - |
| In-frame | ENST00000330688 | ENST00000295569 | RARB | chr3 | 25542814 | + | FAM19A4 | chr3 | 68802169 | - |
| 3UTR-3CDS | ENST00000462272 | ENST00000295569 | RARB | chr3 | 25542814 | + | FAM19A4 | chr3 | 68802169 | - |
| In-frame | ENST00000458646 | ENST00000295569 | RARB | chr3 | 25542814 | + | FAM19A4 | chr3 | 68802169 | - |
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FusionProtFeatures for RARB_FAM19A4 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| RARB | FAM19A4 |
| Receptor for retinoic acid. Retinoic acid receptors bindas heterodimers to their target response elements in response totheir ligands, all-trans or 9-cis retinoic acid, and regulate geneexpression in various biological processes. The RXR/RARheterodimers bind to the retinoic acid response elements (RARE)composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In theabsence or presence of hormone ligand, acts mainly as an activatorof gene expression due to weak binding to corepressors. In concertwith RARG, required for skeletal growth, matrix homeostasis andgrowth plate function. {ECO:0000269|PubMed:12554770}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | RARB | chr3:25542814 | chr3:68802169 | ENST00000404969 | + | 3 | 8 | 88_153 | 156 | 456 | DNA binding | Nuclear receptor |
| Hgene | RARB | chr3:25542814 | chr3:68802169 | ENST00000330688 | + | 3 | 8 | 1_87 | 149 | 449 | Region | Note=Modulating |
| Hgene | RARB | chr3:25542814 | chr3:68802169 | ENST00000404969 | + | 3 | 8 | 1_87 | 156 | 456 | Region | Note=Modulating |
| Hgene | RARB | chr3:25542814 | chr3:68802169 | ENST00000330688 | + | 3 | 8 | 124_148 | 149 | 449 | Zinc finger | NR C4-type |
| Hgene | RARB | chr3:25542814 | chr3:68802169 | ENST00000330688 | + | 3 | 8 | 88_108 | 149 | 449 | Zinc finger | NR C4-type |
| Hgene | RARB | chr3:25542814 | chr3:68802169 | ENST00000404969 | + | 3 | 8 | 124_148 | 156 | 456 | Zinc finger | NR C4-type |
| Hgene | RARB | chr3:25542814 | chr3:68802169 | ENST00000404969 | + | 3 | 8 | 88_108 | 156 | 456 | Zinc finger | NR C4-type |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >RARB | chr3:25542814 | chr3:68802169 | ENST00000330688 | + | 3 | 8 | 88_153 | 149 | 449 | DNA binding | Nuclear receptor |
| Hgene | >RARB | chr3:25542814 | chr3:68802169 | ENST00000437042 | + | 3 | 8 | 88_153 | 37 | 337 | DNA binding | Nuclear receptor |
| Hgene | >RARB | chr3:25542814 | chr3:68802169 | ENST00000458646 | + | 3 | 8 | 88_153 | 37 | 337 | DNA binding | Nuclear receptor |
| Hgene | >RARB | chr3:25542814 | chr3:68802169 | ENST00000330688 | + | 3 | 8 | 183_417 | 149 | 449 | Domain | NR LBD |
| Hgene | >RARB | chr3:25542814 | chr3:68802169 | ENST00000404969 | + | 3 | 8 | 183_417 | 156 | 456 | Domain | NR LBD |
| Hgene | >RARB | chr3:25542814 | chr3:68802169 | ENST00000437042 | + | 3 | 8 | 183_417 | 37 | 337 | Domain | NR LBD |
| Hgene | >RARB | chr3:25542814 | chr3:68802169 | ENST00000458646 | + | 3 | 8 | 183_417 | 37 | 337 | Domain | NR LBD |
| Hgene | >RARB | chr3:25542814 | chr3:68802169 | ENST00000330688 | + | 3 | 8 | 154_182 | 149 | 449 | Region | Note=Hinge |
| Hgene | >RARB | chr3:25542814 | chr3:68802169 | ENST00000404969 | + | 3 | 8 | 154_182 | 156 | 456 | Region | Note=Hinge |
| Hgene | >RARB | chr3:25542814 | chr3:68802169 | ENST00000437042 | + | 3 | 8 | 154_182 | 37 | 337 | Region | Note=Hinge |
| Hgene | >RARB | chr3:25542814 | chr3:68802169 | ENST00000437042 | + | 3 | 8 | 1_87 | 37 | 337 | Region | Note=Modulating |
| Hgene | >RARB | chr3:25542814 | chr3:68802169 | ENST00000458646 | + | 3 | 8 | 154_182 | 37 | 337 | Region | Note=Hinge |
| Hgene | >RARB | chr3:25542814 | chr3:68802169 | ENST00000458646 | + | 3 | 8 | 1_87 | 37 | 337 | Region | Note=Modulating |
| Hgene | >RARB | chr3:25542814 | chr3:68802169 | ENST00000437042 | + | 3 | 8 | 124_148 | 37 | 337 | Zinc finger | NR C4-type |
| Hgene | >RARB | chr3:25542814 | chr3:68802169 | ENST00000437042 | + | 3 | 8 | 88_108 | 37 | 337 | Zinc finger | NR C4-type |
| Hgene | >RARB | chr3:25542814 | chr3:68802169 | ENST00000458646 | + | 3 | 8 | 124_148 | 37 | 337 | Zinc finger | NR C4-type |
| Hgene | >RARB | chr3:25542814 | chr3:68802169 | ENST00000458646 | + | 3 | 8 | 88_108 | 37 | 337 | Zinc finger | NR C4-type |
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FusionGeneSequence for RARB_FAM19A4 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_RARB_ENST00000404969_chr3_25542814_+_FAM19A4_ENST00000295569_chr3_68802169_-_254aa MTTSGHACPVPAVNGHMTHYPATPYPLLFPPVIGGLSLPPLHGLHGHPPPSGCSTPSPATIETQSTSSEELVPSPPSPLPPPRVYKPCFV CQDKSSGYHYGVSACEGCKGFFRRSIQKNMIYTCHRDKNCVINKVTRNRCQYCRLQKCFEVGMSKECHHQIKQGTCEVVAVHRCCNKNRI >In-frame_RARB_ENST00000437042_chr3_25542814_+_FAM19A4_ENST00000295569_chr3_68802169_-_135aa MIYTCHRDKNCVINKVTRNRCQYCRLQKCFEVGMSKECHHQIKQGTCEVVAVHRCCNKNRIEERSQTVKCSCFPGQVAGTTRAQPSCVEA >In-frame_RARB_ENST00000330688_chr3_25542814_+_FAM19A4_ENST00000295569_chr3_68802169_-_247aa MFDCMDVLSVSPGQILDFYTASPSSCMLQEKALKACFSGLTQTEWQHRHTAQSIETQSTSSEELVPSPPSPLPPPRVYKPCFVCQDKSSG YHYGVSACEGCKGFFRRSIQKNMIYTCHRDKNCVINKVTRNRCQYCRLQKCFEVGMSKECHHQIKQGTCEVVAVHRCCNKNRIEERSQTV >In-frame_RARB_ENST00000458646_chr3_25542814_+_FAM19A4_ENST00000295569_chr3_68802169_-_135aa MIYTCHRDKNCVINKVTRNRCQYCRLQKCFEVGMSKECHHQIKQGTCEVVAVHRCCNKNRIEERSQTVKCSCFPGQVAGTTRAQPSCVEA |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_RARB_ENST00000404969_chr3_25542814_+_FAM19A4_ENST00000295569_chr3_68802169_-_762nt ATGACCACCAGCGGCCACGCATGTCCGGTCCCAGCAGTGAACGGACACATGACTCACTATCCAGCCACACCCTACCCGTTACTCTTTCCA CCTGTCATCGGAGGACTTTCCCTGCCTCCCCTCCATGGCCTTCATGGACATCCGCCTCCGAGTGGATGCAGCACCCCGTCGCCGGCAACA ATTGAAACACAGAGCACCAGCTCTGAGGAACTCGTCCCAAGCCCCCCATCTCCACTTCCTCCCCCTCGAGTGTACAAACCCTGCTTCGTC TGCCAGGACAAATCATCAGGGTACCACTATGGGGTCAGCGCCTGTGAGGGATGTAAGGGCTTTTTCCGCAGAAGTATTCAGAAGAATATG ATTTACACTTGTCACCGAGATAAGAACTGTGTTATTAATAAAGTCACCAGGAATCGATGCCAATACTGTCGACTCCAGAAGTGCTTTGAA GTGGGAATGTCCAAAGAATGTCACCACCAAATCAAGCAAGGGACCTGTGAGGTGGTCGCCGTGCACAGGTGCTGCAATAAGAACCGCATA GAAGAGCGGTCACAAACGGTCAAGTGCTCTTGCTTCCCGGGACAGGTGGCGGGCACAACTCGGGCTCAACCTTCTTGTGTTGAAGCTTCC ATTGTGATTCAGAAATGGTGGTGTCACATGAATCCGTGTTTGGAAGGAGAGGATTGTAAAGTGCTGCCAGATTACTCAGGTTGGTCCTGT >In-frame_RARB_ENST00000437042_chr3_25542814_+_FAM19A4_ENST00000295569_chr3_68802169_-_405nt ATGATTTACACTTGTCACCGAGATAAGAACTGTGTTATTAATAAAGTCACCAGGAATCGATGCCAATACTGTCGACTCCAGAAGTGCTTT GAAGTGGGAATGTCCAAAGAATGTCACCACCAAATCAAGCAAGGGACCTGTGAGGTGGTCGCCGTGCACAGGTGCTGCAATAAGAACCGC ATAGAAGAGCGGTCACAAACGGTCAAGTGCTCTTGCTTCCCGGGACAGGTGGCGGGCACAACTCGGGCTCAACCTTCTTGTGTTGAAGCT TCCATTGTGATTCAGAAATGGTGGTGTCACATGAATCCGTGTTTGGAAGGAGAGGATTGTAAAGTGCTGCCAGATTACTCAGGTTGGTCC >In-frame_RARB_ENST00000330688_chr3_25542814_+_FAM19A4_ENST00000295569_chr3_68802169_-_741nt ATGTTTGACTGTATGGATGTTCTGTCAGTGAGTCCTGGGCAAATCCTGGATTTCTACACTGCGAGTCCGTCTTCCTGCATGCTCCAGGAG AAAGCTCTCAAAGCATGCTTCAGTGGATTGACCCAAACCGAATGGCAGCATCGGCACACTGCTCAATCAATTGAAACACAGAGCACCAGC TCTGAGGAACTCGTCCCAAGCCCCCCATCTCCACTTCCTCCCCCTCGAGTGTACAAACCCTGCTTCGTCTGCCAGGACAAATCATCAGGG TACCACTATGGGGTCAGCGCCTGTGAGGGATGTAAGGGCTTTTTCCGCAGAAGTATTCAGAAGAATATGATTTACACTTGTCACCGAGAT AAGAACTGTGTTATTAATAAAGTCACCAGGAATCGATGCCAATACTGTCGACTCCAGAAGTGCTTTGAAGTGGGAATGTCCAAAGAATGT CACCACCAAATCAAGCAAGGGACCTGTGAGGTGGTCGCCGTGCACAGGTGCTGCAATAAGAACCGCATAGAAGAGCGGTCACAAACGGTC AAGTGCTCTTGCTTCCCGGGACAGGTGGCGGGCACAACTCGGGCTCAACCTTCTTGTGTTGAAGCTTCCATTGTGATTCAGAAATGGTGG TGTCACATGAATCCGTGTTTGGAAGGAGAGGATTGTAAAGTGCTGCCAGATTACTCAGGTTGGTCCTGTAGCAGTGGCAATAAAGTCAAA >In-frame_RARB_ENST00000458646_chr3_25542814_+_FAM19A4_ENST00000295569_chr3_68802169_-_405nt ATGATTTACACTTGTCACCGAGATAAGAACTGTGTTATTAATAAAGTCACCAGGAATCGATGCCAATACTGTCGACTCCAGAAGTGCTTT GAAGTGGGAATGTCCAAAGAATGTCACCACCAAATCAAGCAAGGGACCTGTGAGGTGGTCGCCGTGCACAGGTGCTGCAATAAGAACCGC ATAGAAGAGCGGTCACAAACGGTCAAGTGCTCTTGCTTCCCGGGACAGGTGGCGGGCACAACTCGGGCTCAACCTTCTTGTGTTGAAGCT TCCATTGTGATTCAGAAATGGTGGTGTCACATGAATCCGTGTTTGGAAGGAGAGGATTGTAAAGTGCTGCCAGATTACTCAGGTTGGTCC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_RARB_ENST00000404969_chr3_25542814_+_FAM19A4_ENST00000295569_chr3_68802169_-_2138nt ATGACCACCAGCGGCCACGCATGTCCGGTCCCAGCAGTGAACGGACACATGACTCACTATCCAGCCACACCCTACCCGTTACTCTTTCCA CCTGTCATCGGAGGACTTTCCCTGCCTCCCCTCCATGGCCTTCATGGACATCCGCCTCCGAGTGGATGCAGCACCCCGTCGCCGGCAACA ATTGAAACACAGAGCACCAGCTCTGAGGAACTCGTCCCAAGCCCCCCATCTCCACTTCCTCCCCCTCGAGTGTACAAACCCTGCTTCGTC TGCCAGGACAAATCATCAGGGTACCACTATGGGGTCAGCGCCTGTGAGGGATGTAAGGGCTTTTTCCGCAGAAGTATTCAGAAGAATATG ATTTACACTTGTCACCGAGATAAGAACTGTGTTATTAATAAAGTCACCAGGAATCGATGCCAATACTGTCGACTCCAGAAGTGCTTTGAA GTGGGAATGTCCAAAGAATGTCACCACCAAATCAAGCAAGGGACCTGTGAGGTGGTCGCCGTGCACAGGTGCTGCAATAAGAACCGCATA GAAGAGCGGTCACAAACGGTCAAGTGCTCTTGCTTCCCGGGACAGGTGGCGGGCACAACTCGGGCTCAACCTTCTTGTGTTGAAGCTTCC ATTGTGATTCAGAAATGGTGGTGTCACATGAATCCGTGTTTGGAAGGAGAGGATTGTAAAGTGCTGCCAGATTACTCAGGTTGGTCCTGT AGCAGTGGCAATAAAGTCAAAACTACGAAGGTAACGCGGTAGCGAAGAGAGAGGTGTGCTTCAATCCTGGAGGGGCAGCAGGAGGCGGAG CTCTTTTGCTTGGATTCCCATCATGGCCCCTTTGCAGAAAATTGTCTAGGATTTCAGCAACTTCATATTTGTATATGTGAGCTGTGAGAG GTGGCATTCACTTAACTGGCCCAGCCCTCTCTGCTTCGTGATTTTATTTCATTGAATTATAACCACAAGCCACCACCCATTTGACATCCT CTCTGGATTCCCAAGGAGCATACCTCCAAAATCCGAGAAGAGCAAATCAGAGTCTTCAAAATGGATCACCACTAAGGGCATGTTCATTCT TCACTTTCTTTCTGCTTTTACAAAAGAACTTGGATGTATGTTCCAAAGGGTCCTCATTCTGTTCCTCTTTTGAACTTTTCCTTTTGTCCT TGTATTAAAGTGGTTTTAAAGGGGTCTAAAAAGATTTTGGCAAAACATATTTGCAGATGTAGATTAGCTGGTGAAGAAAATTACTGCTAG AGATCAACTGATTAACTGGTAAAGAACGTTTATTTTATAACCCTTGAAGAATAGAAGGACATAGTTGGATTATTGTGTGTGCATTGTATT TTTACTTCTATTTTTTTTTTGCTTTCCATTTTCCAGTTAGCAGAGATAAAATGAGAGCGTTTTAACTTCAATGTACCATTTTACTGAGTG CTAAGGAAGCATATCAATTCCAATATTTTATAACCAAAGCTCTATCAGAACATATTTATAAAACTTGTTGGAATTTTTACGGCTTTTGTG TAGTCATGTAGGTAAATCATTTAAAATATAAAACAATCTCAATTTAGATCAAGGGTTATTTCTTAGATCAAATTTATGCCAATTATATGA AAAGATTTTAACTCCGAGACAGGAGTCTTTCAGTGCTGAATTTTTAGACTGTAAATGAGTTCTTCTTAACTTAGCTGTTTCCCTACTTCT GTGACTTCTGTGTTAGCCATCTTATTTCTTTAAAATCTGAGTCCTGATTGGCTTAATGATTTTGCAGCAGACATGTCTCCACATATTCTC AAATGCTGTCATGCGGAAACGTATGAAACAGATGAAGAATGACTGACCCAGATTTTAGATGTATAATGTTGTTAAAGTACATACTACTGT AAAAATATGGGATGAATTTTATATATTAAGAAATGCCAAAAACATAGTTTCTGCACCAAGTTAATTATCCCTGTCCTTTCACATTTATAG GGGGAAAATAAATACTTTAATGTTGTTTATAGCCTAACAGTTATTTGATTTTATTCTTGCAGAGGGAATGGAAAGGAATGGAAAGATTTG >In-frame_RARB_ENST00000437042_chr3_25542814_+_FAM19A4_ENST00000295569_chr3_68802169_-_2229nt GTGACAGAAGTAGTAGGAAGTGAGCTGTTCAGAGGCAGGAGGGTCTATTCTTTGCCAAAGGGGGGACCAGAATTCCCCCATGCGAGCTGT TTGAGGACTGGGATGCCGAGAACGCGAGCGATCCGAGCAGGGTTTGTCTGGGCACCGTCGGGGTAGGATCCGGAACGCATTCGGAAGGCT TTTTGCAAGCATTTACTTGGAAGGAGAACTTGGGATCTTTCTGGGAACCCCCCGCCCCGGCTGGATTGGCCGAGCAAGCCTGGAAAATGC AATTGAAACACAGAGCACCAGCTCTGAGGAACTCGTCCCAAGCCCCCCATCTCCACTTCCTCCCCCTCGAGTGTACAAACCCTGCTTCGT CTGCCAGGACAAATCATCAGGGTACCACTATGGGGTCAGCGCCTGTGAGGGATGTAAGGGCTTTTTCCGCAGAAGTATTCAGAAGAATAT GATTTACACTTGTCACCGAGATAAGAACTGTGTTATTAATAAAGTCACCAGGAATCGATGCCAATACTGTCGACTCCAGAAGTGCTTTGA AGTGGGAATGTCCAAAGAATGTCACCACCAAATCAAGCAAGGGACCTGTGAGGTGGTCGCCGTGCACAGGTGCTGCAATAAGAACCGCAT AGAAGAGCGGTCACAAACGGTCAAGTGCTCTTGCTTCCCGGGACAGGTGGCGGGCACAACTCGGGCTCAACCTTCTTGTGTTGAAGCTTC CATTGTGATTCAGAAATGGTGGTGTCACATGAATCCGTGTTTGGAAGGAGAGGATTGTAAAGTGCTGCCAGATTACTCAGGTTGGTCCTG TAGCAGTGGCAATAAAGTCAAAACTACGAAGGTAACGCGGTAGCGAAGAGAGAGGTGTGCTTCAATCCTGGAGGGGCAGCAGGAGGCGGA GCTCTTTTGCTTGGATTCCCATCATGGCCCCTTTGCAGAAAATTGTCTAGGATTTCAGCAACTTCATATTTGTATATGTGAGCTGTGAGA GGTGGCATTCACTTAACTGGCCCAGCCCTCTCTGCTTCGTGATTTTATTTCATTGAATTATAACCACAAGCCACCACCCATTTGACATCC TCTCTGGATTCCCAAGGAGCATACCTCCAAAATCCGAGAAGAGCAAATCAGAGTCTTCAAAATGGATCACCACTAAGGGCATGTTCATTC TTCACTTTCTTTCTGCTTTTACAAAAGAACTTGGATGTATGTTCCAAAGGGTCCTCATTCTGTTCCTCTTTTGAACTTTTCCTTTTGTCC TTGTATTAAAGTGGTTTTAAAGGGGTCTAAAAAGATTTTGGCAAAACATATTTGCAGATGTAGATTAGCTGGTGAAGAAAATTACTGCTA GAGATCAACTGATTAACTGGTAAAGAACGTTTATTTTATAACCCTTGAAGAATAGAAGGACATAGTTGGATTATTGTGTGTGCATTGTAT TTTTACTTCTATTTTTTTTTTGCTTTCCATTTTCCAGTTAGCAGAGATAAAATGAGAGCGTTTTAACTTCAATGTACCATTTTACTGAGT GCTAAGGAAGCATATCAATTCCAATATTTTATAACCAAAGCTCTATCAGAACATATTTATAAAACTTGTTGGAATTTTTACGGCTTTTGT GTAGTCATGTAGGTAAATCATTTAAAATATAAAACAATCTCAATTTAGATCAAGGGTTATTTCTTAGATCAAATTTATGCCAATTATATG AAAAGATTTTAACTCCGAGACAGGAGTCTTTCAGTGCTGAATTTTTAGACTGTAAATGAGTTCTTCTTAACTTAGCTGTTTCCCTACTTC TGTGACTTCTGTGTTAGCCATCTTATTTCTTTAAAATCTGAGTCCTGATTGGCTTAATGATTTTGCAGCAGACATGTCTCCACATATTCT CAAATGCTGTCATGCGGAAACGTATGAAACAGATGAAGAATGACTGACCCAGATTTTAGATGTATAATGTTGTTAAAGTACATACTACTG TAAAAATATGGGATGAATTTTATATATTAAGAAATGCCAAAAACATAGTTTCTGCACCAAGTTAATTATCCCTGTCCTTTCACATTTATA GGGGGAAAATAAATACTTTAATGTTGTTTATAGCCTAACAGTTATTTGATTTTATTCTTGCAGAGGGAATGGAAAGGAATGGAAAGATTT >In-frame_RARB_ENST00000330688_chr3_25542814_+_FAM19A4_ENST00000295569_chr3_68802169_-_2538nt TCTTTGCCAAAGGGGGGACCAGAATTCCCCCATGCGAGCTGTTTGAGGACTGGGATGCCGAGAACGCGAGCGATCCGAGCAGGGTTTGTC TGGGCACCGTCGGGGTAGGATCCGGAACGCATTCGGAAGGCTTTTTGCAAGCATTTACTTGGAAGGAGAACTTGGGATCTTTCTGGGAAC CCCCCGCCCCGGCTGGATTGGCCGAGCAAGCCTGGAAAATGGTAAATGATCATTTGGATCAATTACAGGCTTTTAGCTGGCTTGTCTGTC ATAATTCATGATTCGGGGCTGGGAAAAAGACCAACAGCCTACGTGCCAAAAAAGGGGCAGAGTTTGATGGAGTTGGGTGGACTTTTCTAT GCCATTTGCCTCCACACCTAGAGGATAAGCACTTTTGCAGACATTCAGTGCAAGGGAGATCATGTTTGACTGTATGGATGTTCTGTCAGT GAGTCCTGGGCAAATCCTGGATTTCTACACTGCGAGTCCGTCTTCCTGCATGCTCCAGGAGAAAGCTCTCAAAGCATGCTTCAGTGGATT GACCCAAACCGAATGGCAGCATCGGCACACTGCTCAATCAATTGAAACACAGAGCACCAGCTCTGAGGAACTCGTCCCAAGCCCCCCATC TCCACTTCCTCCCCCTCGAGTGTACAAACCCTGCTTCGTCTGCCAGGACAAATCATCAGGGTACCACTATGGGGTCAGCGCCTGTGAGGG ATGTAAGGGCTTTTTCCGCAGAAGTATTCAGAAGAATATGATTTACACTTGTCACCGAGATAAGAACTGTGTTATTAATAAAGTCACCAG GAATCGATGCCAATACTGTCGACTCCAGAAGTGCTTTGAAGTGGGAATGTCCAAAGAATGTCACCACCAAATCAAGCAAGGGACCTGTGA GGTGGTCGCCGTGCACAGGTGCTGCAATAAGAACCGCATAGAAGAGCGGTCACAAACGGTCAAGTGCTCTTGCTTCCCGGGACAGGTGGC GGGCACAACTCGGGCTCAACCTTCTTGTGTTGAAGCTTCCATTGTGATTCAGAAATGGTGGTGTCACATGAATCCGTGTTTGGAAGGAGA GGATTGTAAAGTGCTGCCAGATTACTCAGGTTGGTCCTGTAGCAGTGGCAATAAAGTCAAAACTACGAAGGTAACGCGGTAGCGAAGAGA GAGGTGTGCTTCAATCCTGGAGGGGCAGCAGGAGGCGGAGCTCTTTTGCTTGGATTCCCATCATGGCCCCTTTGCAGAAAATTGTCTAGG ATTTCAGCAACTTCATATTTGTATATGTGAGCTGTGAGAGGTGGCATTCACTTAACTGGCCCAGCCCTCTCTGCTTCGTGATTTTATTTC ATTGAATTATAACCACAAGCCACCACCCATTTGACATCCTCTCTGGATTCCCAAGGAGCATACCTCCAAAATCCGAGAAGAGCAAATCAG AGTCTTCAAAATGGATCACCACTAAGGGCATGTTCATTCTTCACTTTCTTTCTGCTTTTACAAAAGAACTTGGATGTATGTTCCAAAGGG TCCTCATTCTGTTCCTCTTTTGAACTTTTCCTTTTGTCCTTGTATTAAAGTGGTTTTAAAGGGGTCTAAAAAGATTTTGGCAAAACATAT TTGCAGATGTAGATTAGCTGGTGAAGAAAATTACTGCTAGAGATCAACTGATTAACTGGTAAAGAACGTTTATTTTATAACCCTTGAAGA ATAGAAGGACATAGTTGGATTATTGTGTGTGCATTGTATTTTTACTTCTATTTTTTTTTTGCTTTCCATTTTCCAGTTAGCAGAGATAAA ATGAGAGCGTTTTAACTTCAATGTACCATTTTACTGAGTGCTAAGGAAGCATATCAATTCCAATATTTTATAACCAAAGCTCTATCAGAA CATATTTATAAAACTTGTTGGAATTTTTACGGCTTTTGTGTAGTCATGTAGGTAAATCATTTAAAATATAAAACAATCTCAATTTAGATC AAGGGTTATTTCTTAGATCAAATTTATGCCAATTATATGAAAAGATTTTAACTCCGAGACAGGAGTCTTTCAGTGCTGAATTTTTAGACT GTAAATGAGTTCTTCTTAACTTAGCTGTTTCCCTACTTCTGTGACTTCTGTGTTAGCCATCTTATTTCTTTAAAATCTGAGTCCTGATTG GCTTAATGATTTTGCAGCAGACATGTCTCCACATATTCTCAAATGCTGTCATGCGGAAACGTATGAAACAGATGAAGAATGACTGACCCA GATTTTAGATGTATAATGTTGTTAAAGTACATACTACTGTAAAAATATGGGATGAATTTTATATATTAAGAAATGCCAAAAACATAGTTT CTGCACCAAGTTAATTATCCCTGTCCTTTCACATTTATAGGGGGAAAATAAATACTTTAATGTTGTTTATAGCCTAACAGTTATTTGATT TTATTCTTGCAGAGGGAATGGAAAGGAATGGAAAGATTTGTTGGCGTAATTTTTGAATATTTGTTATGATCATATGAATAAGTAAAAAAA >In-frame_RARB_ENST00000458646_chr3_25542814_+_FAM19A4_ENST00000295569_chr3_68802169_-_2044nt AGACAAACCCAAAACATTTATGTGCATAGAAAAAAATTCTGGAAGGTCGTACACAGTGAATTTCTCTGAGTGAAAAGATTGTGGCAATTG AAACACAGAGCACCAGCTCTGAGGAACTCGTCCCAAGCCCCCCATCTCCACTTCCTCCCCCTCGAGTGTACAAACCCTGCTTCGTCTGCC AGGACAAATCATCAGGGTACCACTATGGGGTCAGCGCCTGTGAGGGATGTAAGGGCTTTTTCCGCAGAAGTATTCAGAAGAATATGATTT ACACTTGTCACCGAGATAAGAACTGTGTTATTAATAAAGTCACCAGGAATCGATGCCAATACTGTCGACTCCAGAAGTGCTTTGAAGTGG GAATGTCCAAAGAATGTCACCACCAAATCAAGCAAGGGACCTGTGAGGTGGTCGCCGTGCACAGGTGCTGCAATAAGAACCGCATAGAAG AGCGGTCACAAACGGTCAAGTGCTCTTGCTTCCCGGGACAGGTGGCGGGCACAACTCGGGCTCAACCTTCTTGTGTTGAAGCTTCCATTG TGATTCAGAAATGGTGGTGTCACATGAATCCGTGTTTGGAAGGAGAGGATTGTAAAGTGCTGCCAGATTACTCAGGTTGGTCCTGTAGCA GTGGCAATAAAGTCAAAACTACGAAGGTAACGCGGTAGCGAAGAGAGAGGTGTGCTTCAATCCTGGAGGGGCAGCAGGAGGCGGAGCTCT TTTGCTTGGATTCCCATCATGGCCCCTTTGCAGAAAATTGTCTAGGATTTCAGCAACTTCATATTTGTATATGTGAGCTGTGAGAGGTGG CATTCACTTAACTGGCCCAGCCCTCTCTGCTTCGTGATTTTATTTCATTGAATTATAACCACAAGCCACCACCCATTTGACATCCTCTCT GGATTCCCAAGGAGCATACCTCCAAAATCCGAGAAGAGCAAATCAGAGTCTTCAAAATGGATCACCACTAAGGGCATGTTCATTCTTCAC TTTCTTTCTGCTTTTACAAAAGAACTTGGATGTATGTTCCAAAGGGTCCTCATTCTGTTCCTCTTTTGAACTTTTCCTTTTGTCCTTGTA TTAAAGTGGTTTTAAAGGGGTCTAAAAAGATTTTGGCAAAACATATTTGCAGATGTAGATTAGCTGGTGAAGAAAATTACTGCTAGAGAT CAACTGATTAACTGGTAAAGAACGTTTATTTTATAACCCTTGAAGAATAGAAGGACATAGTTGGATTATTGTGTGTGCATTGTATTTTTA CTTCTATTTTTTTTTTGCTTTCCATTTTCCAGTTAGCAGAGATAAAATGAGAGCGTTTTAACTTCAATGTACCATTTTACTGAGTGCTAA GGAAGCATATCAATTCCAATATTTTATAACCAAAGCTCTATCAGAACATATTTATAAAACTTGTTGGAATTTTTACGGCTTTTGTGTAGT CATGTAGGTAAATCATTTAAAATATAAAACAATCTCAATTTAGATCAAGGGTTATTTCTTAGATCAAATTTATGCCAATTATATGAAAAG ATTTTAACTCCGAGACAGGAGTCTTTCAGTGCTGAATTTTTAGACTGTAAATGAGTTCTTCTTAACTTAGCTGTTTCCCTACTTCTGTGA CTTCTGTGTTAGCCATCTTATTTCTTTAAAATCTGAGTCCTGATTGGCTTAATGATTTTGCAGCAGACATGTCTCCACATATTCTCAAAT GCTGTCATGCGGAAACGTATGAAACAGATGAAGAATGACTGACCCAGATTTTAGATGTATAATGTTGTTAAAGTACATACTACTGTAAAA ATATGGGATGAATTTTATATATTAAGAAATGCCAAAAACATAGTTTCTGCACCAAGTTAATTATCCCTGTCCTTTCACATTTATAGGGGG AAAATAAATACTTTAATGTTGTTTATAGCCTAACAGTTATTTGATTTTATTCTTGCAGAGGGAATGGAAAGGAATGGAAAGATTTGTTGG |
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FusionGenePPI for RARB_FAM19A4 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| RARB | NCOA1, CEBPA, CEBPB, GATA3, RXRG, HR, RXRA, NCOR2, RXRB, PNRC1, MAP6, HACE1, SMAD2, PRKD2, CCNH, ITGB1BP2, MEOX2, ARID1A, SMARCE1, SMARCD3, PSMC5, RARA | FAM19A4 | APP, APPBP2, NRXN3, SEZ6L2, AVL9, VCAN, LRRC4B, PLXNA2, SUSD5, MRC2, TM7SF3, LIFR, LEPR, ITGA5, CNTNAP1, ITPR2, PTS, TGFBR3, GPLD1, INSR, COL6A2, MIOS, ITPR3, MIA3, PLXNA1, NRP1, M6PR, B4GALT6, ITPR1, FAM175B, SSFA2, PTPRU, TMEM67, ZYG11B, ITGA4, DSC2, FREM2, HS6ST1, SORL1, ITGB1, CLN5, POMGNT2, CTAGE5, ZER1, LRP11, MOXD1, TCTN2, FN1, PRCP, TCTN1, MGRN1, LRP2 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for RARB_FAM19A4 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Hgene | RARB | P10826 | DB00210 | Adapalene | Retinoic acid receptor beta | small molecule | approved |
| Hgene | RARB | P10826 | DB00459 | Acitretin | Retinoic acid receptor beta | small molecule | approved |
| Hgene | RARB | P10826 | DB00523 | Alitretinoin | Retinoic acid receptor beta | small molecule | approved|investigational |
| Hgene | RARB | P10826 | DB00799 | Tazarotene | Retinoic acid receptor beta | small molecule | approved|investigational |
| Hgene | RARB | P10826 | DB00755 | Tretinoin | Retinoic acid receptor beta | small molecule | approved|investigational|nutraceutical |
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RelatedDiseases for RARB_FAM19A4 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | RARB | C0001418 | Adenocarcinoma | 1 | CTD_human |
| Hgene | RARB | C0007137 | Squamous cell carcinoma | 1 | CTD_human |
| Hgene | RARB | C0007873 | Uterine Cervical Neoplasm | 1 | CTD_human |
| Hgene | RARB | C0014175 | Endometriosis | 1 | CTD_human |
| Hgene | RARB | C0018671 | Head and Neck Neoplasms | 1 | CTD_human |
| Hgene | RARB | C0024121 | Lung Neoplasms | 1 | CTD_human |
| Hgene | RARB | C0038356 | Stomach Neoplasms | 1 | CTD_human |
| Hgene | RARB | C0149940 | Sciatic Neuropathy | 1 | CTD_human |
| Hgene | RARB | C1458155 | Mammary Neoplasms | 1 | CTD_human |
| Hgene | RARB | C3809803 | MICROPHTHALMIA, SYNDROMIC 12 | 1 | UNIPROT |
| Tgene | FAM19A4 | C1458155 | Mammary Neoplasms | 1 | CTD_human |
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