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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 30368

FusionGeneSummary for RAN_CD74

check button Fusion gene summary
Fusion gene informationFusion gene name: RAN_CD74
Fusion gene ID: 30368
HgeneTgene
Gene symbol

RAN

CD74

Gene ID

5901

972

Gene nameRAN, member RAS oncogene familyCD74 molecule
SynonymsARA24|Gsp1|TC4DHLAG|HLADG|II|Ia-GAMMA
Cytomap

12q24.33

5q33.1

Type of geneprotein-codingprotein-coding
DescriptionGTP-binding nuclear protein RanGTPase RanOK/SW-cl.81RanGTPaseandrogen receptor-associated protein 24guanosine triphosphatase Ranmember RAS oncogene familyras-like protein TC4ras-related nuclear proteinHLA class II histocompatibility antigen gamma chainCD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)CD74 molecule, major histocompatibility complex, class II invariant chainHLA-DR antigens-associated
Modification date2018052620180522
UniProtAcc

P62826

P04233

Ensembl transtripts involved in fusion geneENST00000543796, ENST00000541630, 
ENST00000392369, ENST00000254675, 
ENST00000392367, 
ENST00000377795, 
ENST00000353334, ENST00000524315, 
ENST00000009530, 
Fusion gene scores* DoF score1 X 1 X 1=116 X 15 X 5=1200
# samples 127
** MAII scorelog2(1/1*10)=3.32192809488736log2(27/1200*10)=-2.15200309344505
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RAN [Title/Abstract] AND CD74 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneRAN

GO:0006606

protein import into nucleus

9822603

HgeneRAN

GO:0006611

protein export from nucleus

16449645

HgeneRAN

GO:0032092

positive regulation of protein binding

16449645

HgeneRAN

GO:0046039

GTP metabolic process

26272610

TgeneCD74

GO:0001516

prostaglandin biosynthetic process

12782713

TgeneCD74

GO:0001934

positive regulation of protein phosphorylation

24942581

TgeneCD74

GO:0002792

negative regulation of peptide secretion

19849849

TgeneCD74

GO:0007165

signal transduction

12782713

TgeneCD74

GO:0008283

cell proliferation

12782713

TgeneCD74

GO:0033674

positive regulation of kinase activity

24942581

TgeneCD74

GO:0043066

negative regulation of apoptotic process

12782713

TgeneCD74

GO:0043123

positive regulation of I-kappaB kinase/NF-kappaB signaling

24942581

TgeneCD74

GO:0043410

positive regulation of MAPK cascade

24942581

TgeneCD74

GO:0043518

negative regulation of DNA damage response, signal transduction by p53 class mediator

17045821

TgeneCD74

GO:0045657

positive regulation of monocyte differentiation

24942581

TgeneCD74

GO:0045893

positive regulation of transcription, DNA-templated

24942581

TgeneCD74

GO:0046598

positive regulation of viral entry into host cell

24942581

TgeneCD74

GO:0050731

positive regulation of peptidyl-tyrosine phosphorylation

17045821

TgeneCD74

GO:0051290

protein heterotetramerization

24942581

TgeneCD74

GO:0070374

positive regulation of ERK1 and ERK2 cascade

17045821|24942581


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BX456619RANchr12

131360564

-CD74chr5

149781555

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3UTRENST00000543796ENST00000377795RANchr12

131360564

-CD74chr5

149781555

-
3UTR-3UTRENST00000543796ENST00000353334RANchr12

131360564

-CD74chr5

149781555

-
3UTR-3UTRENST00000543796ENST00000524315RANchr12

131360564

-CD74chr5

149781555

-
3UTR-intronENST00000543796ENST00000009530RANchr12

131360564

-CD74chr5

149781555

-
3UTR-3UTRENST00000541630ENST00000377795RANchr12

131360564

-CD74chr5

149781555

-
3UTR-3UTRENST00000541630ENST00000353334RANchr12

131360564

-CD74chr5

149781555

-
3UTR-3UTRENST00000541630ENST00000524315RANchr12

131360564

-CD74chr5

149781555

-
3UTR-intronENST00000541630ENST00000009530RANchr12

131360564

-CD74chr5

149781555

-
3UTR-3UTRENST00000392369ENST00000377795RANchr12

131360564

-CD74chr5

149781555

-
3UTR-3UTRENST00000392369ENST00000353334RANchr12

131360564

-CD74chr5

149781555

-
3UTR-3UTRENST00000392369ENST00000524315RANchr12

131360564

-CD74chr5

149781555

-
3UTR-intronENST00000392369ENST00000009530RANchr12

131360564

-CD74chr5

149781555

-
3UTR-3UTRENST00000254675ENST00000377795RANchr12

131360564

-CD74chr5

149781555

-
3UTR-3UTRENST00000254675ENST00000353334RANchr12

131360564

-CD74chr5

149781555

-
3UTR-3UTRENST00000254675ENST00000524315RANchr12

131360564

-CD74chr5

149781555

-
3UTR-intronENST00000254675ENST00000009530RANchr12

131360564

-CD74chr5

149781555

-
intron-3UTRENST00000392367ENST00000377795RANchr12

131360564

-CD74chr5

149781555

-
intron-3UTRENST00000392367ENST00000353334RANchr12

131360564

-CD74chr5

149781555

-
intron-3UTRENST00000392367ENST00000524315RANchr12

131360564

-CD74chr5

149781555

-
intron-intronENST00000392367ENST00000009530RANchr12

131360564

-CD74chr5

149781555

-

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FusionProtFeatures for RAN_CD74


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RAN

P62826

CD74

P04233


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for RAN_CD74


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for RAN_CD74


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for RAN_CD74


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for RAN_CD74


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneRANC0024667Animal Mammary Neoplasms2CTD_human
HgeneRANC0024668Mammary Neoplasms, Experimental2CTD_human
HgeneRANC0019693HIV Infections1CTD_human
HgeneRANC0022548Keloid1CTD_human
HgeneRANC0029408Degenerative polyarthritis1CTD_human
TgeneCD74C0007131Non-Small Cell Lung Carcinoma1CTD_human
TgeneCD74C0023893Liver Cirrhosis, Experimental1CTD_human
TgeneCD74C0162557Liver Failure, Acute1CTD_human
TgeneCD74C1458155Mammary Neoplasms1CTD_human