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Fusion gene ID: 30170 |
FusionGeneSummary for RAD50_TCOF1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: RAD50_TCOF1 | Fusion gene ID: 30170 | Hgene | Tgene | Gene symbol | RAD50 | TCOF1 | Gene ID | 10111 | 6949 |
| Gene name | RAD50 double strand break repair protein | treacle ribosome biogenesis factor 1 | |
| Synonyms | NBSLD|RAD502|hRad50 | MFD1|TCS|TCS1|treacle | |
| Cytomap | 5q31.1 | 5q32-q33.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | DNA repair protein RAD50RAD50 homolog, double strand break repair protein | treacle proteinTreacher Collins syndrome proteinTreacher Collins-Franceschetti syndrome 1nucleolar trafficking phosphoprotein | |
| Modification date | 20180523 | 20180522 | |
| UniProtAcc | Q92878 | Q13428 | |
| Ensembl transtripts involved in fusion gene | ENST00000378823, ENST00000265335, ENST00000487596, | ENST00000451292, ENST00000377797, ENST00000445265, ENST00000323668, ENST00000439160, ENST00000394269, ENST00000504761, ENST00000513346, ENST00000506063, | |
| Fusion gene scores | * DoF score | 5 X 4 X 5=100 | 9 X 8 X 8=576 |
| # samples | 5 | 10 | |
| ** MAII score | log2(5/100*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(10/576*10)=-2.52606881166759 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: RAD50 [Title/Abstract] AND TCOF1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | RAD50 | GO:0000019 | regulation of mitotic recombination | 8756642 |
| Hgene | RAD50 | GO:0006281 | DNA repair | 9705271 |
| Hgene | RAD50 | GO:0006310 | DNA recombination | 9705271 |
| Hgene | RAD50 | GO:0006974 | cellular response to DNA damage stimulus | 17500065 |
| Hgene | RAD50 | GO:0007004 | telomere maintenance via telomerase | 9705271 |
| Hgene | RAD50 | GO:0031954 | positive regulation of protein autophosphorylation | 15790808 |
| Hgene | RAD50 | GO:0033674 | positive regulation of kinase activity | 15790808 |
| Hgene | RAD50 | GO:1904354 | negative regulation of telomere capping | 17694070 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BRCA | TCGA-A2-A0EP-01A | RAD50 | chr5 | 131895059 | + | TCOF1 | chr5 | 149767465 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5UTR-3CDS | ENST00000378823 | ENST00000451292 | RAD50 | chr5 | 131895059 | + | TCOF1 | chr5 | 149767465 | + |
| 5UTR-3CDS | ENST00000378823 | ENST00000377797 | RAD50 | chr5 | 131895059 | + | TCOF1 | chr5 | 149767465 | + |
| 5UTR-3CDS | ENST00000378823 | ENST00000445265 | RAD50 | chr5 | 131895059 | + | TCOF1 | chr5 | 149767465 | + |
| 5UTR-3CDS | ENST00000378823 | ENST00000323668 | RAD50 | chr5 | 131895059 | + | TCOF1 | chr5 | 149767465 | + |
| 5UTR-3CDS | ENST00000378823 | ENST00000439160 | RAD50 | chr5 | 131895059 | + | TCOF1 | chr5 | 149767465 | + |
| 5UTR-intron | ENST00000378823 | ENST00000394269 | RAD50 | chr5 | 131895059 | + | TCOF1 | chr5 | 149767465 | + |
| 5UTR-intron | ENST00000378823 | ENST00000504761 | RAD50 | chr5 | 131895059 | + | TCOF1 | chr5 | 149767465 | + |
| 5UTR-intron | ENST00000378823 | ENST00000513346 | RAD50 | chr5 | 131895059 | + | TCOF1 | chr5 | 149767465 | + |
| 5UTR-intron | ENST00000378823 | ENST00000506063 | RAD50 | chr5 | 131895059 | + | TCOF1 | chr5 | 149767465 | + |
| In-frame | ENST00000265335 | ENST00000451292 | RAD50 | chr5 | 131895059 | + | TCOF1 | chr5 | 149767465 | + |
| In-frame | ENST00000265335 | ENST00000377797 | RAD50 | chr5 | 131895059 | + | TCOF1 | chr5 | 149767465 | + |
| In-frame | ENST00000265335 | ENST00000445265 | RAD50 | chr5 | 131895059 | + | TCOF1 | chr5 | 149767465 | + |
| In-frame | ENST00000265335 | ENST00000323668 | RAD50 | chr5 | 131895059 | + | TCOF1 | chr5 | 149767465 | + |
| In-frame | ENST00000265335 | ENST00000439160 | RAD50 | chr5 | 131895059 | + | TCOF1 | chr5 | 149767465 | + |
| 5CDS-intron | ENST00000265335 | ENST00000394269 | RAD50 | chr5 | 131895059 | + | TCOF1 | chr5 | 149767465 | + |
| 5CDS-intron | ENST00000265335 | ENST00000504761 | RAD50 | chr5 | 131895059 | + | TCOF1 | chr5 | 149767465 | + |
| 5CDS-intron | ENST00000265335 | ENST00000513346 | RAD50 | chr5 | 131895059 | + | TCOF1 | chr5 | 149767465 | + |
| 5CDS-intron | ENST00000265335 | ENST00000506063 | RAD50 | chr5 | 131895059 | + | TCOF1 | chr5 | 149767465 | + |
| intron-3CDS | ENST00000487596 | ENST00000451292 | RAD50 | chr5 | 131895059 | + | TCOF1 | chr5 | 149767465 | + |
| intron-3CDS | ENST00000487596 | ENST00000377797 | RAD50 | chr5 | 131895059 | + | TCOF1 | chr5 | 149767465 | + |
| intron-3CDS | ENST00000487596 | ENST00000445265 | RAD50 | chr5 | 131895059 | + | TCOF1 | chr5 | 149767465 | + |
| intron-3CDS | ENST00000487596 | ENST00000323668 | RAD50 | chr5 | 131895059 | + | TCOF1 | chr5 | 149767465 | + |
| intron-3CDS | ENST00000487596 | ENST00000439160 | RAD50 | chr5 | 131895059 | + | TCOF1 | chr5 | 149767465 | + |
| intron-intron | ENST00000487596 | ENST00000394269 | RAD50 | chr5 | 131895059 | + | TCOF1 | chr5 | 149767465 | + |
| intron-intron | ENST00000487596 | ENST00000504761 | RAD50 | chr5 | 131895059 | + | TCOF1 | chr5 | 149767465 | + |
| intron-intron | ENST00000487596 | ENST00000513346 | RAD50 | chr5 | 131895059 | + | TCOF1 | chr5 | 149767465 | + |
| intron-intron | ENST00000487596 | ENST00000506063 | RAD50 | chr5 | 131895059 | + | TCOF1 | chr5 | 149767465 | + |
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FusionProtFeatures for RAD50_TCOF1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| RAD50 | TCOF1 |
| Component of the MRN complex, which plays a central rolein double-strand break (DSB) repair, DNA recombination,maintenance of telomere integrity and meiosis. The complexpossesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11.RAD50 may be required to bind DNA ends and hold them in closeproximity. This could facilitate searches for short or longregions of sequence homology in the recombining DNA templates, andmay also stimulate the activity of DNA ligases and/or restrict thenuclease activity of MRE11 to prevent nucleolytic degradation pasta given point (PubMed:11741547, PubMed:9590181, PubMed:9705271,PubMed:9651580). The complex may also be required for DNA damagesignaling via activation of the ATM kinase (PubMed:15064416). Intelomeres the MRN complex may modulate t-loop formation(PubMed:10888888). {ECO:0000269|PubMed:10888888,ECO:0000269|PubMed:11741547, ECO:0000269|PubMed:15064416,ECO:0000269|PubMed:9590181, ECO:0000269|PubMed:9651580,ECO:0000269|PubMed:9705271}. | Nucleolar protein that acts as a regulator of RNApolymerase I by connecting RNA polymerase I with enzymesresponsible for ribosomal processing and modification(PubMed:12777385, PubMed:26399832). Required for neural crestspecification: following monoubiquitination by the BCR(KBTBD8)complex, associates with NOLC1 and acts as a platform to connectRNA polymerase I with enzymes responsible for ribosomal processingand modification, leading to remodel the translational program ofdifferentiating cells in favor of neural crest specification(PubMed:26399832). {ECO:0000269|PubMed:12777385,ECO:0000269|PubMed:26399832}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for RAD50_TCOF1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_RAD50_ENST00000265335_chr5_131895059_+_TCOF1_ENST00000451292_chr5_149767465_+_607aa MSRIEKMSILGVRSFGIEDKDKQIITFFSPLTILVGPNGAGKTTIIECLKYICTGDFPPGTKGNTFVHDPKVIKPPLIFVDPNRSPAGPA ATPAQAQAASTPRKARASESTARSSSSESEDEDVIPATQCLTPGIRTNVVTMPTAHPRIAPKASMAGASSSKESSRISDGKKQEGPATQV SKKNPASLPLTQAALKVLAQKASEAQPPVARTQPSSGVDSAVGTLPATSPQSTSVQAKGTNKLRKPKLPEVQQATKAPESSDDSEDSSDS SSGSEEDGEGPQGAKSAHTLGPTPSRTETLVEETAAESSEDDVVAPSQSLLSGYMTPGLTPANSQASKATPKLDSSPSVSSTLAAKDDPD GKQEAKPQQAAGMLSPKTGGKEAASGTTPQKSRKPKKGAGNPQASTLALQSNITQCLLGQPWPLNEAQVQASVVKVLTELLEQERKKVVD TTKESSRKGWESRKRKLSGDQPAARTPRSKKKKKLGAGEGGEASVSPEKTSTTSKGKAKRDKASGDVKEKKGKGSLGSQGAKDEPEEELQ >In-frame_RAD50_ENST00000265335_chr5_131895059_+_TCOF1_ENST00000377797_chr5_149767465_+_608aa MSRIEKMSILGVRSFGIEDKDKQIITFFSPLTILVGPNGAGKTTIIECLKYICTGDFPPGTKGNTFVHDPKVIKPPLIFVDPNRSPAGPA ATPAQAQAASTPRKARASESTARSSSSESEDEDVIPATQCLTPGIRTNVVTMPTAHPRIAPKASMAGASSSKESSRISDGKKQEGPATQV SKKNPASLPLTQAALKVLAQKASEAQPPVARTQPSSGVDSAVGTLPATSPQSTSVQAKGTNKLRKPKLPEVQQATKAPESSDDSEDSSDS SSGSEEDGEGPQGAKSAHTLVGPTPSRTETLVEETAAESSEDDVVAPSQSLLSGYMTPGLTPANSQASKATPKLDSSPSVSSTLAAKDDP DGKQEAKPQQAAGMLSPKTGGKEAASGTTPQKSRKPKKGAGNPQASTLALQSNITQCLLGQPWPLNEAQVQASVVKVLTELLEQERKKVV DTTKESSRKGWESRKRKLSGDQPAARTPRSKKKKKLGAGEGGEASVSPEKTSTTSKGKAKRDKASGDVKEKKGKGSLGSQGAKDEPEEEL >In-frame_RAD50_ENST00000265335_chr5_131895059_+_TCOF1_ENST00000445265_chr5_149767465_+_608aa MSRIEKMSILGVRSFGIEDKDKQIITFFSPLTILVGPNGAGKTTIIECLKYICTGDFPPGTKGNTFVHDPKVIKPPLIFVDPNRSPAGPA ATPAQAQAASTPRKARASESTARSSSSESEDEDVIPATQCLTPGIRTNVVTMPTAHPRIAPKASMAGASSSKESSRISDGKKQEGPATQV SKKNPASLPLTQAALKVLAQKASEAQPPVARTQPSSGVDSAVGTLPATSPQSTSVQAKGTNKLRKPKLPEVQQATKAPESSDDSEDSSDS SSGSEEDGEGPQGAKSAHTLVGPTPSRTETLVEETAAESSEDDVVAPSQSLLSGYMTPGLTPANSQASKATPKLDSSPSVSSTLAAKDDP DGKQEAKPQQAAGMLSPKTGGKEAASGTTPQKSRKPKKGAGNPQASTLALQSNITQCLLGQPWPLNEAQVQASVVKVLTELLEQERKKVV DTTKESSRKGWESRKRKLSGDQPAARTPRSKKKKKLGAGEGGEASVSPEKTSTTSKGKAKRDKASGDVKEKKGKGSLGSQGAKDEPEEEL >In-frame_RAD50_ENST00000265335_chr5_131895059_+_TCOF1_ENST00000323668_chr5_149767465_+_607aa MSRIEKMSILGVRSFGIEDKDKQIITFFSPLTILVGPNGAGKTTIIECLKYICTGDFPPGTKGNTFVHDPKVIKPPLIFVDPNRSPAGPA ATPAQAQAASTPRKARASESTARSSSSESEDEDVIPATQCLTPGIRTNVVTMPTAHPRIAPKASMAGASSSKESSRISDGKKQEGPATQV SKKNPASLPLTQAALKVLAQKASEAQPPVARTQPSSGVDSAVGTLPATSPQSTSVQAKGTNKLRKPKLPEVQQATKAPESSDDSEDSSDS SSGSEEDGEGPQGAKSAHTLGPTPSRTETLVEETAAESSEDDVVAPSQSLLSGYMTPGLTPANSQASKATPKLDSSPSVSSTLAAKDDPD GKQEAKPQQAAGMLSPKTGGKEAASGTTPQKSRKPKKGAGNPQASTLALQSNITQCLLGQPWPLNEAQVQASVVKVLTELLEQERKKVVD TTKESSRKGWESRKRKLSGDQPAARTPRSKKKKKLGAGEGGEASVSPEKTSTTSKGKAKRDKASGDVKEKKGKGSLGSQGAKDEPEEELQ >In-frame_RAD50_ENST00000265335_chr5_131895059_+_TCOF1_ENST00000439160_chr5_149767465_+_570aa MSRIEKMSILGVRSFGIEDKDKQIITFFSPLTILVGPNGAGKTTIIECLKYICTGDFPPGTKGNTFVHDPKVIKPPLIFVDPNRSPAGPA ATPAQAQAASTPRKARASESTARSSSSESEDEDVIPATQCLTPGIRTNVVTMPTAHPRIAPKASMAGASSSKESSRISDGKKQEGPATQV DSAVGTLPATSPQSTSVQAKGTNKLRKPKLPEVQQATKAPESSDDSEDSSDSSSGSEEDGEGPQGAKSAHTLVGPTPSRTETLVEETAAE SSEDDVVAPSQSLLSGYMTPGLTPANSQASKATPKLDSSPSVSSTLAAKDDPDGKQEAKPQQAAGMLSPKTGGKEAASGTTPQKSRKPKK GAGNPQASTLALQSNITQCLLGQPWPLNEAQVQASVVKVLTELLEQERKKVVDTTKESSRKGWESRKRKLSGDQPAARTPRSKKKKKLGA GEGGEASVSPEKTSTTSKGKAKRDKASGDVKEKKGKGSLGSQGAKDEPEEELQKGMGTVEGGDQSNPKSKKEKKKSDKRKKDKEKKEKKK |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_RAD50_ENST00000265335_chr5_131895059_+_TCOF1_ENST00000451292_chr5_149767465_+_1821nt ATGTCCCGGATCGAAAAGATGAGCATTCTGGGCGTGCGGAGTTTTGGAATAGAGGACAAAGATAAGCAAATTATCACTTTCTTCAGCCCC CTTACAATTTTGGTTGGACCCAATGGGGCGGGAAAGACGACCATCATTGAATGTCTAAAATATATTTGTACTGGAGATTTCCCTCCTGGA ACCAAAGGAAATACATTTGTACACGATCCCAAGGTGATTAAACCCCCTCTGATTTTTGTCGACCCTAATCGTAGTCCAGCTGGCCCAGCT GCTACACCCGCACAAGCCCAGGCTGCAAGCACCCCGAGGAAGGCCCGAGCCTCGGAGAGCACAGCCAGGAGCTCCTCCTCCGAGAGCGAG GATGAGGACGTGATCCCCGCTACACAGTGCTTGACTCCTGGCATCAGAACCAATGTGGTGACCATGCCCACTGCCCACCCAAGAATAGCC CCCAAAGCCAGCATGGCTGGGGCCAGCAGCAGCAAGGAGTCCAGTCGGATATCAGATGGCAAGAAACAGGAGGGACCAGCCACTCAGGTG TCAAAGAAGAACCCAGCTTCCCTCCCACTGACCCAGGCTGCCCTGAAGGTCCTCGCCCAGAAAGCCAGTGAGGCTCAGCCTCCTGTTGCC AGGACCCAGCCTTCAAGTGGGGTTGACAGTGCTGTGGGAACACTCCCTGCAACAAGTCCCCAGAGCACCTCCGTCCAGGCCAAAGGGACC AACAAGCTCAGAAAACCTAAGCTTCCTGAGGTCCAGCAGGCCACCAAAGCCCCTGAGAGCTCAGATGACAGTGAGGACAGCAGCGACAGT TCTTCAGGGAGTGAGGAAGATGGTGAAGGGCCCCAGGGGGCCAAGTCAGCCCACACGCTGGGTCCCACCCCCTCCAGGACAGAGACCCTG GTGGAGGAGACCGCAGCAGAGTCCAGCGAGGATGATGTGGTGGCGCCATCCCAGTCTCTCCTCTCAGGTTATATGACCCCTGGACTAACC CCAGCCAATTCCCAGGCCTCAAAAGCCACTCCCAAGCTAGACTCCAGCCCCTCAGTTTCCTCTACTCTGGCCGCCAAAGATGACCCAGAT GGCAAGCAGGAGGCAAAGCCCCAACAGGCAGCAGGCATGTTGTCCCCTAAAACAGGTGGAAAAGAGGCTGCTTCAGGCACCACACCTCAG AAGTCCCGGAAGCCCAAGAAAGGGGCTGGGAACCCCCAAGCCTCAACCCTGGCGCTGCAAAGCAACATCACCCAGTGCCTCCTGGGCCAA CCCTGGCCCCTGAATGAGGCCCAGGTGCAGGCCTCAGTGGTGAAGGTCCTGACTGAGCTGCTGGAACAGGAAAGAAAGAAGGTGGTGGAC ACCACCAAGGAGAGCAGCAGGAAGGGCTGGGAGAGCCGCAAGCGGAAGCTATCGGGAGACCAGCCAGCTGCCAGGACCCCCAGGAGCAAG AAGAAGAAGAAGCTGGGGGCCGGGGAAGGTGGGGAGGCCTCTGTTTCCCCAGAAAAGACCTCCACGACTTCCAAGGGGAAAGCAAAGAGA GACAAAGCAAGTGGTGATGTCAAGGAGAAGAAAGGGAAGGGGTCTCTTGGCTCCCAAGGGGCCAAGGACGAGCCAGAAGAGGAGCTTCAG AAGGGGATGGGGACGGTTGAAGGTGGAGATCAAAGCAACCCAAAGAGCAAGAAGGAGAAGAAGAAATCCGACAAGAGAAAAAAAGACAAA GAAAAAAAAGAAAAGAAGAAGAAAGCAAAAAAGGCCTCAACCAAAGATTCTGAGTCACCGTCCCAGAAGAAAAAGAAGAAAAAGAAGAAG >In-frame_RAD50_ENST00000265335_chr5_131895059_+_TCOF1_ENST00000377797_chr5_149767465_+_1824nt ATGTCCCGGATCGAAAAGATGAGCATTCTGGGCGTGCGGAGTTTTGGAATAGAGGACAAAGATAAGCAAATTATCACTTTCTTCAGCCCC CTTACAATTTTGGTTGGACCCAATGGGGCGGGAAAGACGACCATCATTGAATGTCTAAAATATATTTGTACTGGAGATTTCCCTCCTGGA ACCAAAGGAAATACATTTGTACACGATCCCAAGGTGATTAAACCCCCTCTGATTTTTGTCGACCCTAATCGTAGTCCAGCTGGCCCAGCT GCTACACCCGCACAAGCCCAGGCTGCAAGCACCCCGAGGAAGGCCCGAGCCTCGGAGAGCACAGCCAGGAGCTCCTCCTCCGAGAGCGAG GATGAGGACGTGATCCCCGCTACACAGTGCTTGACTCCTGGCATCAGAACCAATGTGGTGACCATGCCCACTGCCCACCCAAGAATAGCC CCCAAAGCCAGCATGGCTGGGGCCAGCAGCAGCAAGGAGTCCAGTCGGATATCAGATGGCAAGAAACAGGAGGGACCAGCCACTCAGGTG TCAAAGAAGAACCCAGCTTCCCTCCCACTGACCCAGGCTGCCCTGAAGGTCCTCGCCCAGAAAGCCAGTGAGGCTCAGCCTCCTGTTGCC AGGACCCAGCCTTCAAGTGGGGTTGACAGTGCTGTGGGAACACTCCCTGCAACAAGTCCCCAGAGCACCTCCGTCCAGGCCAAAGGGACC AACAAGCTCAGAAAACCTAAGCTTCCTGAGGTCCAGCAGGCCACCAAAGCCCCTGAGAGCTCAGATGACAGTGAGGACAGCAGCGACAGT TCTTCAGGGAGTGAGGAAGATGGTGAAGGGCCCCAGGGGGCCAAGTCAGCCCACACGCTGGTAGGTCCCACCCCCTCCAGGACAGAGACC CTGGTGGAGGAGACCGCAGCAGAGTCCAGCGAGGATGATGTGGTGGCGCCATCCCAGTCTCTCCTCTCAGGTTATATGACCCCTGGACTA ACCCCAGCCAATTCCCAGGCCTCAAAAGCCACTCCCAAGCTAGACTCCAGCCCCTCAGTTTCCTCTACTCTGGCCGCCAAAGATGACCCA GATGGCAAGCAGGAGGCAAAGCCCCAACAGGCAGCAGGCATGTTGTCCCCTAAAACAGGTGGAAAAGAGGCTGCTTCAGGCACCACACCT CAGAAGTCCCGGAAGCCCAAGAAAGGGGCTGGGAACCCCCAAGCCTCAACCCTGGCGCTGCAAAGCAACATCACCCAGTGCCTCCTGGGC CAACCCTGGCCCCTGAATGAGGCCCAGGTGCAGGCCTCAGTGGTGAAGGTCCTGACTGAGCTGCTGGAACAGGAAAGAAAGAAGGTGGTG GACACCACCAAGGAGAGCAGCAGGAAGGGCTGGGAGAGCCGCAAGCGGAAGCTATCGGGAGACCAGCCAGCTGCCAGGACCCCCAGGAGC AAGAAGAAGAAGAAGCTGGGGGCCGGGGAAGGTGGGGAGGCCTCTGTTTCCCCAGAAAAGACCTCCACGACTTCCAAGGGGAAAGCAAAG AGAGACAAAGCAAGTGGTGATGTCAAGGAGAAGAAAGGGAAGGGGTCTCTTGGCTCCCAAGGGGCCAAGGACGAGCCAGAAGAGGAGCTT CAGAAGGGGATGGGGACGGTTGAAGGTGGAGATCAAAGCAACCCAAAGAGCAAGAAGGAGAAGAAGAAATCCGACAAGAGAAAAAAAGAC AAAGAAAAAAAAGAAAAGAAGAAGAAAGCAAAAAAGGCCTCAACCAAAGATTCTGAGTCACCGTCCCAGAAGAAAAAGAAGAAAAAGAAG >In-frame_RAD50_ENST00000265335_chr5_131895059_+_TCOF1_ENST00000445265_chr5_149767465_+_1824nt ATGTCCCGGATCGAAAAGATGAGCATTCTGGGCGTGCGGAGTTTTGGAATAGAGGACAAAGATAAGCAAATTATCACTTTCTTCAGCCCC CTTACAATTTTGGTTGGACCCAATGGGGCGGGAAAGACGACCATCATTGAATGTCTAAAATATATTTGTACTGGAGATTTCCCTCCTGGA ACCAAAGGAAATACATTTGTACACGATCCCAAGGTGATTAAACCCCCTCTGATTTTTGTCGACCCTAATCGTAGTCCAGCTGGCCCAGCT GCTACACCCGCACAAGCCCAGGCTGCAAGCACCCCGAGGAAGGCCCGAGCCTCGGAGAGCACAGCCAGGAGCTCCTCCTCCGAGAGCGAG GATGAGGACGTGATCCCCGCTACACAGTGCTTGACTCCTGGCATCAGAACCAATGTGGTGACCATGCCCACTGCCCACCCAAGAATAGCC CCCAAAGCCAGCATGGCTGGGGCCAGCAGCAGCAAGGAGTCCAGTCGGATATCAGATGGCAAGAAACAGGAGGGACCAGCCACTCAGGTG TCAAAGAAGAACCCAGCTTCCCTCCCACTGACCCAGGCTGCCCTGAAGGTCCTCGCCCAGAAAGCCAGTGAGGCTCAGCCTCCTGTTGCC AGGACCCAGCCTTCAAGTGGGGTTGACAGTGCTGTGGGAACACTCCCTGCAACAAGTCCCCAGAGCACCTCCGTCCAGGCCAAAGGGACC AACAAGCTCAGAAAACCTAAGCTTCCTGAGGTCCAGCAGGCCACCAAAGCCCCTGAGAGCTCAGATGACAGTGAGGACAGCAGCGACAGT TCTTCAGGGAGTGAGGAAGATGGTGAAGGGCCCCAGGGGGCCAAGTCAGCCCACACGCTGGTAGGTCCCACCCCCTCCAGGACAGAGACC CTGGTGGAGGAGACCGCAGCAGAGTCCAGCGAGGATGATGTGGTGGCGCCATCCCAGTCTCTCCTCTCAGGTTATATGACCCCTGGACTA ACCCCAGCCAATTCCCAGGCCTCAAAAGCCACTCCCAAGCTAGACTCCAGCCCCTCAGTTTCCTCTACTCTGGCCGCCAAAGATGACCCA GATGGCAAGCAGGAGGCAAAGCCCCAACAGGCAGCAGGCATGTTGTCCCCTAAAACAGGTGGAAAAGAGGCTGCTTCAGGCACCACACCT CAGAAGTCCCGGAAGCCCAAGAAAGGGGCTGGGAACCCCCAAGCCTCAACCCTGGCGCTGCAAAGCAACATCACCCAGTGCCTCCTGGGC CAACCCTGGCCCCTGAATGAGGCCCAGGTGCAGGCCTCAGTGGTGAAGGTCCTGACTGAGCTGCTGGAACAGGAAAGAAAGAAGGTGGTG GACACCACCAAGGAGAGCAGCAGGAAGGGCTGGGAGAGCCGCAAGCGGAAGCTATCGGGAGACCAGCCAGCTGCCAGGACCCCCAGGAGC AAGAAGAAGAAGAAGCTGGGGGCCGGGGAAGGTGGGGAGGCCTCTGTTTCCCCAGAAAAGACCTCCACGACTTCCAAGGGGAAAGCAAAG AGAGACAAAGCAAGTGGTGATGTCAAGGAGAAGAAAGGGAAGGGGTCTCTTGGCTCCCAAGGGGCCAAGGACGAGCCAGAAGAGGAGCTT CAGAAGGGGATGGGGACGGTTGAAGGTGGAGATCAAAGCAACCCAAAGAGCAAGAAGGAGAAGAAGAAATCCGACAAGAGAAAAAAAGAC AAAGAAAAAAAAGAAAAGAAGAAGAAAGCAAAAAAGGCCTCAACCAAAGATTCTGAGTCACCGTCCCAGAAGAAAAAGAAGAAAAAGAAG >In-frame_RAD50_ENST00000265335_chr5_131895059_+_TCOF1_ENST00000323668_chr5_149767465_+_1821nt ATGTCCCGGATCGAAAAGATGAGCATTCTGGGCGTGCGGAGTTTTGGAATAGAGGACAAAGATAAGCAAATTATCACTTTCTTCAGCCCC CTTACAATTTTGGTTGGACCCAATGGGGCGGGAAAGACGACCATCATTGAATGTCTAAAATATATTTGTACTGGAGATTTCCCTCCTGGA ACCAAAGGAAATACATTTGTACACGATCCCAAGGTGATTAAACCCCCTCTGATTTTTGTCGACCCTAATCGTAGTCCAGCTGGCCCAGCT GCTACACCCGCACAAGCCCAGGCTGCAAGCACCCCGAGGAAGGCCCGAGCCTCGGAGAGCACAGCCAGGAGCTCCTCCTCCGAGAGCGAG GATGAGGACGTGATCCCCGCTACACAGTGCTTGACTCCTGGCATCAGAACCAATGTGGTGACCATGCCCACTGCCCACCCAAGAATAGCC CCCAAAGCCAGCATGGCTGGGGCCAGCAGCAGCAAGGAGTCCAGTCGGATATCAGATGGCAAGAAACAGGAGGGACCAGCCACTCAGGTG TCAAAGAAGAACCCAGCTTCCCTCCCACTGACCCAGGCTGCCCTGAAGGTCCTCGCCCAGAAAGCCAGTGAGGCTCAGCCTCCTGTTGCC AGGACCCAGCCTTCAAGTGGGGTTGACAGTGCTGTGGGAACACTCCCTGCAACAAGTCCCCAGAGCACCTCCGTCCAGGCCAAAGGGACC AACAAGCTCAGAAAACCTAAGCTTCCTGAGGTCCAGCAGGCCACCAAAGCCCCTGAGAGCTCAGATGACAGTGAGGACAGCAGCGACAGT TCTTCAGGGAGTGAGGAAGATGGTGAAGGGCCCCAGGGGGCCAAGTCAGCCCACACGCTGGGTCCCACCCCCTCCAGGACAGAGACCCTG GTGGAGGAGACCGCAGCAGAGTCCAGCGAGGATGATGTGGTGGCGCCATCCCAGTCTCTCCTCTCAGGTTATATGACCCCTGGACTAACC CCAGCCAATTCCCAGGCCTCAAAAGCCACTCCCAAGCTAGACTCCAGCCCCTCAGTTTCCTCTACTCTGGCCGCCAAAGATGACCCAGAT GGCAAGCAGGAGGCAAAGCCCCAACAGGCAGCAGGCATGTTGTCCCCTAAAACAGGTGGAAAAGAGGCTGCTTCAGGCACCACACCTCAG AAGTCCCGGAAGCCCAAGAAAGGGGCTGGGAACCCCCAAGCCTCAACCCTGGCGCTGCAAAGCAACATCACCCAGTGCCTCCTGGGCCAA CCCTGGCCCCTGAATGAGGCCCAGGTGCAGGCCTCAGTGGTGAAGGTCCTGACTGAGCTGCTGGAACAGGAAAGAAAGAAGGTGGTGGAC ACCACCAAGGAGAGCAGCAGGAAGGGCTGGGAGAGCCGCAAGCGGAAGCTATCGGGAGACCAGCCAGCTGCCAGGACCCCCAGGAGCAAG AAGAAGAAGAAGCTGGGGGCCGGGGAAGGTGGGGAGGCCTCTGTTTCCCCAGAAAAGACCTCCACGACTTCCAAGGGGAAAGCAAAGAGA GACAAAGCAAGTGGTGATGTCAAGGAGAAGAAAGGGAAGGGGTCTCTTGGCTCCCAAGGGGCCAAGGACGAGCCAGAAGAGGAGCTTCAG AAGGGGATGGGGACGGTTGAAGGTGGAGATCAAAGCAACCCAAAGAGCAAGAAGGAGAAGAAGAAATCCGACAAGAGAAAAAAAGACAAA GAAAAAAAAGAAAAGAAGAAGAAAGCAAAAAAGGCCTCAACCAAAGATTCTGAGTCACCGTCCCAGAAGAAAAAGAAGAAAAAGAAGAAG >In-frame_RAD50_ENST00000265335_chr5_131895059_+_TCOF1_ENST00000439160_chr5_149767465_+_1710nt ATGTCCCGGATCGAAAAGATGAGCATTCTGGGCGTGCGGAGTTTTGGAATAGAGGACAAAGATAAGCAAATTATCACTTTCTTCAGCCCC CTTACAATTTTGGTTGGACCCAATGGGGCGGGAAAGACGACCATCATTGAATGTCTAAAATATATTTGTACTGGAGATTTCCCTCCTGGA ACCAAAGGAAATACATTTGTACACGATCCCAAGGTGATTAAACCCCCTCTGATTTTTGTCGACCCTAATCGTAGTCCAGCTGGCCCAGCT GCTACACCCGCACAAGCCCAGGCTGCAAGCACCCCGAGGAAGGCCCGAGCCTCGGAGAGCACAGCCAGGAGCTCCTCCTCCGAGAGCGAG GATGAGGACGTGATCCCCGCTACACAGTGCTTGACTCCTGGCATCAGAACCAATGTGGTGACCATGCCCACTGCCCACCCAAGAATAGCC CCCAAAGCCAGCATGGCTGGGGCCAGCAGCAGCAAGGAGTCCAGTCGGATATCAGATGGCAAGAAACAGGAGGGACCAGCCACTCAGGTT GACAGTGCTGTGGGAACACTCCCTGCAACAAGTCCCCAGAGCACCTCCGTCCAGGCCAAAGGGACCAACAAGCTCAGAAAACCTAAGCTT CCTGAGGTCCAGCAGGCCACCAAAGCCCCTGAGAGCTCAGATGACAGTGAGGACAGCAGCGACAGTTCTTCAGGGAGTGAGGAAGATGGT GAAGGGCCCCAGGGGGCCAAGTCAGCCCACACGCTGGTAGGTCCCACCCCCTCCAGGACAGAGACCCTGGTGGAGGAGACCGCAGCAGAG TCCAGCGAGGATGATGTGGTGGCGCCATCCCAGTCTCTCCTCTCAGGTTATATGACCCCTGGACTAACCCCAGCCAATTCCCAGGCCTCA AAAGCCACTCCCAAGCTAGACTCCAGCCCCTCAGTTTCCTCTACTCTGGCCGCCAAAGATGACCCAGATGGCAAGCAGGAGGCAAAGCCC CAACAGGCAGCAGGCATGTTGTCCCCTAAAACAGGTGGAAAAGAGGCTGCTTCAGGCACCACACCTCAGAAGTCCCGGAAGCCCAAGAAA GGGGCTGGGAACCCCCAAGCCTCAACCCTGGCGCTGCAAAGCAACATCACCCAGTGCCTCCTGGGCCAACCCTGGCCCCTGAATGAGGCC CAGGTGCAGGCCTCAGTGGTGAAGGTCCTGACTGAGCTGCTGGAACAGGAAAGAAAGAAGGTGGTGGACACCACCAAGGAGAGCAGCAGG AAGGGCTGGGAGAGCCGCAAGCGGAAGCTATCGGGAGACCAGCCAGCTGCCAGGACCCCCAGGAGCAAGAAGAAGAAGAAGCTGGGGGCC GGGGAAGGTGGGGAGGCCTCTGTTTCCCCAGAAAAGACCTCCACGACTTCCAAGGGGAAAGCAAAGAGAGACAAAGCAAGTGGTGATGTC AAGGAGAAGAAAGGGAAGGGGTCTCTTGGCTCCCAAGGGGCCAAGGACGAGCCAGAAGAGGAGCTTCAGAAGGGGATGGGGACGGTTGAA GGTGGAGATCAAAGCAACCCAAAGAGCAAGAAGGAGAAGAAGAAATCCGACAAGAGAAAAAAAGACAAAGAAAAAAAAGAAAAGAAGAAG AAAGCAAAAAAGGCCTCAACCAAAGATTCTGAGTCACCGTCCCAGAAGAAAAAGAAGAAAAAGAAGAAGACAGCAGAGCAGACTGTATGA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_RAD50_ENST00000265335_chr5_131895059_+_TCOF1_ENST00000451292_chr5_149767465_+_2728nt CCAGGAGAGCGGCGTGGACGCGTGCGGGCCTAGAGGCCCACGTGATCCGCAGGGCGGCCGAGGCAGGAAGCTGTGAGTGCGCGGTTGCGG GGTCGCATTGTGGCTACGGCTTTGCGTCCCCGGCGGGCAGCCCCAGGCTGGTCCCCGCCTCCGCTCTCCCCACCGGCGGGGAAAGCAGCT GGTGTGGGAGGAAAGGCTCCATCCCCCGCCCCCTCTCTCCCGCTGTTGGCTGGCAGGATCTTTTGGCAGTCCTGTGGCCTCGCTCCCCGC CCGGATCCTCCTGACCCTGAGATTCGCGGGTCTCACGTCCCGTGCACGCCTTGCTTCGGCCTCAGTTAAGCCTTTGTGGGCTCCAGGTCC CTGGTGAGATTAGAAACGTTTGCAAACATGTCCCGGATCGAAAAGATGAGCATTCTGGGCGTGCGGAGTTTTGGAATAGAGGACAAAGAT AAGCAAATTATCACTTTCTTCAGCCCCCTTACAATTTTGGTTGGACCCAATGGGGCGGGAAAGACGACCATCATTGAATGTCTAAAATAT ATTTGTACTGGAGATTTCCCTCCTGGAACCAAAGGAAATACATTTGTACACGATCCCAAGGTGATTAAACCCCCTCTGATTTTTGTCGAC CCTAATCGTAGTCCAGCTGGCCCAGCTGCTACACCCGCACAAGCCCAGGCTGCAAGCACCCCGAGGAAGGCCCGAGCCTCGGAGAGCACA GCCAGGAGCTCCTCCTCCGAGAGCGAGGATGAGGACGTGATCCCCGCTACACAGTGCTTGACTCCTGGCATCAGAACCAATGTGGTGACC ATGCCCACTGCCCACCCAAGAATAGCCCCCAAAGCCAGCATGGCTGGGGCCAGCAGCAGCAAGGAGTCCAGTCGGATATCAGATGGCAAG AAACAGGAGGGACCAGCCACTCAGGTGTCAAAGAAGAACCCAGCTTCCCTCCCACTGACCCAGGCTGCCCTGAAGGTCCTCGCCCAGAAA GCCAGTGAGGCTCAGCCTCCTGTTGCCAGGACCCAGCCTTCAAGTGGGGTTGACAGTGCTGTGGGAACACTCCCTGCAACAAGTCCCCAG AGCACCTCCGTCCAGGCCAAAGGGACCAACAAGCTCAGAAAACCTAAGCTTCCTGAGGTCCAGCAGGCCACCAAAGCCCCTGAGAGCTCA GATGACAGTGAGGACAGCAGCGACAGTTCTTCAGGGAGTGAGGAAGATGGTGAAGGGCCCCAGGGGGCCAAGTCAGCCCACACGCTGGGT CCCACCCCCTCCAGGACAGAGACCCTGGTGGAGGAGACCGCAGCAGAGTCCAGCGAGGATGATGTGGTGGCGCCATCCCAGTCTCTCCTC TCAGGTTATATGACCCCTGGACTAACCCCAGCCAATTCCCAGGCCTCAAAAGCCACTCCCAAGCTAGACTCCAGCCCCTCAGTTTCCTCT ACTCTGGCCGCCAAAGATGACCCAGATGGCAAGCAGGAGGCAAAGCCCCAACAGGCAGCAGGCATGTTGTCCCCTAAAACAGGTGGAAAA GAGGCTGCTTCAGGCACCACACCTCAGAAGTCCCGGAAGCCCAAGAAAGGGGCTGGGAACCCCCAAGCCTCAACCCTGGCGCTGCAAAGC AACATCACCCAGTGCCTCCTGGGCCAACCCTGGCCCCTGAATGAGGCCCAGGTGCAGGCCTCAGTGGTGAAGGTCCTGACTGAGCTGCTG GAACAGGAAAGAAAGAAGGTGGTGGACACCACCAAGGAGAGCAGCAGGAAGGGCTGGGAGAGCCGCAAGCGGAAGCTATCGGGAGACCAG CCAGCTGCCAGGACCCCCAGGAGCAAGAAGAAGAAGAAGCTGGGGGCCGGGGAAGGTGGGGAGGCCTCTGTTTCCCCAGAAAAGACCTCC ACGACTTCCAAGGGGAAAGCAAAGAGAGACAAAGCAAGTGGTGATGTCAAGGAGAAGAAAGGGAAGGGGTCTCTTGGCTCCCAAGGGGCC AAGGACGAGCCAGAAGAGGAGCTTCAGAAGGGGATGGGGACGGTTGAAGGTGGAGATCAAAGCAACCCAAAGAGCAAGAAGGAGAAGAAG AAATCCGACAAGAGAAAAAAAGACAAAGAAAAAAAAGAAAAGAAGAAGAAAGCAAAAAAGGCCTCAACCAAAGATTCTGAGTCACCGTCC CAGAAGAAAAAGAAGAAAAAGAAGAAGACAGCAGAGCAGACTGTATGACGAGCACCAGCACCAGGCACAGGGATTTCCTAGCCGAGCAGT GGCCATCCCCATGCCTCTGACCTCCACCGACCTCTGCCCACCATGGGTTGGAACTAAACTGTTACCTTCCCTCGCTCCACAGAAGAAGAC AGCCAGCTTCAGGGGTCCCTGTGCTGGCCAAGCCAGTGAGCCTGCGGGGAGGCTGGTCCAAGGAGAAAGTGGACCAGCTCCCATGACCTC ACCCCACTCCCCCAACACAGGACGCTTCATATAGATGTGTACAGTATATGTATTTTTTTAAGTGACCTCCTCTCCTTCCACAGACCCCAC ATGCCCAAAGGCCTCGGGACTTCCCACCACCTTGCTCCACAGATCCAGCTAGGCCTGACCTGTGCCTCATCCCGTGCCGCTCGGTCTCTG GCTGATCCCGAGGCTTTGTCTTCCTCTCGTCAGTTCTTTTGGTTGTGTTTTTTGTTTTTTTTTTAATAACTCAAAAAAAAAATAAAAGAC >In-frame_RAD50_ENST00000265335_chr5_131895059_+_TCOF1_ENST00000377797_chr5_149767465_+_2731nt CCAGGAGAGCGGCGTGGACGCGTGCGGGCCTAGAGGCCCACGTGATCCGCAGGGCGGCCGAGGCAGGAAGCTGTGAGTGCGCGGTTGCGG GGTCGCATTGTGGCTACGGCTTTGCGTCCCCGGCGGGCAGCCCCAGGCTGGTCCCCGCCTCCGCTCTCCCCACCGGCGGGGAAAGCAGCT GGTGTGGGAGGAAAGGCTCCATCCCCCGCCCCCTCTCTCCCGCTGTTGGCTGGCAGGATCTTTTGGCAGTCCTGTGGCCTCGCTCCCCGC CCGGATCCTCCTGACCCTGAGATTCGCGGGTCTCACGTCCCGTGCACGCCTTGCTTCGGCCTCAGTTAAGCCTTTGTGGGCTCCAGGTCC CTGGTGAGATTAGAAACGTTTGCAAACATGTCCCGGATCGAAAAGATGAGCATTCTGGGCGTGCGGAGTTTTGGAATAGAGGACAAAGAT AAGCAAATTATCACTTTCTTCAGCCCCCTTACAATTTTGGTTGGACCCAATGGGGCGGGAAAGACGACCATCATTGAATGTCTAAAATAT ATTTGTACTGGAGATTTCCCTCCTGGAACCAAAGGAAATACATTTGTACACGATCCCAAGGTGATTAAACCCCCTCTGATTTTTGTCGAC CCTAATCGTAGTCCAGCTGGCCCAGCTGCTACACCCGCACAAGCCCAGGCTGCAAGCACCCCGAGGAAGGCCCGAGCCTCGGAGAGCACA GCCAGGAGCTCCTCCTCCGAGAGCGAGGATGAGGACGTGATCCCCGCTACACAGTGCTTGACTCCTGGCATCAGAACCAATGTGGTGACC ATGCCCACTGCCCACCCAAGAATAGCCCCCAAAGCCAGCATGGCTGGGGCCAGCAGCAGCAAGGAGTCCAGTCGGATATCAGATGGCAAG AAACAGGAGGGACCAGCCACTCAGGTGTCAAAGAAGAACCCAGCTTCCCTCCCACTGACCCAGGCTGCCCTGAAGGTCCTCGCCCAGAAA GCCAGTGAGGCTCAGCCTCCTGTTGCCAGGACCCAGCCTTCAAGTGGGGTTGACAGTGCTGTGGGAACACTCCCTGCAACAAGTCCCCAG AGCACCTCCGTCCAGGCCAAAGGGACCAACAAGCTCAGAAAACCTAAGCTTCCTGAGGTCCAGCAGGCCACCAAAGCCCCTGAGAGCTCA GATGACAGTGAGGACAGCAGCGACAGTTCTTCAGGGAGTGAGGAAGATGGTGAAGGGCCCCAGGGGGCCAAGTCAGCCCACACGCTGGTA GGTCCCACCCCCTCCAGGACAGAGACCCTGGTGGAGGAGACCGCAGCAGAGTCCAGCGAGGATGATGTGGTGGCGCCATCCCAGTCTCTC CTCTCAGGTTATATGACCCCTGGACTAACCCCAGCCAATTCCCAGGCCTCAAAAGCCACTCCCAAGCTAGACTCCAGCCCCTCAGTTTCC TCTACTCTGGCCGCCAAAGATGACCCAGATGGCAAGCAGGAGGCAAAGCCCCAACAGGCAGCAGGCATGTTGTCCCCTAAAACAGGTGGA AAAGAGGCTGCTTCAGGCACCACACCTCAGAAGTCCCGGAAGCCCAAGAAAGGGGCTGGGAACCCCCAAGCCTCAACCCTGGCGCTGCAA AGCAACATCACCCAGTGCCTCCTGGGCCAACCCTGGCCCCTGAATGAGGCCCAGGTGCAGGCCTCAGTGGTGAAGGTCCTGACTGAGCTG CTGGAACAGGAAAGAAAGAAGGTGGTGGACACCACCAAGGAGAGCAGCAGGAAGGGCTGGGAGAGCCGCAAGCGGAAGCTATCGGGAGAC CAGCCAGCTGCCAGGACCCCCAGGAGCAAGAAGAAGAAGAAGCTGGGGGCCGGGGAAGGTGGGGAGGCCTCTGTTTCCCCAGAAAAGACC TCCACGACTTCCAAGGGGAAAGCAAAGAGAGACAAAGCAAGTGGTGATGTCAAGGAGAAGAAAGGGAAGGGGTCTCTTGGCTCCCAAGGG GCCAAGGACGAGCCAGAAGAGGAGCTTCAGAAGGGGATGGGGACGGTTGAAGGTGGAGATCAAAGCAACCCAAAGAGCAAGAAGGAGAAG AAGAAATCCGACAAGAGAAAAAAAGACAAAGAAAAAAAAGAAAAGAAGAAGAAAGCAAAAAAGGCCTCAACCAAAGATTCTGAGTCACCG TCCCAGAAGAAAAAGAAGAAAAAGAAGAAGACAGCAGAGCAGACTGTATGACGAGCACCAGCACCAGGCACAGGGATTTCCTAGCCGAGC AGTGGCCATCCCCATGCCTCTGACCTCCACCGACCTCTGCCCACCATGGGTTGGAACTAAACTGTTACCTTCCCTCGCTCCACAGAAGAA GACAGCCAGCTTCAGGGGTCCCTGTGCTGGCCAAGCCAGTGAGCCTGCGGGGAGGCTGGTCCAAGGAGAAAGTGGACCAGCTCCCATGAC CTCACCCCACTCCCCCAACACAGGACGCTTCATATAGATGTGTACAGTATATGTATTTTTTTAAGTGACCTCCTCTCCTTCCACAGACCC CACATGCCCAAAGGCCTCGGGACTTCCCACCACCTTGCTCCACAGATCCAGCTAGGCCTGACCTGTGCCTCATCCCGTGCCGCTCGGTCT CTGGCTGATCCCGAGGCTTTGTCTTCCTCTCGTCAGTTCTTTTGGTTGTGTTTTTTGTTTTTTTTTTAATAACTCAAAAAAAAAATAAAA >In-frame_RAD50_ENST00000265335_chr5_131895059_+_TCOF1_ENST00000445265_chr5_149767465_+_2716nt CCAGGAGAGCGGCGTGGACGCGTGCGGGCCTAGAGGCCCACGTGATCCGCAGGGCGGCCGAGGCAGGAAGCTGTGAGTGCGCGGTTGCGG GGTCGCATTGTGGCTACGGCTTTGCGTCCCCGGCGGGCAGCCCCAGGCTGGTCCCCGCCTCCGCTCTCCCCACCGGCGGGGAAAGCAGCT GGTGTGGGAGGAAAGGCTCCATCCCCCGCCCCCTCTCTCCCGCTGTTGGCTGGCAGGATCTTTTGGCAGTCCTGTGGCCTCGCTCCCCGC CCGGATCCTCCTGACCCTGAGATTCGCGGGTCTCACGTCCCGTGCACGCCTTGCTTCGGCCTCAGTTAAGCCTTTGTGGGCTCCAGGTCC CTGGTGAGATTAGAAACGTTTGCAAACATGTCCCGGATCGAAAAGATGAGCATTCTGGGCGTGCGGAGTTTTGGAATAGAGGACAAAGAT AAGCAAATTATCACTTTCTTCAGCCCCCTTACAATTTTGGTTGGACCCAATGGGGCGGGAAAGACGACCATCATTGAATGTCTAAAATAT ATTTGTACTGGAGATTTCCCTCCTGGAACCAAAGGAAATACATTTGTACACGATCCCAAGGTGATTAAACCCCCTCTGATTTTTGTCGAC CCTAATCGTAGTCCAGCTGGCCCAGCTGCTACACCCGCACAAGCCCAGGCTGCAAGCACCCCGAGGAAGGCCCGAGCCTCGGAGAGCACA GCCAGGAGCTCCTCCTCCGAGAGCGAGGATGAGGACGTGATCCCCGCTACACAGTGCTTGACTCCTGGCATCAGAACCAATGTGGTGACC ATGCCCACTGCCCACCCAAGAATAGCCCCCAAAGCCAGCATGGCTGGGGCCAGCAGCAGCAAGGAGTCCAGTCGGATATCAGATGGCAAG AAACAGGAGGGACCAGCCACTCAGGTGTCAAAGAAGAACCCAGCTTCCCTCCCACTGACCCAGGCTGCCCTGAAGGTCCTCGCCCAGAAA GCCAGTGAGGCTCAGCCTCCTGTTGCCAGGACCCAGCCTTCAAGTGGGGTTGACAGTGCTGTGGGAACACTCCCTGCAACAAGTCCCCAG AGCACCTCCGTCCAGGCCAAAGGGACCAACAAGCTCAGAAAACCTAAGCTTCCTGAGGTCCAGCAGGCCACCAAAGCCCCTGAGAGCTCA GATGACAGTGAGGACAGCAGCGACAGTTCTTCAGGGAGTGAGGAAGATGGTGAAGGGCCCCAGGGGGCCAAGTCAGCCCACACGCTGGTA GGTCCCACCCCCTCCAGGACAGAGACCCTGGTGGAGGAGACCGCAGCAGAGTCCAGCGAGGATGATGTGGTGGCGCCATCCCAGTCTCTC CTCTCAGGTTATATGACCCCTGGACTAACCCCAGCCAATTCCCAGGCCTCAAAAGCCACTCCCAAGCTAGACTCCAGCCCCTCAGTTTCC TCTACTCTGGCCGCCAAAGATGACCCAGATGGCAAGCAGGAGGCAAAGCCCCAACAGGCAGCAGGCATGTTGTCCCCTAAAACAGGTGGA AAAGAGGCTGCTTCAGGCACCACACCTCAGAAGTCCCGGAAGCCCAAGAAAGGGGCTGGGAACCCCCAAGCCTCAACCCTGGCGCTGCAA AGCAACATCACCCAGTGCCTCCTGGGCCAACCCTGGCCCCTGAATGAGGCCCAGGTGCAGGCCTCAGTGGTGAAGGTCCTGACTGAGCTG CTGGAACAGGAAAGAAAGAAGGTGGTGGACACCACCAAGGAGAGCAGCAGGAAGGGCTGGGAGAGCCGCAAGCGGAAGCTATCGGGAGAC CAGCCAGCTGCCAGGACCCCCAGGAGCAAGAAGAAGAAGAAGCTGGGGGCCGGGGAAGGTGGGGAGGCCTCTGTTTCCCCAGAAAAGACC TCCACGACTTCCAAGGGGAAAGCAAAGAGAGACAAAGCAAGTGGTGATGTCAAGGAGAAGAAAGGGAAGGGGTCTCTTGGCTCCCAAGGG GCCAAGGACGAGCCAGAAGAGGAGCTTCAGAAGGGGATGGGGACGGTTGAAGGTGGAGATCAAAGCAACCCAAAGAGCAAGAAGGAGAAG AAGAAATCCGACAAGAGAAAAAAAGACAAAGAAAAAAAAGAAAAGAAGAAGAAAGCAAAAAAGGCCTCAACCAAAGATTCTGAGTCACCG TCCCAGAAGAAAAAGAAGAAAAAGAAGAAGACAGCAGAGCAGACTGTATGACGAGCACCAGCACCAGGCACAGGGATTTCCTAGCCGAGC AGTGGCCATCCCCATGCCTCTGACCTCCACCGACCTCTGCCCACCATGGGTTGGAACTAAACTGTTACCTTCCCTCGCTCCACAGAAGAA GACAGCCAGCTTCAGGGGTCCCTGTGCTGGCCAAGCCAGTGAGCCTGCGGGGAGGCTGGTCCAAGGAGAAAGTGGACCAGCTCCCATGAC CTCACCCCACTCCCCCAACACAGGACGCTTCATATAGATGTGTACAGTATATGTATTTTTTTAAGTGACCTCCTCTCCTTCCACAGACCC CACATGCCCAAAGGCCTCGGGACTTCCCACCACCTTGCTCCACAGATCCAGCTAGGCCTGACCTGTGCCTCATCCCGTGCCGCTCGGTCT CTGGCTGATCCCGAGGCTTTGTCTTCCTCTCGTCAGTTCTTTTGGTTGTGTTTTTTGTTTTTTTTTTAATAACTCAAAAAAAAAATAAAA >In-frame_RAD50_ENST00000265335_chr5_131895059_+_TCOF1_ENST00000323668_chr5_149767465_+_2729nt CCAGGAGAGCGGCGTGGACGCGTGCGGGCCTAGAGGCCCACGTGATCCGCAGGGCGGCCGAGGCAGGAAGCTGTGAGTGCGCGGTTGCGG GGTCGCATTGTGGCTACGGCTTTGCGTCCCCGGCGGGCAGCCCCAGGCTGGTCCCCGCCTCCGCTCTCCCCACCGGCGGGGAAAGCAGCT GGTGTGGGAGGAAAGGCTCCATCCCCCGCCCCCTCTCTCCCGCTGTTGGCTGGCAGGATCTTTTGGCAGTCCTGTGGCCTCGCTCCCCGC CCGGATCCTCCTGACCCTGAGATTCGCGGGTCTCACGTCCCGTGCACGCCTTGCTTCGGCCTCAGTTAAGCCTTTGTGGGCTCCAGGTCC CTGGTGAGATTAGAAACGTTTGCAAACATGTCCCGGATCGAAAAGATGAGCATTCTGGGCGTGCGGAGTTTTGGAATAGAGGACAAAGAT AAGCAAATTATCACTTTCTTCAGCCCCCTTACAATTTTGGTTGGACCCAATGGGGCGGGAAAGACGACCATCATTGAATGTCTAAAATAT ATTTGTACTGGAGATTTCCCTCCTGGAACCAAAGGAAATACATTTGTACACGATCCCAAGGTGATTAAACCCCCTCTGATTTTTGTCGAC CCTAATCGTAGTCCAGCTGGCCCAGCTGCTACACCCGCACAAGCCCAGGCTGCAAGCACCCCGAGGAAGGCCCGAGCCTCGGAGAGCACA GCCAGGAGCTCCTCCTCCGAGAGCGAGGATGAGGACGTGATCCCCGCTACACAGTGCTTGACTCCTGGCATCAGAACCAATGTGGTGACC ATGCCCACTGCCCACCCAAGAATAGCCCCCAAAGCCAGCATGGCTGGGGCCAGCAGCAGCAAGGAGTCCAGTCGGATATCAGATGGCAAG AAACAGGAGGGACCAGCCACTCAGGTGTCAAAGAAGAACCCAGCTTCCCTCCCACTGACCCAGGCTGCCCTGAAGGTCCTCGCCCAGAAA GCCAGTGAGGCTCAGCCTCCTGTTGCCAGGACCCAGCCTTCAAGTGGGGTTGACAGTGCTGTGGGAACACTCCCTGCAACAAGTCCCCAG AGCACCTCCGTCCAGGCCAAAGGGACCAACAAGCTCAGAAAACCTAAGCTTCCTGAGGTCCAGCAGGCCACCAAAGCCCCTGAGAGCTCA GATGACAGTGAGGACAGCAGCGACAGTTCTTCAGGGAGTGAGGAAGATGGTGAAGGGCCCCAGGGGGCCAAGTCAGCCCACACGCTGGGT CCCACCCCCTCCAGGACAGAGACCCTGGTGGAGGAGACCGCAGCAGAGTCCAGCGAGGATGATGTGGTGGCGCCATCCCAGTCTCTCCTC TCAGGTTATATGACCCCTGGACTAACCCCAGCCAATTCCCAGGCCTCAAAAGCCACTCCCAAGCTAGACTCCAGCCCCTCAGTTTCCTCT ACTCTGGCCGCCAAAGATGACCCAGATGGCAAGCAGGAGGCAAAGCCCCAACAGGCAGCAGGCATGTTGTCCCCTAAAACAGGTGGAAAA GAGGCTGCTTCAGGCACCACACCTCAGAAGTCCCGGAAGCCCAAGAAAGGGGCTGGGAACCCCCAAGCCTCAACCCTGGCGCTGCAAAGC AACATCACCCAGTGCCTCCTGGGCCAACCCTGGCCCCTGAATGAGGCCCAGGTGCAGGCCTCAGTGGTGAAGGTCCTGACTGAGCTGCTG GAACAGGAAAGAAAGAAGGTGGTGGACACCACCAAGGAGAGCAGCAGGAAGGGCTGGGAGAGCCGCAAGCGGAAGCTATCGGGAGACCAG CCAGCTGCCAGGACCCCCAGGAGCAAGAAGAAGAAGAAGCTGGGGGCCGGGGAAGGTGGGGAGGCCTCTGTTTCCCCAGAAAAGACCTCC ACGACTTCCAAGGGGAAAGCAAAGAGAGACAAAGCAAGTGGTGATGTCAAGGAGAAGAAAGGGAAGGGGTCTCTTGGCTCCCAAGGGGCC AAGGACGAGCCAGAAGAGGAGCTTCAGAAGGGGATGGGGACGGTTGAAGGTGGAGATCAAAGCAACCCAAAGAGCAAGAAGGAGAAGAAG AAATCCGACAAGAGAAAAAAAGACAAAGAAAAAAAAGAAAAGAAGAAGAAAGCAAAAAAGGCCTCAACCAAAGATTCTGAGTCACCGTCC CAGAAGAAAAAGAAGAAAAAGAAGAAGACAGCAGAGCAGACTGTATGACGAGCACCAGCACCAGGCACAGGGATTTCCTAGCCGAGCAGT GGCCATCCCCATGCCTCTGACCTCCACCGACCTCTGCCCACCATGGGTTGGAACTAAACTGTTACCTTCCCTCGCTCCACAGAAGAAGAC AGCCAGCTTCAGGGGTCCCTGTGCTGGCCAAGCCAGTGAGCCTGCGGGGAGGCTGGTCCAAGGAGAAAGTGGACCAGCTCCCATGACCTC ACCCCACTCCCCCAACACAGGACGCTTCATATAGATGTGTACAGTATATGTATTTTTTTAAGTGACCTCCTCTCCTTCCACAGACCCCAC ATGCCCAAAGGCCTCGGGACTTCCCACCACCTTGCTCCACAGATCCAGCTAGGCCTGACCTGTGCCTCATCCCGTGCCGCTCGGTCTCTG GCTGATCCCGAGGCTTTGTCTTCCTCTCGTCAGTTCTTTTGGTTGTGTTTTTTGTTTTTTTTTTAATAACTCAAAAAAAAAATAAAAGAC >In-frame_RAD50_ENST00000265335_chr5_131895059_+_TCOF1_ENST00000439160_chr5_149767465_+_2352nt CCAGGAGAGCGGCGTGGACGCGTGCGGGCCTAGAGGCCCACGTGATCCGCAGGGCGGCCGAGGCAGGAAGCTGTGAGTGCGCGGTTGCGG GGTCGCATTGTGGCTACGGCTTTGCGTCCCCGGCGGGCAGCCCCAGGCTGGTCCCCGCCTCCGCTCTCCCCACCGGCGGGGAAAGCAGCT GGTGTGGGAGGAAAGGCTCCATCCCCCGCCCCCTCTCTCCCGCTGTTGGCTGGCAGGATCTTTTGGCAGTCCTGTGGCCTCGCTCCCCGC CCGGATCCTCCTGACCCTGAGATTCGCGGGTCTCACGTCCCGTGCACGCCTTGCTTCGGCCTCAGTTAAGCCTTTGTGGGCTCCAGGTCC CTGGTGAGATTAGAAACGTTTGCAAACATGTCCCGGATCGAAAAGATGAGCATTCTGGGCGTGCGGAGTTTTGGAATAGAGGACAAAGAT AAGCAAATTATCACTTTCTTCAGCCCCCTTACAATTTTGGTTGGACCCAATGGGGCGGGAAAGACGACCATCATTGAATGTCTAAAATAT ATTTGTACTGGAGATTTCCCTCCTGGAACCAAAGGAAATACATTTGTACACGATCCCAAGGTGATTAAACCCCCTCTGATTTTTGTCGAC CCTAATCGTAGTCCAGCTGGCCCAGCTGCTACACCCGCACAAGCCCAGGCTGCAAGCACCCCGAGGAAGGCCCGAGCCTCGGAGAGCACA GCCAGGAGCTCCTCCTCCGAGAGCGAGGATGAGGACGTGATCCCCGCTACACAGTGCTTGACTCCTGGCATCAGAACCAATGTGGTGACC ATGCCCACTGCCCACCCAAGAATAGCCCCCAAAGCCAGCATGGCTGGGGCCAGCAGCAGCAAGGAGTCCAGTCGGATATCAGATGGCAAG AAACAGGAGGGACCAGCCACTCAGGTTGACAGTGCTGTGGGAACACTCCCTGCAACAAGTCCCCAGAGCACCTCCGTCCAGGCCAAAGGG ACCAACAAGCTCAGAAAACCTAAGCTTCCTGAGGTCCAGCAGGCCACCAAAGCCCCTGAGAGCTCAGATGACAGTGAGGACAGCAGCGAC AGTTCTTCAGGGAGTGAGGAAGATGGTGAAGGGCCCCAGGGGGCCAAGTCAGCCCACACGCTGGTAGGTCCCACCCCCTCCAGGACAGAG ACCCTGGTGGAGGAGACCGCAGCAGAGTCCAGCGAGGATGATGTGGTGGCGCCATCCCAGTCTCTCCTCTCAGGTTATATGACCCCTGGA CTAACCCCAGCCAATTCCCAGGCCTCAAAAGCCACTCCCAAGCTAGACTCCAGCCCCTCAGTTTCCTCTACTCTGGCCGCCAAAGATGAC CCAGATGGCAAGCAGGAGGCAAAGCCCCAACAGGCAGCAGGCATGTTGTCCCCTAAAACAGGTGGAAAAGAGGCTGCTTCAGGCACCACA CCTCAGAAGTCCCGGAAGCCCAAGAAAGGGGCTGGGAACCCCCAAGCCTCAACCCTGGCGCTGCAAAGCAACATCACCCAGTGCCTCCTG GGCCAACCCTGGCCCCTGAATGAGGCCCAGGTGCAGGCCTCAGTGGTGAAGGTCCTGACTGAGCTGCTGGAACAGGAAAGAAAGAAGGTG GTGGACACCACCAAGGAGAGCAGCAGGAAGGGCTGGGAGAGCCGCAAGCGGAAGCTATCGGGAGACCAGCCAGCTGCCAGGACCCCCAGG AGCAAGAAGAAGAAGAAGCTGGGGGCCGGGGAAGGTGGGGAGGCCTCTGTTTCCCCAGAAAAGACCTCCACGACTTCCAAGGGGAAAGCA AAGAGAGACAAAGCAAGTGGTGATGTCAAGGAGAAGAAAGGGAAGGGGTCTCTTGGCTCCCAAGGGGCCAAGGACGAGCCAGAAGAGGAG CTTCAGAAGGGGATGGGGACGGTTGAAGGTGGAGATCAAAGCAACCCAAAGAGCAAGAAGGAGAAGAAGAAATCCGACAAGAGAAAAAAA GACAAAGAAAAAAAAGAAAAGAAGAAGAAAGCAAAAAAGGCCTCAACCAAAGATTCTGAGTCACCGTCCCAGAAGAAAAAGAAGAAAAAG AAGAAGACAGCAGAGCAGACTGTATGACGAGCACCAGCACCAGGCACAGGGATTTCCTAGCCGAGCAGTGGCCATCCCCATGCCTCTGAC CTCCACCGACCTCTGCCCACCATGGGTTGGAACTAAACTGTTACCTTCCCTCGCTCCACAGAAGAAGACAGCCAGCTTCAGGGGTCCCTG TGCTGGCCAAGCCAGTGAGCCTGCGGGGAGGCTGGTCCAAGGAGAAAGTGGACCAGCTCCCATGACCTCACCCCACTCCCCCAACACAGG |
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FusionGenePPI for RAD50_TCOF1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| RAD50 | HNF4A, H2AFX, BLM, BRCA1, MRE11A, NBN, ATM, MLH1, MSH2, MSH6, RFC1, TERF2, TERF2IP, MDC1, RINT1, CHEK2, RECQL5, USP11, USP42, USP53, DDX1, PHF1, PAXIP1, GEMIN2, DCLRE1B, KAT5, TERF1, HDAC5, EP300, BARD1, RBBP8, SMARCAD1, SKP2, SIRT7, HNRNPA1, MDM2, TFAP4, DCLRE1C, NOP56, NCSTN, HNRNPR, RBL2, RNF8, PAN2, FBXO6, RPA1, RPA2, RPA3, PASK, ATRX, CUL7, OBSL1, EED, RNF2, SUMO2, SIRT6, ILF2, ILF3, MCM5, ZNF511, MAF1, ZFAND2B, CELA2B, LRRC39, FAM219A, MDM4, CHAMP1, SMC5, NTRK1, SCARNA22, MED23, OFD1, FGFR1OP, CEP128, RPGRIP1L, HIST1H3E, HSF2, SLC33A1, TMEM132A, GLI1, FOXL1, USP4, ESR1, SNW1, CDC5L, RNF126, NFATC2, HIST3H3, DUSP23, DUSP28, RGS20, BMP1, ATG14, RAB39B, HS1BP3, FAM196A, RAD50, C15orf26, CCDC150, BRIP1, SPTA1, DLST, HDAC6, MCM9, MCM8 | TCOF1 | ARRB2, ARRB1, USP44, WDR48, GPN1, TERF2, NOP56, TOP1, SIRT7, CAND1, GRK5, NDUFV1, OXCT1, SEC22B, S100A16, HPDL, SEPT11, SIX4, PPT1, SRSF10, NPTX1, ESR1, ECT2, PNKP, PAN2, IGSF8, ICAM1, TM9SF1, SRPK2, RPA1, RPA2, RPA3, LGR4, CSNK2A2, CDK2, LIN28A, PRKRA, TARBP2, CUL7, OBSL1, EED, SIRT6, ZBTB38, DENND2D, RASSF9, NTRK1, OFD1, XPO1, HIST1H3E, AKT1, SORT1, BECN1, RASSF8, L1TD1, BAG6, KBTBD8, NOLC1, POLR1A, POLR1B, DKC1, NHP2, NOP58, CSNK2A1, EGFR, CAMKV, PIP4K2A, UBC, ZNHIT2, TRIM25, BRCA1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for RAD50_TCOF1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for RAD50_TCOF1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | RAD50 | C0004096 | Asthma | 1 | CTD_human |
| Tgene | TCOF1 | C0242387 | Mandibulofacial Dysostosis | 2 | CTD_human;ORPHANET;UNIPROT |
| Tgene | TCOF1 | C0376634 | Craniofacial Abnormalities | 1 | CTD_human |
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