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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 30402

FusionGeneSummary for RAP1GDS1_GSTCD

check button Fusion gene summary
Fusion gene informationFusion gene name: RAP1GDS1_GSTCD
Fusion gene ID: 30402
HgeneTgene
Gene symbol

RAP1GDS1

GSTCD

Gene ID

5910

79807

Gene nameRap1 GTPase-GDP dissociation stimulator 1glutathione S-transferase C-terminal domain containing
SynonymsGDS1|SmgGDS-
Cytomap

4q23

4q24

Type of geneprotein-codingprotein-coding
Descriptionrap1 GTPase-GDP dissociation stimulator 1RAP1, GTP-GDP dissociation stimulator 1SMG GDS proteinSMG P21 stimulatory GDP/GTP exchange proteinexchange factor smgGDSglutathione S-transferase C-terminal domain-containing protein
Modification date2018052320180523
UniProtAcc

P52306

Q8NEC7

Ensembl transtripts involved in fusion geneENST00000380158, ENST00000264572, 
ENST00000408927, ENST00000512857, 
ENST00000453712, ENST00000339360, 
ENST00000408900, 		ENST00000515255, 
ENST00000394730, ENST00000515279, 
ENST00000360505, ENST00000394728, 
ENST00000507281, 
Fusion gene scores* DoF score6 X 5 X 4=1204 X 2 X 3=24
# samples 64
** MAII scorelog2(6/120*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/24*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: RAP1GDS1 [Title/Abstract] AND GSTCD [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVHNSCTCGA-CR-7388-01ARAP1GDS1chr4

99273752

+GSTCDchr4

106766598

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000380158ENST00000515255RAP1GDS1chr4

99273752

+GSTCDchr4

106766598

+
5CDS-3UTRENST00000380158ENST00000394730RAP1GDS1chr4

99273752

+GSTCDchr4

106766598

+
5CDS-3UTRENST00000380158ENST00000515279RAP1GDS1chr4

99273752

+GSTCDchr4

106766598

+
5CDS-3UTRENST00000380158ENST00000360505RAP1GDS1chr4

99273752

+GSTCDchr4

106766598

+
5CDS-3UTRENST00000380158ENST00000394728RAP1GDS1chr4

99273752

+GSTCDchr4

106766598

+
5CDS-intronENST00000380158ENST00000507281RAP1GDS1chr4

99273752

+GSTCDchr4

106766598

+
5CDS-3UTRENST00000264572ENST00000515255RAP1GDS1chr4

99273752

+GSTCDchr4

106766598

+
5CDS-3UTRENST00000264572ENST00000394730RAP1GDS1chr4

99273752

+GSTCDchr4

106766598

+
5CDS-3UTRENST00000264572ENST00000515279RAP1GDS1chr4

99273752

+GSTCDchr4

106766598

+
5CDS-3UTRENST00000264572ENST00000360505RAP1GDS1chr4

99273752

+GSTCDchr4

106766598

+
5CDS-3UTRENST00000264572ENST00000394728RAP1GDS1chr4

99273752

+GSTCDchr4

106766598

+
5CDS-intronENST00000264572ENST00000507281RAP1GDS1chr4

99273752

+GSTCDchr4

106766598

+
5CDS-3UTRENST00000408927ENST00000515255RAP1GDS1chr4

99273752

+GSTCDchr4

106766598

+
5CDS-3UTRENST00000408927ENST00000394730RAP1GDS1chr4

99273752

+GSTCDchr4

106766598

+
5CDS-3UTRENST00000408927ENST00000515279RAP1GDS1chr4

99273752

+GSTCDchr4

106766598

+
5CDS-3UTRENST00000408927ENST00000360505RAP1GDS1chr4

99273752

+GSTCDchr4

106766598

+
5CDS-3UTRENST00000408927ENST00000394728RAP1GDS1chr4

99273752

+GSTCDchr4

106766598

+
5CDS-intronENST00000408927ENST00000507281RAP1GDS1chr4

99273752

+GSTCDchr4

106766598

+
3UTR-3UTRENST00000512857ENST00000515255RAP1GDS1chr4

99273752

+GSTCDchr4

106766598

+
3UTR-3UTRENST00000512857ENST00000394730RAP1GDS1chr4

99273752

+GSTCDchr4

106766598

+
3UTR-3UTRENST00000512857ENST00000515279RAP1GDS1chr4

99273752

+GSTCDchr4

106766598

+
3UTR-3UTRENST00000512857ENST00000360505RAP1GDS1chr4

99273752

+GSTCDchr4

106766598

+
3UTR-3UTRENST00000512857ENST00000394728RAP1GDS1chr4

99273752

+GSTCDchr4

106766598

+
3UTR-intronENST00000512857ENST00000507281RAP1GDS1chr4

99273752

+GSTCDchr4

106766598

+
5CDS-3UTRENST00000453712ENST00000515255RAP1GDS1chr4

99273752

+GSTCDchr4

106766598

+
5CDS-3UTRENST00000453712ENST00000394730RAP1GDS1chr4

99273752

+GSTCDchr4

106766598

+
5CDS-3UTRENST00000453712ENST00000515279RAP1GDS1chr4

99273752

+GSTCDchr4

106766598

+
5CDS-3UTRENST00000453712ENST00000360505RAP1GDS1chr4

99273752

+GSTCDchr4

106766598

+
5CDS-3UTRENST00000453712ENST00000394728RAP1GDS1chr4

99273752

+GSTCDchr4

106766598

+
5CDS-intronENST00000453712ENST00000507281RAP1GDS1chr4

99273752

+GSTCDchr4

106766598

+
5CDS-3UTRENST00000339360ENST00000515255RAP1GDS1chr4

99273752

+GSTCDchr4

106766598

+
5CDS-3UTRENST00000339360ENST00000394730RAP1GDS1chr4

99273752

+GSTCDchr4

106766598

+
5CDS-3UTRENST00000339360ENST00000515279RAP1GDS1chr4

99273752

+GSTCDchr4

106766598

+
5CDS-3UTRENST00000339360ENST00000360505RAP1GDS1chr4

99273752

+GSTCDchr4

106766598

+
5CDS-3UTRENST00000339360ENST00000394728RAP1GDS1chr4

99273752

+GSTCDchr4

106766598

+
5CDS-intronENST00000339360ENST00000507281RAP1GDS1chr4

99273752

+GSTCDchr4

106766598

+
5CDS-3UTRENST00000408900ENST00000515255RAP1GDS1chr4

99273752

+GSTCDchr4

106766598

+
5CDS-3UTRENST00000408900ENST00000394730RAP1GDS1chr4

99273752

+GSTCDchr4

106766598

+
5CDS-3UTRENST00000408900ENST00000515279RAP1GDS1chr4

99273752

+GSTCDchr4

106766598

+
5CDS-3UTRENST00000408900ENST00000360505RAP1GDS1chr4

99273752

+GSTCDchr4

106766598

+
5CDS-3UTRENST00000408900ENST00000394728RAP1GDS1chr4

99273752

+GSTCDchr4

106766598

+
5CDS-intronENST00000408900ENST00000507281RAP1GDS1chr4

99273752

+GSTCDchr4

106766598

+

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FusionProtFeatures for RAP1GDS1_GSTCD


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RAP1GDS1

P52306

GSTCD

Q8NEC7


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for RAP1GDS1_GSTCD


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for RAP1GDS1_GSTCD


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
RAP1GDS1NRAS, RHOA, RAP1A, HRAS, KRAS, RAC1, MBIP, ZNF451, KIFAP3, EGFR, CDC42, DCPS, GAPDH, GINS3, HSPA1L, NAE1, OLA1, PAFAH1B2, PPP1R2, PTMA, ABHD14A, ASNS, CAPN1, ECHS1, GMDS, GSS, HSPA5, HSPA9, MSN, PDIA4, PFAS, PPP5C, TATDN1, UBQLN1, USP14, VCL, YWHAE, DOC2A, PLEKHB1, MOV10, DIRAS3, RAB34, RASD2, HDAC7, APBB2, RAB1B, SNX24, GNAI1, GNAZ, SEPT12, TSC22D4, RAB31, RASL10A, SEPT6, BAIAP2, HSPB9, C2orf48, UNC45A, NTRK1, PUF60, CDK2, DUSP23, DIRAS1, UBTF, DIRAS2, RAC3, PRDM10, RAP2C, RAP1B, DNAL1, RHOF, RHOC, RAB15, RABL3, RBM42, IRGC, VASH1, NKIRAS2, IL13RA1, RAC2, ARL4C, NT5C, TRIM25GSTCDKDM1A, PRMT6, SUV39H2, BMP7, DAPP1, STAT3, TNS4, CLNK, XPO1, PLA2G10, C5AR2, FZD10, PHF19


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for RAP1GDS1_GSTCD


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for RAP1GDS1_GSTCD


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneGSTCDC0033578Prostatic Neoplasms1CTD_human