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Fusion gene ID: 30335 |
FusionGeneSummary for RANBP2_MAP2 |
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Fusion gene information | Fusion gene name: RANBP2_MAP2 | Fusion gene ID: 30335 | Hgene | Tgene | Gene symbol | RANBP2 | MAP2 | Gene ID | 5903 | 10988 |
Gene name | RAN binding protein 2 | methionyl aminopeptidase 2 | |
Synonyms | ADANE|ANE1|IIAE3|NUP358|TRP1|TRP2 | MAP2|MNPEP|p67eIF2 | |
Cytomap | 2q13 | 12q22 | |
Type of gene | protein-coding | protein-coding | |
Description | E3 SUMO-protein ligase RanBP2358 kDa nucleoporinE3 SUMO-protein transferase RanBP2P270acute necrotizing encephalopathy 1 (autosomal dominant)nuclear pore complex protein Nup358nucleoporin 358nucleoporin Nup358ran-binding protein 2transformation-r | methionine aminopeptidase 2eIF-2-associated p67 homologinitiation factor 2-associated 67 kDa glycoproteinpeptidase M 2testicular tissue protein Li 17 | |
Modification date | 20180523 | 20180519 | |
UniProtAcc | P49792 | P11137 | |
Ensembl transtripts involved in fusion gene | ENST00000283195, | ENST00000199940, ENST00000360351, ENST00000361559, ENST00000392194, ENST00000447185, ENST00000475600, | |
Fusion gene scores | * DoF score | 5 X 5 X 4=100 | 6 X 7 X 4=168 |
# samples | 5 | 8 | |
** MAII score | log2(5/100*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(8/168*10)=-1.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: RANBP2 [Title/Abstract] AND MAP2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | RANBP2 | GO:0016925 | protein sumoylation | 17264123|22155184 |
Tgene | MAP2 | GO:0016485 | protein processing | 8858118 |
Tgene | MAP2 | GO:0018206 | peptidyl-methionine modification | 8858118 |
Tgene | MAP2 | GO:0031365 | N-terminal protein amino acid modification | 8858118 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | AA682348 | RANBP2 | chr2 | 109345504 | + | MAP2 | chr2 | 210596951 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000283195 | ENST00000199940 | RANBP2 | chr2 | 109345504 | + | MAP2 | chr2 | 210596951 | - |
intron-3UTR | ENST00000283195 | ENST00000360351 | RANBP2 | chr2 | 109345504 | + | MAP2 | chr2 | 210596951 | - |
intron-intron | ENST00000283195 | ENST00000361559 | RANBP2 | chr2 | 109345504 | + | MAP2 | chr2 | 210596951 | - |
intron-3UTR | ENST00000283195 | ENST00000392194 | RANBP2 | chr2 | 109345504 | + | MAP2 | chr2 | 210596951 | - |
intron-intron | ENST00000283195 | ENST00000447185 | RANBP2 | chr2 | 109345504 | + | MAP2 | chr2 | 210596951 | - |
intron-intron | ENST00000283195 | ENST00000475600 | RANBP2 | chr2 | 109345504 | + | MAP2 | chr2 | 210596951 | - |
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FusionProtFeatures for RANBP2_MAP2 |
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Hgene | Tgene |
RANBP2 | MAP2 |
E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2conjugation by UBE2I (PubMed:11792325, PubMed:12032081,PubMed:15378033, PubMed:22194619, PubMed:15931224). Involved intransport factor (Ran-GTP, karyopherin)-mediated protein importvia the F-G repeat-containing domain which acts as a docking sitefor substrates (PubMed:7775481). Binds single-stranded RNA (invitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Componentof the nuclear export pathway (PubMed:10078529). Specific dockingsite for the nuclear export factor exportin-1 (PubMed:10078529).Sumoylates PML at 'Lys-490' which is essential for the properassembly of PML-NB (PubMed:22155184). Recruits BICD2 to thenuclear envelope and cytoplasmic stacks of nuclear pore complexknown as annulate lamellae during G2 phase of cell cycle(PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357,PubMed:23353830). {ECO:0000269|PubMed:11792325,ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033,ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726,ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184,ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:23353830,ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}. | The exact function of MAP2 is unknown but MAPs maystabilize the microtubules against depolymerization. They alsoseem to have a stiffening effect on microtubules. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for RANBP2_MAP2 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for RANBP2_MAP2 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for RANBP2_MAP2 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Tgene | MAP2 | P11137 | DB01196 | Estramustine | Microtubule-associated protein 2 | small molecule | approved|investigational |
Tgene | MAP2 | P11137 | DB01248 | Docetaxel | Microtubule-associated protein 2 | small molecule | approved|investigational |
Tgene | MAP2 | P11137 | DB01229 | Paclitaxel | Microtubule-associated protein 2 | small molecule | approved|vet_approved |
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RelatedDiseases for RANBP2_MAP2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | RANBP2 | C0018199 | Granuloma, Plasma Cell | 1 | CTD_human |
Hgene | RANBP2 | C2675556 | ENCEPHALOPATHY, ACUTE, INFECTION-INDUCED, SUSCEPTIBILITY TO, 3 | 1 | CTD_human;ORPHANET;UNIPROT |
Tgene | MAP2 | C0000786 | Spontaneous abortion | 1 | CTD_human |
Tgene | MAP2 | C0005586 | Bipolar Disorder | 1 | PSYGENET |
Tgene | MAP2 | C0036341 | Schizophrenia | 1 | PSYGENET |
Tgene | MAP2 | C0041696 | Unipolar Depression | 1 | PSYGENET |
Tgene | MAP2 | C0525045 | Mood Disorders | 1 | PSYGENET |
Tgene | MAP2 | C1269683 | Major Depressive Disorder | 1 | PSYGENET |
Tgene | MAP2 | C3495559 | Juvenile arthritis | 1 | CTD_human |