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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 30137

FusionGeneSummary for RABL6_TMEM141

check button Fusion gene summary
Fusion gene informationFusion gene name: RABL6_TMEM141
Fusion gene ID: 30137
HgeneTgene
Gene symbol

RABL6

TMEM141

Gene ID

55684

85014

Gene nameRAB, member RAS oncogene family like 6transmembrane protein 141
SynonymsC9orf86|PARF|RBEL1|pp8875-
Cytomap

9q34.3

9q34.3

Type of geneprotein-codingprotein-coding
Descriptionrab-like protein 6Rab-like GTP-binding protein 1Cpartner of ARFputative GTP-binding protein Parftransmembrane protein 141
Modification date2018051920180519
UniProtAcc

Q3YEC7

Q96I45

Ensembl transtripts involved in fusion geneENST00000371671, ENST00000371663, 
ENST00000311502, ENST00000357466, 
ENST00000432842, ENST00000371675, 
ENST00000466096, 		ENST00000290079, 
ENST00000465017, 
Fusion gene scores* DoF score2 X 2 X 2=81 X 1 X 1=1
# samples 21
** MAII scorelog2(2/8*10)=1.32192809488736log2(1/1*10)=3.32192809488736
Context

PubMed: RABL6 [Title/Abstract] AND TMEM141 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDOVTCGA-13-0913-01ARABL6chr9

139702778

+TMEM141chr9

139686703

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000371671ENST00000290079RABL6chr9

139702778

+TMEM141chr9

139686703

+
5CDS-3UTRENST00000371671ENST00000465017RABL6chr9

139702778

+TMEM141chr9

139686703

+
In-frameENST00000371663ENST00000290079RABL6chr9

139702778

+TMEM141chr9

139686703

+
5CDS-3UTRENST00000371663ENST00000465017RABL6chr9

139702778

+TMEM141chr9

139686703

+
In-frameENST00000311502ENST00000290079RABL6chr9

139702778

+TMEM141chr9

139686703

+
5CDS-3UTRENST00000311502ENST00000465017RABL6chr9

139702778

+TMEM141chr9

139686703

+
In-frameENST00000357466ENST00000290079RABL6chr9

139702778

+TMEM141chr9

139686703

+
5CDS-3UTRENST00000357466ENST00000465017RABL6chr9

139702778

+TMEM141chr9

139686703

+
intron-3CDSENST00000432842ENST00000290079RABL6chr9

139702778

+TMEM141chr9

139686703

+
intron-3UTRENST00000432842ENST00000465017RABL6chr9

139702778

+TMEM141chr9

139686703

+
intron-3CDSENST00000371675ENST00000290079RABL6chr9

139702778

+TMEM141chr9

139686703

+
intron-3UTRENST00000371675ENST00000465017RABL6chr9

139702778

+TMEM141chr9

139686703

+
intron-3CDSENST00000466096ENST00000290079RABL6chr9

139702778

+TMEM141chr9

139686703

+
intron-3UTRENST00000466096ENST00000465017RABL6chr9

139702778

+TMEM141chr9

139686703

+

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FusionProtFeatures for RABL6_TMEM141


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RABL6

Q3YEC7

TMEM141

Q96I45


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRABL6chr9:139702778chr9:139686703ENST00000311502+115293_38443730Compositional biasNote=Pro-rich
HgeneRABL6chr9:139702778chr9:139686703ENST00000311502+115645_68543730Compositional biasNote=Lys-rich
HgeneRABL6chr9:139702778chr9:139686703ENST00000357466+110293_38443521Compositional biasNote=Pro-rich
HgeneRABL6chr9:139702778chr9:139686703ENST00000357466+110645_68543521Compositional biasNote=Lys-rich
HgeneRABL6chr9:139702778chr9:139686703ENST00000371663+115293_38443731Compositional biasNote=Pro-rich
HgeneRABL6chr9:139702778chr9:139686703ENST00000371663+115645_68543731Compositional biasNote=Lys-rich
HgeneRABL6chr9:139702778chr9:139686703ENST00000371671+18293_38443315Compositional biasNote=Pro-rich
HgeneRABL6chr9:139702778chr9:139686703ENST00000371671+18645_68543315Compositional biasNote=Lys-rich
HgeneRABL6chr9:139702778chr9:139686703ENST00000311502+115100_10443730Nucleotide bindingGTP
HgeneRABL6chr9:139702778chr9:139686703ENST00000311502+115177_17943730Nucleotide bindingGTP
HgeneRABL6chr9:139702778chr9:139686703ENST00000311502+11550_5743730Nucleotide bindingGTP
HgeneRABL6chr9:139702778chr9:139686703ENST00000357466+110100_10443521Nucleotide bindingGTP
HgeneRABL6chr9:139702778chr9:139686703ENST00000357466+110177_17943521Nucleotide bindingGTP
HgeneRABL6chr9:139702778chr9:139686703ENST00000357466+11050_5743521Nucleotide bindingGTP
HgeneRABL6chr9:139702778chr9:139686703ENST00000371663+115100_10443731Nucleotide bindingGTP
HgeneRABL6chr9:139702778chr9:139686703ENST00000371663+115177_17943731Nucleotide bindingGTP
HgeneRABL6chr9:139702778chr9:139686703ENST00000371663+11550_5743731Nucleotide bindingGTP
HgeneRABL6chr9:139702778chr9:139686703ENST00000371671+18100_10443315Nucleotide bindingGTP
HgeneRABL6chr9:139702778chr9:139686703ENST00000371671+18177_17943315Nucleotide bindingGTP
HgeneRABL6chr9:139702778chr9:139686703ENST00000371671+1850_5743315Nucleotide bindingGTP
HgeneRABL6chr9:139702778chr9:139686703ENST00000311502+11539_27943730RegionNote=Small GTPase-like
HgeneRABL6chr9:139702778chr9:139686703ENST00000357466+11039_27943521RegionNote=Small GTPase-like
HgeneRABL6chr9:139702778chr9:139686703ENST00000371663+11539_27943731RegionNote=Small GTPase-like
HgeneRABL6chr9:139702778chr9:139686703ENST00000371671+1839_27943315RegionNote=Small GTPase-like
TgeneTMEM141chr9:139702778chr9:139686703ENST00000290079+2532_5268109TransmembraneHelical
TgeneTMEM141chr9:139702778chr9:139686703ENST00000290079+2558_7868109TransmembraneHelical


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FusionGeneSequence for RABL6_TMEM141


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for RABL6_TMEM141


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
RABL6C19orf57, CALCOCO2, RBPMS, MDFI, SPINK7, MED29, NKX3-1, TP53, MDM2, AP3M1, AP3S1, MYL12A, COG3, CTR9, EPS15, MYH14, GBF1, NUP85, SMC4, MOV10, NXF1, CDKL5, PLK2, BUB1, UQCRB, NTRK1, CEP19, TMEM17, CENPJ, XPO1, CDC42, RAB5A, EMC2, ZWINT, RACGAP1, CHST15, PAPD5, NAF1, SREK1IP1, MTUS2, JMJD6, ID2, ZNF684, AMTN, TMA16, DLSTTMEM141NELFE, MOV10, NXF1, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneRABL6chr9:139702778chr9:139686703ENST00000311502+115655_69343730CDKN2A
HgeneRABL6chr9:139702778chr9:139686703ENST00000357466+110655_69343521CDKN2A
HgeneRABL6chr9:139702778chr9:139686703ENST00000371663+115655_69343731CDKN2A
HgeneRABL6chr9:139702778chr9:139686703ENST00000371671+18655_69343315CDKN2A


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for RABL6_TMEM141


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for RABL6_TMEM141


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneRABL6C3714756Intellectual Disability1CTD_human