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Fusion gene ID: 30232 |
FusionGeneSummary for RAI14_LAPTM4A |
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Fusion gene information | Fusion gene name: RAI14_LAPTM4A | Fusion gene ID: 30232 | Hgene | Tgene | Gene symbol | RAI14 | LAPTM4A | Gene ID | 26064 | 9741 |
Gene name | retinoic acid induced 14 | lysosomal protein transmembrane 4 alpha | |
Synonyms | NORPEG|RAI13 | HUMORF13|LAPTM4|MBNT|Mtrp | |
Cytomap | 5p13.2 | 2p24.1 | |
Type of gene | protein-coding | protein-coding | |
Description | ankycorbinankyrin repeat and coiled-coil structure-containing proteinnovel retinal pigment epithelial cell proteinretinoic acid-induced protein 14 | lysosomal-associated transmembrane protein 4Agolgi 4-transmembrane-spanning transporter MTPlysosomal-associated protein transmembrane 4 alphamembrane nucleoside transporter | |
Modification date | 20180522 | 20180523 | |
UniProtAcc | Q9P0K7 | Q15012 | |
Ensembl transtripts involved in fusion gene | ENST00000265109, ENST00000512629, ENST00000428746, ENST00000503673, ENST00000515799, ENST00000506376, ENST00000507276, ENST00000397449, | ENST00000175091, | |
Fusion gene scores | * DoF score | 11 X 8 X 4=352 | 3 X 3 X 1=9 |
# samples | 13 | 3 | |
** MAII score | log2(13/352*10)=-1.43706380560884 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/9*10)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: RAI14 [Title/Abstract] AND LAPTM4A [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BE930969 | RAI14 | chr5 | 34823850 | - | LAPTM4A | chr2 | 20237114 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000265109 | ENST00000175091 | RAI14 | chr5 | 34823850 | - | LAPTM4A | chr2 | 20237114 | - |
In-frame | ENST00000512629 | ENST00000175091 | RAI14 | chr5 | 34823850 | - | LAPTM4A | chr2 | 20237114 | - |
In-frame | ENST00000428746 | ENST00000175091 | RAI14 | chr5 | 34823850 | - | LAPTM4A | chr2 | 20237114 | - |
In-frame | ENST00000503673 | ENST00000175091 | RAI14 | chr5 | 34823850 | - | LAPTM4A | chr2 | 20237114 | - |
In-frame | ENST00000515799 | ENST00000175091 | RAI14 | chr5 | 34823850 | - | LAPTM4A | chr2 | 20237114 | - |
In-frame | ENST00000506376 | ENST00000175091 | RAI14 | chr5 | 34823850 | - | LAPTM4A | chr2 | 20237114 | - |
intron-3CDS | ENST00000507276 | ENST00000175091 | RAI14 | chr5 | 34823850 | - | LAPTM4A | chr2 | 20237114 | - |
In-frame | ENST00000397449 | ENST00000175091 | RAI14 | chr5 | 34823850 | - | LAPTM4A | chr2 | 20237114 | - |
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FusionProtFeatures for RAI14_LAPTM4A |
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Hgene | Tgene |
RAI14 | LAPTM4A |
Plays a role in actin regulation at the ectoplasmicspecialization, a type of cell junction specific to testis.Important for establishment of sperm polarity and normal spermatidadhesion. May also promote integrity of Sertoli cell tightjunctions at the blood-testis barrier.{ECO:0000250|UniProtKB:Q5U312}. | May function in the transport of nucleosides and/ornucleoside derivatives between the cytosol and the lumen of anintracellular membrane-bound compartment. {ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for RAI14_LAPTM4A |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
>In-frame_RAI14_ENST00000265109_chr5_34823850_-_LAPTM4A_ENST00000175091_chr2_20237114_-_0aa >In-frame_RAI14_ENST00000512629_chr5_34823850_-_LAPTM4A_ENST00000175091_chr2_20237114_-_0aa >In-frame_RAI14_ENST00000428746_chr5_34823850_-_LAPTM4A_ENST00000175091_chr2_20237114_-_0aa >In-frame_RAI14_ENST00000503673_chr5_34823850_-_LAPTM4A_ENST00000175091_chr2_20237114_-_0aa >In-frame_RAI14_ENST00000515799_chr5_34823850_-_LAPTM4A_ENST00000175091_chr2_20237114_-_0aa >In-frame_RAI14_ENST00000506376_chr5_34823850_-_LAPTM4A_ENST00000175091_chr2_20237114_-_0aa >In-frame_RAI14_ENST00000397449_chr5_34823850_-_LAPTM4A_ENST00000175091_chr2_20237114_-_0aa |
* Fusion transcript sequences (only coding sequence (CDS) region). |
>In-frame_RAI14_ENST00000265109_chr5_34823850_-_LAPTM4A_ENST00000175091_chr2_20237114_-_0nt >In-frame_RAI14_ENST00000512629_chr5_34823850_-_LAPTM4A_ENST00000175091_chr2_20237114_-_0nt >In-frame_RAI14_ENST00000428746_chr5_34823850_-_LAPTM4A_ENST00000175091_chr2_20237114_-_0nt >In-frame_RAI14_ENST00000503673_chr5_34823850_-_LAPTM4A_ENST00000175091_chr2_20237114_-_0nt >In-frame_RAI14_ENST00000515799_chr5_34823850_-_LAPTM4A_ENST00000175091_chr2_20237114_-_0nt >In-frame_RAI14_ENST00000506376_chr5_34823850_-_LAPTM4A_ENST00000175091_chr2_20237114_-_0nt >In-frame_RAI14_ENST00000397449_chr5_34823850_-_LAPTM4A_ENST00000175091_chr2_20237114_-_0nt |
* Fusion transcript sequences (Full-length transcript). |
>In-frame_RAI14_ENST00000265109_chr5_34823850_-_LAPTM4A_ENST00000175091_chr2_20237114_-_0nt >In-frame_RAI14_ENST00000512629_chr5_34823850_-_LAPTM4A_ENST00000175091_chr2_20237114_-_0nt >In-frame_RAI14_ENST00000428746_chr5_34823850_-_LAPTM4A_ENST00000175091_chr2_20237114_-_0nt >In-frame_RAI14_ENST00000503673_chr5_34823850_-_LAPTM4A_ENST00000175091_chr2_20237114_-_0nt >In-frame_RAI14_ENST00000515799_chr5_34823850_-_LAPTM4A_ENST00000175091_chr2_20237114_-_0nt >In-frame_RAI14_ENST00000506376_chr5_34823850_-_LAPTM4A_ENST00000175091_chr2_20237114_-_0nt >In-frame_RAI14_ENST00000397449_chr5_34823850_-_LAPTM4A_ENST00000175091_chr2_20237114_-_0nt |
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FusionGenePPI for RAI14_LAPTM4A |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for RAI14_LAPTM4A |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for RAI14_LAPTM4A |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |