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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 30230

FusionGeneSummary for RAI14_CLPTM1L

check button Fusion gene summary
Fusion gene informationFusion gene name: RAI14_CLPTM1L
Fusion gene ID: 30230
HgeneTgene
Gene symbol

RAI14

CLPTM1L

Gene ID

26064

81037

Gene nameretinoic acid induced 14CLPTM1 like
SynonymsNORPEG|RAI13CRR9
Cytomap

5p13.2

5p15.33

Type of geneprotein-codingprotein-coding
Descriptionankycorbinankyrin repeat and coiled-coil structure-containing proteinnovel retinal pigment epithelial cell proteinretinoic acid-induced protein 14cleft lip and palate transmembrane protein 1-like proteinCLPTM1-like proteincisplatin resistance related protein CRR9pcisplatin resistance-related protein 9
Modification date2018052220180519
UniProtAcc

Q9P0K7

Q96KA5

Ensembl transtripts involved in fusion geneENST00000265109, ENST00000512629, 
ENST00000428746, ENST00000503673, 
ENST00000515799, ENST00000506376, 
ENST00000507276, ENST00000397449, 
ENST00000320895, ENST00000507807, 
ENST00000320927, ENST00000506641, 
Fusion gene scores* DoF score11 X 8 X 4=35212 X 8 X 6=576
# samples 1312
** MAII scorelog2(13/352*10)=-1.43706380560884
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(12/576*10)=-2.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RAI14 [Title/Abstract] AND CLPTM1L [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDLUADTCGA-44-7667-01ARAI14chr5

34656580

+CLPTM1Lchr5

1341975

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000265109ENST00000320895RAI14chr5

34656580

+CLPTM1Lchr5

1341975

-
5UTR-intronENST00000265109ENST00000507807RAI14chr5

34656580

+CLPTM1Lchr5

1341975

-
5UTR-intronENST00000265109ENST00000320927RAI14chr5

34656580

+CLPTM1Lchr5

1341975

-
5UTR-intronENST00000265109ENST00000506641RAI14chr5

34656580

+CLPTM1Lchr5

1341975

-
5UTR-3CDSENST00000512629ENST00000320895RAI14chr5

34656580

+CLPTM1Lchr5

1341975

-
5UTR-intronENST00000512629ENST00000507807RAI14chr5

34656580

+CLPTM1Lchr5

1341975

-
5UTR-intronENST00000512629ENST00000320927RAI14chr5

34656580

+CLPTM1Lchr5

1341975

-
5UTR-intronENST00000512629ENST00000506641RAI14chr5

34656580

+CLPTM1Lchr5

1341975

-
intron-3CDSENST00000428746ENST00000320895RAI14chr5

34656580

+CLPTM1Lchr5

1341975

-
intron-intronENST00000428746ENST00000507807RAI14chr5

34656580

+CLPTM1Lchr5

1341975

-
intron-intronENST00000428746ENST00000320927RAI14chr5

34656580

+CLPTM1Lchr5

1341975

-
intron-intronENST00000428746ENST00000506641RAI14chr5

34656580

+CLPTM1Lchr5

1341975

-
intron-3CDSENST00000503673ENST00000320895RAI14chr5

34656580

+CLPTM1Lchr5

1341975

-
intron-intronENST00000503673ENST00000507807RAI14chr5

34656580

+CLPTM1Lchr5

1341975

-
intron-intronENST00000503673ENST00000320927RAI14chr5

34656580

+CLPTM1Lchr5

1341975

-
intron-intronENST00000503673ENST00000506641RAI14chr5

34656580

+CLPTM1Lchr5

1341975

-
intron-3CDSENST00000515799ENST00000320895RAI14chr5

34656580

+CLPTM1Lchr5

1341975

-
intron-intronENST00000515799ENST00000507807RAI14chr5

34656580

+CLPTM1Lchr5

1341975

-
intron-intronENST00000515799ENST00000320927RAI14chr5

34656580

+CLPTM1Lchr5

1341975

-
intron-intronENST00000515799ENST00000506641RAI14chr5

34656580

+CLPTM1Lchr5

1341975

-
intron-3CDSENST00000506376ENST00000320895RAI14chr5

34656580

+CLPTM1Lchr5

1341975

-
intron-intronENST00000506376ENST00000507807RAI14chr5

34656580

+CLPTM1Lchr5

1341975

-
intron-intronENST00000506376ENST00000320927RAI14chr5

34656580

+CLPTM1Lchr5

1341975

-
intron-intronENST00000506376ENST00000506641RAI14chr5

34656580

+CLPTM1Lchr5

1341975

-
intron-3CDSENST00000507276ENST00000320895RAI14chr5

34656580

+CLPTM1Lchr5

1341975

-
intron-intronENST00000507276ENST00000507807RAI14chr5

34656580

+CLPTM1Lchr5

1341975

-
intron-intronENST00000507276ENST00000320927RAI14chr5

34656580

+CLPTM1Lchr5

1341975

-
intron-intronENST00000507276ENST00000506641RAI14chr5

34656580

+CLPTM1Lchr5

1341975

-
intron-3CDSENST00000397449ENST00000320895RAI14chr5

34656580

+CLPTM1Lchr5

1341975

-
intron-intronENST00000397449ENST00000507807RAI14chr5

34656580

+CLPTM1Lchr5

1341975

-
intron-intronENST00000397449ENST00000320927RAI14chr5

34656580

+CLPTM1Lchr5

1341975

-
intron-intronENST00000397449ENST00000506641RAI14chr5

34656580

+CLPTM1Lchr5

1341975

-

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FusionProtFeatures for RAI14_CLPTM1L


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RAI14

Q9P0K7

CLPTM1L

Q96KA5

Plays a role in actin regulation at the ectoplasmicspecialization, a type of cell junction specific to testis.Important for establishment of sperm polarity and normal spermatidadhesion. May also promote integrity of Sertoli cell tightjunctions at the blood-testis barrier.{ECO:0000250|UniProtKB:Q5U312}. Enhances cisplatin-mediated apoptosis, whenoverexpressed. {ECO:0000269|PubMed:11162647}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for RAI14_CLPTM1L


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for RAI14_CLPTM1L


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
RAI14YWHAB, YWHAG, YWHAQ, YWHAZ, FEZ1, FEZ2, DDX58, ITSN1, FBXO25, LRRK2, MDC1, PAN2, RPA1, RPA2, RPA3, PARP16, PSMC3, ZFP41, PLK1, TRIOBP, MED4, RPGRIP1L, TMEM17, CAPZA2, CDK2, DBN1, FLNA, MYH9, MYO1C, PPP1CB, PPP1CC, IQGAP1, PDLIM7, VPS26A, SYNPO, LIMA1, ANLN, MYO5C, MYO19, MYO18A, ZNF746, CDH1, VTN, VAPB, PACSIN1, VAPA, CAV3, BTRC, PACSIN2, NECAB1, PACSIN3, TRIM25, RNF168CLPTM1LPIK3C3, TMEM173, UNC93B1, SPTAN1, MRPL47, UQCRQ, GK, EMC7, NTRK1, TCTN2, TCTN3, TUBG1, ZBTB33, NCSTN, NDE1, NCDN


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for RAI14_CLPTM1L


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for RAI14_CLPTM1L


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneCLPTM1LC0024121Lung Neoplasms3CTD_human
TgeneCLPTM1LC0005695Bladder Neoplasm1CTD_human
TgeneCLPTM1LC0007117Basal cell carcinoma1CTD_human
TgeneCLPTM1LC0007131Non-Small Cell Lung Carcinoma1CTD_human
TgeneCLPTM1LC0007873Uterine Cervical Neoplasm1CTD_human
TgeneCLPTM1LC0023448Lymphoid leukemia1CTD_human
TgeneCLPTM1LC0026640Mouth Neoplasms1CTD_human
TgeneCLPTM1LC0033578Prostatic Neoplasms1CTD_human
TgeneCLPTM1LC0152013Adenocarcinoma of lung (disorder)1CTD_human