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Fusion gene ID: 30333 |
FusionGeneSummary for RANBP2_BMP5 |
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Fusion gene information | Fusion gene name: RANBP2_BMP5 | Fusion gene ID: 30333 | Hgene | Tgene | Gene symbol | RANBP2 | BMP5 | Gene ID | 5903 | 653 |
Gene name | RAN binding protein 2 | bone morphogenetic protein 5 | |
Synonyms | ADANE|ANE1|IIAE3|NUP358|TRP1|TRP2 | - | |
Cytomap | 2q13 | 6p12.1 | |
Type of gene | protein-coding | protein-coding | |
Description | E3 SUMO-protein ligase RanBP2358 kDa nucleoporinE3 SUMO-protein transferase RanBP2P270acute necrotizing encephalopathy 1 (autosomal dominant)nuclear pore complex protein Nup358nucleoporin 358nucleoporin Nup358ran-binding protein 2transformation-r | bone morphogenetic protein 5 | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | P49792 | P22003 | |
Ensembl transtripts involved in fusion gene | ENST00000283195, | ENST00000370830, ENST00000446683, | |
Fusion gene scores | * DoF score | 5 X 5 X 4=100 | 3 X 2 X 3=18 |
# samples | 5 | 3 | |
** MAII score | log2(5/100*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: RANBP2 [Title/Abstract] AND BMP5 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | RANBP2 | GO:0016925 | protein sumoylation | 17264123|22155184 |
Tgene | BMP5 | GO:0003323 | type B pancreatic cell development | 11865031 |
Tgene | BMP5 | GO:0008284 | positive regulation of cell proliferation | 15516325 |
Tgene | BMP5 | GO:0008285 | negative regulation of cell proliferation | 19584291 |
Tgene | BMP5 | GO:0010862 | positive regulation of pathway-restricted SMAD protein phosphorylation | 11580864 |
Tgene | BMP5 | GO:0010894 | negative regulation of steroid biosynthetic process | 19584291 |
Tgene | BMP5 | GO:0032348 | negative regulation of aldosterone biosynthetic process | 19584291 |
Tgene | BMP5 | GO:0043569 | negative regulation of insulin-like growth factor receptor signaling pathway | 19584291 |
Tgene | BMP5 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 15516325 |
Tgene | BMP5 | GO:0050679 | positive regulation of epithelial cell proliferation | 11865031 |
Tgene | BMP5 | GO:1900006 | positive regulation of dendrite development | 11580864 |
Tgene | BMP5 | GO:2000065 | negative regulation of cortisol biosynthetic process | 19584291 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | BRCA | TCGA-C8-A12U-01A | RANBP2 | chr2 | 109371715 | + | BMP5 | chr6 | 55659225 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000283195 | ENST00000370830 | RANBP2 | chr2 | 109371715 | + | BMP5 | chr6 | 55659225 | - |
Frame-shift | ENST00000283195 | ENST00000446683 | RANBP2 | chr2 | 109371715 | + | BMP5 | chr6 | 55659225 | - |
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FusionProtFeatures for RANBP2_BMP5 |
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Hgene | Tgene |
RANBP2 | BMP5 |
E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2conjugation by UBE2I (PubMed:11792325, PubMed:12032081,PubMed:15378033, PubMed:22194619, PubMed:15931224). Involved intransport factor (Ran-GTP, karyopherin)-mediated protein importvia the F-G repeat-containing domain which acts as a docking sitefor substrates (PubMed:7775481). Binds single-stranded RNA (invitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Componentof the nuclear export pathway (PubMed:10078529). Specific dockingsite for the nuclear export factor exportin-1 (PubMed:10078529).Sumoylates PML at 'Lys-490' which is essential for the properassembly of PML-NB (PubMed:22155184). Recruits BICD2 to thenuclear envelope and cytoplasmic stacks of nuclear pore complexknown as annulate lamellae during G2 phase of cell cycle(PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357,PubMed:23353830). {ECO:0000269|PubMed:11792325,ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033,ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726,ECO:0000269|PubMed:20676357, ECO:0000269|PubMed:22155184,ECO:0000269|PubMed:22194619, ECO:0000269|PubMed:23353830,ECO:0000269|PubMed:7775481, ECO:0000303|PubMed:10078529}. | Induces cartilage and bone formation. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for RANBP2_BMP5 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for RANBP2_BMP5 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
RANBP2 | UBE2I, KPNB1, KPNA1, RAN, OPN1LW, CDC73, AIRE, PARK2, LRPAP1, APC, TAF1, IFT140, AKAP13, FHOD1, ARID4B, CDCA8, HDAC4, RANGAP1, MYC, CALM1, CEBPA, PSMD1, SIRT7, SENP1, TP53, CTNNB1, RAPGEF3, KIFAP3, KIF3A, TOP2B, KIF5B, KIF5C, SP100, NUP214, NUP153, PML, CUL2, NXF1, MATR3, ILF2, EEF1A1, HNRNPK, HNRNPF, HNRNPM, DDX17, SMU1, RRS1, CHMP2A, FLNA, IK, HNRNPH1, DHX15, DHX9, RPS14, TRIM55, PRKDC, M6PR, RRP7A, HSPA1L, ALB, MMS19, LMNA, ADRB2, BAG3, KPNA2, CUL1, SUMO1, SUMO2, NLK, UBTD1, LGR4, CHFR, CUL7, OBSL1, CCDC8, SUZ12, EED, RNF2, BMI1, RANBP2, NUP62, NUSAP1, COMTD1, SCGN, NUP50, RCC1, ZACN, IER2, FBXW11, CLTC, EFTUD2, IPO5, COL4A3BP, HNRNPC, MED13, PRPF8, PTGES3, RALY, RPLP0, SNRNP200, SRRM1, TOP2A, TUBB, UQCRC2, VCP, KIF3B, NUP43, NUP85, NUP107, NUP133, NUP160, NUP35, NUPL1, SEH1L, FOXB1, CRY2, FOXL1, PRMT5, FOXQ1, WAS, UBA2, MCM2, SNW1, CDC5L, NFATC2, ZNF746, CTDSPL2, PPM1D, B2M, TMEM194A, TRAF3IP3, MDM2, TES | BMP5 | HBB, VWA8, ANKRD46 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for RANBP2_BMP5 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for RANBP2_BMP5 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | RANBP2 | C0018199 | Granuloma, Plasma Cell | 1 | CTD_human |
Hgene | RANBP2 | C2675556 | ENCEPHALOPATHY, ACUTE, INFECTION-INDUCED, SUSCEPTIBILITY TO, 3 | 1 | CTD_human;ORPHANET;UNIPROT |