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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 30333

FusionGeneSummary for RANBP2_BMP5

check button Fusion gene summary
Fusion gene informationFusion gene name: RANBP2_BMP5
Fusion gene ID: 30333
HgeneTgene
Gene symbol

RANBP2

BMP5

Gene ID

5903

653

Gene nameRAN binding protein 2bone morphogenetic protein 5
SynonymsADANE|ANE1|IIAE3|NUP358|TRP1|TRP2-
Cytomap

2q13

6p12.1

Type of geneprotein-codingprotein-coding
DescriptionE3 SUMO-protein ligase RanBP2358 kDa nucleoporinE3 SUMO-protein transferase RanBP2P270acute necrotizing encephalopathy 1 (autosomal dominant)nuclear pore complex protein Nup358nucleoporin 358nucleoporin Nup358ran-binding protein 2transformation-rbone morphogenetic protein 5
Modification date2018052320180523
UniProtAcc

P49792

P22003

Ensembl transtripts involved in fusion geneENST00000283195, ENST00000370830, 
ENST00000446683, 
Fusion gene scores* DoF score5 X 5 X 4=1003 X 2 X 3=18
# samples 53
** MAII scorelog2(5/100*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: RANBP2 [Title/Abstract] AND BMP5 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneRANBP2

GO:0016925

protein sumoylation

17264123|22155184

TgeneBMP5

GO:0003323

type B pancreatic cell development

11865031

TgeneBMP5

GO:0008284

positive regulation of cell proliferation

15516325

TgeneBMP5

GO:0008285

negative regulation of cell proliferation

19584291

TgeneBMP5

GO:0010862

positive regulation of pathway-restricted SMAD protein phosphorylation

11580864

TgeneBMP5

GO:0010894

negative regulation of steroid biosynthetic process

19584291

TgeneBMP5

GO:0032348

negative regulation of aldosterone biosynthetic process

19584291

TgeneBMP5

GO:0043569

negative regulation of insulin-like growth factor receptor signaling pathway

19584291

TgeneBMP5

GO:0045944

positive regulation of transcription by RNA polymerase II

15516325

TgeneBMP5

GO:0050679

positive regulation of epithelial cell proliferation

11865031

TgeneBMP5

GO:1900006

positive regulation of dendrite development

11580864

TgeneBMP5

GO:2000065

negative regulation of cortisol biosynthetic process

19584291


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-C8-A12U-01ARANBP2chr2

109371715

+BMP5chr6

55659225

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000283195ENST00000370830RANBP2chr2

109371715

+BMP5chr6

55659225

-
Frame-shiftENST00000283195ENST00000446683RANBP2chr2

109371715

+BMP5chr6

55659225

-

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FusionProtFeatures for RANBP2_BMP5


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RANBP2

P49792

BMP5

P22003

E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2conjugation by UBE2I (PubMed:11792325, PubMed:12032081,PubMed:15378033, PubMed:22194619, PubMed:15931224). Involved intransport factor (Ran-GTP, karyopherin)-mediated protein importvia the F-G repeat-containing domain which acts as a docking sitefor substrates (PubMed:7775481). Binds single-stranded RNA (invitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Componentof the nuclear export pathway (PubMed:10078529). Specific dockingsite for the nuclear export factor exportin-1 (PubMed:10078529).Sumoylates PML at 'Lys-490' which is essential for the properassembly of PML-NB (PubMed:22155184). Recruits BICD2 to thenuclear envelope and cytoplasmic stacks of nuclear pore complexknown as annulate lamellae during G2 phase of cell cycle(PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357,PubMed:23353830). {ECO:0000269|PubMed:11792325,ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033,ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726,ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184,ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:23353830,ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}. Induces cartilage and bone formation.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for RANBP2_BMP5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for RANBP2_BMP5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
RANBP2UBE2I, KPNB1, KPNA1, RAN, OPN1LW, CDC73, AIRE, PARK2, LRPAP1, APC, TAF1, IFT140, AKAP13, FHOD1, ARID4B, CDCA8, HDAC4, RANGAP1, MYC, CALM1, CEBPA, PSMD1, SIRT7, SENP1, TP53, CTNNB1, RAPGEF3, KIFAP3, KIF3A, TOP2B, KIF5B, KIF5C, SP100, NUP214, NUP153, PML, CUL2, NXF1, MATR3, ILF2, EEF1A1, HNRNPK, HNRNPF, HNRNPM, DDX17, SMU1, RRS1, CHMP2A, FLNA, IK, HNRNPH1, DHX15, DHX9, RPS14, TRIM55, PRKDC, M6PR, RRP7A, HSPA1L, ALB, MMS19, LMNA, ADRB2, BAG3, KPNA2, CUL1, SUMO1, SUMO2, NLK, UBTD1, LGR4, CHFR, CUL7, OBSL1, CCDC8, SUZ12, EED, RNF2, BMI1, RANBP2, NUP62, NUSAP1, COMTD1, SCGN, NUP50, RCC1, ZACN, IER2, FBXW11, CLTC, EFTUD2, IPO5, COL4A3BP, HNRNPC, MED13, PRPF8, PTGES3, RALY, RPLP0, SNRNP200, SRRM1, TOP2A, TUBB, UQCRC2, VCP, KIF3B, NUP43, NUP85, NUP107, NUP133, NUP160, NUP35, NUPL1, SEH1L, FOXB1, CRY2, FOXL1, PRMT5, FOXQ1, WAS, UBA2, MCM2, SNW1, CDC5L, NFATC2, ZNF746, CTDSPL2, PPM1D, B2M, TMEM194A, TRAF3IP3, MDM2, TESBMP5HBB, VWA8, ANKRD46


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for RANBP2_BMP5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for RANBP2_BMP5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneRANBP2C0018199Granuloma, Plasma Cell1CTD_human
HgeneRANBP2C2675556ENCEPHALOPATHY, ACUTE, INFECTION-INDUCED, SUSCEPTIBILITY TO, 31CTD_human;ORPHANET;UNIPROT