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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 30265

FusionGeneSummary for RALGAPA1_PRRC2B

check button Fusion gene summary
Fusion gene informationFusion gene name: RALGAPA1_PRRC2B
Fusion gene ID: 30265
HgeneTgene
Gene symbol

RALGAPA1

PRRC2B

Gene ID

253959

84726

Gene nameRal GTPase activating protein catalytic alpha subunit 1proline rich coiled-coil 2B
SynonymsGARNL1|GRIPE|RalGAPalpha1|TULIP1|p240BAT2L|BAT2L1|KIAA0515|LQFBS-1
Cytomap

14q13.2

9q34.13

Type of geneprotein-codingprotein-coding
Descriptionral GTPase-activating protein subunit alpha-1GAP-related interacting protein to E12GTPase activating Rap/RanGAP domain-like 1Ral GTPase activating protein, alpha subunit 1 (catalytic)tuberin-like protein 1protein PRRC2BHLA-B associated transcript 2-likeHLA-B-associated transcript 2-like 1proline-rich coiled-coil protein 2Bprotein BAT2-like 1
Modification date2018052320180523
UniProtAcc

Q6GYQ0

Q5JSZ5

Ensembl transtripts involved in fusion geneENST00000389698, ENST00000307138, 
ENST00000258840, ENST00000382366, 
ENST00000554704, 		ENST00000405995, 
ENST00000357304, ENST00000458550, 
ENST00000372249, ENST00000465931, 
Fusion gene scores* DoF score3 X 3 X 2=186 X 8 X 3=144
# samples 49
** MAII scorelog2(4/18*10)=1.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(9/144*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RALGAPA1 [Title/Abstract] AND PRRC2B [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1DQ786317RALGAPA1chr14

36007562

-PRRC2Bchr9

134371910

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000389698ENST00000405995RALGAPA1chr14

36007562

-PRRC2Bchr9

134371910

+
5CDS-3UTRENST00000389698ENST00000357304RALGAPA1chr14

36007562

-PRRC2Bchr9

134371910

+
5CDS-intronENST00000389698ENST00000458550RALGAPA1chr14

36007562

-PRRC2Bchr9

134371910

+
5CDS-intronENST00000389698ENST00000372249RALGAPA1chr14

36007562

-PRRC2Bchr9

134371910

+
5CDS-3UTRENST00000389698ENST00000465931RALGAPA1chr14

36007562

-PRRC2Bchr9

134371910

+
5CDS-3UTRENST00000307138ENST00000405995RALGAPA1chr14

36007562

-PRRC2Bchr9

134371910

+
5CDS-3UTRENST00000307138ENST00000357304RALGAPA1chr14

36007562

-PRRC2Bchr9

134371910

+
5CDS-intronENST00000307138ENST00000458550RALGAPA1chr14

36007562

-PRRC2Bchr9

134371910

+
5CDS-intronENST00000307138ENST00000372249RALGAPA1chr14

36007562

-PRRC2Bchr9

134371910

+
5CDS-3UTRENST00000307138ENST00000465931RALGAPA1chr14

36007562

-PRRC2Bchr9

134371910

+
5CDS-3UTRENST00000258840ENST00000405995RALGAPA1chr14

36007562

-PRRC2Bchr9

134371910

+
5CDS-3UTRENST00000258840ENST00000357304RALGAPA1chr14

36007562

-PRRC2Bchr9

134371910

+
5CDS-intronENST00000258840ENST00000458550RALGAPA1chr14

36007562

-PRRC2Bchr9

134371910

+
5CDS-intronENST00000258840ENST00000372249RALGAPA1chr14

36007562

-PRRC2Bchr9

134371910

+
5CDS-3UTRENST00000258840ENST00000465931RALGAPA1chr14

36007562

-PRRC2Bchr9

134371910

+
intron-3UTRENST00000382366ENST00000405995RALGAPA1chr14

36007562

-PRRC2Bchr9

134371910

+
intron-3UTRENST00000382366ENST00000357304RALGAPA1chr14

36007562

-PRRC2Bchr9

134371910

+
intron-intronENST00000382366ENST00000458550RALGAPA1chr14

36007562

-PRRC2Bchr9

134371910

+
intron-intronENST00000382366ENST00000372249RALGAPA1chr14

36007562

-PRRC2Bchr9

134371910

+
intron-3UTRENST00000382366ENST00000465931RALGAPA1chr14

36007562

-PRRC2Bchr9

134371910

+
intron-3UTRENST00000554704ENST00000405995RALGAPA1chr14

36007562

-PRRC2Bchr9

134371910

+
intron-3UTRENST00000554704ENST00000357304RALGAPA1chr14

36007562

-PRRC2Bchr9

134371910

+
intron-intronENST00000554704ENST00000458550RALGAPA1chr14

36007562

-PRRC2Bchr9

134371910

+
intron-intronENST00000554704ENST00000372249RALGAPA1chr14

36007562

-PRRC2Bchr9

134371910

+
intron-3UTRENST00000554704ENST00000465931RALGAPA1chr14

36007562

-PRRC2Bchr9

134371910

+

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FusionProtFeatures for RALGAPA1_PRRC2B


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RALGAPA1

Q6GYQ0

PRRC2B

Q5JSZ5


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for RALGAPA1_PRRC2B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for RALGAPA1_PRRC2B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for RALGAPA1_PRRC2B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for RALGAPA1_PRRC2B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource