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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 30361

FusionGeneSummary for RANGAP1_GRID2

check button Fusion gene summary
Fusion gene informationFusion gene name: RANGAP1_GRID2
Fusion gene ID: 30361
HgeneTgene
Gene symbol

RANGAP1

GRID2

Gene ID

5905

2895

Gene nameRan GTPase activating protein 1glutamate ionotropic receptor delta type subunit 2
SynonymsFug1|RANGAP|SDGluD2|SCAR18
Cytomap

22q13.2

4q22.1-q22.2

Type of geneprotein-codingprotein-coding
Descriptionran GTPase-activating protein 1segregation distorter homologsegregation distortionglutamate receptor ionotropic, delta-2gluR delta-2 subunitglutamate receptor delta-2 subunitglutamate receptor, ionotropic, delta 2
Modification date2018052220180523
UniProtAcc

P46060

O43424

Ensembl transtripts involved in fusion geneENST00000405486, ENST00000356244, 
ENST00000455915, ENST00000407260, 
ENST00000282020, ENST00000505687, 
ENST00000510992, 
Fusion gene scores* DoF score12 X 10 X 6=7205 X 5 X 5=125
# samples 125
** MAII scorelog2(12/720*10)=-2.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(5/125*10)=-1.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RANGAP1 [Title/Abstract] AND GRID2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneRANGAP1

GO:0046826

negative regulation of protein export from nucleus

16449645

HgeneRANGAP1

GO:0090630

activation of GTPase activity

16428860


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BI042006RANGAP1chr22

41642447

-GRID2chr4

94557617

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000405486ENST00000282020RANGAP1chr22

41642447

-GRID2chr4

94557617

-
intron-intronENST00000405486ENST00000505687RANGAP1chr22

41642447

-GRID2chr4

94557617

-
intron-intronENST00000405486ENST00000510992RANGAP1chr22

41642447

-GRID2chr4

94557617

-
intron-intronENST00000356244ENST00000282020RANGAP1chr22

41642447

-GRID2chr4

94557617

-
intron-intronENST00000356244ENST00000505687RANGAP1chr22

41642447

-GRID2chr4

94557617

-
intron-intronENST00000356244ENST00000510992RANGAP1chr22

41642447

-GRID2chr4

94557617

-
intron-intronENST00000455915ENST00000282020RANGAP1chr22

41642447

-GRID2chr4

94557617

-
intron-intronENST00000455915ENST00000505687RANGAP1chr22

41642447

-GRID2chr4

94557617

-
intron-intronENST00000455915ENST00000510992RANGAP1chr22

41642447

-GRID2chr4

94557617

-
5CDS-intronENST00000407260ENST00000282020RANGAP1chr22

41642447

-GRID2chr4

94557617

-
5CDS-intronENST00000407260ENST00000505687RANGAP1chr22

41642447

-GRID2chr4

94557617

-
5CDS-intronENST00000407260ENST00000510992RANGAP1chr22

41642447

-GRID2chr4

94557617

-

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FusionProtFeatures for RANGAP1_GRID2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RANGAP1

P46060

GRID2

O43424

GTPase activator for RAN (PubMed:8146159,PubMed:8896452, PubMed:16428860). Converts cytoplasmic GTP-boundRAN to GDP-bound RAN, which is essential for RAN-mediated nuclearimport and export (PubMed:8896452, PubMed:27160050). Mediatesdissociation of cargo from nuclear export complexes containingXPO1, RAN and RANBP2 after nuclear export (PubMed:27160050).{ECO:0000269|PubMed:16428860, ECO:0000269|PubMed:27160050,ECO:0000269|PubMed:8146159, ECO:0000269|PubMed:8896452}. Receptor for glutamate. L-glutamate acts as anexcitatory neurotransmitter at many synapses in the centralnervous system. The postsynaptic actions of Glu are mediated by avariety of receptors that are named according to their selectiveagonists. Promotes synaptogenesis and mediates the D-Serine-dependent long term depression signals and AMPA receptorendocytosis of cerebellar parallel fiber-Purkinje cell (PF-PC)synapses through the beta-NRX1-CBLN1-GRID2 triad complex(PubMed:27418511). {ECO:0000269|PubMed:27418511}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for RANGAP1_GRID2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for RANGAP1_GRID2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for RANGAP1_GRID2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneGRID2O43424DB00142Glutamic AcidGlutamate receptor ionotropic, delta-2small moleculeapproved|nutraceutical

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RelatedDiseases for RANGAP1_GRID2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneRANGAP1C0079744Diffuse Large B-Cell Lymphoma1CTD_human
TgeneGRID2C4015505SPINOCEREBELLAR ATAXIA, AUTOSOMAL RECESSIVE 181ORPHANET;UNIPROT