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Fusion gene ID: 30071 |
FusionGeneSummary for RAB7A_CISD2 |
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Fusion gene information | Fusion gene name: RAB7A_CISD2 | Fusion gene ID: 30071 | Hgene | Tgene | Gene symbol | RAB7A | CISD2 | Gene ID | 7879 | 493856 |
Gene name | RAB7A, member RAS oncogene family | CDGSH iron sulfur domain 2 | |
Synonyms | PRO2706|RAB7 | ERIS|Miner1|NAF-1|WFS2|ZCD2 | |
Cytomap | 3q21.3 | 4q24 | |
Type of gene | protein-coding | protein-coding | |
Description | ras-related protein Rab-7aRAB7, member RAS oncogene familyRas-associated protein RAB7 | CDGSH iron-sulfur domain-containing protein 2endoplasmic reticulum intermembrane small proteinmitoNEET-related 1 proteinnutrient-deprivation autophagy factor-1zinc finger, CDGSH-type domain 2 | |
Modification date | 20180527 | 20180527 | |
UniProtAcc | P51149 | Q8N5K1 | |
Ensembl transtripts involved in fusion gene | ENST00000265062, ENST00000482525, ENST00000485280, | ENST00000273986, ENST00000503643, | |
Fusion gene scores | * DoF score | 17 X 11 X 9=1683 | 3 X 2 X 3=18 |
# samples | 18 | 3 | |
** MAII score | log2(18/1683*10)=-3.22496636500027 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: RAB7A [Title/Abstract] AND CISD2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | RAB7A | GO:0022615 | protein to membrane docking | 24344282 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BU617059 | RAB7A | chr3 | 128532450 | - | CISD2 | chr4 | 103809198 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
3UTR-3UTR | ENST00000265062 | ENST00000273986 | RAB7A | chr3 | 128532450 | - | CISD2 | chr4 | 103809198 | - |
3UTR-intron | ENST00000265062 | ENST00000503643 | RAB7A | chr3 | 128532450 | - | CISD2 | chr4 | 103809198 | - |
3UTR-3UTR | ENST00000482525 | ENST00000273986 | RAB7A | chr3 | 128532450 | - | CISD2 | chr4 | 103809198 | - |
3UTR-intron | ENST00000482525 | ENST00000503643 | RAB7A | chr3 | 128532450 | - | CISD2 | chr4 | 103809198 | - |
3UTR-3UTR | ENST00000485280 | ENST00000273986 | RAB7A | chr3 | 128532450 | - | CISD2 | chr4 | 103809198 | - |
3UTR-intron | ENST00000485280 | ENST00000503643 | RAB7A | chr3 | 128532450 | - | CISD2 | chr4 | 103809198 | - |
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FusionProtFeatures for RAB7A_CISD2 |
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Hgene | Tgene |
RAB7A | CISD2 |
Key regulator in endo-lysosomal trafficking. Governsearly-to-late endosomal maturation, microtubule minus-end as wellas plus-end directed endosomal migration and positioning, andendosome-lysosome transport through different protein-proteininteraction cascades. Plays a central role, not only in endosomaltraffic, but also in many other cellular and physiological events,such as growth-factor-mediated cell signaling, nutrient-transportor mediated nutrient uptake, neurotrophin transport inthe axons of neurons and lipid metabolism. Also involved inregulation of some specialized endosomal membrane trafficking,such as maturation of melanosomes, pathogen-induced phagosomes (orvacuoles) and autophagosomes. Plays a role in the maturation andacidification of phagosomes that engulf pathogens, such asS.aureus and M.tuberculosis. Plays a role in the fusion ofphagosomes with lysosomes. Plays important roles in microbialpathogen infection and survival, as well as in participating inthe life cycle of viruses. Microbial pathogens possess survivalstrategies governed by RAB7A, sometimes by employing RAB7Afunction (e.g. Salmonella) and sometimes by excluding RAB7Afunction (e.g. Mycobacterium). In concert with RAC1, plays a rolein regulating the formation of RBs (ruffled borders) inosteoclasts. Controls the endosomal trafficking and neuriteoutgrowth signaling of NTRK1/TRKA (PubMed:11179213,PubMed:12944476, PubMed:14617358, PubMed:20028791,PubMed:21255211). Regulates the endocytic trafficking of the EGF-EGFR complex by regulating its lysosomal degradation. Involved inthe ADRB2-stimulated lipolysis through lipophagy, a cytosoliclipase-independent autophagic pathway (By similarity). Requiredfor the exosomal release of SDCBP, CD63 and syndecan(PubMed:22660413). {ECO:0000250|UniProtKB:P51150,ECO:0000269|PubMed:11179213, ECO:0000269|PubMed:12944476,ECO:0000269|PubMed:14617358, ECO:0000269|PubMed:20028791,ECO:0000269|PubMed:22660413}. | Regulator of autophagy that contributes to antagonizeBECN1-mediated cellular autophagy at the endoplasmic reticulum.Participates in the interaction of BCL2 with BECN1 and is requiredfor BCL2-mediated depression of endoplasmic reticulum Ca(2+)stores during autophagy. Contributes to BIK-initiated autophagy,while it is not involved in BIK-dependent activation of caspases.Involved in life span control, probably via its function asregulator of autophagy. {ECO:0000269|PubMed:17846994,ECO:0000269|PubMed:20010695}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for RAB7A_CISD2 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for RAB7A_CISD2 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for RAB7A_CISD2 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for RAB7A_CISD2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | RAB7A | C0151744 | Myocardial Ischemia | 1 | CTD_human |
Hgene | RAB7A | C1833219 | CHARCOT-MARIE-TOOTH DISEASE, AXONAL, TYPE 2B (disorder) | 1 | CTD_human;ORPHANET;UNIPROT |
Tgene | CISD2 | C1858028 | WOLFRAM SYNDROME 2 | 1 | CTD_human |