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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 30334

FusionGeneSummary for RANBP2_INPP5B

check button Fusion gene summary
Fusion gene informationFusion gene name: RANBP2_INPP5B
Fusion gene ID: 30334
HgeneTgene
Gene symbol

RANBP2

INPP5B

Gene ID

5903

3633

Gene nameRAN binding protein 2inositol polyphosphate-5-phosphatase B
SynonymsADANE|ANE1|IIAE3|NUP358|TRP1|TRP25PTase
Cytomap

2q13

1p34.3

Type of geneprotein-codingprotein-coding
DescriptionE3 SUMO-protein ligase RanBP2358 kDa nucleoporinE3 SUMO-protein transferase RanBP2P270acute necrotizing encephalopathy 1 (autosomal dominant)nuclear pore complex protein Nup358nucleoporin 358nucleoporin Nup358ran-binding protein 2transformation-rtype II inositol 1,4,5-trisphosphate 5-phosphataseinositol polyphosphate-5-phosphatase, 75kDaphosphoinositide 5-phosphatase
Modification date2018052320180523
UniProtAcc

P49792

P32019

Ensembl transtripts involved in fusion geneENST00000283195, ENST00000373023, 
ENST00000373026, ENST00000373024, 
ENST00000373021, ENST00000373027, 
ENST00000458109, ENST00000467066, 
Fusion gene scores* DoF score5 X 5 X 4=1005 X 5 X 3=75
# samples 55
** MAII scorelog2(5/100*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(5/75*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RANBP2 [Title/Abstract] AND INPP5B [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneRANBP2

GO:0016925

protein sumoylation

17264123|22155184

TgeneINPP5B

GO:0046856

phosphatidylinositol dephosphorylation

7721860


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1CR738758RANBP2chr2

109401258

+INPP5Bchr1

38327775

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3UTRENST00000283195ENST00000373023RANBP2chr2

109401258

+INPP5Bchr1

38327775

-
3UTR-3UTRENST00000283195ENST00000373026RANBP2chr2

109401258

+INPP5Bchr1

38327775

-
3UTR-3UTRENST00000283195ENST00000373024RANBP2chr2

109401258

+INPP5Bchr1

38327775

-
3UTR-intronENST00000283195ENST00000373021RANBP2chr2

109401258

+INPP5Bchr1

38327775

-
3UTR-3UTRENST00000283195ENST00000373027RANBP2chr2

109401258

+INPP5Bchr1

38327775

-
3UTR-intronENST00000283195ENST00000458109RANBP2chr2

109401258

+INPP5Bchr1

38327775

-
3UTR-intronENST00000283195ENST00000467066RANBP2chr2

109401258

+INPP5Bchr1

38327775

-

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FusionProtFeatures for RANBP2_INPP5B


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RANBP2

P49792

INPP5B

P32019

E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2conjugation by UBE2I (PubMed:11792325, PubMed:12032081,PubMed:15378033, PubMed:22194619, PubMed:15931224). Involved intransport factor (Ran-GTP, karyopherin)-mediated protein importvia the F-G repeat-containing domain which acts as a docking sitefor substrates (PubMed:7775481). Binds single-stranded RNA (invitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Componentof the nuclear export pathway (PubMed:10078529). Specific dockingsite for the nuclear export factor exportin-1 (PubMed:10078529).Sumoylates PML at 'Lys-490' which is essential for the properassembly of PML-NB (PubMed:22155184). Recruits BICD2 to thenuclear envelope and cytoplasmic stacks of nuclear pore complexknown as annulate lamellae during G2 phase of cell cycle(PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357,PubMed:23353830). {ECO:0000269|PubMed:11792325,ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033,ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726,ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184,ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:23353830,ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for RANBP2_INPP5B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for RANBP2_INPP5B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for RANBP2_INPP5B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for RANBP2_INPP5B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneRANBP2C0018199Granuloma, Plasma Cell1CTD_human
HgeneRANBP2C2675556ENCEPHALOPATHY, ACUTE, INFECTION-INDUCED, SUSCEPTIBILITY TO, 31CTD_human;ORPHANET;UNIPROT