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Fusion gene ID: 30216 |
FusionGeneSummary for RAF1_EIF3L |
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Fusion gene information | Fusion gene name: RAF1_EIF3L | Fusion gene ID: 30216 | Hgene | Tgene | Gene symbol | RAF1 | EIF3L | Gene ID | 5894 | 51386 |
Gene name | Raf-1 proto-oncogene, serine/threonine kinase | eukaryotic translation initiation factor 3 subunit L | |
Synonyms | CMD1NN|CRAF|NS5|Raf-1|c-Raf | EIF3EIP|EIF3S11|EIF3S6IP|HSPC021|HSPC025|MSTP005 | |
Cytomap | 3p25.2 | 22q13.1 | |
Type of gene | protein-coding | protein-coding | |
Description | RAF proto-oncogene serine/threonine-protein kinaseC-Raf proto-oncogene, serine/threonine kinaseOncogene RAF1proto-oncogene c-RAFraf proto-oncogene serine/threonine protein kinasev-raf-1 murine leukemia viral oncogene homolog 1v-raf-1 murine leukemia | eukaryotic translation initiation factor 3 subunit LeIEF associated protein HSPC021eukaryotic translation initiation factor 3 subunit 6-interacting proteineukaryotic translation initiation factor 3 subunit E-interacting protein | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | P04049 | Q9Y262 | |
Ensembl transtripts involved in fusion gene | ENST00000251849, ENST00000442415, ENST00000534997, ENST00000542177, | ENST00000412331, ENST00000381683, ENST00000406934, ENST00000476955, | |
Fusion gene scores | * DoF score | 13 X 7 X 14=1274 | 7 X 8 X 6=336 |
# samples | 27 | 9 | |
** MAII score | log2(27/1274*10)=-2.23833396520547 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(9/336*10)=-1.90046432644909 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: RAF1 [Title/Abstract] AND EIF3L [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation | Oncogene involved fusion gene, in-frame and retained their domain. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | RAF1 | GO:0000186 | activation of MAPKK activity | 10644344 |
Hgene | RAF1 | GO:0007190 | activation of adenylate cyclase activity | 15385642 |
Hgene | RAF1 | GO:0008285 | negative regulation of cell proliferation | 9765203 |
Hgene | RAF1 | GO:0031333 | negative regulation of protein complex assembly | 19667065 |
Hgene | RAF1 | GO:0033138 | positive regulation of peptidyl-serine phosphorylation | 19667065 |
Hgene | RAF1 | GO:0043066 | negative regulation of apoptotic process | 19667065 |
Tgene | EIF3L | GO:0006413 | translational initiation | 17581632 |
Tgene | EIF3L | GO:0075525 | viral translational termination-reinitiation | 21347434 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | DLBC | TCGA-G8-6325-01A | RAF1 | chr3 | 12653449 | - | EIF3L | chr22 | 38282772 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000251849 | ENST00000412331 | RAF1 | chr3 | 12653449 | - | EIF3L | chr22 | 38282772 | + |
In-frame | ENST00000251849 | ENST00000381683 | RAF1 | chr3 | 12653449 | - | EIF3L | chr22 | 38282772 | + |
In-frame | ENST00000251849 | ENST00000406934 | RAF1 | chr3 | 12653449 | - | EIF3L | chr22 | 38282772 | + |
5CDS-intron | ENST00000251849 | ENST00000476955 | RAF1 | chr3 | 12653449 | - | EIF3L | chr22 | 38282772 | + |
In-frame | ENST00000442415 | ENST00000412331 | RAF1 | chr3 | 12653449 | - | EIF3L | chr22 | 38282772 | + |
In-frame | ENST00000442415 | ENST00000381683 | RAF1 | chr3 | 12653449 | - | EIF3L | chr22 | 38282772 | + |
In-frame | ENST00000442415 | ENST00000406934 | RAF1 | chr3 | 12653449 | - | EIF3L | chr22 | 38282772 | + |
5CDS-intron | ENST00000442415 | ENST00000476955 | RAF1 | chr3 | 12653449 | - | EIF3L | chr22 | 38282772 | + |
intron-3CDS | ENST00000534997 | ENST00000412331 | RAF1 | chr3 | 12653449 | - | EIF3L | chr22 | 38282772 | + |
intron-3CDS | ENST00000534997 | ENST00000381683 | RAF1 | chr3 | 12653449 | - | EIF3L | chr22 | 38282772 | + |
intron-3CDS | ENST00000534997 | ENST00000406934 | RAF1 | chr3 | 12653449 | - | EIF3L | chr22 | 38282772 | + |
intron-intron | ENST00000534997 | ENST00000476955 | RAF1 | chr3 | 12653449 | - | EIF3L | chr22 | 38282772 | + |
intron-3CDS | ENST00000542177 | ENST00000412331 | RAF1 | chr3 | 12653449 | - | EIF3L | chr22 | 38282772 | + |
intron-3CDS | ENST00000542177 | ENST00000381683 | RAF1 | chr3 | 12653449 | - | EIF3L | chr22 | 38282772 | + |
intron-3CDS | ENST00000542177 | ENST00000406934 | RAF1 | chr3 | 12653449 | - | EIF3L | chr22 | 38282772 | + |
intron-intron | ENST00000542177 | ENST00000476955 | RAF1 | chr3 | 12653449 | - | EIF3L | chr22 | 38282772 | + |
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FusionProtFeatures for RAF1_EIF3L |
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Hgene | Tgene |
RAF1 | EIF3L |
Serine/threonine-protein kinase that acts as aregulatory link between the membrane-associated Ras GTPases andthe MAPK/ERK cascade, and this critical regulatory link functionsas a switch determining cell fate decisions includingproliferation, differentiation, apoptosis, survival and oncogenictransformation. RAF1 activation initiates a mitogen-activatedprotein kinase (MAPK) cascade that comprises a sequentialphosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 andMAP2K2/MEK2) and the extracellular signal-regulated kinases(MAPK3/ERK1 and MAPK1/ERK2). The phosphorylated form of RAF1 (onresidues Ser-338 and Ser-339, by PAK1) phosphorylates BAD/Bcl2-antagonist of cell death at 'Ser-75'. Phosphorylates adenylylcyclases: ADCY2, ADCY5 and ADCY6, resulting in their activation.Phosphorylates PPP1R12A resulting in inhibition of the phosphataseactivity. Phosphorylates TNNT2/cardiac muscle troponin T. Canpromote NF-kB activation and inhibit signal transducers involvedin motility (ROCK2), apoptosis (MAP3K5/ASK1 and STK3/MST2),proliferation and angiogenesis (RB1). Can protect cells fromapoptosis also by translocating to the mitochondria where it bindsBCL2 and displaces BAD/Bcl2-antagonist of cell death. RegulatesRho signaling and migration, and is required for normal woundhealing. Plays a role in the oncogenic transformation ofepithelial cells via repression of the TJ protein, occludin (OCLN)by inducing the up-regulation of a transcriptional repressorSNAI2/SLUG, which induces down-regulation of OCLN. Restrictscaspase activation in response to selected stimuli, notably Fasstimulation, pathogen-mediated macrophage apoptosis, and erythroiddifferentiation. {ECO:0000269|PubMed:11427728,ECO:0000269|PubMed:11719507, ECO:0000269|PubMed:15385642,ECO:0000269|PubMed:15618521, ECO:0000269|PubMed:15849194,ECO:0000269|PubMed:16892053, ECO:0000269|PubMed:16924233,ECO:0000269|PubMed:9360956}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | >RAF1 | chr3:12653449 | chr22:38282772 | ENST00000251849 | - | 3 | 17 | 349_609 | 106 | 649 | Domain | Protein kinase |
Hgene | >RAF1 | chr3:12653449 | chr22:38282772 | ENST00000251849 | - | 3 | 17 | 56_131 | 106 | 649 | Domain | RBD |
Hgene | >RAF1 | chr3:12653449 | chr22:38282772 | ENST00000442415 | - | 3 | 18 | 349_609 | 106 | 669 | Domain | Protein kinase |
Hgene | >RAF1 | chr3:12653449 | chr22:38282772 | ENST00000442415 | - | 3 | 18 | 56_131 | 106 | 669 | Domain | RBD |
Hgene | >RAF1 | chr3:12653449 | chr22:38282772 | ENST00000251849 | - | 3 | 17 | 355_363 | 106 | 649 | Nucleotide binding | ATP |
Hgene | >RAF1 | chr3:12653449 | chr22:38282772 | ENST00000442415 | - | 3 | 18 | 355_363 | 106 | 669 | Nucleotide binding | ATP |
Hgene | >RAF1 | chr3:12653449 | chr22:38282772 | ENST00000251849 | - | 3 | 17 | 138_184 | 106 | 649 | Zinc finger | Phorbol-ester/DAG-type |
Hgene | >RAF1 | chr3:12653449 | chr22:38282772 | ENST00000442415 | - | 3 | 18 | 138_184 | 106 | 669 | Zinc finger | Phorbol-ester/DAG-type |
Tgene | EIF3L | chr3:12653449 | chr22:38282772 | ENST00000381683 | + | 8 | 11 | 331_537 | 477 | 517 | Domain | PCI |
Tgene | EIF3L | chr3:12653449 | chr22:38282772 | ENST00000412331 | + | 10 | 13 | 331_537 | 525 | 565 | Domain | PCI |
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FusionGeneSequence for RAF1_EIF3L |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
>In-frame_RAF1_ENST00000251849_chr3_12653449_-_EIF3L_ENST00000412331_chr22_38282772_+_146aa MEHIQGAWKTISNGFGFKDAVFDGSSCISPTIVQQFGYQRRASDDGKLTDPSKTSNTIRVFLPNKQRTVVNVRNGMSLHDCLMKALKVRG >In-frame_RAF1_ENST00000251849_chr3_12653449_-_EIF3L_ENST00000381683_chr22_38282772_+_146aa MEHIQGAWKTISNGFGFKDAVFDGSSCISPTIVQQFGYQRRASDDGKLTDPSKTSNTIRVFLPNKQRTVVNVRNGMSLHDCLMKALKVRG >In-frame_RAF1_ENST00000251849_chr3_12653449_-_EIF3L_ENST00000406934_chr22_38282772_+_146aa MEHIQGAWKTISNGFGFKDAVFDGSSCISPTIVQQFGYQRRASDDGKLTDPSKTSNTIRVFLPNKQRTVVNVRNGMSLHDCLMKALKVRG >In-frame_RAF1_ENST00000442415_chr3_12653449_-_EIF3L_ENST00000412331_chr22_38282772_+_146aa MEHIQGAWKTISNGFGFKDAVFDGSSCISPTIVQQFGYQRRASDDGKLTDPSKTSNTIRVFLPNKQRTVVNVRNGMSLHDCLMKALKVRG >In-frame_RAF1_ENST00000442415_chr3_12653449_-_EIF3L_ENST00000381683_chr22_38282772_+_146aa MEHIQGAWKTISNGFGFKDAVFDGSSCISPTIVQQFGYQRRASDDGKLTDPSKTSNTIRVFLPNKQRTVVNVRNGMSLHDCLMKALKVRG >In-frame_RAF1_ENST00000442415_chr3_12653449_-_EIF3L_ENST00000406934_chr22_38282772_+_146aa MEHIQGAWKTISNGFGFKDAVFDGSSCISPTIVQQFGYQRRASDDGKLTDPSKTSNTIRVFLPNKQRTVVNVRNGMSLHDCLMKALKVRG |
* Fusion transcript sequences (only coding sequence (CDS) region). |
>In-frame_RAF1_ENST00000251849_chr3_12653449_-_EIF3L_ENST00000412331_chr22_38282772_+_440nt ATGGAGCACATACAGGGAGCTTGGAAGACGATCAGCAATGGTTTTGGATTCAAAGATGCCGTGTTTGATGGCTCCAGCTGCATCTCTCCT ACAATAGTTCAGCAGTTTGGCTATCAGCGCCGGGCATCAGATGATGGCAAACTCACAGATCCTTCTAAGACAAGCAACACTATCCGTGTT TTCTTGCCGAACAAGCAAAGAACAGTGGTCAATGTGCGAAATGGAATGAGCTTGCATGACTGCCTTATGAAAGCACTCAAGGTGAGGGGC CTGCAACCAGAGTGCTGTGCAGTGTTCAGACTTCTCCACGAACACAAAGGGACATGATCCACATCGCGGACACCAAGGTCGCCAGGCGTT >In-frame_RAF1_ENST00000251849_chr3_12653449_-_EIF3L_ENST00000381683_chr22_38282772_+_440nt ATGGAGCACATACAGGGAGCTTGGAAGACGATCAGCAATGGTTTTGGATTCAAAGATGCCGTGTTTGATGGCTCCAGCTGCATCTCTCCT ACAATAGTTCAGCAGTTTGGCTATCAGCGCCGGGCATCAGATGATGGCAAACTCACAGATCCTTCTAAGACAAGCAACACTATCCGTGTT TTCTTGCCGAACAAGCAAAGAACAGTGGTCAATGTGCGAAATGGAATGAGCTTGCATGACTGCCTTATGAAAGCACTCAAGGTGAGGGGC CTGCAACCAGAGTGCTGTGCAGTGTTCAGACTTCTCCACGAACACAAAGGGACATGATCCACATCGCGGACACCAAGGTCGCCAGGCGTT >In-frame_RAF1_ENST00000251849_chr3_12653449_-_EIF3L_ENST00000406934_chr22_38282772_+_440nt ATGGAGCACATACAGGGAGCTTGGAAGACGATCAGCAATGGTTTTGGATTCAAAGATGCCGTGTTTGATGGCTCCAGCTGCATCTCTCCT ACAATAGTTCAGCAGTTTGGCTATCAGCGCCGGGCATCAGATGATGGCAAACTCACAGATCCTTCTAAGACAAGCAACACTATCCGTGTT TTCTTGCCGAACAAGCAAAGAACAGTGGTCAATGTGCGAAATGGAATGAGCTTGCATGACTGCCTTATGAAAGCACTCAAGGTGAGGGGC CTGCAACCAGAGTGCTGTGCAGTGTTCAGACTTCTCCACGAACACAAAGGGACATGATCCACATCGCGGACACCAAGGTCGCCAGGCGTT >In-frame_RAF1_ENST00000442415_chr3_12653449_-_EIF3L_ENST00000412331_chr22_38282772_+_440nt ATGGAGCACATACAGGGAGCTTGGAAGACGATCAGCAATGGTTTTGGATTCAAAGATGCCGTGTTTGATGGCTCCAGCTGCATCTCTCCT ACAATAGTTCAGCAGTTTGGCTATCAGCGCCGGGCATCAGATGATGGCAAACTCACAGATCCTTCTAAGACAAGCAACACTATCCGTGTT TTCTTGCCGAACAAGCAAAGAACAGTGGTCAATGTGCGAAATGGAATGAGCTTGCATGACTGCCTTATGAAAGCACTCAAGGTGAGGGGC CTGCAACCAGAGTGCTGTGCAGTGTTCAGACTTCTCCACGAACACAAAGGGACATGATCCACATCGCGGACACCAAGGTCGCCAGGCGTT >In-frame_RAF1_ENST00000442415_chr3_12653449_-_EIF3L_ENST00000381683_chr22_38282772_+_440nt ATGGAGCACATACAGGGAGCTTGGAAGACGATCAGCAATGGTTTTGGATTCAAAGATGCCGTGTTTGATGGCTCCAGCTGCATCTCTCCT ACAATAGTTCAGCAGTTTGGCTATCAGCGCCGGGCATCAGATGATGGCAAACTCACAGATCCTTCTAAGACAAGCAACACTATCCGTGTT TTCTTGCCGAACAAGCAAAGAACAGTGGTCAATGTGCGAAATGGAATGAGCTTGCATGACTGCCTTATGAAAGCACTCAAGGTGAGGGGC CTGCAACCAGAGTGCTGTGCAGTGTTCAGACTTCTCCACGAACACAAAGGGACATGATCCACATCGCGGACACCAAGGTCGCCAGGCGTT >In-frame_RAF1_ENST00000442415_chr3_12653449_-_EIF3L_ENST00000406934_chr22_38282772_+_440nt ATGGAGCACATACAGGGAGCTTGGAAGACGATCAGCAATGGTTTTGGATTCAAAGATGCCGTGTTTGATGGCTCCAGCTGCATCTCTCCT ACAATAGTTCAGCAGTTTGGCTATCAGCGCCGGGCATCAGATGATGGCAAACTCACAGATCCTTCTAAGACAAGCAACACTATCCGTGTT TTCTTGCCGAACAAGCAAAGAACAGTGGTCAATGTGCGAAATGGAATGAGCTTGCATGACTGCCTTATGAAAGCACTCAAGGTGAGGGGC CTGCAACCAGAGTGCTGTGCAGTGTTCAGACTTCTCCACGAACACAAAGGGACATGATCCACATCGCGGACACCAAGGTCGCCAGGCGTT |
* Fusion transcript sequences (Full-length transcript). |
>In-frame_RAF1_ENST00000251849_chr3_12653449_-_EIF3L_ENST00000412331_chr22_38282772_+_1823nt AGTCGACTGCCAGTAGGGCTCGCGCAGAATCGGAGAGCCGGTGGCGTCGCAGGTCGGGAGGACGAGCACCGAGTCGAGGGCTCGCTCGTC TGGGCCGCCCGAGAGTCTTAATCGCGGGCGCTTGGGCCGCCATCTTAGATGGCGGGAGTAAGAGGAAAACGATTGTGAGGCGGGAACGGC TTTCTGCTGCCTTTTTTGGGCCCCGAAAAGGGTCAGCTGGCCGGGCTTTGGGGCGCGTGCCCTGAGGCGCGGAGCGCGTTTGCTACGATG CGGGGGCTGCTCGGGGCTCCGTCCCCTGGGCTGGGGACGCGCCGAATGTGACCGCCTCCCGCTCCCTCACCCGCCGCGGGGAGGAGGAGC GGGCGAGAAGCTGCCGCCGAACGACAGGACGTTGGGGCGGCCTGGCTCCCTCAGGTTTAAGAATTGTTTAAGCTGCATCAATGGAGCACA TACAGGGAGCTTGGAAGACGATCAGCAATGGTTTTGGATTCAAAGATGCCGTGTTTGATGGCTCCAGCTGCATCTCTCCTACAATAGTTC AGCAGTTTGGCTATCAGCGCCGGGCATCAGATGATGGCAAACTCACAGATCCTTCTAAGACAAGCAACACTATCCGTGTTTTCTTGCCGA ACAAGCAAAGAACAGTGGTCAATGTGCGAAATGGAATGAGCTTGCATGACTGCCTTATGAAAGCACTCAAGGTGAGGGGCCTGCAACCAG AGTGCTGTGCAGTGTTCAGACTTCTCCACGAACACAAAGGGACATGATCCACATCGCGGACACCAAGGTCGCCAGGCGTTATGGGGATTT CTTCATCCGTCAGATCCACAAATTTGAGGAGCTTAATCGAACCCTGAAGAAGATGGGACAGAGACCTTGATGATATTCACACACATTCAG GAACCTGTTTTGATGTATTATAGGCAGGAAGTGTTTTTGCTACCGTGAAACCTTTACCTAGATCAGCCATCAGCCTGTCAACTCAGTTAA CAAGTTAAGGACCGAAGTGTTTCAAGTGGATCTCAGTAAAGGATCTTTGGAGCCAGATTTGTCGTCTCATTATTGTAGGAGAGAATTTGT GGGTTGTGGCAGTAATACATTTCCCATGTGTCCTGATGCTTTCAGGATACATCAGTTGTTAGTGTTTAAATTGAGTTATTTTTATTTTGT GCTTTTGAGATGGAGTCTCACTCTGTCTCCCAGGCTGGAGTGCAGTAGCGTGATCTCAGTTCGTTGCATCCTCCGCTGCCCAGGTTCAAG CAGTTCTGCCTCAGCCTTCCAAGTAGCTGGGATTACAGGCGTGTGCCACCACACTCAGCTAATTTTTGTATTCTCAGTAGAGATGGGTTT TACCATGTTGGCCAGGCTGGTCTCGAACTCCTGGCCTCAAGTGATTCGCCTGCCTTGGCCTCCCAAAATGTGCTAGGATTACAGGCATGA GCCACCACGCCCCGCCTAAATTCAAAATCTTTTTGTTTTTTTTTAGACGGAGTCTCACTCTGTCGCCCAGGTTGGAGTGTACTGGCGCGA TCTCGGCTCACTGCAAGCTCCACCTCCCAGGTTCCTGCCATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGACTACAGGCACCCGCCACC ATGCCCGGCCAATTTTTTGTATTTTTTAGTAGAGATGGGGTTTCACCGTGTTAGCCAGGATGGTCTCAGATTTCCTGACCTCGTGATCTG CCCATCTCTGCCTCCTAAAGTACTGGGATTACAGGCGTGAGCCACCGTGCCCAGCCCTAAATTGAATTCTTAAATCCCTCTTGTTCATAA >In-frame_RAF1_ENST00000251849_chr3_12653449_-_EIF3L_ENST00000381683_chr22_38282772_+_895nt AGTCGACTGCCAGTAGGGCTCGCGCAGAATCGGAGAGCCGGTGGCGTCGCAGGTCGGGAGGACGAGCACCGAGTCGAGGGCTCGCTCGTC TGGGCCGCCCGAGAGTCTTAATCGCGGGCGCTTGGGCCGCCATCTTAGATGGCGGGAGTAAGAGGAAAACGATTGTGAGGCGGGAACGGC TTTCTGCTGCCTTTTTTGGGCCCCGAAAAGGGTCAGCTGGCCGGGCTTTGGGGCGCGTGCCCTGAGGCGCGGAGCGCGTTTGCTACGATG CGGGGGCTGCTCGGGGCTCCGTCCCCTGGGCTGGGGACGCGCCGAATGTGACCGCCTCCCGCTCCCTCACCCGCCGCGGGGAGGAGGAGC GGGCGAGAAGCTGCCGCCGAACGACAGGACGTTGGGGCGGCCTGGCTCCCTCAGGTTTAAGAATTGTTTAAGCTGCATCAATGGAGCACA TACAGGGAGCTTGGAAGACGATCAGCAATGGTTTTGGATTCAAAGATGCCGTGTTTGATGGCTCCAGCTGCATCTCTCCTACAATAGTTC AGCAGTTTGGCTATCAGCGCCGGGCATCAGATGATGGCAAACTCACAGATCCTTCTAAGACAAGCAACACTATCCGTGTTTTCTTGCCGA ACAAGCAAAGAACAGTGGTCAATGTGCGAAATGGAATGAGCTTGCATGACTGCCTTATGAAAGCACTCAAGGTGAGGGGCCTGCAACCAG AGTGCTGTGCAGTGTTCAGACTTCTCCACGAACACAAAGGGACATGATCCACATCGCGGACACCAAGGTCGCCAGGCGTTATGGGGATTT >In-frame_RAF1_ENST00000251849_chr3_12653449_-_EIF3L_ENST00000406934_chr22_38282772_+_1046nt AGTCGACTGCCAGTAGGGCTCGCGCAGAATCGGAGAGCCGGTGGCGTCGCAGGTCGGGAGGACGAGCACCGAGTCGAGGGCTCGCTCGTC TGGGCCGCCCGAGAGTCTTAATCGCGGGCGCTTGGGCCGCCATCTTAGATGGCGGGAGTAAGAGGAAAACGATTGTGAGGCGGGAACGGC TTTCTGCTGCCTTTTTTGGGCCCCGAAAAGGGTCAGCTGGCCGGGCTTTGGGGCGCGTGCCCTGAGGCGCGGAGCGCGTTTGCTACGATG CGGGGGCTGCTCGGGGCTCCGTCCCCTGGGCTGGGGACGCGCCGAATGTGACCGCCTCCCGCTCCCTCACCCGCCGCGGGGAGGAGGAGC GGGCGAGAAGCTGCCGCCGAACGACAGGACGTTGGGGCGGCCTGGCTCCCTCAGGTTTAAGAATTGTTTAAGCTGCATCAATGGAGCACA TACAGGGAGCTTGGAAGACGATCAGCAATGGTTTTGGATTCAAAGATGCCGTGTTTGATGGCTCCAGCTGCATCTCTCCTACAATAGTTC AGCAGTTTGGCTATCAGCGCCGGGCATCAGATGATGGCAAACTCACAGATCCTTCTAAGACAAGCAACACTATCCGTGTTTTCTTGCCGA ACAAGCAAAGAACAGTGGTCAATGTGCGAAATGGAATGAGCTTGCATGACTGCCTTATGAAAGCACTCAAGGTGAGGGGCCTGCAACCAG AGTGCTGTGCAGTGTTCAGACTTCTCCACGAACACAAAGGGACATGATCCACATCGCGGACACCAAGGTCGCCAGGCGTTATGGGGATTT CTTCATCCGTCAGATCCACAAATTTGAGGAGCTTAATCGAACCCTGAAGAAGATGGGACAGAGACCTTGATGATATTCACACACATTCAG GAACCTGTTTTGATGTATTATAGGCAGGAAGTGTTTTTGCTACCGTGAAACCTTTACCTAGATCAGCCATCAGCCTGTCAACTCAGTTAA >In-frame_RAF1_ENST00000442415_chr3_12653449_-_EIF3L_ENST00000412331_chr22_38282772_+_1745nt GGCTCGCTCGTCTGGGCCGCCCGAGAGTCTTAATCGCGGGCGCTTGGGCCGCCATCTTAGATGGCGGGAGTAAGAGGAAAACGATTGTGA GGCGGGAACGGCTTTCTGCTGCCTTTTTTGGGCCCCGAAAAGGGTCAGCTGGCCGGGCTTTGGGGCGCGTGCCCTGAGGCGCGGAGCGCG TTTGCTACGATGCGGGGGCTGCTCGGGGCTCCGTCCCCTGGGCTGGGGACGCGCCGAATGTGACCGCCTCCCGCTCCCTCACCCGCCGCG GGGAGGAGGAGCGGGCGAGAAGCTGCCGCCGAACGACAGGACGTTGGGGCGGCCTGGCTCCCTCAGGTTTAAGAATTGTTTAAGCTGCAT CAATGGAGCACATACAGGGAGCTTGGAAGACGATCAGCAATGGTTTTGGATTCAAAGATGCCGTGTTTGATGGCTCCAGCTGCATCTCTC CTACAATAGTTCAGCAGTTTGGCTATCAGCGCCGGGCATCAGATGATGGCAAACTCACAGATCCTTCTAAGACAAGCAACACTATCCGTG TTTTCTTGCCGAACAAGCAAAGAACAGTGGTCAATGTGCGAAATGGAATGAGCTTGCATGACTGCCTTATGAAAGCACTCAAGGTGAGGG GCCTGCAACCAGAGTGCTGTGCAGTGTTCAGACTTCTCCACGAACACAAAGGGACATGATCCACATCGCGGACACCAAGGTCGCCAGGCG TTATGGGGATTTCTTCATCCGTCAGATCCACAAATTTGAGGAGCTTAATCGAACCCTGAAGAAGATGGGACAGAGACCTTGATGATATTC ACACACATTCAGGAACCTGTTTTGATGTATTATAGGCAGGAAGTGTTTTTGCTACCGTGAAACCTTTACCTAGATCAGCCATCAGCCTGT CAACTCAGTTAACAAGTTAAGGACCGAAGTGTTTCAAGTGGATCTCAGTAAAGGATCTTTGGAGCCAGATTTGTCGTCTCATTATTGTAG GAGAGAATTTGTGGGTTGTGGCAGTAATACATTTCCCATGTGTCCTGATGCTTTCAGGATACATCAGTTGTTAGTGTTTAAATTGAGTTA TTTTTATTTTGTGCTTTTGAGATGGAGTCTCACTCTGTCTCCCAGGCTGGAGTGCAGTAGCGTGATCTCAGTTCGTTGCATCCTCCGCTG CCCAGGTTCAAGCAGTTCTGCCTCAGCCTTCCAAGTAGCTGGGATTACAGGCGTGTGCCACCACACTCAGCTAATTTTTGTATTCTCAGT AGAGATGGGTTTTACCATGTTGGCCAGGCTGGTCTCGAACTCCTGGCCTCAAGTGATTCGCCTGCCTTGGCCTCCCAAAATGTGCTAGGA TTACAGGCATGAGCCACCACGCCCCGCCTAAATTCAAAATCTTTTTGTTTTTTTTTAGACGGAGTCTCACTCTGTCGCCCAGGTTGGAGT GTACTGGCGCGATCTCGGCTCACTGCAAGCTCCACCTCCCAGGTTCCTGCCATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGACTACAG GCACCCGCCACCATGCCCGGCCAATTTTTTGTATTTTTTAGTAGAGATGGGGTTTCACCGTGTTAGCCAGGATGGTCTCAGATTTCCTGA CCTCGTGATCTGCCCATCTCTGCCTCCTAAAGTACTGGGATTACAGGCGTGAGCCACCGTGCCCAGCCCTAAATTGAATTCTTAAATCCC >In-frame_RAF1_ENST00000442415_chr3_12653449_-_EIF3L_ENST00000381683_chr22_38282772_+_817nt GGCTCGCTCGTCTGGGCCGCCCGAGAGTCTTAATCGCGGGCGCTTGGGCCGCCATCTTAGATGGCGGGAGTAAGAGGAAAACGATTGTGA GGCGGGAACGGCTTTCTGCTGCCTTTTTTGGGCCCCGAAAAGGGTCAGCTGGCCGGGCTTTGGGGCGCGTGCCCTGAGGCGCGGAGCGCG TTTGCTACGATGCGGGGGCTGCTCGGGGCTCCGTCCCCTGGGCTGGGGACGCGCCGAATGTGACCGCCTCCCGCTCCCTCACCCGCCGCG GGGAGGAGGAGCGGGCGAGAAGCTGCCGCCGAACGACAGGACGTTGGGGCGGCCTGGCTCCCTCAGGTTTAAGAATTGTTTAAGCTGCAT CAATGGAGCACATACAGGGAGCTTGGAAGACGATCAGCAATGGTTTTGGATTCAAAGATGCCGTGTTTGATGGCTCCAGCTGCATCTCTC CTACAATAGTTCAGCAGTTTGGCTATCAGCGCCGGGCATCAGATGATGGCAAACTCACAGATCCTTCTAAGACAAGCAACACTATCCGTG TTTTCTTGCCGAACAAGCAAAGAACAGTGGTCAATGTGCGAAATGGAATGAGCTTGCATGACTGCCTTATGAAAGCACTCAAGGTGAGGG GCCTGCAACCAGAGTGCTGTGCAGTGTTCAGACTTCTCCACGAACACAAAGGGACATGATCCACATCGCGGACACCAAGGTCGCCAGGCG TTATGGGGATTTCTTCATCCGTCAGATCCACAAATTTGAGGAGCTTAATCGAACCCTGAAGAAGATGGGACAGAGACCTTGATGATATTC >In-frame_RAF1_ENST00000442415_chr3_12653449_-_EIF3L_ENST00000406934_chr22_38282772_+_968nt GGCTCGCTCGTCTGGGCCGCCCGAGAGTCTTAATCGCGGGCGCTTGGGCCGCCATCTTAGATGGCGGGAGTAAGAGGAAAACGATTGTGA GGCGGGAACGGCTTTCTGCTGCCTTTTTTGGGCCCCGAAAAGGGTCAGCTGGCCGGGCTTTGGGGCGCGTGCCCTGAGGCGCGGAGCGCG TTTGCTACGATGCGGGGGCTGCTCGGGGCTCCGTCCCCTGGGCTGGGGACGCGCCGAATGTGACCGCCTCCCGCTCCCTCACCCGCCGCG GGGAGGAGGAGCGGGCGAGAAGCTGCCGCCGAACGACAGGACGTTGGGGCGGCCTGGCTCCCTCAGGTTTAAGAATTGTTTAAGCTGCAT CAATGGAGCACATACAGGGAGCTTGGAAGACGATCAGCAATGGTTTTGGATTCAAAGATGCCGTGTTTGATGGCTCCAGCTGCATCTCTC CTACAATAGTTCAGCAGTTTGGCTATCAGCGCCGGGCATCAGATGATGGCAAACTCACAGATCCTTCTAAGACAAGCAACACTATCCGTG TTTTCTTGCCGAACAAGCAAAGAACAGTGGTCAATGTGCGAAATGGAATGAGCTTGCATGACTGCCTTATGAAAGCACTCAAGGTGAGGG GCCTGCAACCAGAGTGCTGTGCAGTGTTCAGACTTCTCCACGAACACAAAGGGACATGATCCACATCGCGGACACCAAGGTCGCCAGGCG TTATGGGGATTTCTTCATCCGTCAGATCCACAAATTTGAGGAGCTTAATCGAACCCTGAAGAAGATGGGACAGAGACCTTGATGATATTC ACACACATTCAGGAACCTGTTTTGATGTATTATAGGCAGGAAGTGTTTTTGCTACCGTGAAACCTTTACCTAGATCAGCCATCAGCCTGT |
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FusionGenePPI for RAF1_EIF3L |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
RAF1 | YWHAQ, YWHAG, YWHAZ, SFN, HRAS, VDAC1, PEBP4, CNKSR1, RASD2, CNKSR2, ERAS, SPRY4, SPRY2, YWHAB, OIP5, PHKA2, CCT3, MYC, AR, MRAS, KRAS, LRPAP1, RRAS2, SHOC2, TSC22D3, STK26, MAPK1, MAPK3, PRKCE, BCL2, BCL2L1, PEBP1, MAP2K1, GRB10, NRAS, MAPK8IP3, AKT1, HSP90AA1, GNG4, GNB2, VAV1, RHEB, RAP1A, SRC, FYN, RB1, RBL2, PRKG1, JAK2, YWHAH, CFLAR, CDC25A, BRAF, MAP3K1, PDGFRB, MAP3K5, MAPK7, PHB, BAG1, PAK1, PRKCZ, RRAS, PRPF6, UBE2D2, YWHAE, NR3C1, LCK, LTK, JAK1, XIAP, BIRC2, BIRC3, STUB1, EEF1A1, HSPA8, HSPA5, CALM1, SGK1, NEDD4, SCNN1B, NEDD4L, STK3, BRAP, WDR83, KSR1, LATS1, MAP2K2, RFXANK, PPP1CC, VCP, HSPD1, BAD, BCL6, BIRC7, PIN1, MMS19, PPP2R1A, PPP2R2B, PPP2CA, HSPA4, RAF1, PPP2CB, MAPK8, RBBP8, YY1, PKM, CDK20, HIPK4, TBXA2R, SH3KBP1, ILK, GPRASP2, CDC37, IRS4, FAM96B, HUWE1, RANBP9, TMEM70, PACSIN3, NPLOC4, PRKAR1A, DCAF8, PURA, FYCO1, MYBPC1, COPS7A, MOV10, NXF1, EGFR, CALU, CCT8, DNAJA1, EMD, TIMM50, LOX, ARRB2, AGTR1, CASZ1, MRC2, PDLIM2, HERC2, XPO1, ACOX1, PCDH7, MAD2L1, SYNPO, TMEM63B, EEF1E1, COPS5, SS18L2, NUP133, RPGRIP1L, NCAPG2, NUP107, MSH2, LAS1L, AMER1, NUP160, EIF3D, SPATA7, NPHP4, DYNLL2, DYNLL1, IQCB1, RMDN3, TRIM25 | EIF3L | EIF3K, EIF3A, EIF1B, EIF4A2, EIF3D, EIF3E, EIF3H, EIF3F, H2AFX, TADA2A, AGO3, HDAC5, EIF3B, RGS2, SIRT7, CUL1, EIF3C, EIF3G, EIF3M, EIF3I, NCL, FN1, VCAM1, SMAD2, ITGA4, RRN3, CD81, IGSF8, ICAM1, XRN2, DDX3X, KCMF1, LARP1, RPS13, RPS16, RPS18, RPS20, RPS25, RPS28, RPS4X, RPS5, RPS8, RPS9, RIOK2, RNF2, EIF3CL, EIF2B5, NUMA1, NTRK1, HERC2, XPO1, AHSA1, NPM1, RPL10, CEP170P1, GAN, MCM2, C1orf131, ZNF746, PRRC2B, PSMD12, GNB2, PTP4A1, TTC21B, CYLD, G3BP1, BRCA1, YAP1 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Hgene | RAF1 | chr3:12653449 | chr22:38282772 | ENST00000251849 | - | 3 | 17 | 331_349 | 106 | 649 | PEBP1/RKIP |
Hgene | RAF1 | chr3:12653449 | chr22:38282772 | ENST00000442415 | - | 3 | 18 | 331_349 | 106 | 669 | PEBP1/RKIP |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for RAF1_EIF3L |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Hgene | RAF1 | P04049 | DB08896 | Regorafenib | RAF proto-oncogene serine/threonine-protein kinase | small molecule | approved |
Hgene | RAF1 | P04049 | DB00398 | Sorafenib | RAF proto-oncogene serine/threonine-protein kinase | small molecule | approved|investigational |
Hgene | RAF1 | P04049 | DB08862 | Cholecystokinin | RAF proto-oncogene serine/threonine-protein kinase | small molecule | approved|investigational |
Hgene | RAF1 | P04049 | DB08912 | Dabrafenib | RAF proto-oncogene serine/threonine-protein kinase | small molecule | approved|investigational |
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RelatedDiseases for RAF1_EIF3L |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | RAF1 | C1969057 | Noonan Syndrome 5 | 3 | CTD_human;UNIPROT |
Hgene | RAF1 | C0007194 | Hypertrophic Cardiomyopathy | 2 | CTD_human;HPO |
Hgene | RAF1 | C0028326 | Noonan Syndrome | 2 | CTD_human;ORPHANET |
Hgene | RAF1 | C0007131 | Non-Small Cell Lung Carcinoma | 1 | CTD_human |
Hgene | RAF1 | C0007193 | Cardiomyopathy, Dilated | 1 | CTD_human;HPO |
Hgene | RAF1 | C0017638 | Glioma | 1 | CTD_human |
Hgene | RAF1 | C0020429 | Hyperalgesia | 1 | CTD_human |
Hgene | RAF1 | C0022665 | Kidney Neoplasm | 1 | CTD_human |
Hgene | RAF1 | C0023903 | Liver neoplasms | 1 | CTD_human |
Hgene | RAF1 | C0024121 | Lung Neoplasms | 1 | CTD_human |
Hgene | RAF1 | C0175704 | LEOPARD Syndrome | 1 | CTD_human;ORPHANET |
Hgene | RAF1 | C0345967 | Malignant mesothelioma | 1 | CTD_human |
Hgene | RAF1 | C1458155 | Mammary Neoplasms | 1 | CTD_human |
Hgene | RAF1 | C4014656 | CARDIOMYOPATHY, DILATED, 1NN | 1 | UNIPROT |