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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 3016

FusionGeneSummary for ASPH_DCLK1

check button Fusion gene summary
Fusion gene informationFusion gene name: ASPH_DCLK1
Fusion gene ID: 3016
HgeneTgene
Gene symbol

ASPH

DCLK1

Gene ID

444

9201

Gene nameaspartate beta-hydroxylasedoublecortin like kinase 1
SynonymsAAH|BAH|CASQ2BP1|FDLAB|HAAH|JCTN|junctinCL1|CLICK1|DCAMKL1|DCDC3A|DCLK
Cytomap

8q12.3

13q13.3

Type of geneprotein-codingprotein-coding
Descriptionaspartyl/asparaginyl beta-hydroxylaseA beta H-J-JASP beta-hydroxylasecardiac junctinhumbugjunctatepeptide-aspartate beta-dioxygenaseserine/threonine-protein kinase DCLK1doublecortin domain-containing protein 3Adoublecortin-like and CAM kinase-like 1
Modification date2018051920180527
UniProtAcc

Q12797

O15075

Ensembl transtripts involved in fusion geneENST00000541428, ENST00000379454, 
ENST00000523897, ENST00000522919, 
ENST00000356457, ENST00000518068, 
ENST00000517903, ENST00000445642, 
ENST00000517847, ENST00000522835, 
ENST00000517856, ENST00000389204, 
ENST00000522603, ENST00000379449, 
ENST00000517661, 
ENST00000360631, 
ENST00000255448, ENST00000379892, 
ENST00000379893, ENST00000460982, 
Fusion gene scores* DoF score11 X 9 X 6=5944 X 4 X 4=64
# samples 124
** MAII scorelog2(12/594*10)=-2.30742852519225
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(4/64*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ASPH [Title/Abstract] AND DCLK1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneASPH

GO:0045862

positive regulation of proteolysis

18387192

HgeneASPH

GO:0097202

activation of cysteine-type endopeptidase activity

18387192


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLIHCTCGA-DD-A4NE-01AASPHchr8

62438536

-DCLK1chr13

36397012

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000541428ENST00000360631ASPHchr8

62438536

-DCLK1chr13

36397012

-
Frame-shiftENST00000541428ENST00000255448ASPHchr8

62438536

-DCLK1chr13

36397012

-
5CDS-intronENST00000541428ENST00000379892ASPHchr8

62438536

-DCLK1chr13

36397012

-
5CDS-intronENST00000541428ENST00000379893ASPHchr8

62438536

-DCLK1chr13

36397012

-
5CDS-intronENST00000541428ENST00000460982ASPHchr8

62438536

-DCLK1chr13

36397012

-
Frame-shiftENST00000379454ENST00000360631ASPHchr8

62438536

-DCLK1chr13

36397012

-
Frame-shiftENST00000379454ENST00000255448ASPHchr8

62438536

-DCLK1chr13

36397012

-
5CDS-intronENST00000379454ENST00000379892ASPHchr8

62438536

-DCLK1chr13

36397012

-
5CDS-intronENST00000379454ENST00000379893ASPHchr8

62438536

-DCLK1chr13

36397012

-
5CDS-intronENST00000379454ENST00000460982ASPHchr8

62438536

-DCLK1chr13

36397012

-
intron-3CDSENST00000523897ENST00000360631ASPHchr8

62438536

-DCLK1chr13

36397012

-
intron-3CDSENST00000523897ENST00000255448ASPHchr8

62438536

-DCLK1chr13

36397012

-
intron-intronENST00000523897ENST00000379892ASPHchr8

62438536

-DCLK1chr13

36397012

-
intron-intronENST00000523897ENST00000379893ASPHchr8

62438536

-DCLK1chr13

36397012

-
intron-intronENST00000523897ENST00000460982ASPHchr8

62438536

-DCLK1chr13

36397012

-
intron-3CDSENST00000522919ENST00000360631ASPHchr8

62438536

-DCLK1chr13

36397012

-
intron-3CDSENST00000522919ENST00000255448ASPHchr8

62438536

-DCLK1chr13

36397012

-
intron-intronENST00000522919ENST00000379892ASPHchr8

62438536

-DCLK1chr13

36397012

-
intron-intronENST00000522919ENST00000379893ASPHchr8

62438536

-DCLK1chr13

36397012

-
intron-intronENST00000522919ENST00000460982ASPHchr8

62438536

-DCLK1chr13

36397012

-
intron-3CDSENST00000356457ENST00000360631ASPHchr8

62438536

-DCLK1chr13

36397012

-
intron-3CDSENST00000356457ENST00000255448ASPHchr8

62438536

-DCLK1chr13

36397012

-
intron-intronENST00000356457ENST00000379892ASPHchr8

62438536

-DCLK1chr13

36397012

-
intron-intronENST00000356457ENST00000379893ASPHchr8

62438536

-DCLK1chr13

36397012

-
intron-intronENST00000356457ENST00000460982ASPHchr8

62438536

-DCLK1chr13

36397012

-
intron-3CDSENST00000518068ENST00000360631ASPHchr8

62438536

-DCLK1chr13

36397012

-
intron-3CDSENST00000518068ENST00000255448ASPHchr8

62438536

-DCLK1chr13

36397012

-
intron-intronENST00000518068ENST00000379892ASPHchr8

62438536

-DCLK1chr13

36397012

-
intron-intronENST00000518068ENST00000379893ASPHchr8

62438536

-DCLK1chr13

36397012

-
intron-intronENST00000518068ENST00000460982ASPHchr8

62438536

-DCLK1chr13

36397012

-
intron-3CDSENST00000517903ENST00000360631ASPHchr8

62438536

-DCLK1chr13

36397012

-
intron-3CDSENST00000517903ENST00000255448ASPHchr8

62438536

-DCLK1chr13

36397012

-
intron-intronENST00000517903ENST00000379892ASPHchr8

62438536

-DCLK1chr13

36397012

-
intron-intronENST00000517903ENST00000379893ASPHchr8

62438536

-DCLK1chr13

36397012

-
intron-intronENST00000517903ENST00000460982ASPHchr8

62438536

-DCLK1chr13

36397012

-
intron-3CDSENST00000445642ENST00000360631ASPHchr8

62438536

-DCLK1chr13

36397012

-
intron-3CDSENST00000445642ENST00000255448ASPHchr8

62438536

-DCLK1chr13

36397012

-
intron-intronENST00000445642ENST00000379892ASPHchr8

62438536

-DCLK1chr13

36397012

-
intron-intronENST00000445642ENST00000379893ASPHchr8

62438536

-DCLK1chr13

36397012

-
intron-intronENST00000445642ENST00000460982ASPHchr8

62438536

-DCLK1chr13

36397012

-
intron-3CDSENST00000517847ENST00000360631ASPHchr8

62438536

-DCLK1chr13

36397012

-
intron-3CDSENST00000517847ENST00000255448ASPHchr8

62438536

-DCLK1chr13

36397012

-
intron-intronENST00000517847ENST00000379892ASPHchr8

62438536

-DCLK1chr13

36397012

-
intron-intronENST00000517847ENST00000379893ASPHchr8

62438536

-DCLK1chr13

36397012

-
intron-intronENST00000517847ENST00000460982ASPHchr8

62438536

-DCLK1chr13

36397012

-
intron-3CDSENST00000522835ENST00000360631ASPHchr8

62438536

-DCLK1chr13

36397012

-
intron-3CDSENST00000522835ENST00000255448ASPHchr8

62438536

-DCLK1chr13

36397012

-
intron-intronENST00000522835ENST00000379892ASPHchr8

62438536

-DCLK1chr13

36397012

-
intron-intronENST00000522835ENST00000379893ASPHchr8

62438536

-DCLK1chr13

36397012

-
intron-intronENST00000522835ENST00000460982ASPHchr8

62438536

-DCLK1chr13

36397012

-
intron-3CDSENST00000517856ENST00000360631ASPHchr8

62438536

-DCLK1chr13

36397012

-
intron-3CDSENST00000517856ENST00000255448ASPHchr8

62438536

-DCLK1chr13

36397012

-
intron-intronENST00000517856ENST00000379892ASPHchr8

62438536

-DCLK1chr13

36397012

-
intron-intronENST00000517856ENST00000379893ASPHchr8

62438536

-DCLK1chr13

36397012

-
intron-intronENST00000517856ENST00000460982ASPHchr8

62438536

-DCLK1chr13

36397012

-
intron-3CDSENST00000389204ENST00000360631ASPHchr8

62438536

-DCLK1chr13

36397012

-
intron-3CDSENST00000389204ENST00000255448ASPHchr8

62438536

-DCLK1chr13

36397012

-
intron-intronENST00000389204ENST00000379892ASPHchr8

62438536

-DCLK1chr13

36397012

-
intron-intronENST00000389204ENST00000379893ASPHchr8

62438536

-DCLK1chr13

36397012

-
intron-intronENST00000389204ENST00000460982ASPHchr8

62438536

-DCLK1chr13

36397012

-
intron-3CDSENST00000522603ENST00000360631ASPHchr8

62438536

-DCLK1chr13

36397012

-
intron-3CDSENST00000522603ENST00000255448ASPHchr8

62438536

-DCLK1chr13

36397012

-
intron-intronENST00000522603ENST00000379892ASPHchr8

62438536

-DCLK1chr13

36397012

-
intron-intronENST00000522603ENST00000379893ASPHchr8

62438536

-DCLK1chr13

36397012

-
intron-intronENST00000522603ENST00000460982ASPHchr8

62438536

-DCLK1chr13

36397012

-
intron-3CDSENST00000379449ENST00000360631ASPHchr8

62438536

-DCLK1chr13

36397012

-
intron-3CDSENST00000379449ENST00000255448ASPHchr8

62438536

-DCLK1chr13

36397012

-
intron-intronENST00000379449ENST00000379892ASPHchr8

62438536

-DCLK1chr13

36397012

-
intron-intronENST00000379449ENST00000379893ASPHchr8

62438536

-DCLK1chr13

36397012

-
intron-intronENST00000379449ENST00000460982ASPHchr8

62438536

-DCLK1chr13

36397012

-
intron-3CDSENST00000517661ENST00000360631ASPHchr8

62438536

-DCLK1chr13

36397012

-
intron-3CDSENST00000517661ENST00000255448ASPHchr8

62438536

-DCLK1chr13

36397012

-
intron-intronENST00000517661ENST00000379892ASPHchr8

62438536

-DCLK1chr13

36397012

-
intron-intronENST00000517661ENST00000379893ASPHchr8

62438536

-DCLK1chr13

36397012

-
intron-intronENST00000517661ENST00000460982ASPHchr8

62438536

-DCLK1chr13

36397012

-

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FusionProtFeatures for ASPH_DCLK1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ASPH

Q12797

DCLK1

O15075

Probable kinase that may be involved in a calcium-signaling pathway controlling neuronal migration in the developingbrain. May also participate in functions of the mature nervoussystem.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ASPH_DCLK1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ASPH_DCLK1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ASPHSQSTM1, CUL3, APP, IQCB1, NOS2, TARDBP, ASNA1, PVRL3, HLA-E, FBLN7, PTCH1, OLFM1, ATL3, TCTN1, CCDC109B, MCU, STEAP3, FAM162A, TMEM160, STX4, SMDT1, NDUFAF1, WDYHV1, LEMD2, LYZL2, TMEM192, NELL2, ECSIT, CD93, STXBP3, BCHE, LRRC59, STX8, VTI1B, SERPINA12, EXD2, BNIP1, ACAD9, HTR2C, SLC7A6OS, TRIM25DCLK1APP, CFTR, HAX1, NUFIP1, CDCA8, DGUOK, DNAAF2, DCX, SLC4A1AP, CEP170, SPICE1, CEP128, DCTN1, LCA5, KCTD3, KIF13B, ZBTB21, KSR1, GIGYF1, LRFN1, DENND1A, SH3PXD2A, SRGAP2, EIF4E2, SIPA1L1, LIMA1, MAGI1, TESK2, ZNF638, SRSF12, SYDE1, RTKN, MAST3, PPM1H, AGAP1, CDC25B, CDK16, DENND4C, FAM110B, USP21, FAM53C, ANKRD34A, MAPKAP1, FAM110A, CGN, HDAC4, TBC1D25, NF1, NADK, CBY1, TIAM1, PHLDB2, KIAA1804, RASAL2, GAB2, CAMSAP2, MELK, PLEKHA7, CDC25C, LPIN3, KIF1C, GIGYF2, DEPDC1B, NAV1, MLLT4, DENND4A, PTPN14, STARD13, RPTOR, PLEKHA5, SH3BP4, HDAC7, EDC3, SH3RF3, LARP1, RAB3IP, INPP5E


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ASPH_DCLK1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ASPH_DCLK1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneASPHC1832167Ectopia Lentis, Spontaneous Filtering Blebs, and Craniofacial Dysmorphism1ORPHANET;UNIPROT
TgeneDCLK1C0005586Bipolar Disorder1PSYGENET
TgeneDCLK1C0009404Colorectal Neoplasms1CTD_human
TgeneDCLK1C0036341Schizophrenia1PSYGENET