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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 30400

FusionGeneSummary for RAP1GDS1_ASTN2

check button Fusion gene summary
Fusion gene informationFusion gene name: RAP1GDS1_ASTN2
Fusion gene ID: 30400
HgeneTgene
Gene symbol

RAP1GDS1

ASTN2

Gene ID

5910

23245

Gene nameRap1 GTPase-GDP dissociation stimulator 1astrotactin 2
SynonymsGDS1|SmgGDSbA67K19.1
Cytomap

4q23

9q33.1

Type of geneprotein-codingprotein-coding
Descriptionrap1 GTPase-GDP dissociation stimulator 1RAP1, GTP-GDP dissociation stimulator 1SMG GDS proteinSMG P21 stimulatory GDP/GTP exchange proteinexchange factor smgGDSastrotactin-2
Modification date2018052320180519
UniProtAcc

P52306

O75129

Ensembl transtripts involved in fusion geneENST00000380158, ENST00000264572, 
ENST00000408927, ENST00000512857, 
ENST00000453712, ENST00000339360, 
ENST00000408900, 		ENST00000373996, 
ENST00000313400, ENST00000361209, 
ENST00000361477, ENST00000288520, 
ENST00000341734, ENST00000358637, 
Fusion gene scores* DoF score6 X 5 X 4=12011 X 9 X 8=792
# samples 612
** MAII scorelog2(6/120*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(12/792*10)=-2.72246602447109
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RAP1GDS1 [Title/Abstract] AND ASTN2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVPRADTCGA-G9-6361-01ARAP1GDS1chr4

99342545

+ASTN2chr9

119414072

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000380158ENST00000373996RAP1GDS1chr4

99342545

+ASTN2chr9

119414072

-
Frame-shiftENST00000380158ENST00000313400RAP1GDS1chr4

99342545

+ASTN2chr9

119414072

-
Frame-shiftENST00000380158ENST00000361209RAP1GDS1chr4

99342545

+ASTN2chr9

119414072

-
5CDS-5UTRENST00000380158ENST00000361477RAP1GDS1chr4

99342545

+ASTN2chr9

119414072

-
5CDS-5UTRENST00000380158ENST00000288520RAP1GDS1chr4

99342545

+ASTN2chr9

119414072

-
5CDS-5UTRENST00000380158ENST00000341734RAP1GDS1chr4

99342545

+ASTN2chr9

119414072

-
5CDS-5UTRENST00000380158ENST00000358637RAP1GDS1chr4

99342545

+ASTN2chr9

119414072

-
Frame-shiftENST00000264572ENST00000373996RAP1GDS1chr4

99342545

+ASTN2chr9

119414072

-
Frame-shiftENST00000264572ENST00000313400RAP1GDS1chr4

99342545

+ASTN2chr9

119414072

-
Frame-shiftENST00000264572ENST00000361209RAP1GDS1chr4

99342545

+ASTN2chr9

119414072

-
5CDS-5UTRENST00000264572ENST00000361477RAP1GDS1chr4

99342545

+ASTN2chr9

119414072

-
5CDS-5UTRENST00000264572ENST00000288520RAP1GDS1chr4

99342545

+ASTN2chr9

119414072

-
5CDS-5UTRENST00000264572ENST00000341734RAP1GDS1chr4

99342545

+ASTN2chr9

119414072

-
5CDS-5UTRENST00000264572ENST00000358637RAP1GDS1chr4

99342545

+ASTN2chr9

119414072

-
Frame-shiftENST00000408927ENST00000373996RAP1GDS1chr4

99342545

+ASTN2chr9

119414072

-
Frame-shiftENST00000408927ENST00000313400RAP1GDS1chr4

99342545

+ASTN2chr9

119414072

-
Frame-shiftENST00000408927ENST00000361209RAP1GDS1chr4

99342545

+ASTN2chr9

119414072

-
5CDS-5UTRENST00000408927ENST00000361477RAP1GDS1chr4

99342545

+ASTN2chr9

119414072

-
5CDS-5UTRENST00000408927ENST00000288520RAP1GDS1chr4

99342545

+ASTN2chr9

119414072

-
5CDS-5UTRENST00000408927ENST00000341734RAP1GDS1chr4

99342545

+ASTN2chr9

119414072

-
5CDS-5UTRENST00000408927ENST00000358637RAP1GDS1chr4

99342545

+ASTN2chr9

119414072

-
intron-3CDSENST00000512857ENST00000373996RAP1GDS1chr4

99342545

+ASTN2chr9

119414072

-
intron-3CDSENST00000512857ENST00000313400RAP1GDS1chr4

99342545

+ASTN2chr9

119414072

-
intron-3CDSENST00000512857ENST00000361209RAP1GDS1chr4

99342545

+ASTN2chr9

119414072

-
intron-5UTRENST00000512857ENST00000361477RAP1GDS1chr4

99342545

+ASTN2chr9

119414072

-
intron-5UTRENST00000512857ENST00000288520RAP1GDS1chr4

99342545

+ASTN2chr9

119414072

-
intron-5UTRENST00000512857ENST00000341734RAP1GDS1chr4

99342545

+ASTN2chr9

119414072

-
intron-5UTRENST00000512857ENST00000358637RAP1GDS1chr4

99342545

+ASTN2chr9

119414072

-
Frame-shiftENST00000453712ENST00000373996RAP1GDS1chr4

99342545

+ASTN2chr9

119414072

-
Frame-shiftENST00000453712ENST00000313400RAP1GDS1chr4

99342545

+ASTN2chr9

119414072

-
Frame-shiftENST00000453712ENST00000361209RAP1GDS1chr4

99342545

+ASTN2chr9

119414072

-
5CDS-5UTRENST00000453712ENST00000361477RAP1GDS1chr4

99342545

+ASTN2chr9

119414072

-
5CDS-5UTRENST00000453712ENST00000288520RAP1GDS1chr4

99342545

+ASTN2chr9

119414072

-
5CDS-5UTRENST00000453712ENST00000341734RAP1GDS1chr4

99342545

+ASTN2chr9

119414072

-
5CDS-5UTRENST00000453712ENST00000358637RAP1GDS1chr4

99342545

+ASTN2chr9

119414072

-
Frame-shiftENST00000339360ENST00000373996RAP1GDS1chr4

99342545

+ASTN2chr9

119414072

-
Frame-shiftENST00000339360ENST00000313400RAP1GDS1chr4

99342545

+ASTN2chr9

119414072

-
Frame-shiftENST00000339360ENST00000361209RAP1GDS1chr4

99342545

+ASTN2chr9

119414072

-
5CDS-5UTRENST00000339360ENST00000361477RAP1GDS1chr4

99342545

+ASTN2chr9

119414072

-
5CDS-5UTRENST00000339360ENST00000288520RAP1GDS1chr4

99342545

+ASTN2chr9

119414072

-
5CDS-5UTRENST00000339360ENST00000341734RAP1GDS1chr4

99342545

+ASTN2chr9

119414072

-
5CDS-5UTRENST00000339360ENST00000358637RAP1GDS1chr4

99342545

+ASTN2chr9

119414072

-
Frame-shiftENST00000408900ENST00000373996RAP1GDS1chr4

99342545

+ASTN2chr9

119414072

-
Frame-shiftENST00000408900ENST00000313400RAP1GDS1chr4

99342545

+ASTN2chr9

119414072

-
Frame-shiftENST00000408900ENST00000361209RAP1GDS1chr4

99342545

+ASTN2chr9

119414072

-
5CDS-5UTRENST00000408900ENST00000361477RAP1GDS1chr4

99342545

+ASTN2chr9

119414072

-
5CDS-5UTRENST00000408900ENST00000288520RAP1GDS1chr4

99342545

+ASTN2chr9

119414072

-
5CDS-5UTRENST00000408900ENST00000341734RAP1GDS1chr4

99342545

+ASTN2chr9

119414072

-
5CDS-5UTRENST00000408900ENST00000358637RAP1GDS1chr4

99342545

+ASTN2chr9

119414072

-

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FusionProtFeatures for RAP1GDS1_ASTN2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RAP1GDS1

P52306

ASTN2

O75129


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for RAP1GDS1_ASTN2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for RAP1GDS1_ASTN2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
RAP1GDS1NRAS, RHOA, RAP1A, HRAS, KRAS, RAC1, MBIP, ZNF451, KIFAP3, EGFR, CDC42, DCPS, GAPDH, GINS3, HSPA1L, NAE1, OLA1, PAFAH1B2, PPP1R2, PTMA, ABHD14A, ASNS, CAPN1, ECHS1, GMDS, GSS, HSPA5, HSPA9, MSN, PDIA4, PFAS, PPP5C, TATDN1, UBQLN1, USP14, VCL, YWHAE, DOC2A, PLEKHB1, MOV10, DIRAS3, RAB34, RASD2, HDAC7, APBB2, RAB1B, SNX24, GNAI1, GNAZ, SEPT12, TSC22D4, RAB31, RASL10A, SEPT6, BAIAP2, HSPB9, C2orf48, UNC45A, NTRK1, PUF60, CDK2, DUSP23, DIRAS1, UBTF, DIRAS2, RAC3, PRDM10, RAP2C, RAP1B, DNAL1, RHOF, RHOC, RAB15, RABL3, RBM42, IRGC, VASH1, NKIRAS2, IL13RA1, RAC2, ARL4C, NT5C, TRIM25ASTN2CCT6B, FBXL12, CCT4


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for RAP1GDS1_ASTN2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for RAP1GDS1_ASTN2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneASTN2C0036341Schizophrenia2PSYGENET
TgeneASTN2C0004352Autistic Disorder1CTD_human
TgeneASTN2C0005586Bipolar Disorder1PSYGENET
TgeneASTN2C0236733Amphetamine-Related Disorders1CTD_human
TgeneASTN2C0338480Common Migraine1CTD_human