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Fusion gene ID: 30354 |
FusionGeneSummary for RANBP9_TXNDC5 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: RANBP9_TXNDC5 | Fusion gene ID: 30354 | Hgene | Tgene | Gene symbol | RANBP9 | TXNDC5 | Gene ID | 10048 | 81567 |
| Gene name | RAN binding protein 9 | thioredoxin domain containing 5 | |
| Synonyms | BPM-L|BPM90|RANBPM|RanBP7 | ENDOPDI|ERP46|HCC-2|HCC2|PDIA15|STRF8|UNQ364 | |
| Cytomap | 6p23 | 6p24.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | ran-binding protein 9Ran Binding Protein in the Microtubule organizing centernovel centrosomal protein RanBPMran binding protein, centrosomalran-binding protein M | thioredoxin domain-containing protein 5ER protein 46endoplasmic reticulum protein ERp46endoplasmic reticulum resident protein 46endothelial protein disulphide isomeraseprotein disulfide isomerase family A, member 15thioredoxin domain containing 5 (e | |
| Modification date | 20180522 | 20180523 | |
| UniProtAcc | Q96S59 | Q8NBS9 | |
| Ensembl transtripts involved in fusion gene | ENST00000011619, ENST00000469916, ENST00000539980, | ENST00000539054, ENST00000379757, ENST00000473453, | |
| Fusion gene scores | * DoF score | 9 X 4 X 4=144 | 7 X 7 X 2=98 |
| # samples | 6 | 7 | |
| ** MAII score | log2(6/144*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(7/98*10)=-0.485426827170242 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: RANBP9 [Title/Abstract] AND TXNDC5 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Oncogene involved fusion gene, in-frame and retained their domain. Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LGG | TCGA-HT-7604-01A | RANBP9 | chr6 | 13697017 | - | TXNDC5 | chr6 | 7904956 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000011619 | ENST00000539054 | RANBP9 | chr6 | 13697017 | - | TXNDC5 | chr6 | 7904956 | - |
| In-frame | ENST00000011619 | ENST00000379757 | RANBP9 | chr6 | 13697017 | - | TXNDC5 | chr6 | 7904956 | - |
| 5CDS-5UTR | ENST00000011619 | ENST00000473453 | RANBP9 | chr6 | 13697017 | - | TXNDC5 | chr6 | 7904956 | - |
| intron-3CDS | ENST00000469916 | ENST00000539054 | RANBP9 | chr6 | 13697017 | - | TXNDC5 | chr6 | 7904956 | - |
| intron-3CDS | ENST00000469916 | ENST00000379757 | RANBP9 | chr6 | 13697017 | - | TXNDC5 | chr6 | 7904956 | - |
| intron-5UTR | ENST00000469916 | ENST00000473453 | RANBP9 | chr6 | 13697017 | - | TXNDC5 | chr6 | 7904956 | - |
| intron-3CDS | ENST00000539980 | ENST00000539054 | RANBP9 | chr6 | 13697017 | - | TXNDC5 | chr6 | 7904956 | - |
| intron-3CDS | ENST00000539980 | ENST00000379757 | RANBP9 | chr6 | 13697017 | - | TXNDC5 | chr6 | 7904956 | - |
| intron-5UTR | ENST00000539980 | ENST00000473453 | RANBP9 | chr6 | 13697017 | - | TXNDC5 | chr6 | 7904956 | - |
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FusionProtFeatures for RANBP9_TXNDC5 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| RANBP9 | TXNDC5 |
| May act as an adapter protein to couple membranereceptors to intracellular signaling pathways. May be involved insignaling of ITGB2/LFA-1 and other integrins. Enhances HGF-METsignaling by recruiting Sos and activating the Ras pathway.Enhances dihydrotestosterone-induced transactivation activity ofAR, as well as dexamethasone-induced transactivation activity ofNR3C1, but not affect estrogen-induced transactivation. StabilizesTP73 isoform Alpha, probably by inhibiting its ubiquitination, andincreases its proapoptotic activity. Inhibits the kinase activityof DYRK1A and DYRK1B. Inhibits FMR1 binding to RNA.{ECO:0000269|PubMed:12147692, ECO:0000269|PubMed:12361945,ECO:0000269|PubMed:14500717, ECO:0000269|PubMed:14722085,ECO:0000269|PubMed:15381419, ECO:0000269|PubMed:15558019,ECO:0000269|PubMed:18222118}. | Possesses thioredoxin activity. Has been shown to reduceinsulin disulfide bonds. Also complements protein disulfide-isomerase deficiency in yeast (By similarity). {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | RANBP9 | chr6:13697017 | chr6:7904956 | ENST00000011619 | - | 2 | 14 | 11_18 | 227 | 730 | Compositional bias | Note=Poly-Gln |
| Hgene | RANBP9 | chr6:13697017 | chr6:7904956 | ENST00000011619 | - | 2 | 14 | 21_24 | 227 | 730 | Compositional bias | Note=Poly-Pro |
| Hgene | RANBP9 | chr6:13697017 | chr6:7904956 | ENST00000011619 | - | 2 | 14 | 25_131 | 227 | 730 | Compositional bias | Note=Ala-rich |
| Hgene | RANBP9 | chr6:13697017 | chr6:7904956 | ENST00000011619 | - | 2 | 14 | 5_10 | 227 | 730 | Compositional bias | Note=Poly-Pro |
| Hgene | RANBP9 | chr6:13697017 | chr6:7904956 | ENST00000011619 | - | 2 | 14 | 62_66 | 227 | 730 | Compositional bias | Note=Poly-Ala |
| Hgene | RANBP9 | chr6:13697017 | chr6:7904956 | ENST00000011619 | - | 2 | 14 | 71_77 | 227 | 730 | Compositional bias | Note=Poly-Pro |
| Hgene | RANBP9 | chr6:13697017 | chr6:7904956 | ENST00000011619 | - | 2 | 14 | 82_92 | 227 | 730 | Compositional bias | Note=Poly-Pro |
| Tgene | >TXNDC5 | chr6:13697017 | chr6:7904956 | ENST00000379757 | - | 0 | 10 | 170_295 | 87 | 433 | Domain | Thioredoxin 2 |
| Tgene | >TXNDC5 | chr6:13697017 | chr6:7904956 | ENST00000379757 | - | 0 | 10 | 304_429 | 87 | 433 | Domain | Thioredoxin 3 |
| Tgene | >TXNDC5 | chr6:13697017 | chr6:7904956 | ENST00000473453 | - | 0 | 10 | 170_295 | -21 | 325 | Domain | Thioredoxin 2 |
| Tgene | >TXNDC5 | chr6:13697017 | chr6:7904956 | ENST00000473453 | - | 0 | 10 | 304_429 | -21 | 325 | Domain | Thioredoxin 3 |
| Tgene | >TXNDC5 | chr6:13697017 | chr6:7904956 | ENST00000473453 | - | 0 | 10 | 36_169 | -21 | 325 | Domain | Thioredoxin 1 |
| Tgene | >TXNDC5 | chr6:13697017 | chr6:7904956 | ENST00000379757 | - | 0 | 10 | 429_432 | 87 | 433 | Motif | Prevents secretion from ER |
| Tgene | >TXNDC5 | chr6:13697017 | chr6:7904956 | ENST00000473453 | - | 0 | 10 | 429_432 | -21 | 325 | Motif | Prevents secretion from ER |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >RANBP9 | chr6:13697017 | chr6:7904956 | ENST00000011619 | - | 2 | 14 | 147_334 | 227 | 730 | Domain | B30.2/SPRY |
| Hgene | >RANBP9 | chr6:13697017 | chr6:7904956 | ENST00000011619 | - | 2 | 14 | 365_397 | 227 | 730 | Domain | LisH |
| Hgene | >RANBP9 | chr6:13697017 | chr6:7904956 | ENST00000011619 | - | 2 | 14 | 403_460 | 227 | 730 | Domain | CTLH |
| Tgene | TXNDC5 | chr6:13697017 | chr6:7904956 | ENST00000379757 | - | 0 | 10 | 36_169 | 87 | 433 | Domain | Thioredoxin 1 |
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FusionGeneSequence for RANBP9_TXNDC5 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_RANBP9_ENST00000011619_chr6_13697017_-_TXNDC5_ENST00000539054_chr6_7904956_-_573aa MSGQPPPPPPQQQQQQQQLSPPPPAALAPVSGVVLPAPPAVSAGSSPAGSPGGGAGGEGLGAAAAALLLHPPPPPPPATAAPPPPPPPPP PPASAAAPASGPPAPPGLAAGPGPAGGAPTPALVAGSSAAAPFPHGDSALNEQEKELQRRLKRLYPAVDEQETPLPRSWSPKDKFSYIGL SQNNLRVHYKGHGKTPKDAASVRATHPIPAACGIYYFEVKIVSKGRDGCGHCQRLQPTWNDLGDKYNSMEDAKVYVAKVDCTAHSDVCSA QGVRGYPTLKLFKPGQEAVKYQGPRDFQTLENWMLQTLNEEPVTPEPEVEPPSAPELKQGLYELSASNFELHVAQGDHFIKFFAPWCGHC KALAPTWEQLALGLEHSETVKIGKVDCTQHYELCSGNQVRGYPTLLWFRDGKKVDQYKGKRDLESLREYVESQLQRTETGATETVTPSEA PVLAAEPEADKGTVLALTENNFDDTIAEGITFIKFYAPWCGHCKTLAPTWEELSKKEFPGLAGVKIAEVDCTAERNICSKYSVRGYPTLL >In-frame_RANBP9_ENST00000011619_chr6_13697017_-_TXNDC5_ENST00000379757_chr6_7904956_-_573aa MSGQPPPPPPQQQQQQQQLSPPPPAALAPVSGVVLPAPPAVSAGSSPAGSPGGGAGGEGLGAAAAALLLHPPPPPPPATAAPPPPPPPPP PPASAAAPASGPPAPPGLAAGPGPAGGAPTPALVAGSSAAAPFPHGDSALNEQEKELQRRLKRLYPAVDEQETPLPRSWSPKDKFSYIGL SQNNLRVHYKGHGKTPKDAASVRATHPIPAACGIYYFEVKIVSKGRDGCGHCQRLQPTWNDLGDKYNSMEDAKVYVAKVDCTAHSDVCSA QGVRGYPTLKLFKPGQEAVKYQGPRDFQTLENWMLQTLNEEPVTPEPEVEPPSAPELKQGLYELSASNFELHVAQGDHFIKFFAPWCGHC KALAPTWEQLALGLEHSETVKIGKVDCTQHYELCSGNQVRGYPTLLWFRDGKKVDQYKGKRDLESLREYVESQLQRTETGATETVTPSEA PVLAAEPEADKGTVLALTENNFDDTIAEGITFIKFYAPWCGHCKTLAPTWEELSKKEFPGLAGVKIAEVDCTAERNICSKYSVRGYPTLL |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_RANBP9_ENST00000011619_chr6_13697017_-_TXNDC5_ENST00000539054_chr6_7904956_-_1719nt ATGTCCGGGCAGCCGCCGCCGCCGCCGCCGCAGCAGCAGCAACAGCAGCAGCAGCTGTCGCCGCCACCGCCGGCGGCCTTGGCCCCAGTC TCCGGAGTCGTCCTGCCGGCGCCCCCGGCCGTCAGCGCCGGCTCTTCTCCGGCCGGCTCGCCCGGCGGCGGTGCGGGCGGCGAAGGCTTA GGGGCCGCGGCGGCCGCCCTGCTCCTCCACCCTCCGCCGCCGCCGCCCCCGGCCACCGCGGCCCCGCCGCCCCCGCCGCCGCCCCCGCCT CCCCCTGCCTCAGCGGCTGCCCCCGCCAGCGGGCCGCCCGCTCCCCCGGGCCTTGCAGCGGGCCCCGGCCCGGCTGGAGGAGCCCCGACC CCAGCTCTGGTGGCGGGCAGCAGCGCCGCGGCCCCCTTCCCTCACGGGGACTCGGCCCTGAACGAGCAGGAGAAGGAGTTGCAGCGGCGG CTGAAGCGTCTCTACCCGGCCGTGGACGAACAAGAGACGCCGCTGCCTCGGTCCTGGAGCCCGAAGGACAAGTTCAGCTACATCGGCCTC TCTCAGAACAACCTGCGGGTGCACTACAAAGGTCATGGCAAAACCCCAAAAGATGCCGCGTCAGTTCGAGCCACGCATCCAATACCAGCA GCCTGTGGGATTTATTATTTTGAAGTAAAAATTGTCAGTAAGGGAAGAGATGGGTGTGGACACTGCCAGCGGCTGCAGCCGACTTGGAAT GACCTGGGAGACAAATACAACAGCATGGAAGATGCCAAAGTCTATGTGGCTAAAGTGGACTGCACGGCCCACTCCGACGTGTGCTCCGCC CAGGGGGTGCGAGGATACCCCACCTTAAAGCTTTTCAAGCCAGGCCAAGAAGCTGTGAAGTACCAGGGTCCTCGGGACTTCCAGACACTG GAAAACTGGATGCTGCAGACACTGAACGAGGAGCCAGTGACACCAGAGCCGGAAGTGGAACCGCCCAGTGCCCCCGAGCTCAAGCAAGGG CTGTATGAGCTCTCAGCAAGCAACTTTGAGCTGCACGTTGCACAAGGCGACCACTTTATCAAGTTCTTCGCTCCGTGGTGTGGTCACTGC AAAGCCCTGGCTCCAACCTGGGAGCAGCTGGCTCTGGGCCTTGAACATTCCGAAACTGTCAAGATTGGCAAGGTTGATTGTACACAGCAC TATGAACTCTGCTCCGGAAACCAGGTTCGTGGCTATCCCACTCTTCTCTGGTTCCGAGATGGGAAAAAGGTGGATCAGTACAAGGGAAAG CGGGATTTGGAGTCACTGAGGGAGTACGTGGAGTCGCAGCTGCAGCGCACAGAGACTGGAGCGACGGAGACCGTCACGCCCTCAGAGGCC CCGGTGCTGGCAGCTGAGCCCGAGGCTGACAAGGGCACTGTGTTGGCACTCACTGAAAATAACTTCGATGACACCATTGCAGAAGGAATA ACCTTCATCAAGTTTTATGCTCCATGGTGTGGTCATTGTAAGACTCTGGCTCCTACTTGGGAGGAACTCTCTAAAAAGGAATTCCCTGGT CTGGCGGGGGTCAAGATCGCCGAAGTAGACTGCACTGCTGAACGGAATATCTGCAGCAAGTATTCGGTACGAGGCTACCCCACGTTATTG CTTTTCCGAGGAGGGAAGAAAGTCAGTGAGCACAGTGGAGGCAGAGACCTTGACTCGTTACACCGCTTTGTCCTGAGCCAAGCGAAAGAC >In-frame_RANBP9_ENST00000011619_chr6_13697017_-_TXNDC5_ENST00000379757_chr6_7904956_-_1719nt ATGTCCGGGCAGCCGCCGCCGCCGCCGCCGCAGCAGCAGCAACAGCAGCAGCAGCTGTCGCCGCCACCGCCGGCGGCCTTGGCCCCAGTC TCCGGAGTCGTCCTGCCGGCGCCCCCGGCCGTCAGCGCCGGCTCTTCTCCGGCCGGCTCGCCCGGCGGCGGTGCGGGCGGCGAAGGCTTA GGGGCCGCGGCGGCCGCCCTGCTCCTCCACCCTCCGCCGCCGCCGCCCCCGGCCACCGCGGCCCCGCCGCCCCCGCCGCCGCCCCCGCCT CCCCCTGCCTCAGCGGCTGCCCCCGCCAGCGGGCCGCCCGCTCCCCCGGGCCTTGCAGCGGGCCCCGGCCCGGCTGGAGGAGCCCCGACC CCAGCTCTGGTGGCGGGCAGCAGCGCCGCGGCCCCCTTCCCTCACGGGGACTCGGCCCTGAACGAGCAGGAGAAGGAGTTGCAGCGGCGG CTGAAGCGTCTCTACCCGGCCGTGGACGAACAAGAGACGCCGCTGCCTCGGTCCTGGAGCCCGAAGGACAAGTTCAGCTACATCGGCCTC TCTCAGAACAACCTGCGGGTGCACTACAAAGGTCATGGCAAAACCCCAAAAGATGCCGCGTCAGTTCGAGCCACGCATCCAATACCAGCA GCCTGTGGGATTTATTATTTTGAAGTAAAAATTGTCAGTAAGGGAAGAGATGGGTGTGGACACTGCCAGCGGCTGCAGCCGACTTGGAAT GACCTGGGAGACAAATACAACAGCATGGAAGATGCCAAAGTCTATGTGGCTAAAGTGGACTGCACGGCCCACTCCGACGTGTGCTCCGCC CAGGGGGTGCGAGGATACCCCACCTTAAAGCTTTTCAAGCCAGGCCAAGAAGCTGTGAAGTACCAGGGTCCTCGGGACTTCCAGACACTG GAAAACTGGATGCTGCAGACACTGAACGAGGAGCCAGTGACACCAGAGCCGGAAGTGGAACCGCCCAGTGCCCCCGAGCTCAAGCAAGGG CTGTATGAGCTCTCAGCAAGCAACTTTGAGCTGCACGTTGCACAAGGCGACCACTTTATCAAGTTCTTCGCTCCGTGGTGTGGTCACTGC AAAGCCCTGGCTCCAACCTGGGAGCAGCTGGCTCTGGGCCTTGAACATTCCGAAACTGTCAAGATTGGCAAGGTTGATTGTACACAGCAC TATGAACTCTGCTCCGGAAACCAGGTTCGTGGCTATCCCACTCTTCTCTGGTTCCGAGATGGGAAAAAGGTGGATCAGTACAAGGGAAAG CGGGATTTGGAGTCACTGAGGGAGTACGTGGAGTCGCAGCTGCAGCGCACAGAGACTGGAGCGACGGAGACCGTCACGCCCTCAGAGGCC CCGGTGCTGGCAGCTGAGCCCGAGGCTGACAAGGGCACTGTGTTGGCACTCACTGAAAATAACTTCGATGACACCATTGCAGAAGGAATA ACCTTCATCAAGTTTTATGCTCCATGGTGTGGTCATTGTAAGACTCTGGCTCCTACTTGGGAGGAACTCTCTAAAAAGGAATTCCCTGGT CTGGCGGGGGTCAAGATCGCCGAAGTAGACTGCACTGCTGAACGGAATATCTGCAGCAAGTATTCGGTACGAGGCTACCCCACGTTATTG CTTTTCCGAGGAGGGAAGAAAGTCAGTGAGCACAGTGGAGGCAGAGACCTTGACTCGTTACACCGCTTTGTCCTGAGCCAAGCGAAAGAC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_RANBP9_ENST00000011619_chr6_13697017_-_TXNDC5_ENST00000539054_chr6_7904956_-_3672nt GAAGCAGAGGAGGAAGGAGAGAAGAGGTGGAGGTGGCCGCAGGCTGAGTCGCGGCCGGGATGTCCGGGCAGCCGCCGCCGCCGCCGCCGC AGCAGCAGCAACAGCAGCAGCAGCTGTCGCCGCCACCGCCGGCGGCCTTGGCCCCAGTCTCCGGAGTCGTCCTGCCGGCGCCCCCGGCCG TCAGCGCCGGCTCTTCTCCGGCCGGCTCGCCCGGCGGCGGTGCGGGCGGCGAAGGCTTAGGGGCCGCGGCGGCCGCCCTGCTCCTCCACC CTCCGCCGCCGCCGCCCCCGGCCACCGCGGCCCCGCCGCCCCCGCCGCCGCCCCCGCCTCCCCCTGCCTCAGCGGCTGCCCCCGCCAGCG GGCCGCCCGCTCCCCCGGGCCTTGCAGCGGGCCCCGGCCCGGCTGGAGGAGCCCCGACCCCAGCTCTGGTGGCGGGCAGCAGCGCCGCGG CCCCCTTCCCTCACGGGGACTCGGCCCTGAACGAGCAGGAGAAGGAGTTGCAGCGGCGGCTGAAGCGTCTCTACCCGGCCGTGGACGAAC AAGAGACGCCGCTGCCTCGGTCCTGGAGCCCGAAGGACAAGTTCAGCTACATCGGCCTCTCTCAGAACAACCTGCGGGTGCACTACAAAG GTCATGGCAAAACCCCAAAAGATGCCGCGTCAGTTCGAGCCACGCATCCAATACCAGCAGCCTGTGGGATTTATTATTTTGAAGTAAAAA TTGTCAGTAAGGGAAGAGATGGGTGTGGACACTGCCAGCGGCTGCAGCCGACTTGGAATGACCTGGGAGACAAATACAACAGCATGGAAG ATGCCAAAGTCTATGTGGCTAAAGTGGACTGCACGGCCCACTCCGACGTGTGCTCCGCCCAGGGGGTGCGAGGATACCCCACCTTAAAGC TTTTCAAGCCAGGCCAAGAAGCTGTGAAGTACCAGGGTCCTCGGGACTTCCAGACACTGGAAAACTGGATGCTGCAGACACTGAACGAGG AGCCAGTGACACCAGAGCCGGAAGTGGAACCGCCCAGTGCCCCCGAGCTCAAGCAAGGGCTGTATGAGCTCTCAGCAAGCAACTTTGAGC TGCACGTTGCACAAGGCGACCACTTTATCAAGTTCTTCGCTCCGTGGTGTGGTCACTGCAAAGCCCTGGCTCCAACCTGGGAGCAGCTGG CTCTGGGCCTTGAACATTCCGAAACTGTCAAGATTGGCAAGGTTGATTGTACACAGCACTATGAACTCTGCTCCGGAAACCAGGTTCGTG GCTATCCCACTCTTCTCTGGTTCCGAGATGGGAAAAAGGTGGATCAGTACAAGGGAAAGCGGGATTTGGAGTCACTGAGGGAGTACGTGG AGTCGCAGCTGCAGCGCACAGAGACTGGAGCGACGGAGACCGTCACGCCCTCAGAGGCCCCGGTGCTGGCAGCTGAGCCCGAGGCTGACA AGGGCACTGTGTTGGCACTCACTGAAAATAACTTCGATGACACCATTGCAGAAGGAATAACCTTCATCAAGTTTTATGCTCCATGGTGTG GTCATTGTAAGACTCTGGCTCCTACTTGGGAGGAACTCTCTAAAAAGGAATTCCCTGGTCTGGCGGGGGTCAAGATCGCCGAAGTAGACT GCACTGCTGAACGGAATATCTGCAGCAAGTATTCGGTACGAGGCTACCCCACGTTATTGCTTTTCCGAGGAGGGAAGAAAGTCAGTGAGC ACAGTGGAGGCAGAGACCTTGACTCGTTACACCGCTTTGTCCTGAGCCAAGCGAAAGACGAACTTTAGGAACACAGTTGGAGGTCACCTC TCCTGCCCAGCTCCCGCACCCTGCGTTTAGGAGTTCAGTCCCACAGAGGCCACTGGGTTCCCAGTGGTGGCTGTTCAGAAAGCAGAACAT ACTAAGCGTGAGGTATCTTCTTTGTGTGTGTGTTTTCCAAGCCAACACACTCTACAGATTCTTTATTAAGTTAAGTTTCTCTAAGTAAAT GTGTAACTCATGGTCACTGTGTAAACATTTTCAGTGGCGATATATCCCCTTTGACCTTCTCTTGATGAAATTTACATGGTTTCCTTTGAG ACTAAAATAGCGTTGAGGGAAATGAAATTGCTGGACTATTTGTGGCTCCTGAGTTGAGTGATTTTGGTGAAAGAAAGCACATCCAAAGCA TAGTTTACCTGCCCACGAGTTCTGGAAAGGTGGCCTTGTGGCAGTATTGACGTTCCTCTGATCTTAAGGTCACAGTTGACTCAATACTGT GTTGGTCCGTAGCATGGAGCAGATTGAAATGCAAAAACCCACACCTCTGGAAGATACCTTCACGGCCGCTGCTGGAGCTTCTGTTGCTGT GAATACTTCTCTCAGTGTGAGAGGTTAGCCGTGATGAAAGCAGCGTTACTTCTGACCGTGCCTGAGTAAGAGAATGCTGATGCCATAACT TTATGTGTCGATACTTGTCAAATCAGTTACTGTTCAGGGGATCCTTCTGTTTCTCACGGGGTGAAACATGTCTTTAGTTCCTCATGTTAA CACGAAGCCAGAGCCCACATGAACTGTTGGATGTCTTCCTTAGAAAGGGTAGGCATGGAAAATTCCACGAGGCTCATTCTCAGTATCTCA TTAACTCATTGAAAGATTCCAGTTGTATTTGTCACCTGGGGTGACAAGACCAGACAGGCTTTCCCAGGCCTGGGTATCCAGGGAGGCTCT GCAGCCCTGCTGAAGGGCCCTAACTAGAGTTCTAGAGTTTCTGATTCTGTTTCTCAGTAGTCCTTTTAGAGGCTTGCTATACTTGGTCTG CTTCAAGGAGGTCGACCTTCTAATGTATGAAGAATGGGATGCATTTGATCTCAAGACCAAAGACAGATGTCAGTGGGCTGCTCTGGCCCT GGTGTGCACGGCTGTGGCAGCTGTTGATGCCAGTGTCCTCTAACTCATGCTGTCCTTGTGATTAAACACCTCTATCTCCCTTGGGAATAA GCACATACAGGCTTAAGCTCTAAGATAGATAGGTGTTTGTCCTTTTACCATCGAGCTACTTCCCATAATAACCACTTTGCATCCAACACT CTTCACCCACCTCCCATACGCAAGGGGATGTGGATACTTGGCCCAAAGTAACTGGTGGTAGGAATCTTAGAAACAAGACCACTTATACTG TCTGTCTGAGGCAGAAGATAACAGCAGCATCTCGACCAGCCTCTGCCTTAAAGGAAATCTTTATTAATCACGTATGGTTCACAGATAATT CTTTTTTTAAAAAAACCCAACCTCCTAGAGAAGCACAACTGTCAAGAGTCTTGTACACACAACTTCAGCTTTGCATCACGAGTCTTGTAT TCCAAGAAAATCAAAGTGGTACAATTTGTTTGTTTACACTATGATACTTTCTAAATAAACTCTTTTTTTTTAAAAGTCTGGTCTTTCCTT CAATGTTACAGCAAAACAGATATAAAATAGACAATAAATTATAGTTTATATTTACAAAAAAAGCTGTAAGTGCAAACAGTTGTAGATTAT AAATGTATTATTTAATCAGTTTAGTATGAAATTGCCTTCCCAGTACATGATTGTGAAAAAGACATTTAGAAAATATTCTAAAATTTAATC >In-frame_RANBP9_ENST00000011619_chr6_13697017_-_TXNDC5_ENST00000379757_chr6_7904956_-_3405nt GAAGCAGAGGAGGAAGGAGAGAAGAGGTGGAGGTGGCCGCAGGCTGAGTCGCGGCCGGGATGTCCGGGCAGCCGCCGCCGCCGCCGCCGC AGCAGCAGCAACAGCAGCAGCAGCTGTCGCCGCCACCGCCGGCGGCCTTGGCCCCAGTCTCCGGAGTCGTCCTGCCGGCGCCCCCGGCCG TCAGCGCCGGCTCTTCTCCGGCCGGCTCGCCCGGCGGCGGTGCGGGCGGCGAAGGCTTAGGGGCCGCGGCGGCCGCCCTGCTCCTCCACC CTCCGCCGCCGCCGCCCCCGGCCACCGCGGCCCCGCCGCCCCCGCCGCCGCCCCCGCCTCCCCCTGCCTCAGCGGCTGCCCCCGCCAGCG GGCCGCCCGCTCCCCCGGGCCTTGCAGCGGGCCCCGGCCCGGCTGGAGGAGCCCCGACCCCAGCTCTGGTGGCGGGCAGCAGCGCCGCGG CCCCCTTCCCTCACGGGGACTCGGCCCTGAACGAGCAGGAGAAGGAGTTGCAGCGGCGGCTGAAGCGTCTCTACCCGGCCGTGGACGAAC AAGAGACGCCGCTGCCTCGGTCCTGGAGCCCGAAGGACAAGTTCAGCTACATCGGCCTCTCTCAGAACAACCTGCGGGTGCACTACAAAG GTCATGGCAAAACCCCAAAAGATGCCGCGTCAGTTCGAGCCACGCATCCAATACCAGCAGCCTGTGGGATTTATTATTTTGAAGTAAAAA TTGTCAGTAAGGGAAGAGATGGGTGTGGACACTGCCAGCGGCTGCAGCCGACTTGGAATGACCTGGGAGACAAATACAACAGCATGGAAG ATGCCAAAGTCTATGTGGCTAAAGTGGACTGCACGGCCCACTCCGACGTGTGCTCCGCCCAGGGGGTGCGAGGATACCCCACCTTAAAGC TTTTCAAGCCAGGCCAAGAAGCTGTGAAGTACCAGGGTCCTCGGGACTTCCAGACACTGGAAAACTGGATGCTGCAGACACTGAACGAGG AGCCAGTGACACCAGAGCCGGAAGTGGAACCGCCCAGTGCCCCCGAGCTCAAGCAAGGGCTGTATGAGCTCTCAGCAAGCAACTTTGAGC TGCACGTTGCACAAGGCGACCACTTTATCAAGTTCTTCGCTCCGTGGTGTGGTCACTGCAAAGCCCTGGCTCCAACCTGGGAGCAGCTGG CTCTGGGCCTTGAACATTCCGAAACTGTCAAGATTGGCAAGGTTGATTGTACACAGCACTATGAACTCTGCTCCGGAAACCAGGTTCGTG GCTATCCCACTCTTCTCTGGTTCCGAGATGGGAAAAAGGTGGATCAGTACAAGGGAAAGCGGGATTTGGAGTCACTGAGGGAGTACGTGG AGTCGCAGCTGCAGCGCACAGAGACTGGAGCGACGGAGACCGTCACGCCCTCAGAGGCCCCGGTGCTGGCAGCTGAGCCCGAGGCTGACA AGGGCACTGTGTTGGCACTCACTGAAAATAACTTCGATGACACCATTGCAGAAGGAATAACCTTCATCAAGTTTTATGCTCCATGGTGTG GTCATTGTAAGACTCTGGCTCCTACTTGGGAGGAACTCTCTAAAAAGGAATTCCCTGGTCTGGCGGGGGTCAAGATCGCCGAAGTAGACT GCACTGCTGAACGGAATATCTGCAGCAAGTATTCGGTACGAGGCTACCCCACGTTATTGCTTTTCCGAGGAGGGAAGAAAGTCAGTGAGC ACAGTGGAGGCAGAGACCTTGACTCGTTACACCGCTTTGTCCTGAGCCAAGCGAAAGACGAACTTTAGGAACACAGTTGGAGGTCACCTC TCCTGCCCAGCTCCCGCACCCTGCGTTTAGGAGTTCAGTCCCACAGAGGCCACTGGGTTCCCAGTGGTGGCTGTTCAGAAAGCAGAACAT ACTAAGCGTGAGGTATCTTCTTTGTGTGTGTGTTTTCCAAGCCAACACACTCTACAGATTCTTTATTAAGTTAAGTTTCTCTAAGTAAAT GTGTAACTCATGGTCACTGTGTAAACATTTTCAGTGGCGATATATCCCCTTTGACCTTCTCTTGATGAAATTTACATGGTTTCCTTTGAG ACTAAAATAGCGTTGAGGGAAATGAAATTGCTGGACTATTTGTGGCTCCTGAGTTGAGTGATTTTGGTGAAAGAAAGCACATCCAAAGCA TAGTTTACCTGCCCACGAGTTCTGGAAAGGTGGCCTTGTGGCAGTATTGACGTTCCTCTGATCTTAAGGTCACAGTTGACTCAATACTGT GTTGGTCCGTAGCATGGAGCAGATTGAAATGCAAAAACCCACACCTCTGGAAGATACCTTCACGGCCGCTGCTGGAGCTTCTGTTGCTGT GAATACTTCTCTCAGTGTGAGAGGTTAGCCGTGATGAAAGCAGCGTTACTTCTGACCGTGCCTGAGTAAGAGAATGCTGATGCCATAACT TTATGTGTCGATACTTGTCAAATCAGTTACTGTTCAGGGGATCCTTCTGTTTCTCACGGGGTGAAACATGTCTTTAGTTCCTCATGTTAA CACGAAGCCAGAGCCCACATGAACTGTTGGATGTCTTCCTTAGAAAGGGTAGGCATGGAAAATTCCACGAGGCTCATTCTCAGTATCTCA TTAACTCATTGAAAGATTCCAGTTGTATTTGTCACCTGGGGTGACAAGACCAGACAGGCTTTCCCAGGCCTGGGTATCCAGGGAGGCTCT GCAGCCCTGCTGAAGGGCCCTAACTAGAGTTCTAGAGTTTCTGATTCTGTTTCTCAGTAGTCCTTTTAGAGGCTTGCTATACTTGGTCTG CTTCAAGGAGGTCGACCTTCTAATGTATGAAGAATGGGATGCATTTGATCTCAAGACCAAAGACAGATGTCAGTGGGCTGCTCTGGCCCT GGTGTGCACGGCTGTGGCAGCTGTTGATGCCAGTGTCCTCTAACTCATGCTGTCCTTGTGATTAAACACCTCTATCTCCCTTGGGAATAA GCACATACAGGCTTAAGCTCTAAGATAGATAGGTGTTTGTCCTTTTACCATCGAGCTACTTCCCATAATAACCACTTTGCATCCAACACT CTTCACCCACCTCCCATACGCAAGGGGATGTGGATACTTGGCCCAAAGTAACTGGTGGTAGGAATCTTAGAAACAAGACCACTTATACTG TCTGTCTGAGGCAGAAGATAACAGCAGCATCTCGACCAGCCTCTGCCTTAAAGGAAATCTTTATTAATCACGTATGGTTCACAGATAATT CTTTTTTTAAAAAAACCCAACCTCCTAGAGAAGCACAACTGTCAAGAGTCTTGTACACACAACTTCAGCTTTGCATCACGAGTCTTGTAT |
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FusionGenePPI for RANBP9_TXNDC5 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| RANBP9 | USP11, AR, S100A7, RNPS1, NR3C1, DYRK1B, DISC1, CALB1, UCHL1, MET, HIPK2, RAN, GID8, MPHOSPH8, MKLN1, USP42, PMS1, AIRE, WNK1, APC, PRKACA, TP73, TRAF6, UBC, NCOR2, NCOA6, PPARD, HNF4G, MAPK6, LLGL1, PPP1CA, ARRB1, SPP1, GRK5, MAEA, RMND5A, RANBP9, DDX1, DYNC1H1, DCTN2, PSMC3, DDB1, DCTN1, EEF1A1, BRCA1, NOTCH1, PPP1CC, SMAD9, SMAD3, SMAD2, SPAG8, SOX2, CLEC7A, LTB4R2, TGFBR1, PSMD13, RPS12, RPS13, RPS27, RPS27L, WDR26, TSR1, UBE2I, CBS, HDAC6, FXR1, LRP1, APP, BACE1, HMBS, ADAP1, ADAP2, ITGB2, CD4, ITGB1, TFRC, THRB, THRA, ESR1, L1CAM, PRKCD, PRKCG, DRD1, NTRK2, ENTPD1, CDK11B, FMR1, COPS5, CACNA1G, AXL, RAF1, OPRM1, TP53, GDNF, GLIPR1L2, MMP7, SFRP2, TDGF1, MRPL4, HLA-DPB1, PRG2, EPB41L3, UNK, NTRK1, MED4, EXOC2, CCND1, ILK, NAF1, SKI, TUBA1B, NFATC1, NFATC2, ATM, PIGT, PRG3, BMP1, RANBP10, YPEL5, ARMC8, RMND5B, GID4, ZMYND19, DDX5, RAB8A, EFHC2, PRPF31, LMNA | TXNDC5 | CUL3, DCUN1D1, APP, VCP, TRMT1, TWF1, CSE1L, DBN1, ZNF706, NENF, ZNHIT2, TBCB, HSP90AA1, PRPF4, NDUFB11, UBXN1, UNC45A, PPP1R21, ZNF207, ATP6V1A, HDAC2, HDAC10, GNAI3, ALDOC, BZW1, LDHB, PGD, TGM2, UBE2V1, YWHAG, YWHAQ, TRIM23, EFEMP1, TRIP6, BLZF1, KRT38, SPRY2, GMPPB, KRTAP4-12, KRTAP4-2, LHX4, KRT40, ALS2CR12, MGAT5B, TRIM42, KRTAP10-7, KRTAP10-9, KRTAP10-5, KRTAP10-8, KRTAP10-3, NOTCH2NL, CUL7, EED, SPTB, WDR59, IMPDH1, KLHL26, VRK3, JMJD8, RNF20, RNF40, GDI2, RPA2, SND1, NTRK1, TCTN3, TCTN1, RAB3IP, RBPJ, FOXN1, PTPRN, DUSP13, MTMR8, PTPN2, PTPN5, PTPRA, DCAF7, RNF157 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Hgene | RANBP9 | chr6:13697017 | chr6:7904956 | ENST00000011619 | - | 2 | 14 | 401_407 | 227 | 730 | CALB1 |
| Hgene | RANBP9 | chr6:13697017 | chr6:7904956 | ENST00000011619 | - | 2 | 14 | 615_729 | 227 | 730 | FMR1 |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for RANBP9_TXNDC5 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for RANBP9_TXNDC5 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | RANBP9 | C0036341 | Schizophrenia | 1 | PSYGENET |
| Tgene | TXNDC5 | C0003873 | Rheumatoid Arthritis | 1 | CTD_human |
| Tgene | TXNDC5 | C0027627 | Neoplasm Metastasis | 1 | CTD_human |
| Tgene | TXNDC5 | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
| Tgene | TXNDC5 | C0036341 | Schizophrenia | 1 | PSYGENET |
| Tgene | TXNDC5 | C0993582 | Arthritis, Experimental | 1 | CTD_human |
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