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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 3037

FusionGeneSummary for ASTN1_ATP2A3

check button Fusion gene summary
Fusion gene informationFusion gene name: ASTN1_ATP2A3
Fusion gene ID: 3037
HgeneTgene
Gene symbol

ASTN1

ATP2A3

Gene ID

460

489

Gene nameastrotactin 1ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3
SynonymsASTNSERCA3
Cytomap

1q25.2

17p13.2

Type of geneprotein-codingprotein-coding
Descriptionastrotactin-1sarcoplasmic/endoplasmic reticulum calcium ATPase 3ATPase, Ca(2+)-transporting, ubiquitousATPase, Ca++ transporting, ubiquitousSR Ca(2+)-ATPase 3adenosine triphosphatase, calciumcalcium pump 3calcium-translocating P-type ATPasesarco/endoplasmic ret
Modification date2018032920180523
UniProtAcc

O14525

Q93084

Ensembl transtripts involved in fusion geneENST00000367657, ENST00000361833, 
ENST00000367654, ENST00000424564, 
ENST00000281881, 		ENST00000397035, 
ENST00000397041, ENST00000309890, 
ENST00000397039, ENST00000359983, 
ENST00000352011, ENST00000397043, 
Fusion gene scores* DoF score2 X 2 X 1=45 X 3 X 5=75
# samples 25
** MAII scorelog2(2/4*10)=2.32192809488736log2(5/75*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ASTN1 [Title/Abstract] AND ATP2A3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BI025114ASTN1chr1

176884242

+ATP2A3chr17

3855304

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000367657ENST00000397035ASTN1chr1

176884242

+ATP2A3chr17

3855304

-
intron-intronENST00000367657ENST00000397041ASTN1chr1

176884242

+ATP2A3chr17

3855304

-
intron-intronENST00000367657ENST00000309890ASTN1chr1

176884242

+ATP2A3chr17

3855304

-
intron-intronENST00000367657ENST00000397039ASTN1chr1

176884242

+ATP2A3chr17

3855304

-
intron-intronENST00000367657ENST00000359983ASTN1chr1

176884242

+ATP2A3chr17

3855304

-
intron-intronENST00000367657ENST00000352011ASTN1chr1

176884242

+ATP2A3chr17

3855304

-
intron-intronENST00000367657ENST00000397043ASTN1chr1

176884242

+ATP2A3chr17

3855304

-
intron-intronENST00000361833ENST00000397035ASTN1chr1

176884242

+ATP2A3chr17

3855304

-
intron-intronENST00000361833ENST00000397041ASTN1chr1

176884242

+ATP2A3chr17

3855304

-
intron-intronENST00000361833ENST00000309890ASTN1chr1

176884242

+ATP2A3chr17

3855304

-
intron-intronENST00000361833ENST00000397039ASTN1chr1

176884242

+ATP2A3chr17

3855304

-
intron-intronENST00000361833ENST00000359983ASTN1chr1

176884242

+ATP2A3chr17

3855304

-
intron-intronENST00000361833ENST00000352011ASTN1chr1

176884242

+ATP2A3chr17

3855304

-
intron-intronENST00000361833ENST00000397043ASTN1chr1

176884242

+ATP2A3chr17

3855304

-
intron-intronENST00000367654ENST00000397035ASTN1chr1

176884242

+ATP2A3chr17

3855304

-
intron-intronENST00000367654ENST00000397041ASTN1chr1

176884242

+ATP2A3chr17

3855304

-
intron-intronENST00000367654ENST00000309890ASTN1chr1

176884242

+ATP2A3chr17

3855304

-
intron-intronENST00000367654ENST00000397039ASTN1chr1

176884242

+ATP2A3chr17

3855304

-
intron-intronENST00000367654ENST00000359983ASTN1chr1

176884242

+ATP2A3chr17

3855304

-
intron-intronENST00000367654ENST00000352011ASTN1chr1

176884242

+ATP2A3chr17

3855304

-
intron-intronENST00000367654ENST00000397043ASTN1chr1

176884242

+ATP2A3chr17

3855304

-
intron-intronENST00000424564ENST00000397035ASTN1chr1

176884242

+ATP2A3chr17

3855304

-
intron-intronENST00000424564ENST00000397041ASTN1chr1

176884242

+ATP2A3chr17

3855304

-
intron-intronENST00000424564ENST00000309890ASTN1chr1

176884242

+ATP2A3chr17

3855304

-
intron-intronENST00000424564ENST00000397039ASTN1chr1

176884242

+ATP2A3chr17

3855304

-
intron-intronENST00000424564ENST00000359983ASTN1chr1

176884242

+ATP2A3chr17

3855304

-
intron-intronENST00000424564ENST00000352011ASTN1chr1

176884242

+ATP2A3chr17

3855304

-
intron-intronENST00000424564ENST00000397043ASTN1chr1

176884242

+ATP2A3chr17

3855304

-
intron-intronENST00000281881ENST00000397035ASTN1chr1

176884242

+ATP2A3chr17

3855304

-
intron-intronENST00000281881ENST00000397041ASTN1chr1

176884242

+ATP2A3chr17

3855304

-
intron-intronENST00000281881ENST00000309890ASTN1chr1

176884242

+ATP2A3chr17

3855304

-
intron-intronENST00000281881ENST00000397039ASTN1chr1

176884242

+ATP2A3chr17

3855304

-
intron-intronENST00000281881ENST00000359983ASTN1chr1

176884242

+ATP2A3chr17

3855304

-
intron-intronENST00000281881ENST00000352011ASTN1chr1

176884242

+ATP2A3chr17

3855304

-
intron-intronENST00000281881ENST00000397043ASTN1chr1

176884242

+ATP2A3chr17

3855304

-

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FusionProtFeatures for ASTN1_ATP2A3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ASTN1

O14525

ATP2A3

Q93084

Neuronal adhesion molecule that is required for normalmigration of young postmitotic neuroblasts along glial fibers,especially in the cerebellum. Required for normal rate ofmigration of granule cells during brain development and for normalcerebellum development. {ECO:0000250|UniProtKB:Q61137}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ASTN1_ATP2A3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ASTN1_ATP2A3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ASTN1_ATP2A3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ASTN1_ATP2A3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneASTN1C0001973Alcoholic Intoxication, Chronic1PSYGENET
HgeneASTN1C0740858Substance abuse problem1PSYGENET
TgeneATP2A3C0001430Adenoma1CTD_human
TgeneATP2A3C0011853Diabetes Mellitus, Experimental1CTD_human
TgeneATP2A3C0011860Diabetes Mellitus, Non-Insulin-Dependent1CTD_human