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Fusion gene ID: 30442 |
FusionGeneSummary for RAPGEF5_LUC7L2 |
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Fusion gene information | Fusion gene name: RAPGEF5_LUC7L2 | Fusion gene ID: 30442 | Hgene | Tgene | Gene symbol | RAPGEF5 | LUC7L2 | Gene ID | 9771 | 51631 |
Gene name | Rap guanine nucleotide exchange factor 5 | LUC7 like 2, pre-mRNA splicing factor | |
Synonyms | GFR|MR-GEF|REPAC | CGI-59|CGI-74|LUC7B2 | |
Cytomap | 7p15.3 | 7q34 | |
Type of gene | protein-coding | protein-coding | |
Description | rap guanine nucleotide exchange factor 5M-Ras-regulated GEFM-Ras-regulated Rap GEFRap guanine nucleotide exchange factor (GEF) 5guanine nucleotide exchange factor for Rap1related to Epac | putative RNA-binding protein Luc7-like 2LUC7-like 2 | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | Q92565 | ||
Ensembl transtripts involved in fusion gene | ENST00000344041, ENST00000475788, ENST00000405243, ENST00000401957, | ENST00000541515, | |
Fusion gene scores | * DoF score | 11 X 11 X 6=726 | 8 X 9 X 4=288 |
# samples | 11 | 11 | |
** MAII score | log2(11/726*10)=-2.72246602447109 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(11/288*10)=-1.38856528791765 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: RAPGEF5 [Title/Abstract] AND LUC7L2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | DA302213 | RAPGEF5 | chr7 | 22232984 | - | LUC7L2 | chr7 | 139060804 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000344041 | ENST00000541515 | RAPGEF5 | chr7 | 22232984 | - | LUC7L2 | chr7 | 139060804 | + |
5UTR-3CDS | ENST00000475788 | ENST00000541515 | RAPGEF5 | chr7 | 22232984 | - | LUC7L2 | chr7 | 139060804 | + |
intron-3CDS | ENST00000405243 | ENST00000541515 | RAPGEF5 | chr7 | 22232984 | - | LUC7L2 | chr7 | 139060804 | + |
Frame-shift | ENST00000401957 | ENST00000541515 | RAPGEF5 | chr7 | 22232984 | - | LUC7L2 | chr7 | 139060804 | + |
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FusionProtFeatures for RAPGEF5_LUC7L2 |
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Hgene | Tgene |
RAPGEF5 | LUC7L2 |
Guanine nucleotide exchange factor (GEF) for RAP1A,RAP2A and MRAS/M-Ras-GTP. Its association with MRAS inhibits Rap1activation. {ECO:0000269|PubMed:10777494,ECO:0000269|PubMed:10934204}. | Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | >RAPGEF5 | chr7:22232984 | chr7:139060804 | ENST00000401957 | - | 1 | 16 | 345_579 | 98 | 581 | Domain | Ras-GEF |
Hgene | >RAPGEF5 | chr7:22232984 | chr7:139060804 | ENST00000401957 | - | 1 | 16 | 68_201 | 98 | 581 | Domain | N-terminal Ras-GEF |
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FusionGeneSequence for RAPGEF5_LUC7L2 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
>In-frame_RAPGEF5_ENST00000344041_chr7_22232984_-_LUC7L2_ENST00000541515_chr7_139060804_+_2435nt GCTGCGGCCGCGGCTGAGGGACCTGCCCGCGCTGCTGCGGAGCGGGCTCACGCTGCGGAGGAAGCGGAGCGCCGCTGGGGGCCGGACTCT ATCAAGAAGAATATCTAATCCGTACCTTGAACATACGCCTTCCCAGATTTATGGAGAGAATTCTTCTTGTGCAGGAAGAGCATTGAGGAA TATTATTATCGTTCAAGCAGCTGACCTGATAAAGGACAGAGTGAACCTCAAGGGGTTTTACAGGAGGAGCTGCGTTGGGTCAGAGCTGGT AGACTGGCTTCTAGAACACTGTCCTTTCGTCCAGTGCAGATCTATGGCCATAGGAGTCTGGCAACTCCTACTGGACATGGGAATTATGTT ATCAGTGGACCAGCATCTATACTTTCAAGATACTTATGTTTTCTACCAGTTTTCCTCTGATGAATGTAGCTACTTGTACTGTGAATTTGA AAGAGAAGAAGAATGGCAAAATGGTGTCAAGCTTTTACTGCAACTTGTGCCTCTCATTCCTGCCAGAGGTGGCATCTGTGAACTGTCTCA TCAGAAAATTGAAGACTCCGAAGAAAGCAGTGATGAAATTCTTGTGCGTCTAACATCTGCGGTGCAGAGAGAGCTAGCAGCTGTTATTGC TTTGAAAGCAAGGAAGTCTGCAATTGAACAAGATGAAGAAAACAACGACAAACATGTAGCTGTAACAGAAGCCGAAAGTGTTCCAGATTC TCAGGCAGGGGTGATGTGCAAGCTCCAGGAAAGAGATGAAATCGGACGAATTGAACTAGTCCAGAAGCTGGCAAAAGAAAACTATCAGTT TTTGCAGACGGACAAAAAAGAACAGGAGAAGTCTGAACACCAAGATGATGAAGTGACGACTGTTCAGGTTAAAGAGCAAGACCAGAGCGT CCTGGTGCTGAAGAAAGTGCAGTGCTGTGGCCCAGCCCCCACAGCTGGGAGTGCGGAGAGCCATTGGAGATATGTGGTGGTGTCCGGGAC CCCGGAGAAGATTTTGGAGCACCTTTTGAATGACTTGCACCTGGAAGAAGTCCAGGACAAAGAAACAGGAGATACAACTCGTCAACGAAT CAAATTCAGTGATGACAGAGTATGCAAGAGTCACCTTCTCAACTGTTGTCCTCATGATGTCCTTTCTGGAACTAGAATGGATCTTGGAGA ATGTCTGAAAGTCCATGACCTGGCTTTAAGAGCGGATTATGAAATTGCATCCAAAGAACAAGATTTTTTCTTTGAACTTGATGCCATGGA TCATCTGCAGTCATTCATTGCAGATTGTGATCGTAGAACAGAAGTGGCCAAGAAAAGATTAGCAGAAACTCAAGAAGAGATTAGTGCTGA AGTAGCAGCAAAGGCAGAACGTGTTCATGAGTTAAATGAAGAAATTGGTAAATTGTTAGCCAAGGTGGAACAACTAGGAGCTGAAGGGAA TGTGGAGGAATCCCAGAAAGTAATGGATGAAGTAGAGAAAGCACGGGCAAAGAAAAGAGAAGCAGAGGAAGTTTATCGGAATTCTATGCC AGCTTCCAGTTTTCAGCAGCAGAAACTTCGAGTCTGTGAAGTCTGCTCTGCCTATTTAGGACTTCATGATAATGACAGACGACTGGCTGA TCATTTTGGGGGTAAACTGCACCTGGGATTTATTGAAATAAGAGAGAAGCTTGAAGAATTAAAGAGAGTCGTAGCTGAGAAGCAGGAGAA AAGAAACCAGGAACGGCTGAAACGAAGAGAAGAGAGAGAGAGAGAAGAAAGGGAGAAGCTGAGGAGGTCCCGATCACACAGCAAGAATCC AAAAAGATCCAGGTCCAGAGAGCATCGCAGACATCGATCTCGCTCCATGTCACGTGAACGCAAGAGGAGAACTCGATCCAAATCTCGGGA GAAACGCCATCGCCACAGGTCCCGCTCCAGCAGCCGTAGCCGCAGCCGTAGCCACCAGAGAAGTCGGCACAGTTCTAGAGATAGGAGCAG AGAACGATCCAAGAGGAGATCCTCAAAAGAAAGATTCAGAGACCAAGACTTAGCATCATGTGACAGAGACAGGAGTTCAAGAGACAGATC ACCTCGTGACAGAGATCGGAAAGATAAGAAGCGGTCCTATGAGAGTGCTAATGGCAGATCAGAAGACAGGAGGAGCTCTGAAGAGCGCGA AGCAGGGGAGATCTAACTAGCTGTGTACATTTCTTCAGTCCTTAAGCTTCCTACGGAGTTACGTACTATTGTTTAGTTCACAGCTGTTCA GGGTGACAGTGAGCAGATCCAGACACCAGATCCAGCTAGGCTAGATGTACAGTATCTAACTTGATCTGAACTGAACCTGTTTTCCTTGAT GATGCCTAAAACTACATCCATAGTTTCTGGTGAACCTGTAATACAGTTCTGAAAGTACAGTTTTATATAATAAGATGCTGATCTCTTTAT |
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FusionGenePPI for RAPGEF5_LUC7L2 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
RAPGEF5 | RAP2A, RAP1A, MRAS, KCND3, PLAC9, VANGL1, TMEM253, ANK3, ANK1, MAPK8IP2, ANK2, DDHD2, TUBB1, HSP90AA4P, CCDC88A, UBB, HERC1, PPFIBP1, RICTOR, PLEC, ZNHIT2, WNK1, PRKAR1B, PPP2R5D, PRKACB, PIK3CB, FLNC, ATP2B2 | LUC7L2 | RNPS1, YWHAG, YWHAQ, PTCD3, LUC7L2, PEA15, NKAP, SSFA2, SVIL, KLHL20, ALB, ATRX, LINC00341, NAT9, NDUFA4L2, LPL, UNC119, MAN2A2, MAP1LC3B, FAM173A, NAP1L5, NASP, NUTF2, OFD1, SAT1, ZCCHC10, CDK5RAP2, CCDC53, FXR1, CHD3, KIAA1377, PTN, NSF, ULK2, RRP1B, MEPCE, IKBKG, NEDD4, RBM39, NOP56, NDEL1, EXOC1, GSK3B, GADD45G, AIMP2, PDPK1, CDC37, CDK4, SETDB1, PIK3R3, JMJD6, ELAVL1, CUL3, COPS5, CAND1, HAP1, APP, RPL19, RPL15, RPL18A, RPL7A, RPS4X, SNRPD2, RPLP0P6, BARD1, PAXIP1, CD81, SRPK2, SRPK1, TARDBP, CARS, HSPA4L, ARFIP1, ATP6V1C1, PBDC1, IVNS1ABP, MAN2B1, STAT3, SHMT2, STAU1, HUWE1, NFYA, SRSF6, SRSF7, APPBP2, EZH2, SUZ12, RNF2, EAF1, TRA2A, ZRANB2, LUC7L, CSNK2A2, LARP7, ZC3H18, BCLAF1, THRAP3, PRPF4B, CCDC9, ACIN1, C17orf85, C1QBP, PABPC4, GPATCH8, U2AF2, PAIP1, UBE2O, RBM22, PNN, LARP1, LARP1B, SRSF1, SNW1, CLASRP, PAIP2B, SRRT, CSNK2A1, CCDC12, LUC7L3, MOV10, CDC40, DDX46, SF3A1, ZC3H14, CPSF6, SNRNP27, CLK3, IK, CASC3, FAM98A, FTL, SNRNP70, MKRN2, SCAF11, MKRN1, TRA2B, SRSF8, SRSF12, SRSF10, SREK1, CLK2, HNRNPR, DDX5, PABPC1, PRPF6, PRPF8, RBM8A, RPL22, SNRPD3, SRSF11, TIA1, SF3B3, SNRNP200, SNRPD1, SNRPE, SYNCRIP, U2AF1, SFN, NTRK1, CNTRL, OTUB1, RC3H1, CRBN, FTH1, PPIL4, ISY1, SRRM2, INO80B, RPAP3, FOXA1, TRIM25, UHRF2 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for RAPGEF5_LUC7L2 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for RAPGEF5_LUC7L2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | RAPGEF5 | C0005586 | Bipolar Disorder | 1 | PSYGENET |
Hgene | RAPGEF5 | C0033975 | Psychotic Disorders | 1 | PSYGENET |
Hgene | RAPGEF5 | C0036341 | Schizophrenia | 1 | PSYGENET |
Hgene | RAPGEF5 | C0041696 | Unipolar Depression | 1 | PSYGENET |
Hgene | RAPGEF5 | C0236733 | Amphetamine-Related Disorders | 1 | CTD_human |
Hgene | RAPGEF5 | C0349204 | Nonorganic psychosis | 1 | PSYGENET |
Hgene | RAPGEF5 | C1269683 | Major Depressive Disorder | 1 | PSYGENET |