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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 30232

FusionGeneSummary for RAI14_LAPTM4A

check button Fusion gene summary
Fusion gene informationFusion gene name: RAI14_LAPTM4A
Fusion gene ID: 30232
HgeneTgene
Gene symbol

RAI14

LAPTM4A

Gene ID

26064

9741

Gene nameretinoic acid induced 14lysosomal protein transmembrane 4 alpha
SynonymsNORPEG|RAI13HUMORF13|LAPTM4|MBNT|Mtrp
Cytomap

5p13.2

2p24.1

Type of geneprotein-codingprotein-coding
Descriptionankycorbinankyrin repeat and coiled-coil structure-containing proteinnovel retinal pigment epithelial cell proteinretinoic acid-induced protein 14lysosomal-associated transmembrane protein 4Agolgi 4-transmembrane-spanning transporter MTPlysosomal-associated protein transmembrane 4 alphamembrane nucleoside transporter
Modification date2018052220180523
UniProtAcc

Q9P0K7

Q15012

Ensembl transtripts involved in fusion geneENST00000265109, ENST00000512629, 
ENST00000428746, ENST00000503673, 
ENST00000515799, ENST00000506376, 
ENST00000507276, ENST00000397449, 
ENST00000175091, 
Fusion gene scores* DoF score11 X 8 X 4=3523 X 3 X 1=9
# samples 133
** MAII scorelog2(13/352*10)=-1.43706380560884
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/9*10)=1.73696559416621
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: RAI14 [Title/Abstract] AND LAPTM4A [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BE930969RAI14chr5

34823850

-LAPTM4Achr2

20237114

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000265109ENST00000175091RAI14chr5

34823850

-LAPTM4Achr2

20237114

-
In-frameENST00000512629ENST00000175091RAI14chr5

34823850

-LAPTM4Achr2

20237114

-
In-frameENST00000428746ENST00000175091RAI14chr5

34823850

-LAPTM4Achr2

20237114

-
In-frameENST00000503673ENST00000175091RAI14chr5

34823850

-LAPTM4Achr2

20237114

-
In-frameENST00000515799ENST00000175091RAI14chr5

34823850

-LAPTM4Achr2

20237114

-
In-frameENST00000506376ENST00000175091RAI14chr5

34823850

-LAPTM4Achr2

20237114

-
intron-3CDSENST00000507276ENST00000175091RAI14chr5

34823850

-LAPTM4Achr2

20237114

-
In-frameENST00000397449ENST00000175091RAI14chr5

34823850

-LAPTM4Achr2

20237114

-

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FusionProtFeatures for RAI14_LAPTM4A


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RAI14

Q9P0K7

LAPTM4A

Q15012

Plays a role in actin regulation at the ectoplasmicspecialization, a type of cell junction specific to testis.Important for establishment of sperm polarity and normal spermatidadhesion. May also promote integrity of Sertoli cell tightjunctions at the blood-testis barrier.{ECO:0000250|UniProtKB:Q5U312}. May function in the transport of nucleosides and/ornucleoside derivatives between the cytosol and the lumen of anintracellular membrane-bound compartment. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for RAI14_LAPTM4A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_RAI14_ENST00000265109_chr5_34823850_-_LAPTM4A_ENST00000175091_chr2_20237114_-_0aa

>In-frame_RAI14_ENST00000512629_chr5_34823850_-_LAPTM4A_ENST00000175091_chr2_20237114_-_0aa

>In-frame_RAI14_ENST00000428746_chr5_34823850_-_LAPTM4A_ENST00000175091_chr2_20237114_-_0aa

>In-frame_RAI14_ENST00000503673_chr5_34823850_-_LAPTM4A_ENST00000175091_chr2_20237114_-_0aa

>In-frame_RAI14_ENST00000515799_chr5_34823850_-_LAPTM4A_ENST00000175091_chr2_20237114_-_0aa

>In-frame_RAI14_ENST00000506376_chr5_34823850_-_LAPTM4A_ENST00000175091_chr2_20237114_-_0aa

>In-frame_RAI14_ENST00000397449_chr5_34823850_-_LAPTM4A_ENST00000175091_chr2_20237114_-_0aa


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_RAI14_ENST00000265109_chr5_34823850_-_LAPTM4A_ENST00000175091_chr2_20237114_-_0nt

>In-frame_RAI14_ENST00000512629_chr5_34823850_-_LAPTM4A_ENST00000175091_chr2_20237114_-_0nt

>In-frame_RAI14_ENST00000428746_chr5_34823850_-_LAPTM4A_ENST00000175091_chr2_20237114_-_0nt

>In-frame_RAI14_ENST00000503673_chr5_34823850_-_LAPTM4A_ENST00000175091_chr2_20237114_-_0nt

>In-frame_RAI14_ENST00000515799_chr5_34823850_-_LAPTM4A_ENST00000175091_chr2_20237114_-_0nt

>In-frame_RAI14_ENST00000506376_chr5_34823850_-_LAPTM4A_ENST00000175091_chr2_20237114_-_0nt

>In-frame_RAI14_ENST00000397449_chr5_34823850_-_LAPTM4A_ENST00000175091_chr2_20237114_-_0nt


* Fusion transcript sequences (Full-length transcript).
>In-frame_RAI14_ENST00000265109_chr5_34823850_-_LAPTM4A_ENST00000175091_chr2_20237114_-_0nt

>In-frame_RAI14_ENST00000512629_chr5_34823850_-_LAPTM4A_ENST00000175091_chr2_20237114_-_0nt

>In-frame_RAI14_ENST00000428746_chr5_34823850_-_LAPTM4A_ENST00000175091_chr2_20237114_-_0nt

>In-frame_RAI14_ENST00000503673_chr5_34823850_-_LAPTM4A_ENST00000175091_chr2_20237114_-_0nt

>In-frame_RAI14_ENST00000515799_chr5_34823850_-_LAPTM4A_ENST00000175091_chr2_20237114_-_0nt

>In-frame_RAI14_ENST00000506376_chr5_34823850_-_LAPTM4A_ENST00000175091_chr2_20237114_-_0nt

>In-frame_RAI14_ENST00000397449_chr5_34823850_-_LAPTM4A_ENST00000175091_chr2_20237114_-_0nt


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FusionGenePPI for RAI14_LAPTM4A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for RAI14_LAPTM4A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for RAI14_LAPTM4A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource