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Fusion gene ID: 30367 |
FusionGeneSummary for RANGRF_LRP5 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: RANGRF_LRP5 | Fusion gene ID: 30367 | Hgene | Tgene | Gene symbol | RANGRF | LRP5 | Gene ID | 29098 | 4041 |
| Gene name | RAN guanine nucleotide release factor | LDL receptor related protein 5 | |
| Synonyms | HSPC165|HSPC236|MOG1|RANGNRF | BMND1|EVR1|EVR4|HBM|LR3|LRP-5|LRP7|OPPG|OPS|OPTA1|PCLD4|VBCH2 | |
| Cytomap | 17p13.1 | 11q13.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | ran guanine nucleotide release factorMOG1 homologran-binding protein MOG1 | low-density lipoprotein receptor-related protein 5low density lipoprotein receptor-related protein 5low density lipoprotein receptor-related protein 7 | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q9HD47 | O75197 | |
| Ensembl transtripts involved in fusion gene | ENST00000226105, ENST00000407006, ENST00000580434, ENST00000439238, | ENST00000294304, ENST00000529481, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 10 X 9 X 7=630 |
| # samples | 1 | 12 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(12/630*10)=-2.39231742277876 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: RANGRF [Title/Abstract] AND LRP5 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | RANGRF | GO:0003254 | regulation of membrane depolarization | 18184654 |
| Hgene | RANGRF | GO:0042391 | regulation of membrane potential | 18184654 |
| Hgene | RANGRF | GO:1902305 | regulation of sodium ion transmembrane transport | 18184654 |
| Hgene | RANGRF | GO:2000010 | positive regulation of protein localization to cell surface | 18184654 |
| Hgene | RANGRF | GO:2000649 | regulation of sodium ion transmembrane transporter activity | 18184654 |
| Tgene | LRP5 | GO:0008284 | positive regulation of cell proliferation | 9790987 |
| Tgene | LRP5 | GO:0016055 | Wnt signaling pathway | 17955262 |
| Tgene | LRP5 | GO:0044332 | Wnt signaling pathway involved in dorsal/ventral axis specification | 11029007 |
| Tgene | LRP5 | GO:0045840 | positive regulation of mitotic nuclear division | 9790987 |
| Tgene | LRP5 | GO:0045893 | positive regulation of transcription, DNA-templated | 15035989|17955262 |
| Tgene | LRP5 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 12857724 |
| Tgene | LRP5 | GO:0060070 | canonical Wnt signaling pathway | 12121999|12857724|15035989 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-A2-A0CT-01A | RANGRF | chr17 | 8192732 | + | LRP5 | chr11 | 68177382 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000226105 | ENST00000294304 | RANGRF | chr17 | 8192732 | + | LRP5 | chr11 | 68177382 | + |
| 5CDS-intron | ENST00000226105 | ENST00000529481 | RANGRF | chr17 | 8192732 | + | LRP5 | chr11 | 68177382 | + |
| In-frame | ENST00000407006 | ENST00000294304 | RANGRF | chr17 | 8192732 | + | LRP5 | chr11 | 68177382 | + |
| 5CDS-intron | ENST00000407006 | ENST00000529481 | RANGRF | chr17 | 8192732 | + | LRP5 | chr11 | 68177382 | + |
| In-frame | ENST00000580434 | ENST00000294304 | RANGRF | chr17 | 8192732 | + | LRP5 | chr11 | 68177382 | + |
| 5CDS-intron | ENST00000580434 | ENST00000529481 | RANGRF | chr17 | 8192732 | + | LRP5 | chr11 | 68177382 | + |
| In-frame | ENST00000439238 | ENST00000294304 | RANGRF | chr17 | 8192732 | + | LRP5 | chr11 | 68177382 | + |
| 5CDS-intron | ENST00000439238 | ENST00000529481 | RANGRF | chr17 | 8192732 | + | LRP5 | chr11 | 68177382 | + |
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FusionProtFeatures for RANGRF_LRP5 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| RANGRF | LRP5 |
| May regulate the intracellular trafficking of RAN(PubMed:11290418). Promotes guanine nucleotide release from RANand inhibits binding of new GTP by preventing the binding of theRAN guanine nucleotide exchange factor RCC1 (PubMed:29040603).Regulates the levels of GTP-bound RAN in the nucleus, and therebyplays a role in the regulation of RAN-dependent mitotic spindledynamics (PubMed:29040603). Enhances the expression of SCN5A atthe cell membrane in cardiomyocytes (PubMed:18184654,PubMed:23420830, PubMed:21621375). {ECO:0000269|PubMed:11290418,ECO:0000269|PubMed:18184654, ECO:0000269|PubMed:21621375,ECO:0000269|PubMed:23420830, ECO:0000269|PubMed:29040603}. | Component of the Wnt-Fzd-LRP5-LRP6 complex that triggersbeta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Cell-surfacecoreceptor of Wnt/beta-catenin signaling, which plays a pivotalrole in bone formation. Plays a role in norrin (NDP) signaltransduction (PubMed:27228167). The Wnt-induced Fzd/LRP6coreceptor complex recruits DVL1 polymers to the plasma membranewhich, in turn, recruits the AXIN1/GSK3B-complex to the cellsurface promoting the formation of signalsomes and inhibitingAXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin. Appears be required for postnatal control of vascularregression in the eye (By similarity). Required for posteriorpatterning of the epiblast during gastrulation (By similarity).{ECO:0000250|UniProtKB:Q91VN0, ECO:0000269|PubMed:11336703,ECO:0000269|PubMed:11448771, ECO:0000269|PubMed:14727154,ECO:0000269|PubMed:14731402, ECO:0000269|PubMed:15778503,ECO:0000269|PubMed:27228167}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >LRP5 | chr17:8192732 | chr11:68177382 | ENST00000294304 | + | 8 | 23 | 1495_1610 | 697 | 1616 | Compositional bias | Note=Pro-rich |
| Tgene | >LRP5 | chr17:8192732 | chr11:68177382 | ENST00000294304 | + | 8 | 23 | 1213_1254 | 697 | 1616 | Domain | Note=EGF-like 4 |
| Tgene | >LRP5 | chr17:8192732 | chr11:68177382 | ENST00000294304 | + | 8 | 23 | 1258_1296 | 697 | 1616 | Domain | LDL-receptor class A 1 |
| Tgene | >LRP5 | chr17:8192732 | chr11:68177382 | ENST00000294304 | + | 8 | 23 | 1297_1333 | 697 | 1616 | Domain | LDL-receptor class A 2 |
| Tgene | >LRP5 | chr17:8192732 | chr11:68177382 | ENST00000294304 | + | 8 | 23 | 1335_1371 | 697 | 1616 | Domain | LDL-receptor class A 3 |
| Tgene | >LRP5 | chr17:8192732 | chr11:68177382 | ENST00000294304 | + | 8 | 23 | 902_942 | 697 | 1616 | Domain | Note=EGF-like 3 |
| Tgene | >LRP5 | chr17:8192732 | chr11:68177382 | ENST00000294304 | + | 8 | 23 | 1500_1506 | 697 | 1616 | Motif | Note=PPPSP motif A |
| Tgene | >LRP5 | chr17:8192732 | chr11:68177382 | ENST00000294304 | + | 8 | 23 | 1538_1545 | 697 | 1616 | Motif | Note=PPPSP motif B |
| Tgene | >LRP5 | chr17:8192732 | chr11:68177382 | ENST00000294304 | + | 8 | 23 | 1574_1581 | 697 | 1616 | Motif | Note=PPPSP motif C |
| Tgene | >LRP5 | chr17:8192732 | chr11:68177382 | ENST00000294304 | + | 8 | 23 | 1591_1596 | 697 | 1616 | Motif | Note=PPPSP motif D |
| Tgene | >LRP5 | chr17:8192732 | chr11:68177382 | ENST00000294304 | + | 8 | 23 | 1605_1612 | 697 | 1616 | Motif | Note=PPPSP motif E |
| Tgene | >LRP5 | chr17:8192732 | chr11:68177382 | ENST00000294304 | + | 8 | 23 | 945_1212 | 697 | 1616 | Region | Note=Beta-propeller 4 |
| Tgene | >LRP5 | chr17:8192732 | chr11:68177382 | ENST00000294304 | + | 8 | 23 | 1036_1078 | 697 | 1616 | Repeat | Note=LDL-receptor class B 17 |
| Tgene | >LRP5 | chr17:8192732 | chr11:68177382 | ENST00000294304 | + | 8 | 23 | 1079_1123 | 697 | 1616 | Repeat | Note=LDL-receptor class B 18 |
| Tgene | >LRP5 | chr17:8192732 | chr11:68177382 | ENST00000294304 | + | 8 | 23 | 1124_1164 | 697 | 1616 | Repeat | Note=LDL-receptor class B 19 |
| Tgene | >LRP5 | chr17:8192732 | chr11:68177382 | ENST00000294304 | + | 8 | 23 | 1165_1207 | 697 | 1616 | Repeat | Note=LDL-receptor class B 20 |
| Tgene | >LRP5 | chr17:8192732 | chr11:68177382 | ENST00000294304 | + | 8 | 23 | 730_772 | 697 | 1616 | Repeat | Note=LDL-receptor class B 12 |
| Tgene | >LRP5 | chr17:8192732 | chr11:68177382 | ENST00000294304 | + | 8 | 23 | 773_815 | 697 | 1616 | Repeat | Note=LDL-receptor class B 13 |
| Tgene | >LRP5 | chr17:8192732 | chr11:68177382 | ENST00000294304 | + | 8 | 23 | 816_855 | 697 | 1616 | Repeat | Note=LDL-receptor class B 14 |
| Tgene | >LRP5 | chr17:8192732 | chr11:68177382 | ENST00000294304 | + | 8 | 23 | 819_822 | 697 | 1616 | Repeat | Note=YWTD 10 |
| Tgene | >LRP5 | chr17:8192732 | chr11:68177382 | ENST00000294304 | + | 8 | 23 | 856_898 | 697 | 1616 | Repeat | Note=LDL-receptor class B 15 |
| Tgene | >LRP5 | chr17:8192732 | chr11:68177382 | ENST00000294304 | + | 8 | 23 | 859_862 | 697 | 1616 | Repeat | Note=YWTD 11 |
| Tgene | >LRP5 | chr17:8192732 | chr11:68177382 | ENST00000294304 | + | 8 | 23 | 989_1035 | 697 | 1616 | Repeat | Note=LDL-receptor class B 16 |
| Tgene | >LRP5 | chr17:8192732 | chr11:68177382 | ENST00000294304 | + | 8 | 23 | 1408_1615 | 697 | 1616 | Topological domain | Cytoplasmic |
| Tgene | >LRP5 | chr17:8192732 | chr11:68177382 | ENST00000294304 | + | 8 | 23 | 1385_1407 | 697 | 1616 | Transmembrane | Helical |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | LRP5 | chr17:8192732 | chr11:68177382 | ENST00000294304 | + | 8 | 23 | 295_337 | 697 | 1616 | Domain | Note=EGF-like 1 |
| Tgene | LRP5 | chr17:8192732 | chr11:68177382 | ENST00000294304 | + | 8 | 23 | 601_641 | 697 | 1616 | Domain | Note=EGF-like 2 |
| Tgene | LRP5 | chr17:8192732 | chr11:68177382 | ENST00000294304 | + | 8 | 23 | 32_288 | 697 | 1616 | Region | Note=Beta-propeller 1 |
| Tgene | LRP5 | chr17:8192732 | chr11:68177382 | ENST00000294304 | + | 8 | 23 | 341_602 | 697 | 1616 | Region | Note=Beta-propeller 2 |
| Tgene | LRP5 | chr17:8192732 | chr11:68177382 | ENST00000294304 | + | 8 | 23 | 644_903 | 697 | 1616 | Region | Note=Beta-propeller 3 |
| Tgene | LRP5 | chr17:8192732 | chr11:68177382 | ENST00000294304 | + | 8 | 23 | 120_162 | 697 | 1616 | Repeat | Note=LDL-receptor class B 2 |
| Tgene | LRP5 | chr17:8192732 | chr11:68177382 | ENST00000294304 | + | 8 | 23 | 123_126 | 697 | 1616 | Repeat | Note=YWTD 2 |
| Tgene | LRP5 | chr17:8192732 | chr11:68177382 | ENST00000294304 | + | 8 | 23 | 163_206 | 697 | 1616 | Repeat | Note=LDL-receptor class B 3 |
| Tgene | LRP5 | chr17:8192732 | chr11:68177382 | ENST00000294304 | + | 8 | 23 | 166_169 | 697 | 1616 | Repeat | Note=YWTD 3 |
| Tgene | LRP5 | chr17:8192732 | chr11:68177382 | ENST00000294304 | + | 8 | 23 | 207_247 | 697 | 1616 | Repeat | Note=LDL-receptor class B 4 |
| Tgene | LRP5 | chr17:8192732 | chr11:68177382 | ENST00000294304 | + | 8 | 23 | 248_290 | 697 | 1616 | Repeat | Note=LDL-receptor class B 5 |
| Tgene | LRP5 | chr17:8192732 | chr11:68177382 | ENST00000294304 | + | 8 | 23 | 251_254 | 697 | 1616 | Repeat | Note=YWTD 4 |
| Tgene | LRP5 | chr17:8192732 | chr11:68177382 | ENST00000294304 | + | 8 | 23 | 385_427 | 697 | 1616 | Repeat | Note=LDL-receptor class B 6 |
| Tgene | LRP5 | chr17:8192732 | chr11:68177382 | ENST00000294304 | + | 8 | 23 | 388_391 | 697 | 1616 | Repeat | Note=YWTD 5 |
| Tgene | LRP5 | chr17:8192732 | chr11:68177382 | ENST00000294304 | + | 8 | 23 | 428_470 | 697 | 1616 | Repeat | Note=LDL-receptor class B 7 |
| Tgene | LRP5 | chr17:8192732 | chr11:68177382 | ENST00000294304 | + | 8 | 23 | 431_434 | 697 | 1616 | Repeat | Note=YWTD 6 |
| Tgene | LRP5 | chr17:8192732 | chr11:68177382 | ENST00000294304 | + | 8 | 23 | 471_514 | 697 | 1616 | Repeat | Note=LDL-receptor class B 8 |
| Tgene | LRP5 | chr17:8192732 | chr11:68177382 | ENST00000294304 | + | 8 | 23 | 474_477 | 697 | 1616 | Repeat | Note=YWTD 7 |
| Tgene | LRP5 | chr17:8192732 | chr11:68177382 | ENST00000294304 | + | 8 | 23 | 515_557 | 697 | 1616 | Repeat | Note=LDL-receptor class B 9 |
| Tgene | LRP5 | chr17:8192732 | chr11:68177382 | ENST00000294304 | + | 8 | 23 | 558_600 | 697 | 1616 | Repeat | Note=LDL-receptor class B 10 |
| Tgene | LRP5 | chr17:8192732 | chr11:68177382 | ENST00000294304 | + | 8 | 23 | 559_562 | 697 | 1616 | Repeat | Note=YWTD 8 |
| Tgene | LRP5 | chr17:8192732 | chr11:68177382 | ENST00000294304 | + | 8 | 23 | 687_729 | 697 | 1616 | Repeat | Note=LDL-receptor class B 11 |
| Tgene | LRP5 | chr17:8192732 | chr11:68177382 | ENST00000294304 | + | 8 | 23 | 690_693 | 697 | 1616 | Repeat | Note=YWTD 9 |
| Tgene | LRP5 | chr17:8192732 | chr11:68177382 | ENST00000294304 | + | 8 | 23 | 75_119 | 697 | 1616 | Repeat | Note=LDL-receptor class B 1 |
| Tgene | LRP5 | chr17:8192732 | chr11:68177382 | ENST00000294304 | + | 8 | 23 | 78_81 | 697 | 1616 | Repeat | Note=YWTD 1 |
| Tgene | LRP5 | chr17:8192732 | chr11:68177382 | ENST00000294304 | + | 8 | 23 | 32_1384 | 697 | 1616 | Topological domain | Extracellular |
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FusionGeneSequence for RANGRF_LRP5 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_RANGRF_ENST00000226105_chr17_8192732_+_LRP5_ENST00000294304_chr11_68177382_+_1036aa MEPTRDCPLFGGAFSAILPMGAIDVSDLRPVPDNQEVFCHPVTDQSLIVELLELQAHVRGEAAARYHFEDVGGVQGARAVHVESVQPLSL ENLALRGRCQEAWVLSGKQQIAKENQQTISRAFMNGSSVEHVVEFGLDYPEGMAVDWMGKNLYWADTGTNRIEVARLDGQFRQVLVWRDL DNPRSLALDPTKGYIYWTEWGGKPRIVRAFMDGTNCMTLVDKVGRANDLTIDYADQRLYWTDLDTNMIESSNMLGQERVVIADDLPHPFG LTQYSDYIYWTDWNLHSIERADKTSGRNRTLIQGHLDFVMDILVFHSSRQDGLNDCMHNNGQCGQLCLAIPGGHRCGCASHYTLDPSSRN CSPPTTFLLFSQKSAISRMIPDDQHSPDLILPLHGLRNVKAIDYDPLDKFIYWVDGRQNIKRAKDDGTQPFVLTSLSQGQNPDRQPHDLS IDIYSRTLFWTCEATNTINVHRLSGEAMGVVLRGDRDKPRAIVVNAERGYLYFTNMQDRAAKIERAALDGTEREVLFTTGLIRPVALVVD NTLGKLFWVDADLKRIESCDLSGANRLTLEDANIVQPLGLTILGKHLYWIDRQQQMIERVEKTTGDKRTRIQGRVAHLTGIHAVEEVSLE EFSAHPCARDNGGCSHICIAKGDGTPRCSCPVHLVLLQNLLTCGEPPTCSPDQFACATGEIDCIPGAWRCDGFPECDDQSDEEGCPVCSA AQFPCARGQCVDLRLRCDGEADCQDRSDEADCDAICLPNQFRCASGQCVLIKQQCDSFPDCIDGSDELMCEITKPPSDDSPAHSSAIGPV IGIILSLFVMGGVYFVCQRVVCQRYAGANGPFPHEYVSGTPHVPLNFIAPGGSQHGPFTGIACGKSMMSSVSLMGGRGGVPLYDRNHVTG ASSSSSSSTKATLYPPILNPPPSPATDPSLYNMDMFYSSNIPATARPYRPYIIRGMAPPTTPCSTDVCDSDYSASRWKASKYYLDLNSDS >In-frame_RANGRF_ENST00000407006_chr17_8192732_+_LRP5_ENST00000294304_chr11_68177382_+_1036aa MEPTRDCPLFGGAFSAILPMGAIDVSDLRPVPDNQEVFCHPVTDQSLIVELLELQAHVRGEAAARYHFEDVGGVQGARAVHVESVQPLSL ENLALRGRCQEAWVLSGKQQIAKENQQTISRAFMNGSSVEHVVEFGLDYPEGMAVDWMGKNLYWADTGTNRIEVARLDGQFRQVLVWRDL DNPRSLALDPTKGYIYWTEWGGKPRIVRAFMDGTNCMTLVDKVGRANDLTIDYADQRLYWTDLDTNMIESSNMLGQERVVIADDLPHPFG LTQYSDYIYWTDWNLHSIERADKTSGRNRTLIQGHLDFVMDILVFHSSRQDGLNDCMHNNGQCGQLCLAIPGGHRCGCASHYTLDPSSRN CSPPTTFLLFSQKSAISRMIPDDQHSPDLILPLHGLRNVKAIDYDPLDKFIYWVDGRQNIKRAKDDGTQPFVLTSLSQGQNPDRQPHDLS IDIYSRTLFWTCEATNTINVHRLSGEAMGVVLRGDRDKPRAIVVNAERGYLYFTNMQDRAAKIERAALDGTEREVLFTTGLIRPVALVVD NTLGKLFWVDADLKRIESCDLSGANRLTLEDANIVQPLGLTILGKHLYWIDRQQQMIERVEKTTGDKRTRIQGRVAHLTGIHAVEEVSLE EFSAHPCARDNGGCSHICIAKGDGTPRCSCPVHLVLLQNLLTCGEPPTCSPDQFACATGEIDCIPGAWRCDGFPECDDQSDEEGCPVCSA AQFPCARGQCVDLRLRCDGEADCQDRSDEADCDAICLPNQFRCASGQCVLIKQQCDSFPDCIDGSDELMCEITKPPSDDSPAHSSAIGPV IGIILSLFVMGGVYFVCQRVVCQRYAGANGPFPHEYVSGTPHVPLNFIAPGGSQHGPFTGIACGKSMMSSVSLMGGRGGVPLYDRNHVTG ASSSSSSSTKATLYPPILNPPPSPATDPSLYNMDMFYSSNIPATARPYRPYIIRGMAPPTTPCSTDVCDSDYSASRWKASKYYLDLNSDS >In-frame_RANGRF_ENST00000580434_chr17_8192732_+_LRP5_ENST00000294304_chr11_68177382_+_1036aa MEPTRDCPLFGGAFSAILPMGAIDVSDLRPVPDNQEVFCHPVTDQSLIVELLELQAHVRGEAAARYHFEDVGGVQGARAVHVESVQPLSL ENLALRGRCQEAWVLSGKQQIAKENQQTISRAFMNGSSVEHVVEFGLDYPEGMAVDWMGKNLYWADTGTNRIEVARLDGQFRQVLVWRDL DNPRSLALDPTKGYIYWTEWGGKPRIVRAFMDGTNCMTLVDKVGRANDLTIDYADQRLYWTDLDTNMIESSNMLGQERVVIADDLPHPFG LTQYSDYIYWTDWNLHSIERADKTSGRNRTLIQGHLDFVMDILVFHSSRQDGLNDCMHNNGQCGQLCLAIPGGHRCGCASHYTLDPSSRN CSPPTTFLLFSQKSAISRMIPDDQHSPDLILPLHGLRNVKAIDYDPLDKFIYWVDGRQNIKRAKDDGTQPFVLTSLSQGQNPDRQPHDLS IDIYSRTLFWTCEATNTINVHRLSGEAMGVVLRGDRDKPRAIVVNAERGYLYFTNMQDRAAKIERAALDGTEREVLFTTGLIRPVALVVD NTLGKLFWVDADLKRIESCDLSGANRLTLEDANIVQPLGLTILGKHLYWIDRQQQMIERVEKTTGDKRTRIQGRVAHLTGIHAVEEVSLE EFSAHPCARDNGGCSHICIAKGDGTPRCSCPVHLVLLQNLLTCGEPPTCSPDQFACATGEIDCIPGAWRCDGFPECDDQSDEEGCPVCSA AQFPCARGQCVDLRLRCDGEADCQDRSDEADCDAICLPNQFRCASGQCVLIKQQCDSFPDCIDGSDELMCEITKPPSDDSPAHSSAIGPV IGIILSLFVMGGVYFVCQRVVCQRYAGANGPFPHEYVSGTPHVPLNFIAPGGSQHGPFTGIACGKSMMSSVSLMGGRGGVPLYDRNHVTG ASSSSSSSTKATLYPPILNPPPSPATDPSLYNMDMFYSSNIPATARPYRPYIIRGMAPPTTPCSTDVCDSDYSASRWKASKYYLDLNSDS >In-frame_RANGRF_ENST00000439238_chr17_8192732_+_LRP5_ENST00000294304_chr11_68177382_+_1262aa MEPTRDCPLFGGAFSAILPMGAIDVSDLRPVPDNQEVFCHPVTDQSLIVELLELQAHVRGEAAARYHFEDVGGVQGARAVHVESVQPLSL ENLALRGRCQEAWVLSGKQQIAKENQQVRARECVMSWKGGSGDAEIQVSILTLIPLGSKGRDTSSGLAEAAPVPDXSLAYLQSAPVRRKE RAGISXLGSQENRAGRDRTGRLTGGILQGSRSGPEVWGNXYPGPLGNRNWQFPNLRPGXCSVSICSPTPSPDNRSSLGPENLSPAPWSLG DFEQLVTSLTLHDPNIFGPQXRRXSTAXCCXELGDSVLXGGKEVEKRVSSYFFPVRKHKTIPLQNKLALXSIXTISRAFMNGSSVEHVVE FGLDYPEGMAVDWMGKNLYWADTGTNRIEVARLDGQFRQVLVWRDLDNPRSLALDPTKGYIYWTEWGGKPRIVRAFMDGTNCMTLVDKVG RANDLTIDYADQRLYWTDLDTNMIESSNMLGQERVVIADDLPHPFGLTQYSDYIYWTDWNLHSIERADKTSGRNRTLIQGHLDFVMDILV FHSSRQDGLNDCMHNNGQCGQLCLAIPGGHRCGCASHYTLDPSSRNCSPPTTFLLFSQKSAISRMIPDDQHSPDLILPLHGLRNVKAIDY DPLDKFIYWVDGRQNIKRAKDDGTQPFVLTSLSQGQNPDRQPHDLSIDIYSRTLFWTCEATNTINVHRLSGEAMGVVLRGDRDKPRAIVV NAERGYLYFTNMQDRAAKIERAALDGTEREVLFTTGLIRPVALVVDNTLGKLFWVDADLKRIESCDLSGANRLTLEDANIVQPLGLTILG KHLYWIDRQQQMIERVEKTTGDKRTRIQGRVAHLTGIHAVEEVSLEEFSAHPCARDNGGCSHICIAKGDGTPRCSCPVHLVLLQNLLTCG EPPTCSPDQFACATGEIDCIPGAWRCDGFPECDDQSDEEGCPVCSAAQFPCARGQCVDLRLRCDGEADCQDRSDEADCDAICLPNQFRCA SGQCVLIKQQCDSFPDCIDGSDELMCEITKPPSDDSPAHSSAIGPVIGIILSLFVMGGVYFVCQRVVCQRYAGANGPFPHEYVSGTPHVP LNFIAPGGSQHGPFTGIACGKSMMSSVSLMGGRGGVPLYDRNHVTGASSSSSSSTKATLYPPILNPPPSPATDPSLYNMDMFYSSNIPAT ARPYRPYIIRGMAPPTTPCSTDVCDSDYSASRWKASKYYLDLNSDSDPYPPPPTPHSQYLSAEDSCPPSPATERSYFHLFPPPPSPCTDS |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_RANGRF_ENST00000226105_chr17_8192732_+_LRP5_ENST00000294304_chr11_68177382_+_3108nt ATGGAGCCCACGAGAGACTGCCCGCTGTTCGGGGGCGCCTTTTCCGCCATCCTCCCCATGGGGGCCATTGACGTAAGCGACCTCCGACCG GTCCCGGACAATCAAGAAGTTTTCTGCCATCCCGTGACGGACCAGAGCCTGATAGTGGAACTTCTCGAGCTGCAGGCCCACGTACGGGGC GAAGCGGCTGCGCGGTACCACTTTGAGGATGTTGGTGGCGTGCAGGGGGCTAGGGCTGTCCATGTGGAGTCTGTTCAGCCTCTCAGTTTG GAGAACCTGGCCCTGAGGGGCCGCTGTCAAGAAGCCTGGGTCCTCTCTGGCAAGCAGCAGATAGCTAAGGAAAACCAGCAGACCATCAGC CGCGCCTTCATGAACGGGAGCTCGGTGGAGCACGTGGTGGAGTTTGGCCTTGACTACCCCGAGGGCATGGCCGTTGACTGGATGGGCAAG AACCTCTACTGGGCCGACACTGGGACCAACAGAATCGAAGTGGCGCGGCTGGACGGGCAGTTCCGGCAAGTCCTCGTGTGGAGGGACTTG GACAACCCGAGGTCGCTGGCCCTGGATCCCACCAAGGGCTACATCTACTGGACCGAGTGGGGCGGCAAGCCGAGGATCGTGCGGGCCTTC ATGGACGGGACCAACTGCATGACGCTGGTGGACAAGGTGGGCCGGGCCAACGACCTCACCATTGACTACGCTGACCAGCGCCTCTACTGG ACCGACCTGGACACCAACATGATCGAGTCGTCCAACATGCTGGGTCAGGAGCGGGTCGTGATTGCCGACGATCTCCCGCACCCGTTCGGT CTGACGCAGTACAGCGATTATATCTACTGGACAGACTGGAATCTGCACAGCATTGAGCGGGCCGACAAGACTAGCGGCCGGAACCGCACC CTCATCCAGGGCCACCTGGACTTCGTGATGGACATCCTGGTGTTCCACTCCTCCCGCCAGGATGGCCTCAATGACTGTATGCACAACAAC GGGCAGTGTGGGCAGCTGTGCCTTGCCATCCCCGGCGGCCACCGCTGCGGCTGCGCCTCACACTACACCCTGGACCCCAGCAGCCGCAAC TGCAGCCCGCCCACCACCTTCTTGCTGTTCAGCCAGAAATCTGCCATCAGTCGGATGATCCCGGACGACCAGCACAGCCCGGATCTCATC CTGCCCCTGCATGGACTGAGGAACGTCAAAGCCATCGACTATGACCCACTGGACAAGTTCATCTACTGGGTGGATGGGCGCCAGAACATC AAGCGAGCCAAGGACGACGGGACCCAGCCCTTTGTTTTGACCTCTCTGAGCCAAGGCCAAAACCCAGACAGGCAGCCCCACGACCTCAGC ATCGACATCTACAGCCGGACACTGTTCTGGACGTGCGAGGCCACCAATACCATCAACGTCCACAGGCTGAGCGGGGAAGCCATGGGGGTG GTGCTGCGTGGGGACCGCGACAAGCCCAGGGCCATCGTCGTCAACGCGGAGCGAGGGTACCTGTACTTCACCAACATGCAGGACCGGGCA GCCAAGATCGAACGCGCAGCCCTGGACGGCACCGAGCGCGAGGTCCTCTTCACCACCGGCCTCATCCGCCCTGTGGCCCTGGTGGTGGAC AACACACTGGGCAAGCTGTTCTGGGTGGACGCGGACCTGAAGCGCATTGAGAGCTGTGACCTGTCAGGGGCCAACCGCCTGACCCTGGAG GACGCCAACATCGTGCAGCCTCTGGGCCTGACCATCCTTGGCAAGCATCTCTACTGGATCGACCGCCAGCAGCAGATGATCGAGCGTGTG GAGAAGACCACCGGGGACAAGCGGACTCGCATCCAGGGCCGTGTCGCCCACCTCACTGGCATCCATGCAGTGGAGGAAGTCAGCCTGGAG GAGTTCTCAGCCCACCCATGTGCCCGTGACAATGGTGGCTGCTCCCACATCTGTATTGCCAAGGGTGATGGGACACCACGGTGCTCATGC CCAGTCCACCTCGTGCTCCTGCAGAACCTGCTGACCTGTGGAGAGCCGCCCACCTGCTCCCCGGACCAGTTTGCATGTGCCACAGGGGAG ATCGACTGTATCCCCGGGGCCTGGCGCTGTGACGGCTTTCCCGAGTGCGATGACCAGAGCGACGAGGAGGGCTGCCCCGTGTGCTCCGCC GCCCAGTTCCCCTGCGCGCGGGGTCAGTGTGTGGACCTGCGCCTGCGCTGCGACGGCGAGGCAGACTGTCAGGACCGCTCAGACGAGGCG GACTGTGACGCCATCTGCCTGCCCAACCAGTTCCGGTGTGCGAGCGGCCAGTGTGTCCTCATCAAACAGCAGTGCGACTCCTTCCCCGAC TGTATCGACGGCTCCGACGAGCTCATGTGTGAAATCACCAAGCCGCCCTCAGACGACAGCCCGGCCCACAGCAGTGCCATCGGGCCCGTC ATTGGCATCATCCTCTCTCTCTTCGTCATGGGTGGTGTCTATTTTGTGTGCCAGCGCGTGGTGTGCCAGCGCTATGCGGGGGCCAACGGG CCCTTCCCGCACGAGTATGTCAGCGGGACCCCGCACGTGCCCCTCAATTTCATAGCCCCGGGCGGTTCCCAGCATGGCCCCTTCACAGGC ATCGCATGCGGAAAGTCCATGATGAGCTCCGTGAGCCTGATGGGGGGCCGGGGCGGGGTGCCCCTCTACGACCGGAACCACGTCACAGGG GCCTCGTCCAGCAGCTCGTCCAGCACGAAGGCCACGCTGTACCCGCCGATCCTGAACCCGCCGCCCTCCCCGGCCACGGACCCCTCCCTG TACAACATGGACATGTTCTACTCTTCAAACATTCCGGCCACTGCGAGACCGTACAGGCCCTACATCATTCGAGGAATGGCGCCCCCGACG ACGCCCTGCAGCACCGACGTGTGTGACAGCGACTACAGCGCCAGCCGCTGGAAGGCCAGCAAGTACTACCTGGATTTGAACTCGGACTCA GACCCCTATCCACCCCCACCCACGCCCCACAGCCAGTACCTGTCGGCGGAGGACAGCTGCCCGCCCTCGCCCGCCACCGAGAGGAGCTAC >In-frame_RANGRF_ENST00000407006_chr17_8192732_+_LRP5_ENST00000294304_chr11_68177382_+_3108nt ATGGAGCCCACGAGAGACTGCCCGCTGTTCGGGGGCGCCTTTTCCGCCATCCTCCCCATGGGGGCCATTGACGTAAGCGACCTCCGACCG GTCCCGGACAATCAAGAAGTTTTCTGCCATCCCGTGACGGACCAGAGCCTGATAGTGGAACTTCTCGAGCTGCAGGCCCACGTACGGGGC GAAGCGGCTGCGCGGTACCACTTTGAGGATGTTGGTGGCGTGCAGGGGGCTAGGGCTGTCCATGTGGAGTCTGTTCAGCCTCTCAGTTTG GAGAACCTGGCCCTGAGGGGCCGCTGTCAAGAAGCCTGGGTCCTCTCTGGCAAGCAGCAGATAGCTAAGGAAAACCAGCAGACCATCAGC CGCGCCTTCATGAACGGGAGCTCGGTGGAGCACGTGGTGGAGTTTGGCCTTGACTACCCCGAGGGCATGGCCGTTGACTGGATGGGCAAG AACCTCTACTGGGCCGACACTGGGACCAACAGAATCGAAGTGGCGCGGCTGGACGGGCAGTTCCGGCAAGTCCTCGTGTGGAGGGACTTG GACAACCCGAGGTCGCTGGCCCTGGATCCCACCAAGGGCTACATCTACTGGACCGAGTGGGGCGGCAAGCCGAGGATCGTGCGGGCCTTC ATGGACGGGACCAACTGCATGACGCTGGTGGACAAGGTGGGCCGGGCCAACGACCTCACCATTGACTACGCTGACCAGCGCCTCTACTGG ACCGACCTGGACACCAACATGATCGAGTCGTCCAACATGCTGGGTCAGGAGCGGGTCGTGATTGCCGACGATCTCCCGCACCCGTTCGGT CTGACGCAGTACAGCGATTATATCTACTGGACAGACTGGAATCTGCACAGCATTGAGCGGGCCGACAAGACTAGCGGCCGGAACCGCACC CTCATCCAGGGCCACCTGGACTTCGTGATGGACATCCTGGTGTTCCACTCCTCCCGCCAGGATGGCCTCAATGACTGTATGCACAACAAC GGGCAGTGTGGGCAGCTGTGCCTTGCCATCCCCGGCGGCCACCGCTGCGGCTGCGCCTCACACTACACCCTGGACCCCAGCAGCCGCAAC TGCAGCCCGCCCACCACCTTCTTGCTGTTCAGCCAGAAATCTGCCATCAGTCGGATGATCCCGGACGACCAGCACAGCCCGGATCTCATC CTGCCCCTGCATGGACTGAGGAACGTCAAAGCCATCGACTATGACCCACTGGACAAGTTCATCTACTGGGTGGATGGGCGCCAGAACATC AAGCGAGCCAAGGACGACGGGACCCAGCCCTTTGTTTTGACCTCTCTGAGCCAAGGCCAAAACCCAGACAGGCAGCCCCACGACCTCAGC ATCGACATCTACAGCCGGACACTGTTCTGGACGTGCGAGGCCACCAATACCATCAACGTCCACAGGCTGAGCGGGGAAGCCATGGGGGTG GTGCTGCGTGGGGACCGCGACAAGCCCAGGGCCATCGTCGTCAACGCGGAGCGAGGGTACCTGTACTTCACCAACATGCAGGACCGGGCA GCCAAGATCGAACGCGCAGCCCTGGACGGCACCGAGCGCGAGGTCCTCTTCACCACCGGCCTCATCCGCCCTGTGGCCCTGGTGGTGGAC AACACACTGGGCAAGCTGTTCTGGGTGGACGCGGACCTGAAGCGCATTGAGAGCTGTGACCTGTCAGGGGCCAACCGCCTGACCCTGGAG GACGCCAACATCGTGCAGCCTCTGGGCCTGACCATCCTTGGCAAGCATCTCTACTGGATCGACCGCCAGCAGCAGATGATCGAGCGTGTG GAGAAGACCACCGGGGACAAGCGGACTCGCATCCAGGGCCGTGTCGCCCACCTCACTGGCATCCATGCAGTGGAGGAAGTCAGCCTGGAG GAGTTCTCAGCCCACCCATGTGCCCGTGACAATGGTGGCTGCTCCCACATCTGTATTGCCAAGGGTGATGGGACACCACGGTGCTCATGC CCAGTCCACCTCGTGCTCCTGCAGAACCTGCTGACCTGTGGAGAGCCGCCCACCTGCTCCCCGGACCAGTTTGCATGTGCCACAGGGGAG ATCGACTGTATCCCCGGGGCCTGGCGCTGTGACGGCTTTCCCGAGTGCGATGACCAGAGCGACGAGGAGGGCTGCCCCGTGTGCTCCGCC GCCCAGTTCCCCTGCGCGCGGGGTCAGTGTGTGGACCTGCGCCTGCGCTGCGACGGCGAGGCAGACTGTCAGGACCGCTCAGACGAGGCG GACTGTGACGCCATCTGCCTGCCCAACCAGTTCCGGTGTGCGAGCGGCCAGTGTGTCCTCATCAAACAGCAGTGCGACTCCTTCCCCGAC TGTATCGACGGCTCCGACGAGCTCATGTGTGAAATCACCAAGCCGCCCTCAGACGACAGCCCGGCCCACAGCAGTGCCATCGGGCCCGTC ATTGGCATCATCCTCTCTCTCTTCGTCATGGGTGGTGTCTATTTTGTGTGCCAGCGCGTGGTGTGCCAGCGCTATGCGGGGGCCAACGGG CCCTTCCCGCACGAGTATGTCAGCGGGACCCCGCACGTGCCCCTCAATTTCATAGCCCCGGGCGGTTCCCAGCATGGCCCCTTCACAGGC ATCGCATGCGGAAAGTCCATGATGAGCTCCGTGAGCCTGATGGGGGGCCGGGGCGGGGTGCCCCTCTACGACCGGAACCACGTCACAGGG GCCTCGTCCAGCAGCTCGTCCAGCACGAAGGCCACGCTGTACCCGCCGATCCTGAACCCGCCGCCCTCCCCGGCCACGGACCCCTCCCTG TACAACATGGACATGTTCTACTCTTCAAACATTCCGGCCACTGCGAGACCGTACAGGCCCTACATCATTCGAGGAATGGCGCCCCCGACG ACGCCCTGCAGCACCGACGTGTGTGACAGCGACTACAGCGCCAGCCGCTGGAAGGCCAGCAAGTACTACCTGGATTTGAACTCGGACTCA GACCCCTATCCACCCCCACCCACGCCCCACAGCCAGTACCTGTCGGCGGAGGACAGCTGCCCGCCCTCGCCCGCCACCGAGAGGAGCTAC >In-frame_RANGRF_ENST00000580434_chr17_8192732_+_LRP5_ENST00000294304_chr11_68177382_+_3108nt ATGGAGCCCACGAGAGACTGCCCGCTGTTCGGGGGCGCCTTTTCCGCCATCCTCCCCATGGGGGCCATTGACGTAAGCGACCTCCGACCG GTCCCGGACAATCAAGAAGTTTTCTGCCATCCCGTGACGGACCAGAGCCTGATAGTGGAACTTCTCGAGCTGCAGGCCCACGTACGGGGC GAAGCGGCTGCGCGGTACCACTTTGAGGATGTTGGTGGCGTGCAGGGGGCTAGGGCTGTCCATGTGGAGTCTGTTCAGCCTCTCAGTTTG GAGAACCTGGCCCTGAGGGGCCGCTGTCAAGAAGCCTGGGTCCTCTCTGGCAAGCAGCAGATAGCTAAGGAAAACCAGCAGACCATCAGC CGCGCCTTCATGAACGGGAGCTCGGTGGAGCACGTGGTGGAGTTTGGCCTTGACTACCCCGAGGGCATGGCCGTTGACTGGATGGGCAAG AACCTCTACTGGGCCGACACTGGGACCAACAGAATCGAAGTGGCGCGGCTGGACGGGCAGTTCCGGCAAGTCCTCGTGTGGAGGGACTTG GACAACCCGAGGTCGCTGGCCCTGGATCCCACCAAGGGCTACATCTACTGGACCGAGTGGGGCGGCAAGCCGAGGATCGTGCGGGCCTTC ATGGACGGGACCAACTGCATGACGCTGGTGGACAAGGTGGGCCGGGCCAACGACCTCACCATTGACTACGCTGACCAGCGCCTCTACTGG ACCGACCTGGACACCAACATGATCGAGTCGTCCAACATGCTGGGTCAGGAGCGGGTCGTGATTGCCGACGATCTCCCGCACCCGTTCGGT CTGACGCAGTACAGCGATTATATCTACTGGACAGACTGGAATCTGCACAGCATTGAGCGGGCCGACAAGACTAGCGGCCGGAACCGCACC CTCATCCAGGGCCACCTGGACTTCGTGATGGACATCCTGGTGTTCCACTCCTCCCGCCAGGATGGCCTCAATGACTGTATGCACAACAAC GGGCAGTGTGGGCAGCTGTGCCTTGCCATCCCCGGCGGCCACCGCTGCGGCTGCGCCTCACACTACACCCTGGACCCCAGCAGCCGCAAC TGCAGCCCGCCCACCACCTTCTTGCTGTTCAGCCAGAAATCTGCCATCAGTCGGATGATCCCGGACGACCAGCACAGCCCGGATCTCATC CTGCCCCTGCATGGACTGAGGAACGTCAAAGCCATCGACTATGACCCACTGGACAAGTTCATCTACTGGGTGGATGGGCGCCAGAACATC AAGCGAGCCAAGGACGACGGGACCCAGCCCTTTGTTTTGACCTCTCTGAGCCAAGGCCAAAACCCAGACAGGCAGCCCCACGACCTCAGC ATCGACATCTACAGCCGGACACTGTTCTGGACGTGCGAGGCCACCAATACCATCAACGTCCACAGGCTGAGCGGGGAAGCCATGGGGGTG GTGCTGCGTGGGGACCGCGACAAGCCCAGGGCCATCGTCGTCAACGCGGAGCGAGGGTACCTGTACTTCACCAACATGCAGGACCGGGCA GCCAAGATCGAACGCGCAGCCCTGGACGGCACCGAGCGCGAGGTCCTCTTCACCACCGGCCTCATCCGCCCTGTGGCCCTGGTGGTGGAC AACACACTGGGCAAGCTGTTCTGGGTGGACGCGGACCTGAAGCGCATTGAGAGCTGTGACCTGTCAGGGGCCAACCGCCTGACCCTGGAG GACGCCAACATCGTGCAGCCTCTGGGCCTGACCATCCTTGGCAAGCATCTCTACTGGATCGACCGCCAGCAGCAGATGATCGAGCGTGTG GAGAAGACCACCGGGGACAAGCGGACTCGCATCCAGGGCCGTGTCGCCCACCTCACTGGCATCCATGCAGTGGAGGAAGTCAGCCTGGAG GAGTTCTCAGCCCACCCATGTGCCCGTGACAATGGTGGCTGCTCCCACATCTGTATTGCCAAGGGTGATGGGACACCACGGTGCTCATGC CCAGTCCACCTCGTGCTCCTGCAGAACCTGCTGACCTGTGGAGAGCCGCCCACCTGCTCCCCGGACCAGTTTGCATGTGCCACAGGGGAG ATCGACTGTATCCCCGGGGCCTGGCGCTGTGACGGCTTTCCCGAGTGCGATGACCAGAGCGACGAGGAGGGCTGCCCCGTGTGCTCCGCC GCCCAGTTCCCCTGCGCGCGGGGTCAGTGTGTGGACCTGCGCCTGCGCTGCGACGGCGAGGCAGACTGTCAGGACCGCTCAGACGAGGCG GACTGTGACGCCATCTGCCTGCCCAACCAGTTCCGGTGTGCGAGCGGCCAGTGTGTCCTCATCAAACAGCAGTGCGACTCCTTCCCCGAC TGTATCGACGGCTCCGACGAGCTCATGTGTGAAATCACCAAGCCGCCCTCAGACGACAGCCCGGCCCACAGCAGTGCCATCGGGCCCGTC ATTGGCATCATCCTCTCTCTCTTCGTCATGGGTGGTGTCTATTTTGTGTGCCAGCGCGTGGTGTGCCAGCGCTATGCGGGGGCCAACGGG CCCTTCCCGCACGAGTATGTCAGCGGGACCCCGCACGTGCCCCTCAATTTCATAGCCCCGGGCGGTTCCCAGCATGGCCCCTTCACAGGC ATCGCATGCGGAAAGTCCATGATGAGCTCCGTGAGCCTGATGGGGGGCCGGGGCGGGGTGCCCCTCTACGACCGGAACCACGTCACAGGG GCCTCGTCCAGCAGCTCGTCCAGCACGAAGGCCACGCTGTACCCGCCGATCCTGAACCCGCCGCCCTCCCCGGCCACGGACCCCTCCCTG TACAACATGGACATGTTCTACTCTTCAAACATTCCGGCCACTGCGAGACCGTACAGGCCCTACATCATTCGAGGAATGGCGCCCCCGACG ACGCCCTGCAGCACCGACGTGTGTGACAGCGACTACAGCGCCAGCCGCTGGAAGGCCAGCAAGTACTACCTGGATTTGAACTCGGACTCA GACCCCTATCCACCCCCACCCACGCCCCACAGCCAGTACCTGTCGGCGGAGGACAGCTGCCCGCCCTCGCCCGCCACCGAGAGGAGCTAC >In-frame_RANGRF_ENST00000439238_chr17_8192732_+_LRP5_ENST00000294304_chr11_68177382_+_3786nt ATGGAGCCCACGAGAGACTGCCCGCTGTTCGGGGGCGCCTTTTCCGCCATCCTCCCCATGGGGGCCATTGACGTAAGCGACCTCCGACCG GTCCCGGACAATCAAGAAGTTTTCTGCCATCCCGTGACGGACCAGAGCCTGATAGTGGAACTTCTCGAGCTGCAGGCCCACGTACGGGGC GAAGCGGCTGCGCGGTACCACTTTGAGGATGTTGGTGGCGTGCAGGGGGCTAGGGCTGTCCATGTGGAGTCTGTTCAGCCTCTCAGTTTG GAGAACCTGGCCCTGAGGGGCCGCTGTCAAGAAGCCTGGGTCCTCTCTGGCAAGCAGCAGATAGCTAAGGAAAACCAGCAGGTGAGGGCC CGAGAGTGTGTAATGTCCTGGAAGGGCGGTAGCGGGGACGCAGAGATCCAGGTAAGCATCCTGACTCTGATCCCCTTAGGTAGCAAAGGA CGTGACACTTCATCAGGCCTTGCTGAGGCTGCCCCAGTACCAGACTGATCTCTTGCTTACCTTCAATCAGCCCCCGTAAGGAGGAAGGAA CGGGCGGGTATCTCATGACTGGGTTCCCAGGAGAATCGGGCTGGGAGGGACAGAACAGGGAGACTCACTGGTGGGATCCTCCAAGGAAGC AGGAGTGGGCCAGAGGTTTGGGGTAACTGATACCCAGGTCCTCTGGGGAACAGGAATTGGCAATTTCCAAACCTCAGGCCTGGATGATGT TCTGTCTCCATCTGTTCCCCCACCCCAAGCCCTGACAACAGGTCATCTCTTGGCCCCGAAAATCTGTCACCTGCACCCTGGAGCCTGGGT GACTTTGAACAGCTGGTGACCAGTCTGACCCTTCACGATCCTAACATCTTTGGTCCCCAGTAAAGGCGCTGAAGCACTGCATGATGTTGC TGAGAACTTGGGGACTCGGTTCTGTGAGGGGGAAAAGAGGTTGAAAAGAGGGTTTCCTCTTATTTCTTCCCTGTGCGTAAACATAAGACA ATCCCTCTTCAGAATAAACTTGCTTTATAATCAATATAAACCATCAGCCGCGCCTTCATGAACGGGAGCTCGGTGGAGCACGTGGTGGAG TTTGGCCTTGACTACCCCGAGGGCATGGCCGTTGACTGGATGGGCAAGAACCTCTACTGGGCCGACACTGGGACCAACAGAATCGAAGTG GCGCGGCTGGACGGGCAGTTCCGGCAAGTCCTCGTGTGGAGGGACTTGGACAACCCGAGGTCGCTGGCCCTGGATCCCACCAAGGGCTAC ATCTACTGGACCGAGTGGGGCGGCAAGCCGAGGATCGTGCGGGCCTTCATGGACGGGACCAACTGCATGACGCTGGTGGACAAGGTGGGC CGGGCCAACGACCTCACCATTGACTACGCTGACCAGCGCCTCTACTGGACCGACCTGGACACCAACATGATCGAGTCGTCCAACATGCTG GGTCAGGAGCGGGTCGTGATTGCCGACGATCTCCCGCACCCGTTCGGTCTGACGCAGTACAGCGATTATATCTACTGGACAGACTGGAAT CTGCACAGCATTGAGCGGGCCGACAAGACTAGCGGCCGGAACCGCACCCTCATCCAGGGCCACCTGGACTTCGTGATGGACATCCTGGTG TTCCACTCCTCCCGCCAGGATGGCCTCAATGACTGTATGCACAACAACGGGCAGTGTGGGCAGCTGTGCCTTGCCATCCCCGGCGGCCAC CGCTGCGGCTGCGCCTCACACTACACCCTGGACCCCAGCAGCCGCAACTGCAGCCCGCCCACCACCTTCTTGCTGTTCAGCCAGAAATCT GCCATCAGTCGGATGATCCCGGACGACCAGCACAGCCCGGATCTCATCCTGCCCCTGCATGGACTGAGGAACGTCAAAGCCATCGACTAT GACCCACTGGACAAGTTCATCTACTGGGTGGATGGGCGCCAGAACATCAAGCGAGCCAAGGACGACGGGACCCAGCCCTTTGTTTTGACC TCTCTGAGCCAAGGCCAAAACCCAGACAGGCAGCCCCACGACCTCAGCATCGACATCTACAGCCGGACACTGTTCTGGACGTGCGAGGCC ACCAATACCATCAACGTCCACAGGCTGAGCGGGGAAGCCATGGGGGTGGTGCTGCGTGGGGACCGCGACAAGCCCAGGGCCATCGTCGTC AACGCGGAGCGAGGGTACCTGTACTTCACCAACATGCAGGACCGGGCAGCCAAGATCGAACGCGCAGCCCTGGACGGCACCGAGCGCGAG GTCCTCTTCACCACCGGCCTCATCCGCCCTGTGGCCCTGGTGGTGGACAACACACTGGGCAAGCTGTTCTGGGTGGACGCGGACCTGAAG CGCATTGAGAGCTGTGACCTGTCAGGGGCCAACCGCCTGACCCTGGAGGACGCCAACATCGTGCAGCCTCTGGGCCTGACCATCCTTGGC AAGCATCTCTACTGGATCGACCGCCAGCAGCAGATGATCGAGCGTGTGGAGAAGACCACCGGGGACAAGCGGACTCGCATCCAGGGCCGT GTCGCCCACCTCACTGGCATCCATGCAGTGGAGGAAGTCAGCCTGGAGGAGTTCTCAGCCCACCCATGTGCCCGTGACAATGGTGGCTGC TCCCACATCTGTATTGCCAAGGGTGATGGGACACCACGGTGCTCATGCCCAGTCCACCTCGTGCTCCTGCAGAACCTGCTGACCTGTGGA GAGCCGCCCACCTGCTCCCCGGACCAGTTTGCATGTGCCACAGGGGAGATCGACTGTATCCCCGGGGCCTGGCGCTGTGACGGCTTTCCC GAGTGCGATGACCAGAGCGACGAGGAGGGCTGCCCCGTGTGCTCCGCCGCCCAGTTCCCCTGCGCGCGGGGTCAGTGTGTGGACCTGCGC CTGCGCTGCGACGGCGAGGCAGACTGTCAGGACCGCTCAGACGAGGCGGACTGTGACGCCATCTGCCTGCCCAACCAGTTCCGGTGTGCG AGCGGCCAGTGTGTCCTCATCAAACAGCAGTGCGACTCCTTCCCCGACTGTATCGACGGCTCCGACGAGCTCATGTGTGAAATCACCAAG CCGCCCTCAGACGACAGCCCGGCCCACAGCAGTGCCATCGGGCCCGTCATTGGCATCATCCTCTCTCTCTTCGTCATGGGTGGTGTCTAT TTTGTGTGCCAGCGCGTGGTGTGCCAGCGCTATGCGGGGGCCAACGGGCCCTTCCCGCACGAGTATGTCAGCGGGACCCCGCACGTGCCC CTCAATTTCATAGCCCCGGGCGGTTCCCAGCATGGCCCCTTCACAGGCATCGCATGCGGAAAGTCCATGATGAGCTCCGTGAGCCTGATG GGGGGCCGGGGCGGGGTGCCCCTCTACGACCGGAACCACGTCACAGGGGCCTCGTCCAGCAGCTCGTCCAGCACGAAGGCCACGCTGTAC CCGCCGATCCTGAACCCGCCGCCCTCCCCGGCCACGGACCCCTCCCTGTACAACATGGACATGTTCTACTCTTCAAACATTCCGGCCACT GCGAGACCGTACAGGCCCTACATCATTCGAGGAATGGCGCCCCCGACGACGCCCTGCAGCACCGACGTGTGTGACAGCGACTACAGCGCC AGCCGCTGGAAGGCCAGCAAGTACTACCTGGATTTGAACTCGGACTCAGACCCCTATCCACCCCCACCCACGCCCCACAGCCAGTACCTG TCGGCGGAGGACAGCTGCCCGCCCTCGCCCGCCACCGAGAGGAGCTACTTCCATCTCTTCCCGCCCCCTCCGTCCCCCTGCACGGACTCA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_RANGRF_ENST00000226105_chr17_8192732_+_LRP5_ENST00000294304_chr11_68177382_+_3605nt GGGGGCGACATAGACCCTAACCCTAAGTCCAACCCCAAGGCAGACCCCACCGTCCCGCCAGGCGCACTCCTAAGAGCGCGGCTTCCGGAG CAAAGCCGCTGACCCCCGCCCCCAGGGTCTTGGCGCCGATTGGCCAACGAGAGCGCAGGGCGGAGCCAAATCTTAAAGGATCCGGGAGCT AAGCCAGACCCGGGTGGCGGTGGCAGCTGCGAAACCCAGGGAGCCGATGCCACGTGACCCAATGTGGACTTCTTTTAAACCTTTCTAATG CCCATAACCCAGCCTCAGACCCATGGAGCCCACGAGAGACTGCCCGCTGTTCGGGGGCGCCTTTTCCGCCATCCTCCCCATGGGGGCCAT TGACGTAAGCGACCTCCGACCGGTCCCGGACAATCAAGAAGTTTTCTGCCATCCCGTGACGGACCAGAGCCTGATAGTGGAACTTCTCGA GCTGCAGGCCCACGTACGGGGCGAAGCGGCTGCGCGGTACCACTTTGAGGATGTTGGTGGCGTGCAGGGGGCTAGGGCTGTCCATGTGGA GTCTGTTCAGCCTCTCAGTTTGGAGAACCTGGCCCTGAGGGGCCGCTGTCAAGAAGCCTGGGTCCTCTCTGGCAAGCAGCAGATAGCTAA GGAAAACCAGCAGACCATCAGCCGCGCCTTCATGAACGGGAGCTCGGTGGAGCACGTGGTGGAGTTTGGCCTTGACTACCCCGAGGGCAT GGCCGTTGACTGGATGGGCAAGAACCTCTACTGGGCCGACACTGGGACCAACAGAATCGAAGTGGCGCGGCTGGACGGGCAGTTCCGGCA AGTCCTCGTGTGGAGGGACTTGGACAACCCGAGGTCGCTGGCCCTGGATCCCACCAAGGGCTACATCTACTGGACCGAGTGGGGCGGCAA GCCGAGGATCGTGCGGGCCTTCATGGACGGGACCAACTGCATGACGCTGGTGGACAAGGTGGGCCGGGCCAACGACCTCACCATTGACTA CGCTGACCAGCGCCTCTACTGGACCGACCTGGACACCAACATGATCGAGTCGTCCAACATGCTGGGTCAGGAGCGGGTCGTGATTGCCGA CGATCTCCCGCACCCGTTCGGTCTGACGCAGTACAGCGATTATATCTACTGGACAGACTGGAATCTGCACAGCATTGAGCGGGCCGACAA GACTAGCGGCCGGAACCGCACCCTCATCCAGGGCCACCTGGACTTCGTGATGGACATCCTGGTGTTCCACTCCTCCCGCCAGGATGGCCT CAATGACTGTATGCACAACAACGGGCAGTGTGGGCAGCTGTGCCTTGCCATCCCCGGCGGCCACCGCTGCGGCTGCGCCTCACACTACAC CCTGGACCCCAGCAGCCGCAACTGCAGCCCGCCCACCACCTTCTTGCTGTTCAGCCAGAAATCTGCCATCAGTCGGATGATCCCGGACGA CCAGCACAGCCCGGATCTCATCCTGCCCCTGCATGGACTGAGGAACGTCAAAGCCATCGACTATGACCCACTGGACAAGTTCATCTACTG GGTGGATGGGCGCCAGAACATCAAGCGAGCCAAGGACGACGGGACCCAGCCCTTTGTTTTGACCTCTCTGAGCCAAGGCCAAAACCCAGA CAGGCAGCCCCACGACCTCAGCATCGACATCTACAGCCGGACACTGTTCTGGACGTGCGAGGCCACCAATACCATCAACGTCCACAGGCT GAGCGGGGAAGCCATGGGGGTGGTGCTGCGTGGGGACCGCGACAAGCCCAGGGCCATCGTCGTCAACGCGGAGCGAGGGTACCTGTACTT CACCAACATGCAGGACCGGGCAGCCAAGATCGAACGCGCAGCCCTGGACGGCACCGAGCGCGAGGTCCTCTTCACCACCGGCCTCATCCG CCCTGTGGCCCTGGTGGTGGACAACACACTGGGCAAGCTGTTCTGGGTGGACGCGGACCTGAAGCGCATTGAGAGCTGTGACCTGTCAGG GGCCAACCGCCTGACCCTGGAGGACGCCAACATCGTGCAGCCTCTGGGCCTGACCATCCTTGGCAAGCATCTCTACTGGATCGACCGCCA GCAGCAGATGATCGAGCGTGTGGAGAAGACCACCGGGGACAAGCGGACTCGCATCCAGGGCCGTGTCGCCCACCTCACTGGCATCCATGC AGTGGAGGAAGTCAGCCTGGAGGAGTTCTCAGCCCACCCATGTGCCCGTGACAATGGTGGCTGCTCCCACATCTGTATTGCCAAGGGTGA TGGGACACCACGGTGCTCATGCCCAGTCCACCTCGTGCTCCTGCAGAACCTGCTGACCTGTGGAGAGCCGCCCACCTGCTCCCCGGACCA GTTTGCATGTGCCACAGGGGAGATCGACTGTATCCCCGGGGCCTGGCGCTGTGACGGCTTTCCCGAGTGCGATGACCAGAGCGACGAGGA GGGCTGCCCCGTGTGCTCCGCCGCCCAGTTCCCCTGCGCGCGGGGTCAGTGTGTGGACCTGCGCCTGCGCTGCGACGGCGAGGCAGACTG TCAGGACCGCTCAGACGAGGCGGACTGTGACGCCATCTGCCTGCCCAACCAGTTCCGGTGTGCGAGCGGCCAGTGTGTCCTCATCAAACA GCAGTGCGACTCCTTCCCCGACTGTATCGACGGCTCCGACGAGCTCATGTGTGAAATCACCAAGCCGCCCTCAGACGACAGCCCGGCCCA CAGCAGTGCCATCGGGCCCGTCATTGGCATCATCCTCTCTCTCTTCGTCATGGGTGGTGTCTATTTTGTGTGCCAGCGCGTGGTGTGCCA GCGCTATGCGGGGGCCAACGGGCCCTTCCCGCACGAGTATGTCAGCGGGACCCCGCACGTGCCCCTCAATTTCATAGCCCCGGGCGGTTC CCAGCATGGCCCCTTCACAGGCATCGCATGCGGAAAGTCCATGATGAGCTCCGTGAGCCTGATGGGGGGCCGGGGCGGGGTGCCCCTCTA CGACCGGAACCACGTCACAGGGGCCTCGTCCAGCAGCTCGTCCAGCACGAAGGCCACGCTGTACCCGCCGATCCTGAACCCGCCGCCCTC CCCGGCCACGGACCCCTCCCTGTACAACATGGACATGTTCTACTCTTCAAACATTCCGGCCACTGCGAGACCGTACAGGCCCTACATCAT TCGAGGAATGGCGCCCCCGACGACGCCCTGCAGCACCGACGTGTGTGACAGCGACTACAGCGCCAGCCGCTGGAAGGCCAGCAAGTACTA CCTGGATTTGAACTCGGACTCAGACCCCTATCCACCCCCACCCACGCCCCACAGCCAGTACCTGTCGGCGGAGGACAGCTGCCCGCCCTC GCCCGCCACCGAGAGGAGCTACTTCCATCTCTTCCCGCCCCCTCCGTCCCCCTGCACGGACTCATCCTGACCTCGGCCGGGCCACTCTGG CTTCTCTGTGCCCCTGTAAATAGTTTTAAATATGAACAAAGAAAAAAATATATTTTATGATTTAAAAAATAAATATAATTGGGATTTTAA AAACATGAGAAATGTGAACTGTGATGGGGTGGGCAGGGCTGGGAGAACTTTGTACAGTGGAGAAATATTTATAAACTTAATTTTGTAAAA >In-frame_RANGRF_ENST00000407006_chr17_8192732_+_LRP5_ENST00000294304_chr11_68177382_+_3448nt AAATCTTAAAGGATCCGGGAGCTAAGCCAGACCCGGGTGGCGGTGGCAGCTGCGAAACCCAGGGAGCCGATGCCACGTGACCCAATGTGG ACTTCTTTTAAACCTTTCTAATGCCCATAACCCAGCCTCAGACCCATGGAGCCCACGAGAGACTGCCCGCTGTTCGGGGGCGCCTTTTCC GCCATCCTCCCCATGGGGGCCATTGACGTAAGCGACCTCCGACCGGTCCCGGACAATCAAGAAGTTTTCTGCCATCCCGTGACGGACCAG AGCCTGATAGTGGAACTTCTCGAGCTGCAGGCCCACGTACGGGGCGAAGCGGCTGCGCGGTACCACTTTGAGGATGTTGGTGGCGTGCAG GGGGCTAGGGCTGTCCATGTGGAGTCTGTTCAGCCTCTCAGTTTGGAGAACCTGGCCCTGAGGGGCCGCTGTCAAGAAGCCTGGGTCCTC TCTGGCAAGCAGCAGATAGCTAAGGAAAACCAGCAGACCATCAGCCGCGCCTTCATGAACGGGAGCTCGGTGGAGCACGTGGTGGAGTTT GGCCTTGACTACCCCGAGGGCATGGCCGTTGACTGGATGGGCAAGAACCTCTACTGGGCCGACACTGGGACCAACAGAATCGAAGTGGCG CGGCTGGACGGGCAGTTCCGGCAAGTCCTCGTGTGGAGGGACTTGGACAACCCGAGGTCGCTGGCCCTGGATCCCACCAAGGGCTACATC TACTGGACCGAGTGGGGCGGCAAGCCGAGGATCGTGCGGGCCTTCATGGACGGGACCAACTGCATGACGCTGGTGGACAAGGTGGGCCGG GCCAACGACCTCACCATTGACTACGCTGACCAGCGCCTCTACTGGACCGACCTGGACACCAACATGATCGAGTCGTCCAACATGCTGGGT CAGGAGCGGGTCGTGATTGCCGACGATCTCCCGCACCCGTTCGGTCTGACGCAGTACAGCGATTATATCTACTGGACAGACTGGAATCTG CACAGCATTGAGCGGGCCGACAAGACTAGCGGCCGGAACCGCACCCTCATCCAGGGCCACCTGGACTTCGTGATGGACATCCTGGTGTTC CACTCCTCCCGCCAGGATGGCCTCAATGACTGTATGCACAACAACGGGCAGTGTGGGCAGCTGTGCCTTGCCATCCCCGGCGGCCACCGC TGCGGCTGCGCCTCACACTACACCCTGGACCCCAGCAGCCGCAACTGCAGCCCGCCCACCACCTTCTTGCTGTTCAGCCAGAAATCTGCC ATCAGTCGGATGATCCCGGACGACCAGCACAGCCCGGATCTCATCCTGCCCCTGCATGGACTGAGGAACGTCAAAGCCATCGACTATGAC CCACTGGACAAGTTCATCTACTGGGTGGATGGGCGCCAGAACATCAAGCGAGCCAAGGACGACGGGACCCAGCCCTTTGTTTTGACCTCT CTGAGCCAAGGCCAAAACCCAGACAGGCAGCCCCACGACCTCAGCATCGACATCTACAGCCGGACACTGTTCTGGACGTGCGAGGCCACC AATACCATCAACGTCCACAGGCTGAGCGGGGAAGCCATGGGGGTGGTGCTGCGTGGGGACCGCGACAAGCCCAGGGCCATCGTCGTCAAC GCGGAGCGAGGGTACCTGTACTTCACCAACATGCAGGACCGGGCAGCCAAGATCGAACGCGCAGCCCTGGACGGCACCGAGCGCGAGGTC CTCTTCACCACCGGCCTCATCCGCCCTGTGGCCCTGGTGGTGGACAACACACTGGGCAAGCTGTTCTGGGTGGACGCGGACCTGAAGCGC ATTGAGAGCTGTGACCTGTCAGGGGCCAACCGCCTGACCCTGGAGGACGCCAACATCGTGCAGCCTCTGGGCCTGACCATCCTTGGCAAG CATCTCTACTGGATCGACCGCCAGCAGCAGATGATCGAGCGTGTGGAGAAGACCACCGGGGACAAGCGGACTCGCATCCAGGGCCGTGTC GCCCACCTCACTGGCATCCATGCAGTGGAGGAAGTCAGCCTGGAGGAGTTCTCAGCCCACCCATGTGCCCGTGACAATGGTGGCTGCTCC CACATCTGTATTGCCAAGGGTGATGGGACACCACGGTGCTCATGCCCAGTCCACCTCGTGCTCCTGCAGAACCTGCTGACCTGTGGAGAG CCGCCCACCTGCTCCCCGGACCAGTTTGCATGTGCCACAGGGGAGATCGACTGTATCCCCGGGGCCTGGCGCTGTGACGGCTTTCCCGAG TGCGATGACCAGAGCGACGAGGAGGGCTGCCCCGTGTGCTCCGCCGCCCAGTTCCCCTGCGCGCGGGGTCAGTGTGTGGACCTGCGCCTG CGCTGCGACGGCGAGGCAGACTGTCAGGACCGCTCAGACGAGGCGGACTGTGACGCCATCTGCCTGCCCAACCAGTTCCGGTGTGCGAGC GGCCAGTGTGTCCTCATCAAACAGCAGTGCGACTCCTTCCCCGACTGTATCGACGGCTCCGACGAGCTCATGTGTGAAATCACCAAGCCG CCCTCAGACGACAGCCCGGCCCACAGCAGTGCCATCGGGCCCGTCATTGGCATCATCCTCTCTCTCTTCGTCATGGGTGGTGTCTATTTT GTGTGCCAGCGCGTGGTGTGCCAGCGCTATGCGGGGGCCAACGGGCCCTTCCCGCACGAGTATGTCAGCGGGACCCCGCACGTGCCCCTC AATTTCATAGCCCCGGGCGGTTCCCAGCATGGCCCCTTCACAGGCATCGCATGCGGAAAGTCCATGATGAGCTCCGTGAGCCTGATGGGG GGCCGGGGCGGGGTGCCCCTCTACGACCGGAACCACGTCACAGGGGCCTCGTCCAGCAGCTCGTCCAGCACGAAGGCCACGCTGTACCCG CCGATCCTGAACCCGCCGCCCTCCCCGGCCACGGACCCCTCCCTGTACAACATGGACATGTTCTACTCTTCAAACATTCCGGCCACTGCG AGACCGTACAGGCCCTACATCATTCGAGGAATGGCGCCCCCGACGACGCCCTGCAGCACCGACGTGTGTGACAGCGACTACAGCGCCAGC CGCTGGAAGGCCAGCAAGTACTACCTGGATTTGAACTCGGACTCAGACCCCTATCCACCCCCACCCACGCCCCACAGCCAGTACCTGTCG GCGGAGGACAGCTGCCCGCCCTCGCCCGCCACCGAGAGGAGCTACTTCCATCTCTTCCCGCCCCCTCCGTCCCCCTGCACGGACTCATCC TGACCTCGGCCGGGCCACTCTGGCTTCTCTGTGCCCCTGTAAATAGTTTTAAATATGAACAAAGAAAAAAATATATTTTATGATTTAAAA AATAAATATAATTGGGATTTTAAAAACATGAGAAATGTGAACTGTGATGGGGTGGGCAGGGCTGGGAGAACTTTGTACAGTGGAGAAATA >In-frame_RANGRF_ENST00000580434_chr17_8192732_+_LRP5_ENST00000294304_chr11_68177382_+_3431nt GGAGCTAAGCCAGACCCGGGTGGCGGTGGCAGCTGCGAAACCCAGGGAGCCGATGCCACGTGACCCAATGTGGACTTCTTTTAAACCTTT CTAATGCCCATAACCCAGCCTCAGACCCATGGAGCCCACGAGAGACTGCCCGCTGTTCGGGGGCGCCTTTTCCGCCATCCTCCCCATGGG GGCCATTGACGTAAGCGACCTCCGACCGGTCCCGGACAATCAAGAAGTTTTCTGCCATCCCGTGACGGACCAGAGCCTGATAGTGGAACT TCTCGAGCTGCAGGCCCACGTACGGGGCGAAGCGGCTGCGCGGTACCACTTTGAGGATGTTGGTGGCGTGCAGGGGGCTAGGGCTGTCCA TGTGGAGTCTGTTCAGCCTCTCAGTTTGGAGAACCTGGCCCTGAGGGGCCGCTGTCAAGAAGCCTGGGTCCTCTCTGGCAAGCAGCAGAT AGCTAAGGAAAACCAGCAGACCATCAGCCGCGCCTTCATGAACGGGAGCTCGGTGGAGCACGTGGTGGAGTTTGGCCTTGACTACCCCGA GGGCATGGCCGTTGACTGGATGGGCAAGAACCTCTACTGGGCCGACACTGGGACCAACAGAATCGAAGTGGCGCGGCTGGACGGGCAGTT CCGGCAAGTCCTCGTGTGGAGGGACTTGGACAACCCGAGGTCGCTGGCCCTGGATCCCACCAAGGGCTACATCTACTGGACCGAGTGGGG CGGCAAGCCGAGGATCGTGCGGGCCTTCATGGACGGGACCAACTGCATGACGCTGGTGGACAAGGTGGGCCGGGCCAACGACCTCACCAT TGACTACGCTGACCAGCGCCTCTACTGGACCGACCTGGACACCAACATGATCGAGTCGTCCAACATGCTGGGTCAGGAGCGGGTCGTGAT TGCCGACGATCTCCCGCACCCGTTCGGTCTGACGCAGTACAGCGATTATATCTACTGGACAGACTGGAATCTGCACAGCATTGAGCGGGC CGACAAGACTAGCGGCCGGAACCGCACCCTCATCCAGGGCCACCTGGACTTCGTGATGGACATCCTGGTGTTCCACTCCTCCCGCCAGGA TGGCCTCAATGACTGTATGCACAACAACGGGCAGTGTGGGCAGCTGTGCCTTGCCATCCCCGGCGGCCACCGCTGCGGCTGCGCCTCACA CTACACCCTGGACCCCAGCAGCCGCAACTGCAGCCCGCCCACCACCTTCTTGCTGTTCAGCCAGAAATCTGCCATCAGTCGGATGATCCC GGACGACCAGCACAGCCCGGATCTCATCCTGCCCCTGCATGGACTGAGGAACGTCAAAGCCATCGACTATGACCCACTGGACAAGTTCAT CTACTGGGTGGATGGGCGCCAGAACATCAAGCGAGCCAAGGACGACGGGACCCAGCCCTTTGTTTTGACCTCTCTGAGCCAAGGCCAAAA CCCAGACAGGCAGCCCCACGACCTCAGCATCGACATCTACAGCCGGACACTGTTCTGGACGTGCGAGGCCACCAATACCATCAACGTCCA CAGGCTGAGCGGGGAAGCCATGGGGGTGGTGCTGCGTGGGGACCGCGACAAGCCCAGGGCCATCGTCGTCAACGCGGAGCGAGGGTACCT GTACTTCACCAACATGCAGGACCGGGCAGCCAAGATCGAACGCGCAGCCCTGGACGGCACCGAGCGCGAGGTCCTCTTCACCACCGGCCT CATCCGCCCTGTGGCCCTGGTGGTGGACAACACACTGGGCAAGCTGTTCTGGGTGGACGCGGACCTGAAGCGCATTGAGAGCTGTGACCT GTCAGGGGCCAACCGCCTGACCCTGGAGGACGCCAACATCGTGCAGCCTCTGGGCCTGACCATCCTTGGCAAGCATCTCTACTGGATCGA CCGCCAGCAGCAGATGATCGAGCGTGTGGAGAAGACCACCGGGGACAAGCGGACTCGCATCCAGGGCCGTGTCGCCCACCTCACTGGCAT CCATGCAGTGGAGGAAGTCAGCCTGGAGGAGTTCTCAGCCCACCCATGTGCCCGTGACAATGGTGGCTGCTCCCACATCTGTATTGCCAA GGGTGATGGGACACCACGGTGCTCATGCCCAGTCCACCTCGTGCTCCTGCAGAACCTGCTGACCTGTGGAGAGCCGCCCACCTGCTCCCC GGACCAGTTTGCATGTGCCACAGGGGAGATCGACTGTATCCCCGGGGCCTGGCGCTGTGACGGCTTTCCCGAGTGCGATGACCAGAGCGA CGAGGAGGGCTGCCCCGTGTGCTCCGCCGCCCAGTTCCCCTGCGCGCGGGGTCAGTGTGTGGACCTGCGCCTGCGCTGCGACGGCGAGGC AGACTGTCAGGACCGCTCAGACGAGGCGGACTGTGACGCCATCTGCCTGCCCAACCAGTTCCGGTGTGCGAGCGGCCAGTGTGTCCTCAT CAAACAGCAGTGCGACTCCTTCCCCGACTGTATCGACGGCTCCGACGAGCTCATGTGTGAAATCACCAAGCCGCCCTCAGACGACAGCCC GGCCCACAGCAGTGCCATCGGGCCCGTCATTGGCATCATCCTCTCTCTCTTCGTCATGGGTGGTGTCTATTTTGTGTGCCAGCGCGTGGT GTGCCAGCGCTATGCGGGGGCCAACGGGCCCTTCCCGCACGAGTATGTCAGCGGGACCCCGCACGTGCCCCTCAATTTCATAGCCCCGGG CGGTTCCCAGCATGGCCCCTTCACAGGCATCGCATGCGGAAAGTCCATGATGAGCTCCGTGAGCCTGATGGGGGGCCGGGGCGGGGTGCC CCTCTACGACCGGAACCACGTCACAGGGGCCTCGTCCAGCAGCTCGTCCAGCACGAAGGCCACGCTGTACCCGCCGATCCTGAACCCGCC GCCCTCCCCGGCCACGGACCCCTCCCTGTACAACATGGACATGTTCTACTCTTCAAACATTCCGGCCACTGCGAGACCGTACAGGCCCTA CATCATTCGAGGAATGGCGCCCCCGACGACGCCCTGCAGCACCGACGTGTGTGACAGCGACTACAGCGCCAGCCGCTGGAAGGCCAGCAA GTACTACCTGGATTTGAACTCGGACTCAGACCCCTATCCACCCCCACCCACGCCCCACAGCCAGTACCTGTCGGCGGAGGACAGCTGCCC GCCCTCGCCCGCCACCGAGAGGAGCTACTTCCATCTCTTCCCGCCCCCTCCGTCCCCCTGCACGGACTCATCCTGACCTCGGCCGGGCCA CTCTGGCTTCTCTGTGCCCCTGTAAATAGTTTTAAATATGAACAAAGAAAAAAATATATTTTATGATTTAAAAAATAAATATAATTGGGA TTTTAAAAACATGAGAAATGTGAACTGTGATGGGGTGGGCAGGGCTGGGAGAACTTTGTACAGTGGAGAAATATTTATAAACTTAATTTT >In-frame_RANGRF_ENST00000439238_chr17_8192732_+_LRP5_ENST00000294304_chr11_68177382_+_4109nt GGAGCTAAGCCAGACCCGGGTGGCGGTGGCAGCTGCGAAACCCAGGGAGCCGATGCCACGTGACCCAATGTGGACTTCTTTTAAACCTTT CTAATGCCCATAACCCAGCCTCAGACCCATGGAGCCCACGAGAGACTGCCCGCTGTTCGGGGGCGCCTTTTCCGCCATCCTCCCCATGGG GGCCATTGACGTAAGCGACCTCCGACCGGTCCCGGACAATCAAGAAGTTTTCTGCCATCCCGTGACGGACCAGAGCCTGATAGTGGAACT TCTCGAGCTGCAGGCCCACGTACGGGGCGAAGCGGCTGCGCGGTACCACTTTGAGGATGTTGGTGGCGTGCAGGGGGCTAGGGCTGTCCA TGTGGAGTCTGTTCAGCCTCTCAGTTTGGAGAACCTGGCCCTGAGGGGCCGCTGTCAAGAAGCCTGGGTCCTCTCTGGCAAGCAGCAGAT AGCTAAGGAAAACCAGCAGGTGAGGGCCCGAGAGTGTGTAATGTCCTGGAAGGGCGGTAGCGGGGACGCAGAGATCCAGGTAAGCATCCT GACTCTGATCCCCTTAGGTAGCAAAGGACGTGACACTTCATCAGGCCTTGCTGAGGCTGCCCCAGTACCAGACTGATCTCTTGCTTACCT TCAATCAGCCCCCGTAAGGAGGAAGGAACGGGCGGGTATCTCATGACTGGGTTCCCAGGAGAATCGGGCTGGGAGGGACAGAACAGGGAG ACTCACTGGTGGGATCCTCCAAGGAAGCAGGAGTGGGCCAGAGGTTTGGGGTAACTGATACCCAGGTCCTCTGGGGAACAGGAATTGGCA ATTTCCAAACCTCAGGCCTGGATGATGTTCTGTCTCCATCTGTTCCCCCACCCCAAGCCCTGACAACAGGTCATCTCTTGGCCCCGAAAA TCTGTCACCTGCACCCTGGAGCCTGGGTGACTTTGAACAGCTGGTGACCAGTCTGACCCTTCACGATCCTAACATCTTTGGTCCCCAGTA AAGGCGCTGAAGCACTGCATGATGTTGCTGAGAACTTGGGGACTCGGTTCTGTGAGGGGGAAAAGAGGTTGAAAAGAGGGTTTCCTCTTA TTTCTTCCCTGTGCGTAAACATAAGACAATCCCTCTTCAGAATAAACTTGCTTTATAATCAATATAAACCATCAGCCGCGCCTTCATGAA CGGGAGCTCGGTGGAGCACGTGGTGGAGTTTGGCCTTGACTACCCCGAGGGCATGGCCGTTGACTGGATGGGCAAGAACCTCTACTGGGC CGACACTGGGACCAACAGAATCGAAGTGGCGCGGCTGGACGGGCAGTTCCGGCAAGTCCTCGTGTGGAGGGACTTGGACAACCCGAGGTC GCTGGCCCTGGATCCCACCAAGGGCTACATCTACTGGACCGAGTGGGGCGGCAAGCCGAGGATCGTGCGGGCCTTCATGGACGGGACCAA CTGCATGACGCTGGTGGACAAGGTGGGCCGGGCCAACGACCTCACCATTGACTACGCTGACCAGCGCCTCTACTGGACCGACCTGGACAC CAACATGATCGAGTCGTCCAACATGCTGGGTCAGGAGCGGGTCGTGATTGCCGACGATCTCCCGCACCCGTTCGGTCTGACGCAGTACAG CGATTATATCTACTGGACAGACTGGAATCTGCACAGCATTGAGCGGGCCGACAAGACTAGCGGCCGGAACCGCACCCTCATCCAGGGCCA CCTGGACTTCGTGATGGACATCCTGGTGTTCCACTCCTCCCGCCAGGATGGCCTCAATGACTGTATGCACAACAACGGGCAGTGTGGGCA GCTGTGCCTTGCCATCCCCGGCGGCCACCGCTGCGGCTGCGCCTCACACTACACCCTGGACCCCAGCAGCCGCAACTGCAGCCCGCCCAC CACCTTCTTGCTGTTCAGCCAGAAATCTGCCATCAGTCGGATGATCCCGGACGACCAGCACAGCCCGGATCTCATCCTGCCCCTGCATGG ACTGAGGAACGTCAAAGCCATCGACTATGACCCACTGGACAAGTTCATCTACTGGGTGGATGGGCGCCAGAACATCAAGCGAGCCAAGGA CGACGGGACCCAGCCCTTTGTTTTGACCTCTCTGAGCCAAGGCCAAAACCCAGACAGGCAGCCCCACGACCTCAGCATCGACATCTACAG CCGGACACTGTTCTGGACGTGCGAGGCCACCAATACCATCAACGTCCACAGGCTGAGCGGGGAAGCCATGGGGGTGGTGCTGCGTGGGGA CCGCGACAAGCCCAGGGCCATCGTCGTCAACGCGGAGCGAGGGTACCTGTACTTCACCAACATGCAGGACCGGGCAGCCAAGATCGAACG CGCAGCCCTGGACGGCACCGAGCGCGAGGTCCTCTTCACCACCGGCCTCATCCGCCCTGTGGCCCTGGTGGTGGACAACACACTGGGCAA GCTGTTCTGGGTGGACGCGGACCTGAAGCGCATTGAGAGCTGTGACCTGTCAGGGGCCAACCGCCTGACCCTGGAGGACGCCAACATCGT GCAGCCTCTGGGCCTGACCATCCTTGGCAAGCATCTCTACTGGATCGACCGCCAGCAGCAGATGATCGAGCGTGTGGAGAAGACCACCGG GGACAAGCGGACTCGCATCCAGGGCCGTGTCGCCCACCTCACTGGCATCCATGCAGTGGAGGAAGTCAGCCTGGAGGAGTTCTCAGCCCA CCCATGTGCCCGTGACAATGGTGGCTGCTCCCACATCTGTATTGCCAAGGGTGATGGGACACCACGGTGCTCATGCCCAGTCCACCTCGT GCTCCTGCAGAACCTGCTGACCTGTGGAGAGCCGCCCACCTGCTCCCCGGACCAGTTTGCATGTGCCACAGGGGAGATCGACTGTATCCC CGGGGCCTGGCGCTGTGACGGCTTTCCCGAGTGCGATGACCAGAGCGACGAGGAGGGCTGCCCCGTGTGCTCCGCCGCCCAGTTCCCCTG CGCGCGGGGTCAGTGTGTGGACCTGCGCCTGCGCTGCGACGGCGAGGCAGACTGTCAGGACCGCTCAGACGAGGCGGACTGTGACGCCAT CTGCCTGCCCAACCAGTTCCGGTGTGCGAGCGGCCAGTGTGTCCTCATCAAACAGCAGTGCGACTCCTTCCCCGACTGTATCGACGGCTC CGACGAGCTCATGTGTGAAATCACCAAGCCGCCCTCAGACGACAGCCCGGCCCACAGCAGTGCCATCGGGCCCGTCATTGGCATCATCCT CTCTCTCTTCGTCATGGGTGGTGTCTATTTTGTGTGCCAGCGCGTGGTGTGCCAGCGCTATGCGGGGGCCAACGGGCCCTTCCCGCACGA GTATGTCAGCGGGACCCCGCACGTGCCCCTCAATTTCATAGCCCCGGGCGGTTCCCAGCATGGCCCCTTCACAGGCATCGCATGCGGAAA GTCCATGATGAGCTCCGTGAGCCTGATGGGGGGCCGGGGCGGGGTGCCCCTCTACGACCGGAACCACGTCACAGGGGCCTCGTCCAGCAG CTCGTCCAGCACGAAGGCCACGCTGTACCCGCCGATCCTGAACCCGCCGCCCTCCCCGGCCACGGACCCCTCCCTGTACAACATGGACAT GTTCTACTCTTCAAACATTCCGGCCACTGCGAGACCGTACAGGCCCTACATCATTCGAGGAATGGCGCCCCCGACGACGCCCTGCAGCAC CGACGTGTGTGACAGCGACTACAGCGCCAGCCGCTGGAAGGCCAGCAAGTACTACCTGGATTTGAACTCGGACTCAGACCCCTATCCACC CCCACCCACGCCCCACAGCCAGTACCTGTCGGCGGAGGACAGCTGCCCGCCCTCGCCCGCCACCGAGAGGAGCTACTTCCATCTCTTCCC GCCCCCTCCGTCCCCCTGCACGGACTCATCCTGACCTCGGCCGGGCCACTCTGGCTTCTCTGTGCCCCTGTAAATAGTTTTAAATATGAA CAAAGAAAAAAATATATTTTATGATTTAAAAAATAAATATAATTGGGATTTTAAAAACATGAGAAATGTGAACTGTGATGGGGTGGGCAG |
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FusionGenePPI for RANGRF_LRP5 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| RANGRF | RAN, THUMPD1, HGS, ZDHHC17, PHF19, RAB3A, SGCZ, AGO3, PDLIM1, SAPCD1, LRRC56, TSEN15, RAB30, IGSF6, WDR59, MUC20, ZNF266, B2M, PTPN11 | LRP5 | AXIN1, SMAD9, CAPRIN2, SOST, DKK1, FZD8, TAZ, RASD2, SUSD4, PARP16, POMK, B3GALT2, ETV6, CHST9, LIPH, PRSS37, CSNK1A1, TGIF2LY, DKKL1, SERPINA12, ST8SIA4, SCGB1D1, DKK4, MGAT4C, F9, FAM3B, C4orf26, FCGRT, PODN, ADAM33, BRINP3, LRRC4C, CLPSL1, NXPH2, TRIM25 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| Hgene | RANGRF | chr17:8192732 | chr11:68177382 | ENST00000226105 | + | 3 | 5 | 27_70 | 117 | 187 | RAN |
| Hgene | RANGRF | chr17:8192732 | chr11:68177382 | ENST00000407006 | + | 3 | 4 | 27_70 | 117 | 147 | RAN |
| Hgene | RANGRF | chr17:8192732 | chr11:68177382 | ENST00000580434 | + | 3 | 4 | 27_70 | 117 | 119 | RAN |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Hgene | RANGRF | chr17:8192732 | chr11:68177382 | ENST00000439238 | + | 1 | 3 | 27_70 | -37 | 166 | RAN |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for RANGRF_LRP5 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for RANGRF_LRP5 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | LRP5 | C0432252 | Osteoporosis with pseudoglioma | 8 | CTD_human;ORPHANET;UNIPROT |
| Tgene | LRP5 | C1866176 | EXUDATIVE VITREORETINOPATHY 4 (disorder) | 8 | CTD_human;UNIPROT |
| Tgene | LRP5 | C1866079 | BONE MINERAL DENSITY QUANTITATIVE TRAIT LOCUS 1 | 5 | UNIPROT |
| Tgene | LRP5 | C0242852 | Proliferative vitreoretinopathy | 1 | CTD_human |
| Tgene | LRP5 | C0432273 | Worth disease | 1 | CTD_human;ORPHANET;UNIPROT |
| Tgene | LRP5 | C1843330 | OSTEOPETROSIS, AUTOSOMAL DOMINANT 1 | 1 | CTD_human;ORPHANET;UNIPROT |
| Tgene | LRP5 | C1851402 | Exudative vitreoretinopathy 1 | 1 | ORPHANET;UNIPROT |
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