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Fusion gene ID: 30031 |
FusionGeneSummary for RAB40C_CPB1 |
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Fusion gene information | Fusion gene name: RAB40C_CPB1 | Fusion gene ID: 30031 | Hgene | Tgene | Gene symbol | RAB40C | CPB1 | Gene ID | 57799 | 1360 |
Gene name | RAB40C, member RAS oncogene family | carboxypeptidase B1 | |
Synonyms | RARL|RASL8C | CPB|PASP|PCPB | |
Cytomap | 16p13.3 | 3q24 | |
Type of gene | protein-coding | protein-coding | |
Description | ras-related protein Rab-40CRAR (RAS like GTPASE) likeRAR likeRAS-like GTPaseRAS-like, family 8, member CSOCS box-containing protein RAR3rar-like proteinras-like protein family member 8C | carboxypeptidase Bcarboxypeptidase B1 (tissue)pancreas-specific proteinpancreatic carboxypeptidase Bprocarboxypeptidase Bprotaminasetissue carboxypeptidase B | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q96S21 | P15086 | |
Ensembl transtripts involved in fusion gene | ENST00000535977, ENST00000539661, ENST00000538492, ENST00000248139, | ENST00000491148, ENST00000282957, ENST00000498639, | |
Fusion gene scores | * DoF score | 9 X 3 X 8=216 | 21 X 24 X 3=1512 |
# samples | 8 | 19 | |
** MAII score | log2(8/216*10)=-1.43295940727611 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(19/1512*10)=-2.99238681589013 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: RAB40C [Title/Abstract] AND CPB1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | BRCA | TCGA-A8-A091-01A | RAB40C | chr16 | 678302 | + | CPB1 | chr3 | 148577606 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
3UTR-3CDS | ENST00000535977 | ENST00000491148 | RAB40C | chr16 | 678302 | + | CPB1 | chr3 | 148577606 | + |
3UTR-3CDS | ENST00000535977 | ENST00000282957 | RAB40C | chr16 | 678302 | + | CPB1 | chr3 | 148577606 | + |
3UTR-3UTR | ENST00000535977 | ENST00000498639 | RAB40C | chr16 | 678302 | + | CPB1 | chr3 | 148577606 | + |
3UTR-3CDS | ENST00000539661 | ENST00000491148 | RAB40C | chr16 | 678302 | + | CPB1 | chr3 | 148577606 | + |
3UTR-3CDS | ENST00000539661 | ENST00000282957 | RAB40C | chr16 | 678302 | + | CPB1 | chr3 | 148577606 | + |
3UTR-3UTR | ENST00000539661 | ENST00000498639 | RAB40C | chr16 | 678302 | + | CPB1 | chr3 | 148577606 | + |
3UTR-3CDS | ENST00000538492 | ENST00000491148 | RAB40C | chr16 | 678302 | + | CPB1 | chr3 | 148577606 | + |
3UTR-3CDS | ENST00000538492 | ENST00000282957 | RAB40C | chr16 | 678302 | + | CPB1 | chr3 | 148577606 | + |
3UTR-3UTR | ENST00000538492 | ENST00000498639 | RAB40C | chr16 | 678302 | + | CPB1 | chr3 | 148577606 | + |
3UTR-3CDS | ENST00000248139 | ENST00000491148 | RAB40C | chr16 | 678302 | + | CPB1 | chr3 | 148577606 | + |
3UTR-3CDS | ENST00000248139 | ENST00000282957 | RAB40C | chr16 | 678302 | + | CPB1 | chr3 | 148577606 | + |
3UTR-3UTR | ENST00000248139 | ENST00000498639 | RAB40C | chr16 | 678302 | + | CPB1 | chr3 | 148577606 | + |
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FusionProtFeatures for RAB40C_CPB1 |
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Hgene | Tgene |
RAB40C | CPB1 |
Probable substrate-recognition component of a SCF-likeECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complexwhich mediates the ubiquitination and subsequent proteasomaldegradation of target proteins. {ECO:0000269|PubMed:15601820}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for RAB40C_CPB1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for RAB40C_CPB1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
RAB40C | CUL5, DCUN1D1, RNF7, TCEB2, TCEB1, RAB40C, RAB40B, RABGGTB, ANKRD27 | CPB1 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for RAB40C_CPB1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Tgene | CPB1 | P15086 | DB04272 | Citric Acid | Carboxypeptidase B | small molecule | approved|nutraceutical|vet_approved |
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RelatedDiseases for RAB40C_CPB1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |