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Fusion gene ID: 30133 |
FusionGeneSummary for RABIF_MKNK1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: RABIF_MKNK1 | Fusion gene ID: 30133 | Hgene | Tgene | Gene symbol | RABIF | MKNK1 | Gene ID | 5877 | 8569 |
| Gene name | RAB interacting factor | MAP kinase interacting serine/threonine kinase 1 | |
| Synonyms | MSS4|RASGFR3|RASGRF3 | MNK1 | |
| Cytomap | 1q32.1 | 1p33 | |
| Type of gene | protein-coding | protein-coding | |
| Description | guanine nucleotide exchange factor MSS4Ras-specific guanine-releasing factor 3mammalian suppressor of SEC4rab-interacting factor | MAP kinase-interacting serine/threonine-protein kinase 1MAP kinase signal-integrating kinase 1MAPK signal-integrating kinase 1 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | P47224 | Q9BUB5 | |
| Ensembl transtripts involved in fusion gene | ENST00000367262, | ENST00000371946, ENST00000371945, ENST00000341183, ENST00000428112, ENST00000545730, ENST00000465783, ENST00000525888, ENST00000371944, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 1 X 1 X 1=1 |
| # samples | 1 | 1 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: RABIF [Title/Abstract] AND MKNK1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | MKNK1 | GO:0006468 | protein phosphorylation | 9155018 |
| Tgene | MKNK1 | GO:0018105 | peptidyl-serine phosphorylation | 17130135 |
| Tgene | MKNK1 | GO:0035556 | intracellular signal transduction | 9155018 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | SARC | TCGA-DX-AB2O-01A | RABIF | chr1 | 202858101 | - | MKNK1 | chr1 | 47059952 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-5UTR | ENST00000367262 | ENST00000371946 | RABIF | chr1 | 202858101 | - | MKNK1 | chr1 | 47059952 | - |
| 5CDS-5UTR | ENST00000367262 | ENST00000371945 | RABIF | chr1 | 202858101 | - | MKNK1 | chr1 | 47059952 | - |
| 5CDS-5UTR | ENST00000367262 | ENST00000341183 | RABIF | chr1 | 202858101 | - | MKNK1 | chr1 | 47059952 | - |
| 5CDS-5UTR | ENST00000367262 | ENST00000428112 | RABIF | chr1 | 202858101 | - | MKNK1 | chr1 | 47059952 | - |
| 5CDS-5UTR | ENST00000367262 | ENST00000545730 | RABIF | chr1 | 202858101 | - | MKNK1 | chr1 | 47059952 | - |
| 5CDS-5UTR | ENST00000367262 | ENST00000465783 | RABIF | chr1 | 202858101 | - | MKNK1 | chr1 | 47059952 | - |
| 5CDS-5UTR | ENST00000367262 | ENST00000525888 | RABIF | chr1 | 202858101 | - | MKNK1 | chr1 | 47059952 | - |
| 5CDS-intron | ENST00000367262 | ENST00000371944 | RABIF | chr1 | 202858101 | - | MKNK1 | chr1 | 47059952 | - |
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FusionProtFeatures for RABIF_MKNK1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| RABIF | MKNK1 |
| Guanine-nucleotide-releasing protein that acts onmembers of the SEC4/YPT1/RAB subfamily. Stimulates GDP releasefrom both YPT1 and RAB3A, but is less active on these proteinsthan on the SEC4 protein. Might play a general role in vesiculartransport. | May play a role in the response to environmental stressand cytokines. Appears to regulate translation by phosphorylatingEIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap. {ECO:0000269|PubMed:11463832,ECO:0000269|PubMed:15350534, ECO:0000269|PubMed:9155018,ECO:0000269|PubMed:9878069}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for RABIF_MKNK1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for RABIF_MKNK1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| RABIF | ITGA3, RAB1A, CCBL2, LAMTOR5, UTP14A, RAB3A, RAB15, ITGA2, ITGA5, ITGA6, TERF2IP, REL, TCF4, RASSF5, AHSA1, KIAA0368, NARS, CBR3, CLIC4, MAT1A, PDXK, PFAS, PNPO, TSTA3, WARS, ZNF544, RAB8B, RAB1B, LHFPL4 | MKNK1 | FANCA, MAPK1, EIF4E, EIF4G1, EIF4G2, MAPK3, MAPK14, CREBBP, HSP90AB1, PRKDC, DNAJC7, EIF4G3, DDAH2, ATXN3, UBE2D1, PHAX, SPRY2, APP, RCN3, TNIP2, HGS, HIPK2, MAPK11, MOV10, XPO1, ID1, LLGL2, PDK1, PPIA, RAB5A, MYH13, KIF1C, RNASEH2B, KIF18A, PARD6B, BOD1L1, PAK2, TRIM25 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for RABIF_MKNK1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for RABIF_MKNK1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | MKNK1 | C0236969 | Substance-Related Disorders | 1 | CTD_human |
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