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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 30031

FusionGeneSummary for RAB40C_CPB1

check button Fusion gene summary
Fusion gene informationFusion gene name: RAB40C_CPB1
Fusion gene ID: 30031
HgeneTgene
Gene symbol

RAB40C

CPB1

Gene ID

57799

1360

Gene nameRAB40C, member RAS oncogene familycarboxypeptidase B1
SynonymsRARL|RASL8CCPB|PASP|PCPB
Cytomap

16p13.3

3q24

Type of geneprotein-codingprotein-coding
Descriptionras-related protein Rab-40CRAR (RAS like GTPASE) likeRAR likeRAS-like GTPaseRAS-like, family 8, member CSOCS box-containing protein RAR3rar-like proteinras-like protein family member 8Ccarboxypeptidase Bcarboxypeptidase B1 (tissue)pancreas-specific proteinpancreatic carboxypeptidase Bprocarboxypeptidase Bprotaminasetissue carboxypeptidase B
Modification date2018052320180523
UniProtAcc

Q96S21

P15086

Ensembl transtripts involved in fusion geneENST00000535977, ENST00000539661, 
ENST00000538492, ENST00000248139, 
ENST00000491148, ENST00000282957, 
ENST00000498639, 
Fusion gene scores* DoF score9 X 3 X 8=21621 X 24 X 3=1512
# samples 819
** MAII scorelog2(8/216*10)=-1.43295940727611
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(19/1512*10)=-2.99238681589013
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RAB40C [Title/Abstract] AND CPB1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-A8-A091-01ARAB40Cchr16

678302

+CPB1chr3

148577606

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000535977ENST00000491148RAB40Cchr16

678302

+CPB1chr3

148577606

+
3UTR-3CDSENST00000535977ENST00000282957RAB40Cchr16

678302

+CPB1chr3

148577606

+
3UTR-3UTRENST00000535977ENST00000498639RAB40Cchr16

678302

+CPB1chr3

148577606

+
3UTR-3CDSENST00000539661ENST00000491148RAB40Cchr16

678302

+CPB1chr3

148577606

+
3UTR-3CDSENST00000539661ENST00000282957RAB40Cchr16

678302

+CPB1chr3

148577606

+
3UTR-3UTRENST00000539661ENST00000498639RAB40Cchr16

678302

+CPB1chr3

148577606

+
3UTR-3CDSENST00000538492ENST00000491148RAB40Cchr16

678302

+CPB1chr3

148577606

+
3UTR-3CDSENST00000538492ENST00000282957RAB40Cchr16

678302

+CPB1chr3

148577606

+
3UTR-3UTRENST00000538492ENST00000498639RAB40Cchr16

678302

+CPB1chr3

148577606

+
3UTR-3CDSENST00000248139ENST00000491148RAB40Cchr16

678302

+CPB1chr3

148577606

+
3UTR-3CDSENST00000248139ENST00000282957RAB40Cchr16

678302

+CPB1chr3

148577606

+
3UTR-3UTRENST00000248139ENST00000498639RAB40Cchr16

678302

+CPB1chr3

148577606

+

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FusionProtFeatures for RAB40C_CPB1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RAB40C

Q96S21

CPB1

P15086

Probable substrate-recognition component of a SCF-likeECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complexwhich mediates the ubiquitination and subsequent proteasomaldegradation of target proteins. {ECO:0000269|PubMed:15601820}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for RAB40C_CPB1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for RAB40C_CPB1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
RAB40CCUL5, DCUN1D1, RNF7, TCEB2, TCEB1, RAB40C, RAB40B, RABGGTB, ANKRD27CPB1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for RAB40C_CPB1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneCPB1P15086DB04272Citric AcidCarboxypeptidase Bsmall moleculeapproved|nutraceutical|vet_approved

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RelatedDiseases for RAB40C_CPB1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource