FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 30150

FusionGeneSummary for RAD17_ASPH

check button Fusion gene summary
Fusion gene informationFusion gene name: RAD17_ASPH
Fusion gene ID: 30150
HgeneTgene
Gene symbol

RAD17

ASPH

Gene ID

5884

444

Gene nameRAD17 checkpoint clamp loader componentaspartate beta-hydroxylase
SynonymsCCYC|HRAD17|R24L|RAD17SP|RAD24AAH|BAH|CASQ2BP1|FDLAB|HAAH|JCTN|junctin
Cytomap

5q13.2

8q12.3

Type of geneprotein-codingprotein-coding
Descriptioncell cycle checkpoint protein RAD17RAD1 homologRAD17 homologRF-C activator 1 homologRad17-like proteincell cycle checkpoint protein (RAD17)aspartyl/asparaginyl beta-hydroxylaseA beta H-J-JASP beta-hydroxylasecardiac junctinhumbugjunctatepeptide-aspartate beta-dioxygenase
Modification date2018052320180519
UniProtAcc

O75943

Q12797

Ensembl transtripts involved in fusion geneENST00000361732, ENST00000509734, 
ENST00000354868, ENST00000521422, 
ENST00000504177, ENST00000354312, 
ENST00000345306, ENST00000305138, 
ENST00000282891, ENST00000358030, 
ENST00000380774, 
ENST00000541428, 
ENST00000379454, ENST00000523897, 
ENST00000522919, ENST00000356457, 
ENST00000518068, ENST00000517903, 
ENST00000445642, ENST00000517847, 
ENST00000522835, ENST00000517856, 
ENST00000389204, ENST00000522603, 
ENST00000379449, ENST00000517661, 
Fusion gene scores* DoF score3 X 3 X 3=2712 X 12 X 3=432
# samples 316
** MAII scorelog2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(16/432*10)=-1.43295940727611
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RAD17 [Title/Abstract] AND ASPH [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneASPH

GO:0045862

positive regulation of proteolysis

18387192

TgeneASPH

GO:0097202

activation of cysteine-type endopeptidase activity

18387192


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1CD674690RAD17chr5

68696856

+ASPHchr8

62560042

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000361732ENST00000541428RAD17chr5

68696856

+ASPHchr8

62560042

-
intron-intronENST00000361732ENST00000379454RAD17chr5

68696856

+ASPHchr8

62560042

-
intron-intronENST00000361732ENST00000523897RAD17chr5

68696856

+ASPHchr8

62560042

-
intron-intronENST00000361732ENST00000522919RAD17chr5

68696856

+ASPHchr8

62560042

-
intron-intronENST00000361732ENST00000356457RAD17chr5

68696856

+ASPHchr8

62560042

-
intron-intronENST00000361732ENST00000518068RAD17chr5

68696856

+ASPHchr8

62560042

-
intron-intronENST00000361732ENST00000517903RAD17chr5

68696856

+ASPHchr8

62560042

-
intron-intronENST00000361732ENST00000445642RAD17chr5

68696856

+ASPHchr8

62560042

-
intron-intronENST00000361732ENST00000517847RAD17chr5

68696856

+ASPHchr8

62560042

-
intron-intronENST00000361732ENST00000522835RAD17chr5

68696856

+ASPHchr8

62560042

-
intron-intronENST00000361732ENST00000517856RAD17chr5

68696856

+ASPHchr8

62560042

-
intron-intronENST00000361732ENST00000389204RAD17chr5

68696856

+ASPHchr8

62560042

-
intron-intronENST00000361732ENST00000522603RAD17chr5

68696856

+ASPHchr8

62560042

-
intron-intronENST00000361732ENST00000379449RAD17chr5

68696856

+ASPHchr8

62560042

-
intron-intronENST00000361732ENST00000517661RAD17chr5

68696856

+ASPHchr8

62560042

-
intron-intronENST00000509734ENST00000541428RAD17chr5

68696856

+ASPHchr8

62560042

-
intron-intronENST00000509734ENST00000379454RAD17chr5

68696856

+ASPHchr8

62560042

-
intron-intronENST00000509734ENST00000523897RAD17chr5

68696856

+ASPHchr8

62560042

-
intron-intronENST00000509734ENST00000522919RAD17chr5

68696856

+ASPHchr8

62560042

-
intron-intronENST00000509734ENST00000356457RAD17chr5

68696856

+ASPHchr8

62560042

-
intron-intronENST00000509734ENST00000518068RAD17chr5

68696856

+ASPHchr8

62560042

-
intron-intronENST00000509734ENST00000517903RAD17chr5

68696856

+ASPHchr8

62560042

-
intron-intronENST00000509734ENST00000445642RAD17chr5

68696856

+ASPHchr8

62560042

-
intron-intronENST00000509734ENST00000517847RAD17chr5

68696856

+ASPHchr8

62560042

-
intron-intronENST00000509734ENST00000522835RAD17chr5

68696856

+ASPHchr8

62560042

-
intron-intronENST00000509734ENST00000517856RAD17chr5

68696856

+ASPHchr8

62560042

-
intron-intronENST00000509734ENST00000389204RAD17chr5

68696856

+ASPHchr8

62560042

-
intron-intronENST00000509734ENST00000522603RAD17chr5

68696856

+ASPHchr8

62560042

-
intron-intronENST00000509734ENST00000379449RAD17chr5

68696856

+ASPHchr8

62560042

-
intron-intronENST00000509734ENST00000517661RAD17chr5

68696856

+ASPHchr8

62560042

-
intron-intronENST00000354868ENST00000541428RAD17chr5

68696856

+ASPHchr8

62560042

-
intron-intronENST00000354868ENST00000379454RAD17chr5

68696856

+ASPHchr8

62560042

-
intron-intronENST00000354868ENST00000523897RAD17chr5

68696856

+ASPHchr8

62560042

-
intron-intronENST00000354868ENST00000522919RAD17chr5

68696856

+ASPHchr8

62560042

-
intron-intronENST00000354868ENST00000356457RAD17chr5

68696856

+ASPHchr8

62560042

-
intron-intronENST00000354868ENST00000518068RAD17chr5

68696856

+ASPHchr8

62560042

-
intron-intronENST00000354868ENST00000517903RAD17chr5

68696856

+ASPHchr8

62560042

-
intron-intronENST00000354868ENST00000445642RAD17chr5

68696856

+ASPHchr8

62560042

-
intron-intronENST00000354868ENST00000517847RAD17chr5

68696856

+ASPHchr8

62560042

-
intron-intronENST00000354868ENST00000522835RAD17chr5

68696856

+ASPHchr8

62560042

-
intron-intronENST00000354868ENST00000517856RAD17chr5

68696856

+ASPHchr8

62560042

-
intron-intronENST00000354868ENST00000389204RAD17chr5

68696856

+ASPHchr8

62560042

-
intron-intronENST00000354868ENST00000522603RAD17chr5

68696856

+ASPHchr8

62560042

-
intron-intronENST00000354868ENST00000379449RAD17chr5

68696856

+ASPHchr8

62560042

-
intron-intronENST00000354868ENST00000517661RAD17chr5

68696856

+ASPHchr8

62560042

-
intron-intronENST00000521422ENST00000541428RAD17chr5

68696856

+ASPHchr8

62560042

-
intron-intronENST00000521422ENST00000379454RAD17chr5

68696856

+ASPHchr8

62560042

-
intron-intronENST00000521422ENST00000523897RAD17chr5

68696856

+ASPHchr8

62560042

-
intron-intronENST00000521422ENST00000522919RAD17chr5

68696856

+ASPHchr8

62560042

-
intron-intronENST00000521422ENST00000356457RAD17chr5

68696856

+ASPHchr8

62560042

-
intron-intronENST00000521422ENST00000518068RAD17chr5

68696856

+ASPHchr8

62560042

-
intron-intronENST00000521422ENST00000517903RAD17chr5

68696856

+ASPHchr8

62560042

-
intron-intronENST00000521422ENST00000445642RAD17chr5

68696856

+ASPHchr8

62560042

-
intron-intronENST00000521422ENST00000517847RAD17chr5

68696856

+ASPHchr8

62560042

-
intron-intronENST00000521422ENST00000522835RAD17chr5

68696856

+ASPHchr8

62560042

-
intron-intronENST00000521422ENST00000517856RAD17chr5

68696856

+ASPHchr8

62560042

-
intron-intronENST00000521422ENST00000389204RAD17chr5

68696856

+ASPHchr8

62560042

-
intron-intronENST00000521422ENST00000522603RAD17chr5

68696856

+ASPHchr8

62560042

-
intron-intronENST00000521422ENST00000379449RAD17chr5

68696856

+ASPHchr8

62560042

-
intron-intronENST00000521422ENST00000517661RAD17chr5

68696856

+ASPHchr8

62560042

-
intron-intronENST00000504177ENST00000541428RAD17chr5

68696856

+ASPHchr8

62560042

-
intron-intronENST00000504177ENST00000379454RAD17chr5

68696856

+ASPHchr8

62560042

-
intron-intronENST00000504177ENST00000523897RAD17chr5

68696856

+ASPHchr8

62560042

-
intron-intronENST00000504177ENST00000522919RAD17chr5

68696856

+ASPHchr8

62560042

-
intron-intronENST00000504177ENST00000356457RAD17chr5

68696856

+ASPHchr8

62560042

-
intron-intronENST00000504177ENST00000518068RAD17chr5

68696856

+ASPHchr8

62560042

-
intron-intronENST00000504177ENST00000517903RAD17chr5

68696856

+ASPHchr8

62560042

-
intron-intronENST00000504177ENST00000445642RAD17chr5

68696856

+ASPHchr8

62560042

-
intron-intronENST00000504177ENST00000517847RAD17chr5

68696856

+ASPHchr8

62560042

-
intron-intronENST00000504177ENST00000522835RAD17chr5

68696856

+ASPHchr8

62560042

-
intron-intronENST00000504177ENST00000517856RAD17chr5

68696856

+ASPHchr8

62560042

-
intron-intronENST00000504177ENST00000389204RAD17chr5

68696856

+ASPHchr8

62560042

-
intron-intronENST00000504177ENST00000522603RAD17chr5

68696856

+ASPHchr8

62560042

-
intron-intronENST00000504177ENST00000379449RAD17chr5

68696856

+ASPHchr8

62560042

-
intron-intronENST00000504177ENST00000517661RAD17chr5

68696856

+ASPHchr8

62560042

-
intron-intronENST00000354312ENST00000541428RAD17chr5

68696856

+ASPHchr8

62560042

-
intron-intronENST00000354312ENST00000379454RAD17chr5

68696856

+ASPHchr8

62560042

-
intron-intronENST00000354312ENST00000523897RAD17chr5

68696856

+ASPHchr8

62560042

-
intron-intronENST00000354312ENST00000522919RAD17chr5

68696856

+ASPHchr8

62560042

-
intron-intronENST00000354312ENST00000356457RAD17chr5

68696856

+ASPHchr8

62560042

-
intron-intronENST00000354312ENST00000518068RAD17chr5

68696856

+ASPHchr8

62560042

-
intron-intronENST00000354312ENST00000517903RAD17chr5

68696856

+ASPHchr8

62560042

-
intron-intronENST00000354312ENST00000445642RAD17chr5

68696856

+ASPHchr8

62560042

-
intron-intronENST00000354312ENST00000517847RAD17chr5

68696856

+ASPHchr8

62560042

-
intron-intronENST00000354312ENST00000522835RAD17chr5

68696856

+ASPHchr8

62560042

-
intron-intronENST00000354312ENST00000517856RAD17chr5

68696856

+ASPHchr8

62560042

-
intron-intronENST00000354312ENST00000389204RAD17chr5

68696856

+ASPHchr8

62560042

-
intron-intronENST00000354312ENST00000522603RAD17chr5

68696856

+ASPHchr8

62560042

-
intron-intronENST00000354312ENST00000379449RAD17chr5

68696856

+ASPHchr8

62560042

-
intron-intronENST00000354312ENST00000517661RAD17chr5

68696856

+ASPHchr8

62560042

-
intron-intronENST00000345306ENST00000541428RAD17chr5

68696856

+ASPHchr8

62560042

-
intron-intronENST00000345306ENST00000379454RAD17chr5

68696856

+ASPHchr8

62560042

-
intron-intronENST00000345306ENST00000523897RAD17chr5

68696856

+ASPHchr8

62560042

-
intron-intronENST00000345306ENST00000522919RAD17chr5

68696856

+ASPHchr8

62560042

-
intron-intronENST00000345306ENST00000356457RAD17chr5

68696856

+ASPHchr8

62560042

-
intron-intronENST00000345306ENST00000518068RAD17chr5

68696856

+ASPHchr8

62560042

-
intron-intronENST00000345306ENST00000517903RAD17chr5

68696856

+ASPHchr8

62560042

-
intron-intronENST00000345306ENST00000445642RAD17chr5

68696856

+ASPHchr8

62560042

-
intron-intronENST00000345306ENST00000517847RAD17chr5

68696856

+ASPHchr8

62560042

-
intron-intronENST00000345306ENST00000522835RAD17chr5

68696856

+ASPHchr8

62560042

-
intron-intronENST00000345306ENST00000517856RAD17chr5

68696856

+ASPHchr8

62560042

-
intron-intronENST00000345306ENST00000389204RAD17chr5

68696856

+ASPHchr8

62560042

-
intron-intronENST00000345306ENST00000522603RAD17chr5

68696856

+ASPHchr8

62560042

-
intron-intronENST00000345306ENST00000379449RAD17chr5

68696856

+ASPHchr8

62560042

-
intron-intronENST00000345306ENST00000517661RAD17chr5

68696856

+ASPHchr8

62560042

-
intron-intronENST00000305138ENST00000541428RAD17chr5

68696856

+ASPHchr8

62560042

-
intron-intronENST00000305138ENST00000379454RAD17chr5

68696856

+ASPHchr8

62560042

-
intron-intronENST00000305138ENST00000523897RAD17chr5

68696856

+ASPHchr8

62560042

-
intron-intronENST00000305138ENST00000522919RAD17chr5

68696856

+ASPHchr8

62560042

-
intron-intronENST00000305138ENST00000356457RAD17chr5

68696856

+ASPHchr8

62560042

-
intron-intronENST00000305138ENST00000518068RAD17chr5

68696856

+ASPHchr8

62560042

-
intron-intronENST00000305138ENST00000517903RAD17chr5

68696856

+ASPHchr8

62560042

-
intron-intronENST00000305138ENST00000445642RAD17chr5

68696856

+ASPHchr8

62560042

-
intron-intronENST00000305138ENST00000517847RAD17chr5

68696856

+ASPHchr8

62560042

-
intron-intronENST00000305138ENST00000522835RAD17chr5

68696856

+ASPHchr8

62560042

-
intron-intronENST00000305138ENST00000517856RAD17chr5

68696856

+ASPHchr8

62560042

-
intron-intronENST00000305138ENST00000389204RAD17chr5

68696856

+ASPHchr8

62560042

-
intron-intronENST00000305138ENST00000522603RAD17chr5

68696856

+ASPHchr8

62560042

-
intron-intronENST00000305138ENST00000379449RAD17chr5

68696856

+ASPHchr8

62560042

-
intron-intronENST00000305138ENST00000517661RAD17chr5

68696856

+ASPHchr8

62560042

-
intron-intronENST00000282891ENST00000541428RAD17chr5

68696856

+ASPHchr8

62560042

-
intron-intronENST00000282891ENST00000379454RAD17chr5

68696856

+ASPHchr8

62560042

-
intron-intronENST00000282891ENST00000523897RAD17chr5

68696856

+ASPHchr8

62560042

-
intron-intronENST00000282891ENST00000522919RAD17chr5

68696856

+ASPHchr8

62560042

-
intron-intronENST00000282891ENST00000356457RAD17chr5

68696856

+ASPHchr8

62560042

-
intron-intronENST00000282891ENST00000518068RAD17chr5

68696856

+ASPHchr8

62560042

-
intron-intronENST00000282891ENST00000517903RAD17chr5

68696856

+ASPHchr8

62560042

-
intron-intronENST00000282891ENST00000445642RAD17chr5

68696856

+ASPHchr8

62560042

-
intron-intronENST00000282891ENST00000517847RAD17chr5

68696856

+ASPHchr8

62560042

-
intron-intronENST00000282891ENST00000522835RAD17chr5

68696856

+ASPHchr8

62560042

-
intron-intronENST00000282891ENST00000517856RAD17chr5

68696856

+ASPHchr8

62560042

-
intron-intronENST00000282891ENST00000389204RAD17chr5

68696856

+ASPHchr8

62560042

-
intron-intronENST00000282891ENST00000522603RAD17chr5

68696856

+ASPHchr8

62560042

-
intron-intronENST00000282891ENST00000379449RAD17chr5

68696856

+ASPHchr8

62560042

-
intron-intronENST00000282891ENST00000517661RAD17chr5

68696856

+ASPHchr8

62560042

-
intron-intronENST00000358030ENST00000541428RAD17chr5

68696856

+ASPHchr8

62560042

-
intron-intronENST00000358030ENST00000379454RAD17chr5

68696856

+ASPHchr8

62560042

-
intron-intronENST00000358030ENST00000523897RAD17chr5

68696856

+ASPHchr8

62560042

-
intron-intronENST00000358030ENST00000522919RAD17chr5

68696856

+ASPHchr8

62560042

-
intron-intronENST00000358030ENST00000356457RAD17chr5

68696856

+ASPHchr8

62560042

-
intron-intronENST00000358030ENST00000518068RAD17chr5

68696856

+ASPHchr8

62560042

-
intron-intronENST00000358030ENST00000517903RAD17chr5

68696856

+ASPHchr8

62560042

-
intron-intronENST00000358030ENST00000445642RAD17chr5

68696856

+ASPHchr8

62560042

-
intron-intronENST00000358030ENST00000517847RAD17chr5

68696856

+ASPHchr8

62560042

-
intron-intronENST00000358030ENST00000522835RAD17chr5

68696856

+ASPHchr8

62560042

-
intron-intronENST00000358030ENST00000517856RAD17chr5

68696856

+ASPHchr8

62560042

-
intron-intronENST00000358030ENST00000389204RAD17chr5

68696856

+ASPHchr8

62560042

-
intron-intronENST00000358030ENST00000522603RAD17chr5

68696856

+ASPHchr8

62560042

-
intron-intronENST00000358030ENST00000379449RAD17chr5

68696856

+ASPHchr8

62560042

-
intron-intronENST00000358030ENST00000517661RAD17chr5

68696856

+ASPHchr8

62560042

-
intron-intronENST00000380774ENST00000541428RAD17chr5

68696856

+ASPHchr8

62560042

-
intron-intronENST00000380774ENST00000379454RAD17chr5

68696856

+ASPHchr8

62560042

-
intron-intronENST00000380774ENST00000523897RAD17chr5

68696856

+ASPHchr8

62560042

-
intron-intronENST00000380774ENST00000522919RAD17chr5

68696856

+ASPHchr8

62560042

-
intron-intronENST00000380774ENST00000356457RAD17chr5

68696856

+ASPHchr8

62560042

-
intron-intronENST00000380774ENST00000518068RAD17chr5

68696856

+ASPHchr8

62560042

-
intron-intronENST00000380774ENST00000517903RAD17chr5

68696856

+ASPHchr8

62560042

-
intron-intronENST00000380774ENST00000445642RAD17chr5

68696856

+ASPHchr8

62560042

-
intron-intronENST00000380774ENST00000517847RAD17chr5

68696856

+ASPHchr8

62560042

-
intron-intronENST00000380774ENST00000522835RAD17chr5

68696856

+ASPHchr8

62560042

-
intron-intronENST00000380774ENST00000517856RAD17chr5

68696856

+ASPHchr8

62560042

-
intron-intronENST00000380774ENST00000389204RAD17chr5

68696856

+ASPHchr8

62560042

-
intron-intronENST00000380774ENST00000522603RAD17chr5

68696856

+ASPHchr8

62560042

-
intron-intronENST00000380774ENST00000379449RAD17chr5

68696856

+ASPHchr8

62560042

-
intron-intronENST00000380774ENST00000517661RAD17chr5

68696856

+ASPHchr8

62560042

-

Top

FusionProtFeatures for RAD17_ASPH


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RAD17

O75943

ASPH

Q12797


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for RAD17_ASPH


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for RAD17_ASPH


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for RAD17_ASPH


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for RAD17_ASPH


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneASPHC1832167Ectopia Lentis, Spontaneous Filtering Blebs, and Craniofacial Dysmorphism1ORPHANET;UNIPROT