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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 30174

FusionGeneSummary for RAD51B_BAZ1A

check button Fusion gene summary
Fusion gene informationFusion gene name: RAD51B_BAZ1A
Fusion gene ID: 30174
HgeneTgene
Gene symbol

RAD51B

BAZ1A

Gene ID

5890

11177

Gene nameRAD51 paralog Bbromodomain adjacent to zinc finger domain 1A
SynonymsR51H2|RAD51L1|REC2ACF1|WALp1|WCRF180|hACF1
Cytomap

14q24.1

14q13.1-q13.2

Type of geneprotein-codingprotein-coding
DescriptionDNA repair protein RAD51 homolog 2RAD51 homolog BRecA-like proteinrecombination repair proteinbromodomain adjacent to zinc finger domain protein 1AATP-dependent chromatin remodeling proteinATP-utilizing chromatin assembly and remodeling factor 1CHRAC subunit ACF1hWALp1williams syndrome transcription factor-related chromatin-remodeling factor
Modification date2018052320180519
UniProtAcc

O15315

Q9NRL2

Ensembl transtripts involved in fusion geneENST00000487861, ENST00000471583, 
ENST00000487270, ENST00000488612, 
ENST00000390683, ENST00000469165, 
ENST00000358716, ENST00000382422, 
ENST00000360310, ENST00000553853, 
Fusion gene scores* DoF score13 X 9 X 7=8194 X 4 X 4=64
# samples 154
** MAII scorelog2(15/819*10)=-2.44890095114513
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/64*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RAD51B [Title/Abstract] AND BAZ1A [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationDDR (DNA damage repair) gene involved fusion gene, retained protein feature but frameshift.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneBAZ1A

GO:0006261

DNA-dependent DNA replication

12434153


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDACCTCGA-OR-A5J9-01ARAD51Bchr14

68353921

+BAZ1Achr14

35228052

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000487861ENST00000358716RAD51Bchr14

68353921

+BAZ1Achr14

35228052

-
Frame-shiftENST00000487861ENST00000382422RAD51Bchr14

68353921

+BAZ1Achr14

35228052

-
Frame-shiftENST00000487861ENST00000360310RAD51Bchr14

68353921

+BAZ1Achr14

35228052

-
5CDS-intronENST00000487861ENST00000553853RAD51Bchr14

68353921

+BAZ1Achr14

35228052

-
Frame-shiftENST00000471583ENST00000358716RAD51Bchr14

68353921

+BAZ1Achr14

35228052

-
Frame-shiftENST00000471583ENST00000382422RAD51Bchr14

68353921

+BAZ1Achr14

35228052

-
Frame-shiftENST00000471583ENST00000360310RAD51Bchr14

68353921

+BAZ1Achr14

35228052

-
5CDS-intronENST00000471583ENST00000553853RAD51Bchr14

68353921

+BAZ1Achr14

35228052

-
Frame-shiftENST00000487270ENST00000358716RAD51Bchr14

68353921

+BAZ1Achr14

35228052

-
Frame-shiftENST00000487270ENST00000382422RAD51Bchr14

68353921

+BAZ1Achr14

35228052

-
Frame-shiftENST00000487270ENST00000360310RAD51Bchr14

68353921

+BAZ1Achr14

35228052

-
5CDS-intronENST00000487270ENST00000553853RAD51Bchr14

68353921

+BAZ1Achr14

35228052

-
Frame-shiftENST00000488612ENST00000358716RAD51Bchr14

68353921

+BAZ1Achr14

35228052

-
Frame-shiftENST00000488612ENST00000382422RAD51Bchr14

68353921

+BAZ1Achr14

35228052

-
Frame-shiftENST00000488612ENST00000360310RAD51Bchr14

68353921

+BAZ1Achr14

35228052

-
5CDS-intronENST00000488612ENST00000553853RAD51Bchr14

68353921

+BAZ1Achr14

35228052

-
Frame-shiftENST00000390683ENST00000358716RAD51Bchr14

68353921

+BAZ1Achr14

35228052

-
Frame-shiftENST00000390683ENST00000382422RAD51Bchr14

68353921

+BAZ1Achr14

35228052

-
Frame-shiftENST00000390683ENST00000360310RAD51Bchr14

68353921

+BAZ1Achr14

35228052

-
5CDS-intronENST00000390683ENST00000553853RAD51Bchr14

68353921

+BAZ1Achr14

35228052

-
3UTR-3CDSENST00000469165ENST00000358716RAD51Bchr14

68353921

+BAZ1Achr14

35228052

-
3UTR-3CDSENST00000469165ENST00000382422RAD51Bchr14

68353921

+BAZ1Achr14

35228052

-
3UTR-3CDSENST00000469165ENST00000360310RAD51Bchr14

68353921

+BAZ1Achr14

35228052

-
3UTR-intronENST00000469165ENST00000553853RAD51Bchr14

68353921

+BAZ1Achr14

35228052

-

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FusionProtFeatures for RAD51B_BAZ1A


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RAD51B

O15315

BAZ1A

Q9NRL2

Component of the ACF complex, an ATP-dependent chromatinremodeling complex, that regulates spacing of nucleosomes usingATP to generate evenly spaced nucleosomes along the chromatin. TheATPase activity of the complex is regulated by the length offlanking DNA. Also involved in facilitating the DNA replicationprocess. BAZ1A is the accessory, non-catalytic subunit of thecomplex which can enhance and direct the process provided by theATPase subunit, SMARCA5, probably through targetingpericentromeric heterochromatin in late S phase. Moves end-positioned nucleosomes to a predominantly central position. Mayhave a role in nuclear receptor-mediated transcription repression. Component of the histone-fold protein complex CHRACcomplex which facilitates nucleosome sliding by the ACF complexand enhances ACF-mediated chromatin assembly. The C-terminalregions of both CHRAC1 and POLE1 are required for these functions.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for RAD51B_BAZ1A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for RAD51B_BAZ1A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
RAD51BRAD51, RAD51C, RAD51D, XRCC2, SWSAP1, FAM9B, DKKL1, ARL4C, MUC20, ADAMTS4, HELQBAZ1ASMARCA5, POLE3, BAZ1B, SATB1, SMARCA2, CHRAC1, NCOR1, XRCC5, XRCC6, SMARCAD1, ELAVL1, GRK5, RBBP4, SMAD9, SMAD2, CCDC8, SUMO2, SRPK2, RHOA, CCDC22, UGGT1, MAX, TEAD2, FOXE1, HIST1H4A, H2AFX, HIST1H3A, HIST1H2BB, FOXL1, BMI1, CAPN6, MECP2, MTNR1A


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for RAD51B_BAZ1A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for RAD51B_BAZ1A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneRAD51BC0236969Substance-Related Disorders1CTD_human
HgeneRAD51BC0242788Breast Neoplasms, Male1CTD_human
HgeneRAD51BC1458155Mammary Neoplasms1CTD_human