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Fusion gene ID: 3016 |
FusionGeneSummary for ASPH_DCLK1 |
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Fusion gene information | Fusion gene name: ASPH_DCLK1 | Fusion gene ID: 3016 | Hgene | Tgene | Gene symbol | ASPH | DCLK1 | Gene ID | 444 | 9201 |
Gene name | aspartate beta-hydroxylase | doublecortin like kinase 1 | |
Synonyms | AAH|BAH|CASQ2BP1|FDLAB|HAAH|JCTN|junctin | CL1|CLICK1|DCAMKL1|DCDC3A|DCLK | |
Cytomap | 8q12.3 | 13q13.3 | |
Type of gene | protein-coding | protein-coding | |
Description | aspartyl/asparaginyl beta-hydroxylaseA beta H-J-JASP beta-hydroxylasecardiac junctinhumbugjunctatepeptide-aspartate beta-dioxygenase | serine/threonine-protein kinase DCLK1doublecortin domain-containing protein 3Adoublecortin-like and CAM kinase-like 1 | |
Modification date | 20180519 | 20180527 | |
UniProtAcc | Q12797 | O15075 | |
Ensembl transtripts involved in fusion gene | ENST00000541428, ENST00000379454, ENST00000523897, ENST00000522919, ENST00000356457, ENST00000518068, ENST00000517903, ENST00000445642, ENST00000517847, ENST00000522835, ENST00000517856, ENST00000389204, ENST00000522603, ENST00000379449, ENST00000517661, | ENST00000360631, ENST00000255448, ENST00000379892, ENST00000379893, ENST00000460982, | |
Fusion gene scores | * DoF score | 11 X 9 X 6=594 | 4 X 4 X 4=64 |
# samples | 12 | 4 | |
** MAII score | log2(12/594*10)=-2.30742852519225 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/64*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: ASPH [Title/Abstract] AND DCLK1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | ASPH | GO:0045862 | positive regulation of proteolysis | 18387192 |
Hgene | ASPH | GO:0097202 | activation of cysteine-type endopeptidase activity | 18387192 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | LIHC | TCGA-DD-A4NE-01A | ASPH | chr8 | 62438536 | - | DCLK1 | chr13 | 36397012 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000541428 | ENST00000360631 | ASPH | chr8 | 62438536 | - | DCLK1 | chr13 | 36397012 | - |
Frame-shift | ENST00000541428 | ENST00000255448 | ASPH | chr8 | 62438536 | - | DCLK1 | chr13 | 36397012 | - |
5CDS-intron | ENST00000541428 | ENST00000379892 | ASPH | chr8 | 62438536 | - | DCLK1 | chr13 | 36397012 | - |
5CDS-intron | ENST00000541428 | ENST00000379893 | ASPH | chr8 | 62438536 | - | DCLK1 | chr13 | 36397012 | - |
5CDS-intron | ENST00000541428 | ENST00000460982 | ASPH | chr8 | 62438536 | - | DCLK1 | chr13 | 36397012 | - |
Frame-shift | ENST00000379454 | ENST00000360631 | ASPH | chr8 | 62438536 | - | DCLK1 | chr13 | 36397012 | - |
Frame-shift | ENST00000379454 | ENST00000255448 | ASPH | chr8 | 62438536 | - | DCLK1 | chr13 | 36397012 | - |
5CDS-intron | ENST00000379454 | ENST00000379892 | ASPH | chr8 | 62438536 | - | DCLK1 | chr13 | 36397012 | - |
5CDS-intron | ENST00000379454 | ENST00000379893 | ASPH | chr8 | 62438536 | - | DCLK1 | chr13 | 36397012 | - |
5CDS-intron | ENST00000379454 | ENST00000460982 | ASPH | chr8 | 62438536 | - | DCLK1 | chr13 | 36397012 | - |
intron-3CDS | ENST00000523897 | ENST00000360631 | ASPH | chr8 | 62438536 | - | DCLK1 | chr13 | 36397012 | - |
intron-3CDS | ENST00000523897 | ENST00000255448 | ASPH | chr8 | 62438536 | - | DCLK1 | chr13 | 36397012 | - |
intron-intron | ENST00000523897 | ENST00000379892 | ASPH | chr8 | 62438536 | - | DCLK1 | chr13 | 36397012 | - |
intron-intron | ENST00000523897 | ENST00000379893 | ASPH | chr8 | 62438536 | - | DCLK1 | chr13 | 36397012 | - |
intron-intron | ENST00000523897 | ENST00000460982 | ASPH | chr8 | 62438536 | - | DCLK1 | chr13 | 36397012 | - |
intron-3CDS | ENST00000522919 | ENST00000360631 | ASPH | chr8 | 62438536 | - | DCLK1 | chr13 | 36397012 | - |
intron-3CDS | ENST00000522919 | ENST00000255448 | ASPH | chr8 | 62438536 | - | DCLK1 | chr13 | 36397012 | - |
intron-intron | ENST00000522919 | ENST00000379892 | ASPH | chr8 | 62438536 | - | DCLK1 | chr13 | 36397012 | - |
intron-intron | ENST00000522919 | ENST00000379893 | ASPH | chr8 | 62438536 | - | DCLK1 | chr13 | 36397012 | - |
intron-intron | ENST00000522919 | ENST00000460982 | ASPH | chr8 | 62438536 | - | DCLK1 | chr13 | 36397012 | - |
intron-3CDS | ENST00000356457 | ENST00000360631 | ASPH | chr8 | 62438536 | - | DCLK1 | chr13 | 36397012 | - |
intron-3CDS | ENST00000356457 | ENST00000255448 | ASPH | chr8 | 62438536 | - | DCLK1 | chr13 | 36397012 | - |
intron-intron | ENST00000356457 | ENST00000379892 | ASPH | chr8 | 62438536 | - | DCLK1 | chr13 | 36397012 | - |
intron-intron | ENST00000356457 | ENST00000379893 | ASPH | chr8 | 62438536 | - | DCLK1 | chr13 | 36397012 | - |
intron-intron | ENST00000356457 | ENST00000460982 | ASPH | chr8 | 62438536 | - | DCLK1 | chr13 | 36397012 | - |
intron-3CDS | ENST00000518068 | ENST00000360631 | ASPH | chr8 | 62438536 | - | DCLK1 | chr13 | 36397012 | - |
intron-3CDS | ENST00000518068 | ENST00000255448 | ASPH | chr8 | 62438536 | - | DCLK1 | chr13 | 36397012 | - |
intron-intron | ENST00000518068 | ENST00000379892 | ASPH | chr8 | 62438536 | - | DCLK1 | chr13 | 36397012 | - |
intron-intron | ENST00000518068 | ENST00000379893 | ASPH | chr8 | 62438536 | - | DCLK1 | chr13 | 36397012 | - |
intron-intron | ENST00000518068 | ENST00000460982 | ASPH | chr8 | 62438536 | - | DCLK1 | chr13 | 36397012 | - |
intron-3CDS | ENST00000517903 | ENST00000360631 | ASPH | chr8 | 62438536 | - | DCLK1 | chr13 | 36397012 | - |
intron-3CDS | ENST00000517903 | ENST00000255448 | ASPH | chr8 | 62438536 | - | DCLK1 | chr13 | 36397012 | - |
intron-intron | ENST00000517903 | ENST00000379892 | ASPH | chr8 | 62438536 | - | DCLK1 | chr13 | 36397012 | - |
intron-intron | ENST00000517903 | ENST00000379893 | ASPH | chr8 | 62438536 | - | DCLK1 | chr13 | 36397012 | - |
intron-intron | ENST00000517903 | ENST00000460982 | ASPH | chr8 | 62438536 | - | DCLK1 | chr13 | 36397012 | - |
intron-3CDS | ENST00000445642 | ENST00000360631 | ASPH | chr8 | 62438536 | - | DCLK1 | chr13 | 36397012 | - |
intron-3CDS | ENST00000445642 | ENST00000255448 | ASPH | chr8 | 62438536 | - | DCLK1 | chr13 | 36397012 | - |
intron-intron | ENST00000445642 | ENST00000379892 | ASPH | chr8 | 62438536 | - | DCLK1 | chr13 | 36397012 | - |
intron-intron | ENST00000445642 | ENST00000379893 | ASPH | chr8 | 62438536 | - | DCLK1 | chr13 | 36397012 | - |
intron-intron | ENST00000445642 | ENST00000460982 | ASPH | chr8 | 62438536 | - | DCLK1 | chr13 | 36397012 | - |
intron-3CDS | ENST00000517847 | ENST00000360631 | ASPH | chr8 | 62438536 | - | DCLK1 | chr13 | 36397012 | - |
intron-3CDS | ENST00000517847 | ENST00000255448 | ASPH | chr8 | 62438536 | - | DCLK1 | chr13 | 36397012 | - |
intron-intron | ENST00000517847 | ENST00000379892 | ASPH | chr8 | 62438536 | - | DCLK1 | chr13 | 36397012 | - |
intron-intron | ENST00000517847 | ENST00000379893 | ASPH | chr8 | 62438536 | - | DCLK1 | chr13 | 36397012 | - |
intron-intron | ENST00000517847 | ENST00000460982 | ASPH | chr8 | 62438536 | - | DCLK1 | chr13 | 36397012 | - |
intron-3CDS | ENST00000522835 | ENST00000360631 | ASPH | chr8 | 62438536 | - | DCLK1 | chr13 | 36397012 | - |
intron-3CDS | ENST00000522835 | ENST00000255448 | ASPH | chr8 | 62438536 | - | DCLK1 | chr13 | 36397012 | - |
intron-intron | ENST00000522835 | ENST00000379892 | ASPH | chr8 | 62438536 | - | DCLK1 | chr13 | 36397012 | - |
intron-intron | ENST00000522835 | ENST00000379893 | ASPH | chr8 | 62438536 | - | DCLK1 | chr13 | 36397012 | - |
intron-intron | ENST00000522835 | ENST00000460982 | ASPH | chr8 | 62438536 | - | DCLK1 | chr13 | 36397012 | - |
intron-3CDS | ENST00000517856 | ENST00000360631 | ASPH | chr8 | 62438536 | - | DCLK1 | chr13 | 36397012 | - |
intron-3CDS | ENST00000517856 | ENST00000255448 | ASPH | chr8 | 62438536 | - | DCLK1 | chr13 | 36397012 | - |
intron-intron | ENST00000517856 | ENST00000379892 | ASPH | chr8 | 62438536 | - | DCLK1 | chr13 | 36397012 | - |
intron-intron | ENST00000517856 | ENST00000379893 | ASPH | chr8 | 62438536 | - | DCLK1 | chr13 | 36397012 | - |
intron-intron | ENST00000517856 | ENST00000460982 | ASPH | chr8 | 62438536 | - | DCLK1 | chr13 | 36397012 | - |
intron-3CDS | ENST00000389204 | ENST00000360631 | ASPH | chr8 | 62438536 | - | DCLK1 | chr13 | 36397012 | - |
intron-3CDS | ENST00000389204 | ENST00000255448 | ASPH | chr8 | 62438536 | - | DCLK1 | chr13 | 36397012 | - |
intron-intron | ENST00000389204 | ENST00000379892 | ASPH | chr8 | 62438536 | - | DCLK1 | chr13 | 36397012 | - |
intron-intron | ENST00000389204 | ENST00000379893 | ASPH | chr8 | 62438536 | - | DCLK1 | chr13 | 36397012 | - |
intron-intron | ENST00000389204 | ENST00000460982 | ASPH | chr8 | 62438536 | - | DCLK1 | chr13 | 36397012 | - |
intron-3CDS | ENST00000522603 | ENST00000360631 | ASPH | chr8 | 62438536 | - | DCLK1 | chr13 | 36397012 | - |
intron-3CDS | ENST00000522603 | ENST00000255448 | ASPH | chr8 | 62438536 | - | DCLK1 | chr13 | 36397012 | - |
intron-intron | ENST00000522603 | ENST00000379892 | ASPH | chr8 | 62438536 | - | DCLK1 | chr13 | 36397012 | - |
intron-intron | ENST00000522603 | ENST00000379893 | ASPH | chr8 | 62438536 | - | DCLK1 | chr13 | 36397012 | - |
intron-intron | ENST00000522603 | ENST00000460982 | ASPH | chr8 | 62438536 | - | DCLK1 | chr13 | 36397012 | - |
intron-3CDS | ENST00000379449 | ENST00000360631 | ASPH | chr8 | 62438536 | - | DCLK1 | chr13 | 36397012 | - |
intron-3CDS | ENST00000379449 | ENST00000255448 | ASPH | chr8 | 62438536 | - | DCLK1 | chr13 | 36397012 | - |
intron-intron | ENST00000379449 | ENST00000379892 | ASPH | chr8 | 62438536 | - | DCLK1 | chr13 | 36397012 | - |
intron-intron | ENST00000379449 | ENST00000379893 | ASPH | chr8 | 62438536 | - | DCLK1 | chr13 | 36397012 | - |
intron-intron | ENST00000379449 | ENST00000460982 | ASPH | chr8 | 62438536 | - | DCLK1 | chr13 | 36397012 | - |
intron-3CDS | ENST00000517661 | ENST00000360631 | ASPH | chr8 | 62438536 | - | DCLK1 | chr13 | 36397012 | - |
intron-3CDS | ENST00000517661 | ENST00000255448 | ASPH | chr8 | 62438536 | - | DCLK1 | chr13 | 36397012 | - |
intron-intron | ENST00000517661 | ENST00000379892 | ASPH | chr8 | 62438536 | - | DCLK1 | chr13 | 36397012 | - |
intron-intron | ENST00000517661 | ENST00000379893 | ASPH | chr8 | 62438536 | - | DCLK1 | chr13 | 36397012 | - |
intron-intron | ENST00000517661 | ENST00000460982 | ASPH | chr8 | 62438536 | - | DCLK1 | chr13 | 36397012 | - |
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FusionProtFeatures for ASPH_DCLK1 |
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Hgene | Tgene |
ASPH | DCLK1 |
Probable kinase that may be involved in a calcium-signaling pathway controlling neuronal migration in the developingbrain. May also participate in functions of the mature nervoussystem. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ASPH_DCLK1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ASPH_DCLK1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
ASPH | SQSTM1, CUL3, APP, IQCB1, NOS2, TARDBP, ASNA1, PVRL3, HLA-E, FBLN7, PTCH1, OLFM1, ATL3, TCTN1, CCDC109B, MCU, STEAP3, FAM162A, TMEM160, STX4, SMDT1, NDUFAF1, WDYHV1, LEMD2, LYZL2, TMEM192, NELL2, ECSIT, CD93, STXBP3, BCHE, LRRC59, STX8, VTI1B, SERPINA12, EXD2, BNIP1, ACAD9, HTR2C, SLC7A6OS, TRIM25 | DCLK1 | APP, CFTR, HAX1, NUFIP1, CDCA8, DGUOK, DNAAF2, DCX, SLC4A1AP, CEP170, SPICE1, CEP128, DCTN1, LCA5, KCTD3, KIF13B, ZBTB21, KSR1, GIGYF1, LRFN1, DENND1A, SH3PXD2A, SRGAP2, EIF4E2, SIPA1L1, LIMA1, MAGI1, TESK2, ZNF638, SRSF12, SYDE1, RTKN, MAST3, PPM1H, AGAP1, CDC25B, CDK16, DENND4C, FAM110B, USP21, FAM53C, ANKRD34A, MAPKAP1, FAM110A, CGN, HDAC4, TBC1D25, NF1, NADK, CBY1, TIAM1, PHLDB2, KIAA1804, RASAL2, GAB2, CAMSAP2, MELK, PLEKHA7, CDC25C, LPIN3, KIF1C, GIGYF2, DEPDC1B, NAV1, MLLT4, DENND4A, PTPN14, STARD13, RPTOR, PLEKHA5, SH3BP4, HDAC7, EDC3, SH3RF3, LARP1, RAB3IP, INPP5E |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ASPH_DCLK1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ASPH_DCLK1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | ASPH | C1832167 | Ectopia Lentis, Spontaneous Filtering Blebs, and Craniofacial Dysmorphism | 1 | ORPHANET;UNIPROT |
Tgene | DCLK1 | C0005586 | Bipolar Disorder | 1 | PSYGENET |
Tgene | DCLK1 | C0009404 | Colorectal Neoplasms | 1 | CTD_human |
Tgene | DCLK1 | C0036341 | Schizophrenia | 1 | PSYGENET |