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Fusion gene ID: 30405 |
FusionGeneSummary for RAP1GDS1_SCD5 |
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Fusion gene information | Fusion gene name: RAP1GDS1_SCD5 | Fusion gene ID: 30405 | Hgene | Tgene | Gene symbol | RAP1GDS1 | SCD5 | Gene ID | 5910 | 79966 |
Gene name | Rap1 GTPase-GDP dissociation stimulator 1 | stearoyl-CoA desaturase 5 | |
Synonyms | GDS1|SmgGDS | ACOD4|FADS4|HSCD5|SCD2|SCD4 | |
Cytomap | 4q23 | 4q21.22 | |
Type of gene | protein-coding | protein-coding | |
Description | rap1 GTPase-GDP dissociation stimulator 1RAP1, GTP-GDP dissociation stimulator 1SMG GDS proteinSMG P21 stimulatory GDP/GTP exchange proteinexchange factor smgGDS | stearoyl-CoA desaturase 5acyl-CoA-desaturase 4stearoyl-CoA 9-desaturasestearoyl-CoA desaturase 2stearoyl-CoA desaturase 4 | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | P52306 | Q86SK9 | |
Ensembl transtripts involved in fusion gene | ENST00000380158, ENST00000264572, ENST00000408927, ENST00000512857, ENST00000453712, ENST00000339360, ENST00000408900, | ENST00000319540, ENST00000273908, ENST00000282709, | |
Fusion gene scores | * DoF score | 6 X 5 X 4=120 | 4 X 2 X 5=40 |
# samples | 6 | 5 | |
** MAII score | log2(6/120*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/40*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: RAP1GDS1 [Title/Abstract] AND SCD5 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | SCD5 | GO:0006636 | unsaturated fatty acid biosynthetic process | 15907797 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | PRAD | TCGA-HC-7212-01A | RAP1GDS1 | chr4 | 99325753 | + | SCD5 | chr4 | 83557976 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000380158 | ENST00000319540 | RAP1GDS1 | chr4 | 99325753 | + | SCD5 | chr4 | 83557976 | - |
5CDS-intron | ENST00000380158 | ENST00000273908 | RAP1GDS1 | chr4 | 99325753 | + | SCD5 | chr4 | 83557976 | - |
5CDS-intron | ENST00000380158 | ENST00000282709 | RAP1GDS1 | chr4 | 99325753 | + | SCD5 | chr4 | 83557976 | - |
Frame-shift | ENST00000264572 | ENST00000319540 | RAP1GDS1 | chr4 | 99325753 | + | SCD5 | chr4 | 83557976 | - |
5CDS-intron | ENST00000264572 | ENST00000273908 | RAP1GDS1 | chr4 | 99325753 | + | SCD5 | chr4 | 83557976 | - |
5CDS-intron | ENST00000264572 | ENST00000282709 | RAP1GDS1 | chr4 | 99325753 | + | SCD5 | chr4 | 83557976 | - |
Frame-shift | ENST00000408927 | ENST00000319540 | RAP1GDS1 | chr4 | 99325753 | + | SCD5 | chr4 | 83557976 | - |
5CDS-intron | ENST00000408927 | ENST00000273908 | RAP1GDS1 | chr4 | 99325753 | + | SCD5 | chr4 | 83557976 | - |
5CDS-intron | ENST00000408927 | ENST00000282709 | RAP1GDS1 | chr4 | 99325753 | + | SCD5 | chr4 | 83557976 | - |
intron-3CDS | ENST00000512857 | ENST00000319540 | RAP1GDS1 | chr4 | 99325753 | + | SCD5 | chr4 | 83557976 | - |
intron-intron | ENST00000512857 | ENST00000273908 | RAP1GDS1 | chr4 | 99325753 | + | SCD5 | chr4 | 83557976 | - |
intron-intron | ENST00000512857 | ENST00000282709 | RAP1GDS1 | chr4 | 99325753 | + | SCD5 | chr4 | 83557976 | - |
Frame-shift | ENST00000453712 | ENST00000319540 | RAP1GDS1 | chr4 | 99325753 | + | SCD5 | chr4 | 83557976 | - |
5CDS-intron | ENST00000453712 | ENST00000273908 | RAP1GDS1 | chr4 | 99325753 | + | SCD5 | chr4 | 83557976 | - |
5CDS-intron | ENST00000453712 | ENST00000282709 | RAP1GDS1 | chr4 | 99325753 | + | SCD5 | chr4 | 83557976 | - |
Frame-shift | ENST00000339360 | ENST00000319540 | RAP1GDS1 | chr4 | 99325753 | + | SCD5 | chr4 | 83557976 | - |
5CDS-intron | ENST00000339360 | ENST00000273908 | RAP1GDS1 | chr4 | 99325753 | + | SCD5 | chr4 | 83557976 | - |
5CDS-intron | ENST00000339360 | ENST00000282709 | RAP1GDS1 | chr4 | 99325753 | + | SCD5 | chr4 | 83557976 | - |
Frame-shift | ENST00000408900 | ENST00000319540 | RAP1GDS1 | chr4 | 99325753 | + | SCD5 | chr4 | 83557976 | - |
5CDS-intron | ENST00000408900 | ENST00000273908 | RAP1GDS1 | chr4 | 99325753 | + | SCD5 | chr4 | 83557976 | - |
5CDS-intron | ENST00000408900 | ENST00000282709 | RAP1GDS1 | chr4 | 99325753 | + | SCD5 | chr4 | 83557976 | - |
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FusionProtFeatures for RAP1GDS1_SCD5 |
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Hgene | Tgene |
RAP1GDS1 | SCD5 |
Stearyl-CoA desaturase that utilizes O(2) and electronsfrom reduced cytochrome b5 to introduce the first double bond intosaturated fatty acyl-CoA substrates. Catalyzes the insertion of acis double bond at the delta-9 position into fatty acyl-CoAsubstrates including palmitoyl-CoA and stearoyl-CoA(PubMed:15907797, PubMed:15610069). Gives rise to a mixture of16:1 and 18:1 unsaturated fatty acids.{ECO:0000269|PubMed:15610069, ECO:0000269|PubMed:15907797}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for RAP1GDS1_SCD5 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for RAP1GDS1_SCD5 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
RAP1GDS1 | NRAS, RHOA, RAP1A, HRAS, KRAS, RAC1, MBIP, ZNF451, KIFAP3, EGFR, CDC42, DCPS, GAPDH, GINS3, HSPA1L, NAE1, OLA1, PAFAH1B2, PPP1R2, PTMA, ABHD14A, ASNS, CAPN1, ECHS1, GMDS, GSS, HSPA5, HSPA9, MSN, PDIA4, PFAS, PPP5C, TATDN1, UBQLN1, USP14, VCL, YWHAE, DOC2A, PLEKHB1, MOV10, DIRAS3, RAB34, RASD2, HDAC7, APBB2, RAB1B, SNX24, GNAI1, GNAZ, SEPT12, TSC22D4, RAB31, RASL10A, SEPT6, BAIAP2, HSPB9, C2orf48, UNC45A, NTRK1, PUF60, CDK2, DUSP23, DIRAS1, UBTF, DIRAS2, RAC3, PRDM10, RAP2C, RAP1B, DNAL1, RHOF, RHOC, RAB15, RABL3, RBM42, IRGC, VASH1, NKIRAS2, IL13RA1, RAC2, ARL4C, NT5C, TRIM25 | SCD5 | CNDP1, PPP2R1A, UQCRC2, TCTN2, TCTN3 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for RAP1GDS1_SCD5 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for RAP1GDS1_SCD5 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |