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Fusion gene ID: 30359 |
FusionGeneSummary for RANGAP1_FAM53A |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: RANGAP1_FAM53A | Fusion gene ID: 30359 | Hgene | Tgene | Gene symbol | RANGAP1 | FAM53A | Gene ID | 5905 | 152877 |
| Gene name | Ran GTPase activating protein 1 | family with sequence similarity 53 member A | |
| Synonyms | Fug1|RANGAP|SD | DNTNP | |
| Cytomap | 22q13.2 | 4p16.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | ran GTPase-activating protein 1segregation distorter homologsegregation distortion | protein FAM53Adorsal neural-tube nuclear protein | |
| Modification date | 20180522 | 20180519 | |
| UniProtAcc | P46060 | Q6NSI3 | |
| Ensembl transtripts involved in fusion gene | ENST00000405486, ENST00000356244, ENST00000455915, ENST00000407260, | ENST00000308132, ENST00000489363, ENST00000461064, ENST00000472884, | |
| Fusion gene scores | * DoF score | 12 X 10 X 6=720 | 2 X 2 X 2=8 |
| # samples | 12 | 2 | |
| ** MAII score | log2(12/720*10)=-2.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: RANGAP1 [Title/Abstract] AND FAM53A [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | RANGAP1 | GO:0046826 | negative regulation of protein export from nucleus | 16449645 |
| Hgene | RANGAP1 | GO:0090630 | activation of GTPase activity | 16428860 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | SKCM | TCGA-EE-A2ME-06A | RANGAP1 | chr22 | 41676937 | - | FAM53A | chr4 | 1643334 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000405486 | ENST00000308132 | RANGAP1 | chr22 | 41676937 | - | FAM53A | chr4 | 1643334 | - |
| Frame-shift | ENST00000405486 | ENST00000489363 | RANGAP1 | chr22 | 41676937 | - | FAM53A | chr4 | 1643334 | - |
| In-frame | ENST00000405486 | ENST00000461064 | RANGAP1 | chr22 | 41676937 | - | FAM53A | chr4 | 1643334 | - |
| Frame-shift | ENST00000405486 | ENST00000472884 | RANGAP1 | chr22 | 41676937 | - | FAM53A | chr4 | 1643334 | - |
| In-frame | ENST00000356244 | ENST00000308132 | RANGAP1 | chr22 | 41676937 | - | FAM53A | chr4 | 1643334 | - |
| In-frame | ENST00000356244 | ENST00000489363 | RANGAP1 | chr22 | 41676937 | - | FAM53A | chr4 | 1643334 | - |
| Frame-shift | ENST00000356244 | ENST00000461064 | RANGAP1 | chr22 | 41676937 | - | FAM53A | chr4 | 1643334 | - |
| In-frame | ENST00000356244 | ENST00000472884 | RANGAP1 | chr22 | 41676937 | - | FAM53A | chr4 | 1643334 | - |
| In-frame | ENST00000455915 | ENST00000308132 | RANGAP1 | chr22 | 41676937 | - | FAM53A | chr4 | 1643334 | - |
| In-frame | ENST00000455915 | ENST00000489363 | RANGAP1 | chr22 | 41676937 | - | FAM53A | chr4 | 1643334 | - |
| Frame-shift | ENST00000455915 | ENST00000461064 | RANGAP1 | chr22 | 41676937 | - | FAM53A | chr4 | 1643334 | - |
| In-frame | ENST00000455915 | ENST00000472884 | RANGAP1 | chr22 | 41676937 | - | FAM53A | chr4 | 1643334 | - |
| intron-3CDS | ENST00000407260 | ENST00000308132 | RANGAP1 | chr22 | 41676937 | - | FAM53A | chr4 | 1643334 | - |
| intron-3CDS | ENST00000407260 | ENST00000489363 | RANGAP1 | chr22 | 41676937 | - | FAM53A | chr4 | 1643334 | - |
| intron-3CDS | ENST00000407260 | ENST00000461064 | RANGAP1 | chr22 | 41676937 | - | FAM53A | chr4 | 1643334 | - |
| intron-3CDS | ENST00000407260 | ENST00000472884 | RANGAP1 | chr22 | 41676937 | - | FAM53A | chr4 | 1643334 | - |
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FusionProtFeatures for RANGAP1_FAM53A |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| RANGAP1 | FAM53A |
| GTPase activator for RAN (PubMed:8146159,PubMed:8896452, PubMed:16428860). Converts cytoplasmic GTP-boundRAN to GDP-bound RAN, which is essential for RAN-mediated nuclearimport and export (PubMed:8896452, PubMed:27160050). Mediatesdissociation of cargo from nuclear export complexes containingXPO1, RAN and RANBP2 after nuclear export (PubMed:27160050).{ECO:0000269|PubMed:16428860, ECO:0000269|PubMed:27160050,ECO:0000269|PubMed:8146159, ECO:0000269|PubMed:8896452}. | May play an important role in neural development; thedorsomedial roof of the third ventricle.{ECO:0000250|UniProtKB:Q5ZKN5}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for RANGAP1_FAM53A |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_RANGAP1_ENST00000405486_chr22_41676937_-_FAM53A_ENST00000461064_chr4_1643334_-_142aa MASEDIAKLAETLAKTQVAGGQLSFKGKSLKLNTAEDDFKKFKKPLLPQLRRXRXGXHPSEDGSVLPMXLPGPPWHHHAWLQPEGPQDQP >In-frame_RANGAP1_ENST00000356244_chr22_41676937_-_FAM53A_ENST00000308132_chr4_1643334_-_142aa MASEDIAKLAETLAKTQVAGGQLSFKGKSLKLNTAEDDFKKFKKPLLPQLRRXRXGXHPSEDGSVLPMXLPGPPWHHHAWLQPEGPQDQP >In-frame_RANGAP1_ENST00000356244_chr22_41676937_-_FAM53A_ENST00000489363_chr4_1643334_-_53aa >In-frame_RANGAP1_ENST00000356244_chr22_41676937_-_FAM53A_ENST00000472884_chr4_1643334_-_142aa MASEDIAKLAETLAKTQVAGGQLSFKGKSLKLNTAEDDFKKFKKPLLPQLRRXRXGXHPSEDGSVLPMXLPGPPWHHHAWLQPEGPQDQP >In-frame_RANGAP1_ENST00000455915_chr22_41676937_-_FAM53A_ENST00000308132_chr4_1643334_-_142aa MASEDIAKLAETLAKTQVAGGQLSFKGKSLKLNTAEDDFKKFKKPLLPQLRRXRXGXHPSEDGSVLPMXLPGPPWHHHAWLQPEGPQDQP >In-frame_RANGAP1_ENST00000455915_chr22_41676937_-_FAM53A_ENST00000489363_chr4_1643334_-_53aa >In-frame_RANGAP1_ENST00000455915_chr22_41676937_-_FAM53A_ENST00000472884_chr4_1643334_-_142aa MASEDIAKLAETLAKTQVAGGQLSFKGKSLKLNTAEDDFKKFKKPLLPQLRRXRXGXHPSEDGSVLPMXLPGPPWHHHAWLQPEGPQDQP |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_RANGAP1_ENST00000405486_chr22_41676937_-_FAM53A_ENST00000461064_chr4_1643334_-_427nt ATGGCCTCGGAAGACATTGCCAAGCTGGCAGAGACACTTGCCAAGACTCAGGTGGCCGGGGGACAGCTGAGTTTCAAAGGCAAGAGCCTC AAACTCAACACTGCAGAAGATGACTTTAAAAAATTCAAAAAGCCTTTGCTCCCTCAATTACGAAGATGACGATGAGGATGACACCCCAGT GAAGACGGTTCTGTCCTCCCCATGTGACTCCCGGGGCCTCCCTGGCATCACCATGCCTGGCTGCAGCCAGAGGGGCCTCAGGACCAGCCC TGTCCACCCCAACCTGTGGGCCTCTAGGGAGTCGGTGACCAGTGATGGCTCCCGCAGGAGCAGCGGGGACCCCCGTGATGGGGACAGTGT >In-frame_RANGAP1_ENST00000356244_chr22_41676937_-_FAM53A_ENST00000308132_chr4_1643334_-_427nt ATGGCCTCGGAAGACATTGCCAAGCTGGCAGAGACACTTGCCAAGACTCAGGTGGCCGGGGGACAGCTGAGTTTCAAAGGCAAGAGCCTC AAACTCAACACTGCAGAAGATGACTTTAAAAAATTCAAAAAGCCTTTGCTCCCTCAATTACGAAGATGACGATGAGGATGACACCCCAGT GAAGACGGTTCTGTCCTCCCCATGTGACTCCCGGGGCCTCCCTGGCATCACCATGCCTGGCTGCAGCCAGAGGGGCCTCAGGACCAGCCC TGTCCACCCCAACCTGTGGGCCTCTAGGGAGTCGGTGACCAGTGATGGCTCCCGCAGGAGCAGCGGGGACCCCCGTGATGGGGACAGTGT >In-frame_RANGAP1_ENST00000356244_chr22_41676937_-_FAM53A_ENST00000489363_chr4_1643334_-_159nt ATGGCCTCGGAAGACATTGCCAAGCTGGCAGAGACACTTGCCAAGACTCAGGTGGCCGGGGGACAGCTGAGTTTCAAAGGCAAGAGCCTC >In-frame_RANGAP1_ENST00000356244_chr22_41676937_-_FAM53A_ENST00000472884_chr4_1643334_-_427nt ATGGCCTCGGAAGACATTGCCAAGCTGGCAGAGACACTTGCCAAGACTCAGGTGGCCGGGGGACAGCTGAGTTTCAAAGGCAAGAGCCTC AAACTCAACACTGCAGAAGATGACTTTAAAAAATTCAAAAAGCCTTTGCTCCCTCAATTACGAAGATGACGATGAGGATGACACCCCAGT GAAGACGGTTCTGTCCTCCCCATGTGACTCCCGGGGCCTCCCTGGCATCACCATGCCTGGCTGCAGCCAGAGGGGCCTCAGGACCAGCCC TGTCCACCCCAACCTGTGGGCCTCTAGGGAGTCGGTGACCAGTGATGGCTCCCGCAGGAGCAGCGGGGACCCCCGTGATGGGGACAGTGT >In-frame_RANGAP1_ENST00000455915_chr22_41676937_-_FAM53A_ENST00000308132_chr4_1643334_-_427nt ATGGCCTCGGAAGACATTGCCAAGCTGGCAGAGACACTTGCCAAGACTCAGGTGGCCGGGGGACAGCTGAGTTTCAAAGGCAAGAGCCTC AAACTCAACACTGCAGAAGATGACTTTAAAAAATTCAAAAAGCCTTTGCTCCCTCAATTACGAAGATGACGATGAGGATGACACCCCAGT GAAGACGGTTCTGTCCTCCCCATGTGACTCCCGGGGCCTCCCTGGCATCACCATGCCTGGCTGCAGCCAGAGGGGCCTCAGGACCAGCCC TGTCCACCCCAACCTGTGGGCCTCTAGGGAGTCGGTGACCAGTGATGGCTCCCGCAGGAGCAGCGGGGACCCCCGTGATGGGGACAGTGT >In-frame_RANGAP1_ENST00000455915_chr22_41676937_-_FAM53A_ENST00000489363_chr4_1643334_-_159nt ATGGCCTCGGAAGACATTGCCAAGCTGGCAGAGACACTTGCCAAGACTCAGGTGGCCGGGGGACAGCTGAGTTTCAAAGGCAAGAGCCTC >In-frame_RANGAP1_ENST00000455915_chr22_41676937_-_FAM53A_ENST00000472884_chr4_1643334_-_427nt ATGGCCTCGGAAGACATTGCCAAGCTGGCAGAGACACTTGCCAAGACTCAGGTGGCCGGGGGACAGCTGAGTTTCAAAGGCAAGAGCCTC AAACTCAACACTGCAGAAGATGACTTTAAAAAATTCAAAAAGCCTTTGCTCCCTCAATTACGAAGATGACGATGAGGATGACACCCCAGT GAAGACGGTTCTGTCCTCCCCATGTGACTCCCGGGGCCTCCCTGGCATCACCATGCCTGGCTGCAGCCAGAGGGGCCTCAGGACCAGCCC TGTCCACCCCAACCTGTGGGCCTCTAGGGAGTCGGTGACCAGTGATGGCTCCCGCAGGAGCAGCGGGGACCCCCGTGATGGGGACAGTGT |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_RANGAP1_ENST00000405486_chr22_41676937_-_FAM53A_ENST00000461064_chr4_1643334_-_1938nt CTTTCCCCGTCACCTGCCTGGAACAGGGGTGCGGGGCGAGGAGGGCGTGGCGCCCGTGTGCGCCTTCTGCCTGCCCCCTCGGCCTTCTTC ACTTAGCCTTCGACGGCCGAGCGCCCCAGGGGTGGCGGTGGGAGTGGGGTTGTTGAGCGGCGCTGGCTCCTTTCACAAATGGGGAAACTG AGGCTTAAAGGGCGTCTGACTCGCCAGAGCAGCTCAGCCTGCAGCTGCTAGCAGTGGCGTCTCATATTAGCATTGTTGTCAACCGGAGGC GGTGCGAGTCCGCCGGGGATTCCAGATGGGGCTCCTGCGCCGCCCGCCTATCATTTGCGGCCTGTATTCGCGCGTCGCTCCCGCAGAGCC ACCTCCCAGCAGGCCCACGCCCGCGGGGGCCCCGGGCTGGCGCCGCTGTCCCTGGAATCGATAGACGGTCTCCTTCTGTCACCCAGGCTG GAGTGTAGTGGAACGATCACCGCTGAACTGCAGCGTCGGCTTCCTGGGCTCAAGCGATCCTCCCACCTCAACCTCCCAAGTCATGGGGAC TACAGATGCCATCACACCTGGCTAATTTTTAAATTTTTCTGTGGAGACAGGGTCTCATTCTGTTGCCCAGGCTTGTCTCGAACCCTGGTC TAAAGTGATCTTCCCGCCTAGCCTCCCAAAATGTTGGAATTACAGTCTGCAGATCTCCAGGGGAGCCCACCAGCCTAGTCAACATGGCCT CGGAAGACATTGCCAAGCTGGCAGAGACACTTGCCAAGACTCAGGTGGCCGGGGGACAGCTGAGTTTCAAAGGCAAGAGCCTCAAACTCA ACACTGCAGAAGATGACTTTAAAAAATTCAAAAAGCCTTTGCTCCCTCAATTACGAAGATGACGATGAGGATGACACCCCAGTGAAGACG GTTCTGTCCTCCCCATGTGACTCCCGGGGCCTCCCTGGCATCACCATGCCTGGCTGCAGCCAGAGGGGCCTCAGGACCAGCCCTGTCCAC CCCAACCTGTGGGCCTCTAGGGAGTCGGTGACCAGTGATGGCTCCCGCAGGAGCAGCGGGGACCCCCGTGATGGGGACAGTGTCGGGGAG GAGGGCGTCTTCCCCCGGGCCCGCTGGGAGCTGGACCTGGAGCAGATCGAGAACAACTGAGGCTGGTGGGGGCTGGTCGGGGCCATGGCT GCCGCCTGCACCTGCCCTGGGGCACAGAGTAGGTTTCCTGTGAGCTGGTCGGGGCCACGGCCCGGCACCTGCCCTGGGGCACAGAGTAGG TTTCCTGTGAGCTGGTCGGGGCCACGGCTGCCGCCGGCACCTGCCCTGGGGCACAGAGTAGGTTTCCTGTGAGCTGGTCGGGGCCACGGC TGCCGCCGGCACCTGCCCTGGGGCACAGAGTAGGTTTCCTGTGAGCTGGTCGGGGCCACGGCTGCCACCGGCACCTGCCCTGGGGCACAG AGTAGGTTTCCTGTGAGCTGGTCGGGGCCACGGCTGCCGCCTGCACTGCCCTGGGGCACAGACTAGGTTTCCTGTGAGCTGGTCGGGGCC ATGGCTGCTGCCTGCACCTGCCCCAGGGCACAGAGTAGGTTTCCTGTGAGCTGGTCGGGGCCATGGCTGCCGCCTGCACCTGCCCCGGGG CACAGAGTAGGTTTCCTGTGAGCTGGTCGGGGCCATGGCTGCCACCGGCACCTGCCCTGGGGCACAGAGTAGGTTTCCTGTGAGTTGGTC GGGGCCACGGCTGCCGCCTGCACTGCCCTGGGGCACAGACTAGGTTTCATGTGAGCTGGTCGGGGCCATGGCTGCTGCCGGCACCTGCCC TGGGGCACAGAGTAGGTTTCGTGTTGCTTGGAACATTAAGGCGTAATTTTGATTCAGTTTTTCCTAAAGAAGCATTTTGCATTTTTATGG >In-frame_RANGAP1_ENST00000356244_chr22_41676937_-_FAM53A_ENST00000308132_chr4_1643334_-_2143nt GAACAAATCAAATCGAAGCAAAGAAACTGCCGGCTTTCAAAATCCTCCTCCTCCGCCATCATCCGCCGCGGTGCGGAGAGCAGGTGGTGC TGGAAGCGCGTGAGGCCGGGAGCTCGAGAGAGCTAACAGACTAGCCGGCTGGACATCTGGACCGCTGGATCCGGAGGTGGCGACCCCGGC CTGACCCGGACCCTAAATCCGTCCCCGCCCCAGAGGGCGGAGGCGCGCGCTCGATTCCCCCCACGCGGCGGCGCCGCCTGTTTACGTCTG CAGATCTCCAGGGGAGCCCACCAGCCTAGTCAACATGGCCTCGGAAGACATTGCCAAGCTGGCAGAGACACTTGCCAAGACTCAGGTGGC CGGGGGACAGCTGAGTTTCAAAGGCAAGAGCCTCAAACTCAACACTGCAGAAGATGACTTTAAAAAATTCAAAAAGCCTTTGCTCCCTCA ATTACGAAGATGACGATGAGGATGACACCCCAGTGAAGACGGTTCTGTCCTCCCCATGTGACTCCCGGGGCCTCCCTGGCATCACCATGC CTGGCTGCAGCCAGAGGGGCCTCAGGACCAGCCCTGTCCACCCCAACCTGTGGGCCTCTAGGGAGTCGGTGACCAGTGATGGCTCCCGCA GGAGCAGCGGGGACCCCCGTGATGGGGACAGTGTCGGGGAGGAGGGCGTCTTCCCCCGGGCCCGCTGGGAGCTGGACCTGGAGCAGATCG AGAACAACTGAGGCTGGTGGGGGCTGGTCGGGGCCATGGCTGCCGCCTGCACCTGCCCTGGGGCACAGAGTAGGTTTCCTGTGAGCTGGT CGGGGCCACGGCCCGGCACCTGCCCTGGGGCACAGAGTAGGTTTCCTGTGAGCTGGTCGGGGCCACGGCTGCCGCCGGCACCTGCCCTGG GGCACAGAGTAGGTTTCCTGTGAGCTGGTCGGGGCCACGGCTGCCGCCGGCACCTGCCCTGGGGCACAGAGTAGGTTTCCTGTGAGCTGG TCGGGGCCACGGCTGCCACCGGCACCTGCCCTGGGGCACAGAGTAGGTTTCCTGTGAGCTGGTCGGGGCCACGGCTGCCGCCTGCACTGC CCTGGGGCACAGACTAGGTTTCCTGTGAGCTGGTCGGGGCCATGGCTGCTGCCTGCACCTGCCCCAGGGCACAGAGTAGGTTTCCTGTGA GCTGGTCGGGGCCATGGCTGCCGCCTGCACCTGCCCCGGGGCACAGAGTAGGTTTCCTGTGAGCTGGTCGGGGCCATGGCTGCCACCGGC ACCTGCCCTGGGGCACAGAGTAGGTTTCCTGTGAGTTGGTCGGGGCCACGGCTGCCGCCTGCACTGCCCTGGGGCACAGACTAGGTTTCA TGTGAGCTGGTCGGGGCCATGGCTGCTGCCGGCACCTGCCCTGGGGCACAGAGTAGGTTTCGTGTTGCTTGGAACATTAAGGCGTAATTT TGATTCAGTTTTTCCTAAAGAAGCATTTTGCATTTTTATGGCTTTTGCAGTTCGGGAGAAAGCTTCTCTATTTTGGATGCATTTCAGAAG GGCGTTCTATTAAACATGAATCTGCAAACAGATTAACATGCGTCTGTGTTCCCCACGAAAGGCCTGCTGTGCAGGGCGCCTTGTGTGCTT TAGTTGCTAGGAAACCCCGGGCGTTGGTGGTCAGAGTCCCACTGGCCCCGTGTGTCCCCCCCTCCCGACGGGTCACGGTGCTTGGGGCTT GCGCATGGGCATCTGTGCCCATGAACCTTGTCACCCACGTGCCAGTGAACCGCCAGCTTGTGGCCGCCTGGTTTTCCACCGGTGGCAGTG ATGGCCTTTGGGGCAGACCAAGGTGCCATGAGTCCCTGCTTCCCGTGGCCTGGGAGGGCCCTTGCACCTTCAGGTGGGGTGTAGTGCCAG ACCTCTGGGAAGGCTGTCCTGCCGGCAGCACCCGTCAGCACCCACTCTGTGAATTTAATACAAGGCCTTTGCTTTGTGCATACGACTTCT GATTAATTTTCGTTTCCACCATCTGAAGTGGGCCTGGCTGCGCCTCAGGCCTCTGGTCTCTGGCTCAGAACCAGACAAGGCAAGGGATTT >In-frame_RANGAP1_ENST00000356244_chr22_41676937_-_FAM53A_ENST00000489363_chr4_1643334_-_1558nt GAACAAATCAAATCGAAGCAAAGAAACTGCCGGCTTTCAAAATCCTCCTCCTCCGCCATCATCCGCCGCGGTGCGGAGAGCAGGTGGTGC TGGAAGCGCGTGAGGCCGGGAGCTCGAGAGAGCTAACAGACTAGCCGGCTGGACATCTGGACCGCTGGATCCGGAGGTGGCGACCCCGGC CTGACCCGGACCCTAAATCCGTCCCCGCCCCAGAGGGCGGAGGCGCGCGCTCGATTCCCCCCACGCGGCGGCGCCGCCTGTTTACGTCTG CAGATCTCCAGGGGAGCCCACCAGCCTAGTCAACATGGCCTCGGAAGACATTGCCAAGCTGGCAGAGACACTTGCCAAGACTCAGGTGGC CGGGGGACAGCTGAGTTTCAAAGGCAAGAGCCTCAAACTCAACACTGCAGAAGATGACTTTAAAAAATTCAAAAAGCCTTTGCTCCCTCA ATTACGAAGATGACGATGAGGATGACACCCCAGTGAAGACGGTTCTGTCCTCCCCATGTGACTCCCGGGGCCTCCCTGGCATCACCATGC CTGGCTGCAGCCAGAGGGGCCTCAGGACCAGCCCTGTCCACCCCAACCTGTGGGCCTCTAGGGAGTCGGTGACCAGTGATGGCTCCCGCA GGAGCAGCGGGGACCCCCGTGATGGGGACAGTGTCGGGGAGGAGGGCGTCTTCCCCCGGGCCCGCTGGGAGCTGGACCTGGAGCAGATCG AGAACAACTGAGGCTGGTGGGGGCTGGTCGGGGCCATGGCTGCCGCCTGCACCTGCCCTGGGGCACAGAGTAGGTTTCCTGTGAGCTGGT CGGGGCCACGGCCCGGCACCTGCCCTGGGGCACAGAGTAGGTTTCCTGTGAGCTGGTCGGGGCCACGGCTGCCGCCGGCACCTGCCCTGG GGCACAGAGTAGGTTTCCTGTGAGCTGGTCGGGGCCACGGCTGCCGCCGGCACCTGCCCTGGGGCACAGAGTAGGTTTCCTGTGAGCTGG TCGGGGCCACGGCTGCCACCGGCACCTGCCCTGGGGCACAGAGTAGGTTTCCTGTGAGCTGGTCGGGGCCACGGCTGCCGCCTGCACTGC CCTGGGGCACAGACTAGGTTTCCTGTGAGCTGGTCGGGGCCATGGCTGCTGCCTGCACCTGCCCCAGGGCACAGAGTAGGTTTCCTGTGA GCTGGTCGGGGCCATGGCTGCCGCCTGCACCTGCCCCGGGGCACAGAGTAGGTTTCCTGTGAGCTGGTCGGGGCCATGGCTGCCACCGGC ACCTGCCCTGGGGCACAGAGTAGGTTTCCTGTGAGTTGGTCGGGGCCACGGCTGCCGCCTGCACTGCCCTGGGGCACAGACTAGGTTTCA TGTGAGCTGGTCGGGGCCATGGCTGCTGCCGGCACCTGCCCTGGGGCACAGAGTAGGTTTCGTGTTGCTTGGAACATTAAGGCGTAATTT TGATTCAGTTTTTCCTAAAGAAGCATTTTGCATTTTTATGGCTTTTGCAGTTCGGGAGAAAGCTTCTCTATTTTGGATGCATTTCAGAAG >In-frame_RANGAP1_ENST00000356244_chr22_41676937_-_FAM53A_ENST00000472884_chr4_1643334_-_1422nt GAACAAATCAAATCGAAGCAAAGAAACTGCCGGCTTTCAAAATCCTCCTCCTCCGCCATCATCCGCCGCGGTGCGGAGAGCAGGTGGTGC TGGAAGCGCGTGAGGCCGGGAGCTCGAGAGAGCTAACAGACTAGCCGGCTGGACATCTGGACCGCTGGATCCGGAGGTGGCGACCCCGGC CTGACCCGGACCCTAAATCCGTCCCCGCCCCAGAGGGCGGAGGCGCGCGCTCGATTCCCCCCACGCGGCGGCGCCGCCTGTTTACGTCTG CAGATCTCCAGGGGAGCCCACCAGCCTAGTCAACATGGCCTCGGAAGACATTGCCAAGCTGGCAGAGACACTTGCCAAGACTCAGGTGGC CGGGGGACAGCTGAGTTTCAAAGGCAAGAGCCTCAAACTCAACACTGCAGAAGATGACTTTAAAAAATTCAAAAAGCCTTTGCTCCCTCA ATTACGAAGATGACGATGAGGATGACACCCCAGTGAAGACGGTTCTGTCCTCCCCATGTGACTCCCGGGGCCTCCCTGGCATCACCATGC CTGGCTGCAGCCAGAGGGGCCTCAGGACCAGCCCTGTCCACCCCAACCTGTGGGCCTCTAGGGAGTCGGTGACCAGTGATGGCTCCCGCA GGAGCAGCGGGGACCCCCGTGATGGGGACAGTGTCGGGGAGGAGGGCGTCTTCCCCCGGGCCCGCTGGGAGCTGGACCTGGAGCAGATCG AGAACAACTGAGGCTGGTGGGGGCTGGTCGGGGCCATGGCTGCCGCCTGCACCTGCCCTGGGGCACAGAGTAGGTTTCCTGTGAGCTGGT CGGGGCCACGGCCCGGCACCTGCCCTGGGGCACAGAGTAGGTTTCCTGTGAGCTGGTCGGGGCCACGGCTGCCGCCGGCACCTGCCCTGG GGCACAGAGTAGGTTTCCTGTGAGCTGGTCGGGGCCACGGCTGCCGCCGGCACCTGCCCTGGGGCACAGAGTAGGTTTCCTGTGAGCTGG TCGGGGCCACGGCTGCCACCGGCACCTGCCCTGGGGCACAGAGTAGGTTTCCTGTGAGCTGGTCGGGGCCACGGCTGCCGCCTGCACTGC CCTGGGGCACAGACTAGGTTTCCTGTGAGCTGGTCGGGGCCATGGCTGCTGCCTGCACCTGCCCCAGGGCACAGAGTAGGTTTCCTGTGA GCTGGTCGGGGCCATGGCTGCCGCCTGCACCTGCCCCGGGGCACAGAGTAGGTTTCCTGTGAGCTGGTCGGGGCCATGGCTGCCACCGGC ACCTGCCCTGGGGCACAGAGTAGGTTTCCTGTGAGTTGGTCGGGGCCACGGCTGCCGCCTGCACTGCCCTGGGGCACAGACTAGGTTTCA >In-frame_RANGAP1_ENST00000455915_chr22_41676937_-_FAM53A_ENST00000308132_chr4_1643334_-_3309nt CCCTGTCTCTACTAAAAATACAAAAAAATTAGCTGGACATGGTGGTGGGTGCCTGTAATCCCAGCTACTCAGGAGGCTGAGGCAGGAGAA TGACATGAACCTTGGAGGCGGAGCTTGCAGTGAGCCCAGATGGCGCCACTGTGCTCCAGCCTGGGCGACTGAGCGAGACTCCGTCTCAAA AAAAAAAAATTCTTTCATTTATTTAGTTACTTTTAGAGATAGAGCCTCCCGCTGTTGCCCAGGCTGGAGTGCAGTGGCAGTCATAGCTTA CTGCAGCTTTGAACTCCTGGGCTCAAATGATCCTCCTGCCTCAGCCTCTCCAGTAGCTGGGACTGACTACAGGCACGTGCCACCACACCC AGCTAATTTTTATTTTTATTTTTATTTTTTTGAGACAGGGTTTTACTCTGTCACCCAGGCTAGAGTGCAGTGGTGAGATCATGGCTCACT GTAGCCTCTGTCTCCGGGGCTCAATCAATCCTCCCACCTCAGCCTCCCCAGTGGCTGGGATTACTGGTGCACACCACCATACCCTGCTAA TTGTATTTATTTTTAGTAGAGATGGGATTTTGCCATGTTGCCCAGACTGGTCTTGAGCTGCTGGGCTCAAGCGATCTTCCCATCACAGCT TCCCAATGTGCTGGGATTACAGGTGTGAGCCACTGTACCTGGCCAGCTTTACTTCTTTTACCAGCACTCCTGATTTTATAAATAGTGAGG CTTATCAACCCCATTTCTACCCAAATCTTCTGGTAGACTTGAGTATAGTAGGGCTTCATAGGTAGCAGCCCTGTCCCTGTCCTATTATGA TGGTAGCTGTTGTGATGTGGCGATCTCTGATCTAGAAACCCCTGAGGGGCCATTGTGGCCTGCCCAGTCTCCCGGCCACGGTTGAAACCA GACGTGCAGTGGGGCTGACCCCTGTGCCCCACCCCAGAGTCATGCCAGCGTGGGTGGTGGGGCATTCTCTGGGATGAATGATCTGGATCC CATAGCCATCTGTGTCCTGTTTGAGGAATGGGACCCTCAAACAGAGAACAGCCAAGATGCTCAAGCAGGTGTGTGCTTGGGCCAGACTCT GCAGCCTTTGGTTTGGGACTTGACTGCCATTCACTGAAGGGGCCCAGGAAATGGGCAGCTCACATGGTGTTGCTGGGTGTCCAGCTGCGG CAGTTTAGCAGAGGAGGACTTGTAATGAGATGGTAGCTTCTTATAGGCTAAGACATGATTTTTCTGTTCTTTTACTACCTCCTGCACCTT CTAGAACTGTTCCTTCTCTGATGCTGTTTTCCTTTCTTCCAGTGATTTATCTCTAGGGTCTCCATAGCAGGGGAGGTAGGGTCAGACTCC TGAGATGGCTGATGTCCTACCCTGCCCCCAACCAGGGGCCCCAGGAGACTCCTTTTTCTTACTGCAACTTTGGCCTCCTCAGTCTGCAGA TCTCCAGGGGAGCCCACCAGCCTAGTCAACATGGCCTCGGAAGACATTGCCAAGCTGGCAGAGACACTTGCCAAGACTCAGGTGGCCGGG GGACAGCTGAGTTTCAAAGGCAAGAGCCTCAAACTCAACACTGCAGAAGATGACTTTAAAAAATTCAAAAAGCCTTTGCTCCCTCAATTA CGAAGATGACGATGAGGATGACACCCCAGTGAAGACGGTTCTGTCCTCCCCATGTGACTCCCGGGGCCTCCCTGGCATCACCATGCCTGG CTGCAGCCAGAGGGGCCTCAGGACCAGCCCTGTCCACCCCAACCTGTGGGCCTCTAGGGAGTCGGTGACCAGTGATGGCTCCCGCAGGAG CAGCGGGGACCCCCGTGATGGGGACAGTGTCGGGGAGGAGGGCGTCTTCCCCCGGGCCCGCTGGGAGCTGGACCTGGAGCAGATCGAGAA CAACTGAGGCTGGTGGGGGCTGGTCGGGGCCATGGCTGCCGCCTGCACCTGCCCTGGGGCACAGAGTAGGTTTCCTGTGAGCTGGTCGGG GCCACGGCCCGGCACCTGCCCTGGGGCACAGAGTAGGTTTCCTGTGAGCTGGTCGGGGCCACGGCTGCCGCCGGCACCTGCCCTGGGGCA CAGAGTAGGTTTCCTGTGAGCTGGTCGGGGCCACGGCTGCCGCCGGCACCTGCCCTGGGGCACAGAGTAGGTTTCCTGTGAGCTGGTCGG GGCCACGGCTGCCACCGGCACCTGCCCTGGGGCACAGAGTAGGTTTCCTGTGAGCTGGTCGGGGCCACGGCTGCCGCCTGCACTGCCCTG GGGCACAGACTAGGTTTCCTGTGAGCTGGTCGGGGCCATGGCTGCTGCCTGCACCTGCCCCAGGGCACAGAGTAGGTTTCCTGTGAGCTG GTCGGGGCCATGGCTGCCGCCTGCACCTGCCCCGGGGCACAGAGTAGGTTTCCTGTGAGCTGGTCGGGGCCATGGCTGCCACCGGCACCT GCCCTGGGGCACAGAGTAGGTTTCCTGTGAGTTGGTCGGGGCCACGGCTGCCGCCTGCACTGCCCTGGGGCACAGACTAGGTTTCATGTG AGCTGGTCGGGGCCATGGCTGCTGCCGGCACCTGCCCTGGGGCACAGAGTAGGTTTCGTGTTGCTTGGAACATTAAGGCGTAATTTTGAT TCAGTTTTTCCTAAAGAAGCATTTTGCATTTTTATGGCTTTTGCAGTTCGGGAGAAAGCTTCTCTATTTTGGATGCATTTCAGAAGGGCG TTCTATTAAACATGAATCTGCAAACAGATTAACATGCGTCTGTGTTCCCCACGAAAGGCCTGCTGTGCAGGGCGCCTTGTGTGCTTTAGT TGCTAGGAAACCCCGGGCGTTGGTGGTCAGAGTCCCACTGGCCCCGTGTGTCCCCCCCTCCCGACGGGTCACGGTGCTTGGGGCTTGCGC ATGGGCATCTGTGCCCATGAACCTTGTCACCCACGTGCCAGTGAACCGCCAGCTTGTGGCCGCCTGGTTTTCCACCGGTGGCAGTGATGG CCTTTGGGGCAGACCAAGGTGCCATGAGTCCCTGCTTCCCGTGGCCTGGGAGGGCCCTTGCACCTTCAGGTGGGGTGTAGTGCCAGACCT CTGGGAAGGCTGTCCTGCCGGCAGCACCCGTCAGCACCCACTCTGTGAATTTAATACAAGGCCTTTGCTTTGTGCATACGACTTCTGATT AATTTTCGTTTCCACCATCTGAAGTGGGCCTGGCTGCGCCTCAGGCCTCTGGTCTCTGGCTCAGAACCAGACAAGGCAAGGGATTTCCTG >In-frame_RANGAP1_ENST00000455915_chr22_41676937_-_FAM53A_ENST00000489363_chr4_1643334_-_2724nt CCCTGTCTCTACTAAAAATACAAAAAAATTAGCTGGACATGGTGGTGGGTGCCTGTAATCCCAGCTACTCAGGAGGCTGAGGCAGGAGAA TGACATGAACCTTGGAGGCGGAGCTTGCAGTGAGCCCAGATGGCGCCACTGTGCTCCAGCCTGGGCGACTGAGCGAGACTCCGTCTCAAA AAAAAAAAATTCTTTCATTTATTTAGTTACTTTTAGAGATAGAGCCTCCCGCTGTTGCCCAGGCTGGAGTGCAGTGGCAGTCATAGCTTA CTGCAGCTTTGAACTCCTGGGCTCAAATGATCCTCCTGCCTCAGCCTCTCCAGTAGCTGGGACTGACTACAGGCACGTGCCACCACACCC AGCTAATTTTTATTTTTATTTTTATTTTTTTGAGACAGGGTTTTACTCTGTCACCCAGGCTAGAGTGCAGTGGTGAGATCATGGCTCACT GTAGCCTCTGTCTCCGGGGCTCAATCAATCCTCCCACCTCAGCCTCCCCAGTGGCTGGGATTACTGGTGCACACCACCATACCCTGCTAA TTGTATTTATTTTTAGTAGAGATGGGATTTTGCCATGTTGCCCAGACTGGTCTTGAGCTGCTGGGCTCAAGCGATCTTCCCATCACAGCT TCCCAATGTGCTGGGATTACAGGTGTGAGCCACTGTACCTGGCCAGCTTTACTTCTTTTACCAGCACTCCTGATTTTATAAATAGTGAGG CTTATCAACCCCATTTCTACCCAAATCTTCTGGTAGACTTGAGTATAGTAGGGCTTCATAGGTAGCAGCCCTGTCCCTGTCCTATTATGA TGGTAGCTGTTGTGATGTGGCGATCTCTGATCTAGAAACCCCTGAGGGGCCATTGTGGCCTGCCCAGTCTCCCGGCCACGGTTGAAACCA GACGTGCAGTGGGGCTGACCCCTGTGCCCCACCCCAGAGTCATGCCAGCGTGGGTGGTGGGGCATTCTCTGGGATGAATGATCTGGATCC CATAGCCATCTGTGTCCTGTTTGAGGAATGGGACCCTCAAACAGAGAACAGCCAAGATGCTCAAGCAGGTGTGTGCTTGGGCCAGACTCT GCAGCCTTTGGTTTGGGACTTGACTGCCATTCACTGAAGGGGCCCAGGAAATGGGCAGCTCACATGGTGTTGCTGGGTGTCCAGCTGCGG CAGTTTAGCAGAGGAGGACTTGTAATGAGATGGTAGCTTCTTATAGGCTAAGACATGATTTTTCTGTTCTTTTACTACCTCCTGCACCTT CTAGAACTGTTCCTTCTCTGATGCTGTTTTCCTTTCTTCCAGTGATTTATCTCTAGGGTCTCCATAGCAGGGGAGGTAGGGTCAGACTCC TGAGATGGCTGATGTCCTACCCTGCCCCCAACCAGGGGCCCCAGGAGACTCCTTTTTCTTACTGCAACTTTGGCCTCCTCAGTCTGCAGA TCTCCAGGGGAGCCCACCAGCCTAGTCAACATGGCCTCGGAAGACATTGCCAAGCTGGCAGAGACACTTGCCAAGACTCAGGTGGCCGGG GGACAGCTGAGTTTCAAAGGCAAGAGCCTCAAACTCAACACTGCAGAAGATGACTTTAAAAAATTCAAAAAGCCTTTGCTCCCTCAATTA CGAAGATGACGATGAGGATGACACCCCAGTGAAGACGGTTCTGTCCTCCCCATGTGACTCCCGGGGCCTCCCTGGCATCACCATGCCTGG CTGCAGCCAGAGGGGCCTCAGGACCAGCCCTGTCCACCCCAACCTGTGGGCCTCTAGGGAGTCGGTGACCAGTGATGGCTCCCGCAGGAG CAGCGGGGACCCCCGTGATGGGGACAGTGTCGGGGAGGAGGGCGTCTTCCCCCGGGCCCGCTGGGAGCTGGACCTGGAGCAGATCGAGAA CAACTGAGGCTGGTGGGGGCTGGTCGGGGCCATGGCTGCCGCCTGCACCTGCCCTGGGGCACAGAGTAGGTTTCCTGTGAGCTGGTCGGG GCCACGGCCCGGCACCTGCCCTGGGGCACAGAGTAGGTTTCCTGTGAGCTGGTCGGGGCCACGGCTGCCGCCGGCACCTGCCCTGGGGCA CAGAGTAGGTTTCCTGTGAGCTGGTCGGGGCCACGGCTGCCGCCGGCACCTGCCCTGGGGCACAGAGTAGGTTTCCTGTGAGCTGGTCGG GGCCACGGCTGCCACCGGCACCTGCCCTGGGGCACAGAGTAGGTTTCCTGTGAGCTGGTCGGGGCCACGGCTGCCGCCTGCACTGCCCTG GGGCACAGACTAGGTTTCCTGTGAGCTGGTCGGGGCCATGGCTGCTGCCTGCACCTGCCCCAGGGCACAGAGTAGGTTTCCTGTGAGCTG GTCGGGGCCATGGCTGCCGCCTGCACCTGCCCCGGGGCACAGAGTAGGTTTCCTGTGAGCTGGTCGGGGCCATGGCTGCCACCGGCACCT GCCCTGGGGCACAGAGTAGGTTTCCTGTGAGTTGGTCGGGGCCACGGCTGCCGCCTGCACTGCCCTGGGGCACAGACTAGGTTTCATGTG AGCTGGTCGGGGCCATGGCTGCTGCCGGCACCTGCCCTGGGGCACAGAGTAGGTTTCGTGTTGCTTGGAACATTAAGGCGTAATTTTGAT TCAGTTTTTCCTAAAGAAGCATTTTGCATTTTTATGGCTTTTGCAGTTCGGGAGAAAGCTTCTCTATTTTGGATGCATTTCAGAAGGGCG >In-frame_RANGAP1_ENST00000455915_chr22_41676937_-_FAM53A_ENST00000472884_chr4_1643334_-_2588nt CCCTGTCTCTACTAAAAATACAAAAAAATTAGCTGGACATGGTGGTGGGTGCCTGTAATCCCAGCTACTCAGGAGGCTGAGGCAGGAGAA TGACATGAACCTTGGAGGCGGAGCTTGCAGTGAGCCCAGATGGCGCCACTGTGCTCCAGCCTGGGCGACTGAGCGAGACTCCGTCTCAAA AAAAAAAAATTCTTTCATTTATTTAGTTACTTTTAGAGATAGAGCCTCCCGCTGTTGCCCAGGCTGGAGTGCAGTGGCAGTCATAGCTTA CTGCAGCTTTGAACTCCTGGGCTCAAATGATCCTCCTGCCTCAGCCTCTCCAGTAGCTGGGACTGACTACAGGCACGTGCCACCACACCC AGCTAATTTTTATTTTTATTTTTATTTTTTTGAGACAGGGTTTTACTCTGTCACCCAGGCTAGAGTGCAGTGGTGAGATCATGGCTCACT GTAGCCTCTGTCTCCGGGGCTCAATCAATCCTCCCACCTCAGCCTCCCCAGTGGCTGGGATTACTGGTGCACACCACCATACCCTGCTAA TTGTATTTATTTTTAGTAGAGATGGGATTTTGCCATGTTGCCCAGACTGGTCTTGAGCTGCTGGGCTCAAGCGATCTTCCCATCACAGCT TCCCAATGTGCTGGGATTACAGGTGTGAGCCACTGTACCTGGCCAGCTTTACTTCTTTTACCAGCACTCCTGATTTTATAAATAGTGAGG CTTATCAACCCCATTTCTACCCAAATCTTCTGGTAGACTTGAGTATAGTAGGGCTTCATAGGTAGCAGCCCTGTCCCTGTCCTATTATGA TGGTAGCTGTTGTGATGTGGCGATCTCTGATCTAGAAACCCCTGAGGGGCCATTGTGGCCTGCCCAGTCTCCCGGCCACGGTTGAAACCA GACGTGCAGTGGGGCTGACCCCTGTGCCCCACCCCAGAGTCATGCCAGCGTGGGTGGTGGGGCATTCTCTGGGATGAATGATCTGGATCC CATAGCCATCTGTGTCCTGTTTGAGGAATGGGACCCTCAAACAGAGAACAGCCAAGATGCTCAAGCAGGTGTGTGCTTGGGCCAGACTCT GCAGCCTTTGGTTTGGGACTTGACTGCCATTCACTGAAGGGGCCCAGGAAATGGGCAGCTCACATGGTGTTGCTGGGTGTCCAGCTGCGG CAGTTTAGCAGAGGAGGACTTGTAATGAGATGGTAGCTTCTTATAGGCTAAGACATGATTTTTCTGTTCTTTTACTACCTCCTGCACCTT CTAGAACTGTTCCTTCTCTGATGCTGTTTTCCTTTCTTCCAGTGATTTATCTCTAGGGTCTCCATAGCAGGGGAGGTAGGGTCAGACTCC TGAGATGGCTGATGTCCTACCCTGCCCCCAACCAGGGGCCCCAGGAGACTCCTTTTTCTTACTGCAACTTTGGCCTCCTCAGTCTGCAGA TCTCCAGGGGAGCCCACCAGCCTAGTCAACATGGCCTCGGAAGACATTGCCAAGCTGGCAGAGACACTTGCCAAGACTCAGGTGGCCGGG GGACAGCTGAGTTTCAAAGGCAAGAGCCTCAAACTCAACACTGCAGAAGATGACTTTAAAAAATTCAAAAAGCCTTTGCTCCCTCAATTA CGAAGATGACGATGAGGATGACACCCCAGTGAAGACGGTTCTGTCCTCCCCATGTGACTCCCGGGGCCTCCCTGGCATCACCATGCCTGG CTGCAGCCAGAGGGGCCTCAGGACCAGCCCTGTCCACCCCAACCTGTGGGCCTCTAGGGAGTCGGTGACCAGTGATGGCTCCCGCAGGAG CAGCGGGGACCCCCGTGATGGGGACAGTGTCGGGGAGGAGGGCGTCTTCCCCCGGGCCCGCTGGGAGCTGGACCTGGAGCAGATCGAGAA CAACTGAGGCTGGTGGGGGCTGGTCGGGGCCATGGCTGCCGCCTGCACCTGCCCTGGGGCACAGAGTAGGTTTCCTGTGAGCTGGTCGGG GCCACGGCCCGGCACCTGCCCTGGGGCACAGAGTAGGTTTCCTGTGAGCTGGTCGGGGCCACGGCTGCCGCCGGCACCTGCCCTGGGGCA CAGAGTAGGTTTCCTGTGAGCTGGTCGGGGCCACGGCTGCCGCCGGCACCTGCCCTGGGGCACAGAGTAGGTTTCCTGTGAGCTGGTCGG GGCCACGGCTGCCACCGGCACCTGCCCTGGGGCACAGAGTAGGTTTCCTGTGAGCTGGTCGGGGCCACGGCTGCCGCCTGCACTGCCCTG GGGCACAGACTAGGTTTCCTGTGAGCTGGTCGGGGCCATGGCTGCTGCCTGCACCTGCCCCAGGGCACAGAGTAGGTTTCCTGTGAGCTG GTCGGGGCCATGGCTGCCGCCTGCACCTGCCCCGGGGCACAGAGTAGGTTTCCTGTGAGCTGGTCGGGGCCATGGCTGCCACCGGCACCT GCCCTGGGGCACAGAGTAGGTTTCCTGTGAGTTGGTCGGGGCCACGGCTGCCGCCTGCACTGCCCTGGGGCACAGACTAGGTTTCATGTG |
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FusionGenePPI for RANGAP1_FAM53A |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| RANGAP1 | UBE2I, SUMO1, RAN, RANGAP1, BABAM1, MEPCE, PMS1, TOPORS, RANBP2, ARRB2, SIRT7, USPL1, CSNK2A1, PCGF2, NXF1, PRDX6, NDUFA7, SORD, PRPF8, DYNC1LI1, EFTUD2, HUWE1, PPIF, PNPT1, NCOA6, PPIB, MMS19, SOX2, LMNA, EGFR, GNAI3, GNAI1, CCL5, SENP1, NLK, MIB1, KIAA1279, ACTR2, ACTR3, ARPC1B, ARPC2, BAG1, CALU, DBNL, EEF2K, EFTUD1, IPO11, LPP, NIF3L1, NSUN2, OSGEP, PANK4, PPP2R5D, RPRD1B, SAE1, SH3GLB1, THG1L, TP53RK, TPD52L2, TPRKB, UFM1, SENP2, CUL7, OBSL1, RNF2, UBE2E3, RCC1, C11orf58, COL4A3BP, CPSF4, EEF1G, GNL1, GTF3C3, IPO5, KDM2A, NCL, PCF11, POLR3C, RALY, CPSF1, PTBP1, U2AF2, UBR5, XPO1, RGPD2, RGPD5, RGPD6, SUB1, SUPT5H, UBR4, NTRK1, SCARNA22, NUP85, NUP107, NUP35, KPNB1, NUP153, ATP6AP2, SEH1L, MYO18A, JUN, RBPJ, FOXB1, FOXE1, FOXJ3, TMUB1, FOXL1, FOXQ1, SNW1, CDC5L, CDH1, CTDSPL2, B2M, TMEM194A, DLD, DLST, PDHA1, TRIM25, BRCA1 | FAM53A | APP |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for RANGAP1_FAM53A |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for RANGAP1_FAM53A |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | RANGAP1 | C0079744 | Diffuse Large B-Cell Lymphoma | 1 | CTD_human |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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