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Fusion gene ID: 30191 |
FusionGeneSummary for RAD51_CDCA5 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: RAD51_CDCA5 | Fusion gene ID: 30191 | Hgene | Tgene | Gene symbol | RAD51 | CDCA5 | Gene ID | 5888 | 113130 |
| Gene name | RAD51 recombinase | cell division cycle associated 5 | |
| Synonyms | BRCC5|FANCR|HRAD51|HsRad51|HsT16930|MRMV2|RAD51A|RECA | SORORIN | |
| Cytomap | 15q15.1 | 11q13.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | DNA repair protein RAD51 homolog 1BRCA1/BRCA2-containing complex, subunit 5RAD51 homolog ARecA, E. coli, homolog ofRecA-like proteinrecombination protein A | sororincell division cycle-associated protein 5p35 | |
| Modification date | 20180527 | 20180523 | |
| UniProtAcc | Q06609 | Q96FF9 | |
| Ensembl transtripts involved in fusion gene | ENST00000423169, ENST00000267868, ENST00000557850, ENST00000532743, ENST00000382643, ENST00000530766, | ENST00000438878, ENST00000275517, ENST00000404147, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 1 X 1 X 1=1 |
| # samples | 1 | 1 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: RAD51 [Title/Abstract] AND CDCA5 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | RAD51 | GO:0000724 | double-strand break repair via homologous recombination | 16428451 |
| Hgene | RAD51 | GO:0006268 | DNA unwinding involved in DNA replication | 7988572 |
| Hgene | RAD51 | GO:0006974 | cellular response to DNA damage stimulus | 23509288|25585578 |
| Hgene | RAD51 | GO:0010569 | regulation of double-strand break repair via homologous recombination | 23754376 |
| Hgene | RAD51 | GO:0031297 | replication fork processing | 25585578 |
| Hgene | RAD51 | GO:0051106 | positive regulation of DNA ligation | 8929543 |
| Hgene | RAD51 | GO:0071479 | cellular response to ionizing radiation | 23509288|23754376 |
| Hgene | RAD51 | GO:0072757 | cellular response to camptothecin | 23509288 |
| Tgene | CDCA5 | GO:0000278 | mitotic cell cycle | 15837422 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | AW363804 | RAD51 | chr15 | 41022163 | + | CDCA5 | chr11 | 64845475 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-intron | ENST00000423169 | ENST00000438878 | RAD51 | chr15 | 41022163 | + | CDCA5 | chr11 | 64845475 | - |
| intron-3UTR | ENST00000423169 | ENST00000275517 | RAD51 | chr15 | 41022163 | + | CDCA5 | chr11 | 64845475 | - |
| intron-intron | ENST00000423169 | ENST00000404147 | RAD51 | chr15 | 41022163 | + | CDCA5 | chr11 | 64845475 | - |
| 5CDS-intron | ENST00000267868 | ENST00000438878 | RAD51 | chr15 | 41022163 | + | CDCA5 | chr11 | 64845475 | - |
| 5CDS-3UTR | ENST00000267868 | ENST00000275517 | RAD51 | chr15 | 41022163 | + | CDCA5 | chr11 | 64845475 | - |
| 5CDS-intron | ENST00000267868 | ENST00000404147 | RAD51 | chr15 | 41022163 | + | CDCA5 | chr11 | 64845475 | - |
| 5CDS-intron | ENST00000557850 | ENST00000438878 | RAD51 | chr15 | 41022163 | + | CDCA5 | chr11 | 64845475 | - |
| 5CDS-3UTR | ENST00000557850 | ENST00000275517 | RAD51 | chr15 | 41022163 | + | CDCA5 | chr11 | 64845475 | - |
| 5CDS-intron | ENST00000557850 | ENST00000404147 | RAD51 | chr15 | 41022163 | + | CDCA5 | chr11 | 64845475 | - |
| 5CDS-intron | ENST00000532743 | ENST00000438878 | RAD51 | chr15 | 41022163 | + | CDCA5 | chr11 | 64845475 | - |
| 5CDS-3UTR | ENST00000532743 | ENST00000275517 | RAD51 | chr15 | 41022163 | + | CDCA5 | chr11 | 64845475 | - |
| 5CDS-intron | ENST00000532743 | ENST00000404147 | RAD51 | chr15 | 41022163 | + | CDCA5 | chr11 | 64845475 | - |
| 5CDS-intron | ENST00000382643 | ENST00000438878 | RAD51 | chr15 | 41022163 | + | CDCA5 | chr11 | 64845475 | - |
| 5CDS-3UTR | ENST00000382643 | ENST00000275517 | RAD51 | chr15 | 41022163 | + | CDCA5 | chr11 | 64845475 | - |
| 5CDS-intron | ENST00000382643 | ENST00000404147 | RAD51 | chr15 | 41022163 | + | CDCA5 | chr11 | 64845475 | - |
| intron-intron | ENST00000530766 | ENST00000438878 | RAD51 | chr15 | 41022163 | + | CDCA5 | chr11 | 64845475 | - |
| intron-3UTR | ENST00000530766 | ENST00000275517 | RAD51 | chr15 | 41022163 | + | CDCA5 | chr11 | 64845475 | - |
| intron-intron | ENST00000530766 | ENST00000404147 | RAD51 | chr15 | 41022163 | + | CDCA5 | chr11 | 64845475 | - |
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FusionProtFeatures for RAD51_CDCA5 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| RAD51 | CDCA5 |
| Plays an important role in homologous strand exchange, akey step in DNA repair through homologous recombination (HR)(PubMed:28575658). Binds to single and double-stranded DNA andexhibits DNA-dependent ATPase activity. Catalyzes the recognitionof homology and strand exchange between homologous DNA partners toform a joint molecule between a processed DNA break and the repairtemplate. Binds to single-stranded DNA in an ATP-dependent mannerto form nucleoprotein filaments which are essential for thehomology search and strand exchange (PubMed:26681308). Part of aPALB2-scaffolded HR complex containing BRCA2 and RAD51C and whichis thought to play a role in DNA repair by HR. Plays a role inregulating mitochondrial DNA copy number under conditions ofoxidative stress in the presence of RAD51C and XRCC3. Alsoinvolved in interstrand cross-link repair (PubMed:26253028).{ECO:0000269|PubMed:12205100, ECO:0000269|PubMed:12442171,ECO:0000269|PubMed:18417535, ECO:0000269|PubMed:20231364,ECO:0000269|PubMed:20348101, ECO:0000269|PubMed:20413593,ECO:0000269|PubMed:23509288, ECO:0000269|PubMed:23754376,ECO:0000269|PubMed:26253028, ECO:0000269|PubMed:26681308,ECO:0000269|PubMed:28575658}. | Regulator of sister chromatid cohesion in mitosisstabilizing cohesin complex association with chromatin. Mayantagonize the action of WAPL which stimulates cohesindissociation from chromatin. Cohesion ensures that chromosomepartitioning is accurate in both meiotic and mitotic cells andplays an important role in DNA repair. Required for efficient DNAdouble-stranded break repair. {ECO:0000269|PubMed:15837422,ECO:0000269|PubMed:17349791, ECO:0000269|PubMed:21111234}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for RAD51_CDCA5 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for RAD51_CDCA5 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for RAD51_CDCA5 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for RAD51_CDCA5 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | RAD51 | C0006142 | Malignant neoplasm of breast | 1 | UNIPROT |
| Hgene | RAD51 | C0018671 | Head and Neck Neoplasms | 1 | CTD_human |
| Hgene | RAD51 | C1449861 | Micronuclei, Chromosome-Defective | 1 | CTD_human |
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