	FusionGeneSummary
	FusionProtFeature
	FusionGeneSequence
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Fusion gene ID: 29991

FusionGeneSummary for RAB3B_PKN2

Fusion gene summary

Fusion gene information	Fusion gene name: RAB3B_PKN2
	Fusion gene ID: 29991
		Hgene	Tgene
	Gene symbol	RAB3B	PKN2
	Gene ID	5865	5586
	Gene name	RAB3B, member RAS oncogene family	protein kinase N2
	Synonyms	-	PAK2\|PRK2\|PRKCL2\|PRO2042\|Pak-2\|STK7
	Cytomap	1p32.3	1p22.2
	Type of gene	protein-coding	protein-coding
	Description	ras-related protein Rab-3Bbrain antigen RAB3B	serine/threonine-protein kinase N2PKN gammacardiolipin-activated protein kinase Pak2protein kinase C-like 2protein-kinase C-related kinase 2
	Modification date	20180523	20180523
	UniProtAcc	P20337	Q16513
	Ensembl transtripts involved in fusion gene	ENST00000371655,	ENST00000316005, ENST00000370521, ENST00000370505, ENST00000370513, ENST00000544045, ENST00000495119,
Fusion gene scores	* DoF score	2 X 2 X 1=4	4 X 2 X 3=24
	# samples	2	3
	** MAII score	log2(2/4*10)=2.32192809488736	log2(3/24*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: RAB3B [Title/Abstract] AND PKN2 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation	Oncogene involved fusion gene, in-frame and retained their domain. Kinase involved fusion gene, inframe and retained kinase domain.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	RAB3B	GO:0051586	positive regulation of dopamine uptake involved in synaptic transmission	20007772
Hgene	RAB3B	GO:0097494	regulation of vesicle size	20007772
Tgene	PKN2	GO:0006468	protein phosphorylation	17332740
Tgene	PKN2	GO:0010631	epithelial cell migration	21754995

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	RV	SARC	TCGA-DX-A23U-01A	RAB3B	chr1	52442562	-	PKN2	chr1	89206671	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
In-frame	ENST00000371655	ENST00000316005	RAB3B	chr1	52442562	-	PKN2	chr1	89206671	+
In-frame	ENST00000371655	ENST00000370521	RAB3B	chr1	52442562	-	PKN2	chr1	89206671	+
5CDS-intron	ENST00000371655	ENST00000370505	RAB3B	chr1	52442562	-	PKN2	chr1	89206671	+
5CDS-intron	ENST00000371655	ENST00000370513	RAB3B	chr1	52442562	-	PKN2	chr1	89206671	+
5CDS-intron	ENST00000371655	ENST00000544045	RAB3B	chr1	52442562	-	PKN2	chr1	89206671	+
5CDS-intron	ENST00000371655	ENST00000495119	RAB3B	chr1	52442562	-	PKN2	chr1	89206671	+

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FusionProtFeatures for RAB3B_PKN2

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
RAB3B P20337	PKN2 Q16513
Protein transport. Probably involved in vesiculartraffic (By similarity). {ECO:0000250}.	PKC-related serine/threonine-protein kinase and Rho/Raceffector protein that participates in specific signal transductionresponses in the cell. Plays a role in the regulation of cellcycle progression, actin cytoskeleton assembly, cell migration,cell adhesion, tumor cell invasion and transcription activationsignaling processes. Phosphorylates CTTN in hyaluronan-inducedastrocytes and hence decreases CTTN ability to associate withfilamentous actin. Phosphorylates HDAC5, therefore lead to impairHDAC5 import. Direct RhoA target required for the regulation ofthe maturation of primordial junctions into apical junctionformation in bronchial epithelial cells. Required for G2/M phasesof the cell cycle progression and abscission during cytokinesis ina ECT2-dependent manner. Stimulates FYN kinase activity that isrequired for establishment of skin cell-cell adhesion duringkeratinocytes differentiation. Regulates epithelial bladder cellsspeed and direction of movement during cell migration and tumorcell invasion. Inhibits Akt pro-survival-induced kinase activity.Mediates Rho protein-induced transcriptional activation via the c-fos serum response factor (SRF). Phosphorylates HCV NS5B leadingto stimulation of HCV RNA replication. Involved in the negativeregulation of ciliogenesis (PubMed:27104747).{ECO:0000269\|PubMed:10226025, ECO:0000269\|PubMed:10926925,ECO:0000269\|PubMed:11777936, ECO:0000269\|PubMed:11781095,ECO:0000269\|PubMed:15364941, ECO:0000269\|PubMed:17332740,ECO:0000269\|PubMed:20188095, ECO:0000269\|PubMed:20974804,ECO:0000269\|PubMed:21754995, ECO:0000269\|PubMed:27104747,ECO:0000269\|PubMed:9121475}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
.

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

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Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

RAB3B

chr1:52442562

chr1:89206671

ENST00000371655

51_59

220

Motif

Effector region

Hgene

RAB3B

chr1:52442562

chr1:89206671

ENST00000371655

29_37

220

Nucleotide binding

GTP

Hgene

RAB3B

chr1:52442562

chr1:89206671

ENST00000371655

48_54

220

Nucleotide binding

GTP

Tgene

PKN2

chr1:52442562

chr1:89206671

ENST00000370505

121_203

-147

828

Domain

REM-1 2

Tgene

PKN2

chr1:52442562

chr1:89206671

ENST00000370505

204_284

-147

828

Domain

REM-1 3

Tgene

PKN2

chr1:52442562

chr1:89206671

ENST00000370505

330_463

-147

828

Domain

Note=C2

Tgene

PKN2

chr1:52442562

chr1:89206671

ENST00000370505

33_109

-147

828

Domain

REM-1 1

Tgene

PKN2

chr1:52442562

chr1:89206671

ENST00000370505

657_916

-147

828

Domain

Protein kinase

Tgene

PKN2

chr1:52442562

chr1:89206671

ENST00000370505

917_984

-147

828

Domain

Note=AGC-kinase C-terminal

Tgene

PKN2

chr1:52442562

chr1:89206671

ENST00000370513

121_203

937

Domain

REM-1 2

Tgene

PKN2

chr1:52442562

chr1:89206671

ENST00000370513

204_284

937

Domain

REM-1 3

Tgene

PKN2

chr1:52442562

chr1:89206671

ENST00000370513

330_463

937

Domain

Note=C2

Tgene

PKN2

chr1:52442562

chr1:89206671

ENST00000370513

33_109

937

Domain

REM-1 1

Tgene

PKN2

chr1:52442562

chr1:89206671

ENST00000370513

657_916

937

Domain

Protein kinase

Tgene

PKN2

chr1:52442562

chr1:89206671

ENST00000370513

917_984

937

Domain

Note=AGC-kinase C-terminal

Tgene

PKN2

chr1:52442562

chr1:89206671

ENST00000370521

121_203

985

Domain

REM-1 2

Tgene

PKN2

chr1:52442562

chr1:89206671

ENST00000370521

204_284

985

Domain

REM-1 3

Tgene

PKN2

chr1:52442562

chr1:89206671

ENST00000370521

330_463

985

Domain

Note=C2

Tgene

PKN2

chr1:52442562

chr1:89206671

ENST00000370521

33_109

985

Domain

REM-1 1

Tgene

PKN2

chr1:52442562

chr1:89206671

ENST00000370521

657_916

985

Domain

Protein kinase

Tgene

PKN2

chr1:52442562

chr1:89206671

ENST00000370521

917_984

985

Domain

Note=AGC-kinase C-terminal

Tgene

PKN2

chr1:52442562

chr1:89206671

ENST00000544045

121_203

-37

659

Domain

REM-1 2

Tgene

PKN2

chr1:52442562

chr1:89206671

ENST00000544045

204_284

-37

659

Domain

REM-1 3

Tgene

PKN2

chr1:52442562

chr1:89206671

ENST00000544045

330_463

-37

659

Domain

Note=C2

Tgene

PKN2

chr1:52442562

chr1:89206671

ENST00000544045

33_109

-37

659

Domain

REM-1 1

Tgene

PKN2

chr1:52442562

chr1:89206671

ENST00000544045

657_916

-37

659

Domain

Protein kinase

Tgene

PKN2

chr1:52442562

chr1:89206671

ENST00000544045

917_984

-37

659

Domain

Note=AGC-kinase C-terminal

Tgene

PKN2

chr1:52442562

chr1:89206671

ENST00000370505

663_671

-147

828

Nucleotide binding

ATP

Tgene

PKN2

chr1:52442562

chr1:89206671

ENST00000370513

663_671

937

Nucleotide binding

ATP

Tgene

PKN2

chr1:52442562

chr1:89206671

ENST00000370521

663_671

985

Nucleotide binding

ATP

Tgene

PKN2

chr1:52442562

chr1:89206671

ENST00000544045

663_671

-37

659

Nucleotide binding

ATP

Tgene

PKN2

chr1:52442562

chr1:89206671

ENST00000370505

382_463

-147

828

Region

Necessary to rescue apical junction formation

Tgene

PKN2

chr1:52442562

chr1:89206671

ENST00000370505

917_977

-147

828

Region

Note=Necessary for the catalytic activity

Tgene

PKN2

chr1:52442562

chr1:89206671

ENST00000370505

978_984

-147

828

Region

Note=Negatively regulates the responsiveness of the catalytic activity by cardiolipin and is required for optimal activation by the GTP-bound RhoA

Tgene

PKN2

chr1:52442562

chr1:89206671

ENST00000370513

382_463

937

Region

Necessary to rescue apical junction formation

Tgene

PKN2

chr1:52442562

chr1:89206671

ENST00000370513

917_977

937

Region

Note=Necessary for the catalytic activity

Tgene

PKN2

chr1:52442562

chr1:89206671

ENST00000370513

978_984

937

Region

Note=Negatively regulates the responsiveness of the catalytic activity by cardiolipin and is required for optimal activation by the GTP-bound RhoA

Tgene

PKN2

chr1:52442562

chr1:89206671

ENST00000370521

382_463

985

Region

Necessary to rescue apical junction formation

Tgene

PKN2

chr1:52442562

chr1:89206671

ENST00000370521

917_977

985

Region

Note=Necessary for the catalytic activity

Tgene

PKN2

chr1:52442562

chr1:89206671

ENST00000370521

978_984

985

Region

Note=Negatively regulates the responsiveness of the catalytic activity by cardiolipin and is required for optimal activation by the GTP-bound RhoA

Tgene

PKN2

chr1:52442562

chr1:89206671

ENST00000544045

382_463

-37

659

Region

Necessary to rescue apical junction formation

Tgene

PKN2

chr1:52442562

chr1:89206671

ENST00000544045

917_977

-37

659

Region

Note=Necessary for the catalytic activity

Tgene

PKN2

chr1:52442562

chr1:89206671

ENST00000544045

978_984

-37

659

Region

Note=Negatively regulates the responsiveness of the catalytic activity by cardiolipin and is required for optimal activation by the GTP-bound RhoA

- In-frame and not-retained protein feature among the 13 regional features.

>>>

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

RAB3B

chr1:52442562

chr1:89206671

ENST00000371655

135_138

220

Nucleotide binding

GTP

Hgene

RAB3B

chr1:52442562

chr1:89206671

ENST00000371655

165_167

220

Nucleotide binding

GTP

Hgene

RAB3B

chr1:52442562

chr1:89206671

ENST00000371655

77_81

220

Nucleotide binding

GTP

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FusionGeneSequence for RAB3B_PKN2

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

>In-frame_RAB3B_ENST00000371655_chr1_52442562_-_PKN2_ENST00000316005_chr1_89206671_+_665aa
MASVTDGKTGVKDASDQNFDYMFKLLIIGNSSVGKTSFLFRYADDTFTPAFVSTVGIDFKVKTVYRHEKRVKLQIWGDSRSLPFSENVSA
VQKLDFSDTMVQQKLDDIKDRIKREIRKELKIKEGAENLRKVTTDKKSLAYVDNILKKSNKKLEELHHKLQELNAHIVVSDPEDITDCPR
TPDTPNNDPRCSTSNNRLKALQKQLDIELKVKQGAENMIQMYSNGSSKDRKLHGTAQQLLQDSKTKIEVIRMQILQAVQTNELAFDNAKP
VISPLELRMEELRHHFRIEFAVAEGAKNVMKLLGSGKVTDRKALSEAQARFNESSQKLDLLKYSLEQRLNEVPKNHPKSRIIIEELSLVA
ASPTLSPRQSMISTQNQYSTLSKPAALTGTLEVRLMGCQDILENVPGRSKATSVALPGWSPSETRSSFMSRTSKSKSGSSRNLLKTDDLS
NDVCAVLKLDNTVVGQTSWKPISNQSWDQKFTLELDRSRELEISVYWRDWRSLCAVKFLRLEDFLDNQRHGMCLYLEPQGTLFAEVTFFN
PVIERRPKLQRQKKIFSKQQGKTFLRAPQMNINIATWGRLVRRAIPTVNHSGTFSPQAPVPTTVPVVDVRIPQLAPPARYVSEILSISYT

>In-frame_RAB3B_ENST00000371655_chr1_52442562_-_PKN2_ENST00000370521_chr1_89206671_+_1045aa
MASVTDGKTGVKDASDQNFDYMFKLLIIGNSSVGKTSFLFRYADDTFTPAFVSTVGIDFKVKTVYRHEKRVKLQIWGDSRSLPFSENVSA
VQKLDFSDTMVQQKLDDIKDRIKREIRKELKIKEGAENLRKVTTDKKSLAYVDNILKKSNKKLEELHHKLQELNAHIVVSDPEDITDCPR
TPDTPNNDPRCSTSNNRLKALQKQLDIELKVKQGAENMIQMYSNGSSKDRKLHGTAQQLLQDSKTKIEVIRMQILQAVQTNELAFDNAKP
VISPLELRMEELRHHFRIEFAVAEGAKNVMKLLGSGKVTDRKALSEAQARFNESSQKLDLLKYSLEQRLNEVPKNHPKSRIIIEELSLVA
ASPTLSPRQSMISTQNQYSTLSKPAALTGTLEVRLMGCQDILENVPGRSKATSVALPGWSPSETRSSFMSRTSKSKSGSSRNLLKTDDLS
NDVCAVLKLDNTVVGQTSWKPISNQSWDQKFTLELDRSRELEISVYWRDWRSLCAVKFLRLEDFLDNQRHGMCLYLEPQGTLFAEVTFFN
PVIERRPKLQRQKKIFSKQQGKTFLRAPQMNINIATWGRLVRRAIPTVNHSGTFSPQAPVPTTVPVVDVRIPQLAPPASDSTVTKLDFDL
EPEPPPAPPRASSLGEIDESSELRVLDIPGQDSETVFDIQNDRNSILPKSQSEYKPDTPQSGLEYSGIQELEDRRSQQRFQFNLQDFRCC
AVLGRGHFGKVLLAEYKNTNEMFAIKALKKGDIVARDEVDSLMCEKRIFETVNSVRHPFLVNLFACFQTKEHVCFVMEYAAGGDLMMHIH
TDVFSEPRAVFYAACVVLGLQYLHEHKIVYRDLKLDNLLLDTEGFVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTETSYTRAVDW
WGLGVLIYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSTEAISIMRRLLRRNPERRLGASEKDAEDVKKHPFFRLIDWSALMDKKVK

* Fusion transcript sequences (only coding sequence (CDS) region).

>In-frame_RAB3B_ENST00000371655_chr1_52442562_-_PKN2_ENST00000316005_chr1_89206671_+_1995nt
ATGGCTTCAGTGACAGATGGTAAAACTGGAGTCAAAGATGCCTCTGACCAGAATTTTGACTACATGTTTAAACTGCTTATCATTGGCAAC
AGCAGTGTTGGCAAGACCTCCTTCCTCTTCCGCTATGCTGATGACACGTTCACCCCAGCCTTCGTTAGCACCGTGGGCATCGACTTCAAG
GTGAAGACAGTCTACCGTCACGAGAAGCGGGTGAAACTGCAGATCTGGGGGGATTCCCGAAGTCTTCCGTTTTCTGAGAATGTGAGTGCT
GTTCAAAAATTAGACTTTTCAGATACAATGGTGCAGCAGAAATTGGATGATATCAAGGATCGAATTAAGAGAGAAATAAGGAAAGAACTG
AAAATCAAAGAAGGAGCTGAAAATCTGAGGAAAGTCACAACAGATAAAAAAAGTTTGGCTTATGTAGACAACATTTTGAAAAAATCAAAT
AAAAAATTAGAAGAACTACATCACAAGCTGCAGGAATTAAATGCACATATTGTTGTATCAGATCCAGAAGATATTACAGATTGCCCAAGG
ACTCCAGATACTCCAAATAATGACCCTCGTTGTTCTACTAGCAACAATAGATTGAAGGCCTTACAAAAACAATTGGATATAGAACTTAAA
GTAAAACAAGGTGCAGAGAATATGATACAGATGTATTCAAATGGATCTTCAAAGGATCGGAAACTCCATGGTACAGCTCAGCAACTGCTC
CAGGACAGCAAGACAAAAATAGAAGTCATACGAATGCAGATTCTTCAGGCAGTCCAGACTAATGAATTGGCTTTTGATAATGCAAAACCT
GTGATAAGTCCTCTTGAACTTCGGATGGAAGAATTAAGGCATCATTTTAGGATAGAGTTTGCAGTAGCAGAAGGTGCAAAGAATGTAATG
AAATTACTTGGCTCAGGAAAAGTAACAGACAGAAAAGCACTTTCAGAAGCTCAAGCAAGATTTAATGAATCAAGTCAGAAGTTGGACCTT
TTAAAGTATTCATTAGAGCAAAGATTAAACGAAGTCCCCAAGAATCATCCCAAAAGCAGGATTATTATTGAAGAACTTTCACTTGTTGCT
GCATCACCAACACTAAGTCCACGTCAAAGTATGATATCTACGCAAAATCAATATAGTACACTATCCAAACCAGCAGCACTAACAGGTACT
TTGGAAGTTCGTCTTATGGGCTGCCAAGATATCCTAGAGAATGTCCCTGGACGGTCAAAAGCAACATCAGTTGCACTGCCTGGTTGGAGT
CCAAGTGAAACCAGATCATCTTTCATGAGCAGAACGAGTAAAAGTAAAAGCGGAAGTAGTCGAAATCTTCTAAAAACCGATGACTTGTCC
AATGATGTCTGTGCTGTTTTGAAGCTCGATAATACTGTGGTTGGCCAAACTAGCTGGAAACCCATTTCCAATCAGTCATGGGACCAGAAG
TTTACACTGGAACTGGACAGGTCACGTGAACTGGAAATTTCAGTTTATTGGCGTGATTGGCGGTCTCTGTGTGCTGTAAAATTTCTGAGG
TTAGAAGATTTTTTAGACAACCAACGGCATGGCATGTGTCTCTATTTGGAACCACAGGGTACTTTATTTGCAGAGGTTACCTTTTTTAAT
CCAGTTATTGAAAGAAGACCAAAACTTCAAAGACAAAAGAAAATTTTTTCAAAGCAACAAGGCAAAACATTTCTCAGAGCTCCTCAAATG
AATATTAATATTGCCACTTGGGGAAGGCTAGTAAGAAGAGCTATTCCTACAGTAAATCATTCTGGCACCTTCAGCCCTCAAGCTCCTGTG
CCTACTACAGTGCCAGTGGTTGATGTACGCATCCCTCAACTAGCACCTCCAGCTAGGTATGTGTCTGAGATTTTAAGCATCTCTTATACA
AAGTTATTGGGACATTCTTACGTACTGATTATAGCAGGTGTACTGAGTCTTGCTTTTTTCCCAAGTAGTATTTTGAAAGTAGTGTTCTGT

>In-frame_RAB3B_ENST00000371655_chr1_52442562_-_PKN2_ENST00000370521_chr1_89206671_+_3135nt
ATGGCTTCAGTGACAGATGGTAAAACTGGAGTCAAAGATGCCTCTGACCAGAATTTTGACTACATGTTTAAACTGCTTATCATTGGCAAC
AGCAGTGTTGGCAAGACCTCCTTCCTCTTCCGCTATGCTGATGACACGTTCACCCCAGCCTTCGTTAGCACCGTGGGCATCGACTTCAAG
GTGAAGACAGTCTACCGTCACGAGAAGCGGGTGAAACTGCAGATCTGGGGGGATTCCCGAAGTCTTCCGTTTTCTGAGAATGTGAGTGCT
GTTCAAAAATTAGACTTTTCAGATACAATGGTGCAGCAGAAATTGGATGATATCAAGGATCGAATTAAGAGAGAAATAAGGAAAGAACTG
AAAATCAAAGAAGGAGCTGAAAATCTGAGGAAAGTCACAACAGATAAAAAAAGTTTGGCTTATGTAGACAACATTTTGAAAAAATCAAAT
AAAAAATTAGAAGAACTACATCACAAGCTGCAGGAATTAAATGCACATATTGTTGTATCAGATCCAGAAGATATTACAGATTGCCCAAGG
ACTCCAGATACTCCAAATAATGACCCTCGTTGTTCTACTAGCAACAATAGATTGAAGGCCTTACAAAAACAATTGGATATAGAACTTAAA
GTAAAACAAGGTGCAGAGAATATGATACAGATGTATTCAAATGGATCTTCAAAGGATCGGAAACTCCATGGTACAGCTCAGCAACTGCTC
CAGGACAGCAAGACAAAAATAGAAGTCATACGAATGCAGATTCTTCAGGCAGTCCAGACTAATGAATTGGCTTTTGATAATGCAAAACCT
GTGATAAGTCCTCTTGAACTTCGGATGGAAGAATTAAGGCATCATTTTAGGATAGAGTTTGCAGTAGCAGAAGGTGCAAAGAATGTAATG
AAATTACTTGGCTCAGGAAAAGTAACAGACAGAAAAGCACTTTCAGAAGCTCAAGCAAGATTTAATGAATCAAGTCAGAAGTTGGACCTT
TTAAAGTATTCATTAGAGCAAAGATTAAACGAAGTCCCCAAGAATCATCCCAAAAGCAGGATTATTATTGAAGAACTTTCACTTGTTGCT
GCATCACCAACACTAAGTCCACGTCAAAGTATGATATCTACGCAAAATCAATATAGTACACTATCCAAACCAGCAGCACTAACAGGTACT
TTGGAAGTTCGTCTTATGGGCTGCCAAGATATCCTAGAGAATGTCCCTGGACGGTCAAAAGCAACATCAGTTGCACTGCCTGGTTGGAGT
CCAAGTGAAACCAGATCATCTTTCATGAGCAGAACGAGTAAAAGTAAAAGCGGAAGTAGTCGAAATCTTCTAAAAACCGATGACTTGTCC
AATGATGTCTGTGCTGTTTTGAAGCTCGATAATACTGTGGTTGGCCAAACTAGCTGGAAACCCATTTCCAATCAGTCATGGGACCAGAAG
TTTACACTGGAACTGGACAGGTCACGTGAACTGGAAATTTCAGTTTATTGGCGTGATTGGCGGTCTCTGTGTGCTGTAAAATTTCTGAGG
TTAGAAGATTTTTTAGACAACCAACGGCATGGCATGTGTCTCTATTTGGAACCACAGGGTACTTTATTTGCAGAGGTTACCTTTTTTAAT
CCAGTTATTGAAAGAAGACCAAAACTTCAAAGACAAAAGAAAATTTTTTCAAAGCAACAAGGCAAAACATTTCTCAGAGCTCCTCAAATG
AATATTAATATTGCCACTTGGGGAAGGCTAGTAAGAAGAGCTATTCCTACAGTAAATCATTCTGGCACCTTCAGCCCTCAAGCTCCTGTG
CCTACTACAGTGCCAGTGGTTGATGTACGCATCCCTCAACTAGCACCTCCAGCTAGTGATTCTACAGTAACCAAATTGGACTTTGATCTT
GAGCCTGAACCTCCTCCAGCCCCACCACGAGCTTCTTCTCTTGGAGAAATAGATGAATCTTCTGAATTAAGAGTTTTGGATATACCAGGA
CAGGATTCAGAGACTGTTTTTGATATTCAGAATGACAGAAATAGTATACTTCCAAAATCTCAATCTGAATACAAGCCTGATACTCCTCAG
TCAGGCCTAGAATATAGTGGTATTCAAGAACTTGAGGACAGAAGATCTCAGCAAAGGTTTCAGTTTAATCTACAAGATTTCAGGTGTTGT
GCTGTCTTGGGAAGAGGACATTTTGGAAAGGTGCTTTTAGCTGAATATAAAAACACAAATGAGATGTTTGCTATAAAAGCCTTAAAGAAA
GGAGATATTGTGGCTCGAGATGAAGTAGACAGCCTGATGTGTGAAAAAAGAATTTTTGAAACTGTGAATAGTGTAAGGCATCCCTTTTTG
GTGAACCTTTTTGCATGTTTCCAAACCAAAGAGCATGTTTGCTTTGTAATGGAATATGCTGCCGGTGGGGACCTAATGATGCACATTCAT
ACTGATGTCTTTTCTGAACCAAGAGCTGTATTTTATGCTGCTTGTGTAGTTCTTGGGTTGCAGTATTTACATGAACACAAAATTGTTTAT
AGAGATTTGAAATTGGATAACTTATTGCTAGATACAGAGGGCTTTGTGAAAATTGCTGATTTTGGTCTTTGCAAAGAAGGAATGGGATAT
GGAGATAGAACAAGCACATTTTGTGGCACTCCTGAATTTCTTGCCCCAGAAGTATTAACAGAAACTTCTTATACAAGGGCTGTAGATTGG
TGGGGCCTTGGCGTGCTTATATATGAAATGCTTGTTGGTGAGTCTCCCTTTCCTGGTGATGATGAAGAGGAAGTTTTTGACAGTATTGTA
AATGATGAAGTAAGGTATCCAAGGTTCTTATCTACAGAAGCCATTTCTATAATGAGAAGGCTGTTAAGAAGAAATCCTGAACGGCGCCTT
GGGGCTAGCGAGAAAGATGCAGAGGATGTAAAAAAGCACCCATTTTTCCGGCTAATTGATTGGAGCGCTCTGATGGACAAAAAAGTAAAG
CCACCATTTATACCTACCATAAGAGGACGAGAAGATGTTAGTAATTTTGATGATGAATTTACCTCAGAAGCACCTATTCTGACTCCACCT

* Fusion transcript sequences (Full-length transcript).

>In-frame_RAB3B_ENST00000371655_chr1_52442562_-_PKN2_ENST00000316005_chr1_89206671_+_2666nt
AGACTCCGCCCTTGGGCGGGGCCTGGATGCGGCCGGAGCGGAGCAGTGCTGGAGCGGGAGCCTCAGCCCTCAGGCGCCACTGTGAGGACC
TGACCGGACCAGACCATCCCGCAGCGCCCCGCCCCGGCCCCCTCCGCGCCCTCCCGACGCCAGGTCCTGCCGTCCCGCCGACCGTCCGGG
AGCGAACCCGTCGTCCCGCACTCGGAGTCCGCGATGGCTTCAGTGACAGATGGTAAAACTGGAGTCAAAGATGCCTCTGACCAGAATTTT
GACTACATGTTTAAACTGCTTATCATTGGCAACAGCAGTGTTGGCAAGACCTCCTTCCTCTTCCGCTATGCTGATGACACGTTCACCCCA
GCCTTCGTTAGCACCGTGGGCATCGACTTCAAGGTGAAGACAGTCTACCGTCACGAGAAGCGGGTGAAACTGCAGATCTGGGGGGATTCC
CGAAGTCTTCCGTTTTCTGAGAATGTGAGTGCTGTTCAAAAATTAGACTTTTCAGATACAATGGTGCAGCAGAAATTGGATGATATCAAG
GATCGAATTAAGAGAGAAATAAGGAAAGAACTGAAAATCAAAGAAGGAGCTGAAAATCTGAGGAAAGTCACAACAGATAAAAAAAGTTTG
GCTTATGTAGACAACATTTTGAAAAAATCAAATAAAAAATTAGAAGAACTACATCACAAGCTGCAGGAATTAAATGCACATATTGTTGTA
TCAGATCCAGAAGATATTACAGATTGCCCAAGGACTCCAGATACTCCAAATAATGACCCTCGTTGTTCTACTAGCAACAATAGATTGAAG
GCCTTACAAAAACAATTGGATATAGAACTTAAAGTAAAACAAGGTGCAGAGAATATGATACAGATGTATTCAAATGGATCTTCAAAGGAT
CGGAAACTCCATGGTACAGCTCAGCAACTGCTCCAGGACAGCAAGACAAAAATAGAAGTCATACGAATGCAGATTCTTCAGGCAGTCCAG
ACTAATGAATTGGCTTTTGATAATGCAAAACCTGTGATAAGTCCTCTTGAACTTCGGATGGAAGAATTAAGGCATCATTTTAGGATAGAG
TTTGCAGTAGCAGAAGGTGCAAAGAATGTAATGAAATTACTTGGCTCAGGAAAAGTAACAGACAGAAAAGCACTTTCAGAAGCTCAAGCA
AGATTTAATGAATCAAGTCAGAAGTTGGACCTTTTAAAGTATTCATTAGAGCAAAGATTAAACGAAGTCCCCAAGAATCATCCCAAAAGC
AGGATTATTATTGAAGAACTTTCACTTGTTGCTGCATCACCAACACTAAGTCCACGTCAAAGTATGATATCTACGCAAAATCAATATAGT
ACACTATCCAAACCAGCAGCACTAACAGGTACTTTGGAAGTTCGTCTTATGGGCTGCCAAGATATCCTAGAGAATGTCCCTGGACGGTCA
AAAGCAACATCAGTTGCACTGCCTGGTTGGAGTCCAAGTGAAACCAGATCATCTTTCATGAGCAGAACGAGTAAAAGTAAAAGCGGAAGT
AGTCGAAATCTTCTAAAAACCGATGACTTGTCCAATGATGTCTGTGCTGTTTTGAAGCTCGATAATACTGTGGTTGGCCAAACTAGCTGG
AAACCCATTTCCAATCAGTCATGGGACCAGAAGTTTACACTGGAACTGGACAGGTCACGTGAACTGGAAATTTCAGTTTATTGGCGTGAT
TGGCGGTCTCTGTGTGCTGTAAAATTTCTGAGGTTAGAAGATTTTTTAGACAACCAACGGCATGGCATGTGTCTCTATTTGGAACCACAG
GGTACTTTATTTGCAGAGGTTACCTTTTTTAATCCAGTTATTGAAAGAAGACCAAAACTTCAAAGACAAAAGAAAATTTTTTCAAAGCAA
CAAGGCAAAACATTTCTCAGAGCTCCTCAAATGAATATTAATATTGCCACTTGGGGAAGGCTAGTAAGAAGAGCTATTCCTACAGTAAAT
CATTCTGGCACCTTCAGCCCTCAAGCTCCTGTGCCTACTACAGTGCCAGTGGTTGATGTACGCATCCCTCAACTAGCACCTCCAGCTAGG
TATGTGTCTGAGATTTTAAGCATCTCTTATACAAAGTTATTGGGACATTCTTACGTACTGATTATAGCAGGTGTACTGAGTCTTGCTTTT
TTCCCAAGTAGTATTTTGAAAGTAGTGTTCTGTTTACTTAAAAAGTAAATTGTTTGCTTTAATTTTAAAGCTGTTTAAAATACAGACTTT
CTATTACTGTTTTGGTGAGTTACTTTATCTTCTATAAGTGATTCTACAGTAACCAAATTGGACTTTGATCTTGAGCCTGAACCTCCTCCA
GCCCCACCACGAGCTTCTTCTCTTGGAGAAATAGATGAATCTTCTGAATTAAGAGTTTTGGATATACCAGGACAGGCAAGCCATTTTAAA
CCTTGCATAATTCCTCTTCACTGAATGAATTAGCAATAAAAGCATCATAGTGAATAAGGCGTGTCTTTCCATTTAAAATTGCCACTGAAC
TGTGAATTTATGGTTTTTTGTTTGTTTTTTGTTTTTGTTTTTGTTTTTTGAGACAGAGTTTCACTCTTGTTACCCAGGCTGGAGTGCAAT

>In-frame_RAB3B_ENST00000371655_chr1_52442562_-_PKN2_ENST00000370521_chr1_89206671_+_6155nt
AGACTCCGCCCTTGGGCGGGGCCTGGATGCGGCCGGAGCGGAGCAGTGCTGGAGCGGGAGCCTCAGCCCTCAGGCGCCACTGTGAGGACC
TGACCGGACCAGACCATCCCGCAGCGCCCCGCCCCGGCCCCCTCCGCGCCCTCCCGACGCCAGGTCCTGCCGTCCCGCCGACCGTCCGGG
AGCGAACCCGTCGTCCCGCACTCGGAGTCCGCGATGGCTTCAGTGACAGATGGTAAAACTGGAGTCAAAGATGCCTCTGACCAGAATTTT
GACTACATGTTTAAACTGCTTATCATTGGCAACAGCAGTGTTGGCAAGACCTCCTTCCTCTTCCGCTATGCTGATGACACGTTCACCCCA
GCCTTCGTTAGCACCGTGGGCATCGACTTCAAGGTGAAGACAGTCTACCGTCACGAGAAGCGGGTGAAACTGCAGATCTGGGGGGATTCC
CGAAGTCTTCCGTTTTCTGAGAATGTGAGTGCTGTTCAAAAATTAGACTTTTCAGATACAATGGTGCAGCAGAAATTGGATGATATCAAG
GATCGAATTAAGAGAGAAATAAGGAAAGAACTGAAAATCAAAGAAGGAGCTGAAAATCTGAGGAAAGTCACAACAGATAAAAAAAGTTTG
GCTTATGTAGACAACATTTTGAAAAAATCAAATAAAAAATTAGAAGAACTACATCACAAGCTGCAGGAATTAAATGCACATATTGTTGTA
TCAGATCCAGAAGATATTACAGATTGCCCAAGGACTCCAGATACTCCAAATAATGACCCTCGTTGTTCTACTAGCAACAATAGATTGAAG
GCCTTACAAAAACAATTGGATATAGAACTTAAAGTAAAACAAGGTGCAGAGAATATGATACAGATGTATTCAAATGGATCTTCAAAGGAT
CGGAAACTCCATGGTACAGCTCAGCAACTGCTCCAGGACAGCAAGACAAAAATAGAAGTCATACGAATGCAGATTCTTCAGGCAGTCCAG
ACTAATGAATTGGCTTTTGATAATGCAAAACCTGTGATAAGTCCTCTTGAACTTCGGATGGAAGAATTAAGGCATCATTTTAGGATAGAG
TTTGCAGTAGCAGAAGGTGCAAAGAATGTAATGAAATTACTTGGCTCAGGAAAAGTAACAGACAGAAAAGCACTTTCAGAAGCTCAAGCA
AGATTTAATGAATCAAGTCAGAAGTTGGACCTTTTAAAGTATTCATTAGAGCAAAGATTAAACGAAGTCCCCAAGAATCATCCCAAAAGC
AGGATTATTATTGAAGAACTTTCACTTGTTGCTGCATCACCAACACTAAGTCCACGTCAAAGTATGATATCTACGCAAAATCAATATAGT
ACACTATCCAAACCAGCAGCACTAACAGGTACTTTGGAAGTTCGTCTTATGGGCTGCCAAGATATCCTAGAGAATGTCCCTGGACGGTCA
AAAGCAACATCAGTTGCACTGCCTGGTTGGAGTCCAAGTGAAACCAGATCATCTTTCATGAGCAGAACGAGTAAAAGTAAAAGCGGAAGT
AGTCGAAATCTTCTAAAAACCGATGACTTGTCCAATGATGTCTGTGCTGTTTTGAAGCTCGATAATACTGTGGTTGGCCAAACTAGCTGG
AAACCCATTTCCAATCAGTCATGGGACCAGAAGTTTACACTGGAACTGGACAGGTCACGTGAACTGGAAATTTCAGTTTATTGGCGTGAT
TGGCGGTCTCTGTGTGCTGTAAAATTTCTGAGGTTAGAAGATTTTTTAGACAACCAACGGCATGGCATGTGTCTCTATTTGGAACCACAG
GGTACTTTATTTGCAGAGGTTACCTTTTTTAATCCAGTTATTGAAAGAAGACCAAAACTTCAAAGACAAAAGAAAATTTTTTCAAAGCAA
CAAGGCAAAACATTTCTCAGAGCTCCTCAAATGAATATTAATATTGCCACTTGGGGAAGGCTAGTAAGAAGAGCTATTCCTACAGTAAAT
CATTCTGGCACCTTCAGCCCTCAAGCTCCTGTGCCTACTACAGTGCCAGTGGTTGATGTACGCATCCCTCAACTAGCACCTCCAGCTAGT
GATTCTACAGTAACCAAATTGGACTTTGATCTTGAGCCTGAACCTCCTCCAGCCCCACCACGAGCTTCTTCTCTTGGAGAAATAGATGAA
TCTTCTGAATTAAGAGTTTTGGATATACCAGGACAGGATTCAGAGACTGTTTTTGATATTCAGAATGACAGAAATAGTATACTTCCAAAA
TCTCAATCTGAATACAAGCCTGATACTCCTCAGTCAGGCCTAGAATATAGTGGTATTCAAGAACTTGAGGACAGAAGATCTCAGCAAAGG
TTTCAGTTTAATCTACAAGATTTCAGGTGTTGTGCTGTCTTGGGAAGAGGACATTTTGGAAAGGTGCTTTTAGCTGAATATAAAAACACA
AATGAGATGTTTGCTATAAAAGCCTTAAAGAAAGGAGATATTGTGGCTCGAGATGAAGTAGACAGCCTGATGTGTGAAAAAAGAATTTTT
GAAACTGTGAATAGTGTAAGGCATCCCTTTTTGGTGAACCTTTTTGCATGTTTCCAAACCAAAGAGCATGTTTGCTTTGTAATGGAATAT
GCTGCCGGTGGGGACCTAATGATGCACATTCATACTGATGTCTTTTCTGAACCAAGAGCTGTATTTTATGCTGCTTGTGTAGTTCTTGGG
TTGCAGTATTTACATGAACACAAAATTGTTTATAGAGATTTGAAATTGGATAACTTATTGCTAGATACAGAGGGCTTTGTGAAAATTGCT
GATTTTGGTCTTTGCAAAGAAGGAATGGGATATGGAGATAGAACAAGCACATTTTGTGGCACTCCTGAATTTCTTGCCCCAGAAGTATTA
ACAGAAACTTCTTATACAAGGGCTGTAGATTGGTGGGGCCTTGGCGTGCTTATATATGAAATGCTTGTTGGTGAGTCTCCCTTTCCTGGT
GATGATGAAGAGGAAGTTTTTGACAGTATTGTAAATGATGAAGTAAGGTATCCAAGGTTCTTATCTACAGAAGCCATTTCTATAATGAGA
AGGCTGTTAAGAAGAAATCCTGAACGGCGCCTTGGGGCTAGCGAGAAAGATGCAGAGGATGTAAAAAAGCACCCATTTTTCCGGCTAATT
GATTGGAGCGCTCTGATGGACAAAAAAGTAAAGCCACCATTTATACCTACCATAAGAGGACGAGAAGATGTTAGTAATTTTGATGATGAA
TTTACCTCAGAAGCACCTATTCTGACTCCACCTCGAGAACCAAGGATACTTTCGGAAGAGGAGCAGGAAATGTTCAGAGATTTTGACTAC
ATTGCTGATTGGTGTTAAGTTGCTAGACACTGCGAAACCAAGCTGACTCACAAGAAGACCTCTTAAAAATAGCAACCCTTCATTTGCTCT
CTGTGCCACCAATAGCTTCTGAGTTTTTTGTTGTTGTTGTTTTTATTGAAACACGTGAAGATTTGTTTAAAAGTACCATTCTAATACTTC
TTCAAAAGTGGCTCCTCATTGTACTTCAGCGTAAATATGAGCACTGGAAACAGTTTCATGGAGTTTAAGTTGAGTGAACATCGGCCATGA
AAATCCATCACGAATACTTTTGGATCAATAGTCTATTTTTAAAAAGAAAGAAAAAAACCACTTTTTTATAGTCCCTAGCTTTGCCATATG
CCCGCCTTAAGTGGAAGGAAAGTTAATCACTTAACTATGTTTTATAAAAAGAAAAAAGGGCTTGGAATGCTATTACTGTTCACACAAAGT
ATGATTCTGTTTGAATAAGGCAAATGCTCCTTTTTTTAAAAAAAAAGACATTACTGTAATATCAAAAACCGTGGCAGTTTGTATACAACT
CGGGGCTTGATTTTTTTTAAAAAAACAGAATGAATTGATGTCTTATTTTATAAATGTTCTATATTTATTAGGAGAAAACTTTATATTGCC
TTTTTTATCAATCATGTAACAGGCTTATAGCTTTCCAACAGAGCTGCTTGCCAAACAATTTTTTTTGTTTATTAAACAGTGCTGAAACAA
ACAGGATCAGCATTTACTTAAGATGTTAAGAATGAGGACTTTTAATCAGCCGAACCAAGATATTGTTACCTGTATGCATTCCCAAAGTCT
AGATGCTCAGTATGTTCAGTCATATCTTTCAGAATCAGTGAACCGATTACCCTTTTTTTGGTATTCACTCTACATCTGCCAACCTAGTTC
ACCTTGGTTTTGTGTCTGCTGTAGAAGGGAACCATAACTTGGTTAAACCGTAGGGATTATCATTGTATACATGCTGTGAACATGTATATG
TGCAAGTTTTAATGTATTCTATGTTGTAGGCTTATTATTTAATTTTACCACTTCATCACTTTTGTACAGTGGCCAAGCAGACACCTCAAA
CTCCAGCATTTACATTAAGTGCATTTGTACATTTTAGGCCACTGGATCCAGATTTTATATTGGCAGTTATTGAGGGCAAAAGCAATATAT
TGTAACAGAATGTATAAATATTTTTGATAAAACAGTCTATATTTTATTAAAAAATGAATTATAACACTAAAGCTGTACCTCAAAAGTCTC
AAAAATAATTTGATGAAATATTTTATACAACTCTTCAAAGGATCCGTCTGTGGCTTTTTATACTCTTTTAGGGTTGTCTTTTTACAAACC
ATGACTTTCCACTTGCCTGTAGTTTTTTGTTTGTTTTGGTTTGGTTTGATTTTATATTTTTTTCTCCTAATCTATGACTTTATTGTTTTT
TCTTAGTTTAGTAATAGCATCTTTGATCCTGTGCTTAGCATGTTAGGGTCATTATACCTCAGGAATAGCAAGCTGTTAAGTAACCATACT
GAATTAACTATTTAATTACAGTGAGCTCATCTCTTAAAAATTGTTCAGGTGTAAATCTTATGAGAAACATGAAAAAGCACACTGATTTAT
GGAGAGTTGAGCTAAAAACATTTATAAATATTTGCTGGGATGTTTTAGCATCTTTTCATTGTACTCTGAGAACAATTAAAATTGTCCAGA
GATCATTTATATTACCTTCCAAATTGTTTATTACCCAAGATCCTTTGGGAGAAAATCTTATAGAATGGGGGAACAATATGTGGTTTAAAG
TTATTTTAAAATGCCAGTTAATTTCCTCGGCAAAGGACAATAGAGGAACTTAGCTTAATTGTCTGGCTTTAATTTAAACTGTGTTAATAC
AACATTAAAATAAAACACTAAATACTTTTGAGGTACAGTCTGCTCACTTTTTTGGTTCTCAAATAGCAAAGAAAGTAATGTCTAAAATAG
GCTCTTAGCATTAAAAACTGACAGCATTTCGTAACTACACAGTGTACAGAATTTTTTTTTAATTGAAGTCAATCACTAAAAAAATTAGAA
GGCAGGGTCTATTTACACAATTAAGCTGAAGAAAGCACTAATTTTTTGTAGTTTAAAATATATATATATTTTAGTCAGATTTAAAATTTT
AAGCTTTATAGAGTGTAAATATATTTTGCTATTACTGTATGTGTATGTGACTGCTCAAGCACTTTGTAAAGAAATTAGGATATTTTAGAA
TGGTACACTATGCATTCAAATGAAATGTGCCTTTCACTATGTCATTCTAAGAAAACAAGTGTTTTTTGCAGTCATAAATTATCACAAATG
CACAAATTAAAGTCTATATAGATTGAAATTTGTAACTTTGGTTTTAAGTATTCTTTCCTTTTAGAAACTTCCTAATGATTAAAATATACT
TTAACTTTTCTGTGTTCAAAATCTCAAAGACTAATTAACTTTAATAAACATTCTTGCAAGTACTTTTTGTCCTAGTGAAGGCTTAAAACC
ATGAACATTCAGAGCAAACTGTCCACTTCATTGGGAATAATGGGAAAAGTTTGTATTCTGCTCCTGTAAGGTCAGTAGCATCTTTTATTT
GAAGCATATTTATGGACTGCTTACTGTGTATAGATACTGAGAATAGGAAGTTTTTTTTTTTAAAGCAACAAAATGTTGATGAATGAAGAA
CAGCCTGTTTTAATTAAGATGCAAGCACCAGTATTGTATGTACTTTTCTCTTGTTTGAGGTTAGCTTATTTTAATTTAGGACCTGGCTTC

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FusionGenePPI for RAB3B_PKN2

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page
.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene	Hgene's interactors	Tgene	Tgene's interactors
RAB3B	GDI1, RPH3A, PIGR, RAB3A, NUFIP1, SLAMF1, TGOLN2, CNDP1, RAB8A, RAB11A, MYO5B, SYTL4, STX3, RAET1E, SLC5A8, GRPR, MAS1, SLC15A1, LAMP3, APLNR, IL13RA2, IL12A, CHRM4	PKN2	PTPN13, NCK1, PLCG1, RHOA, PDPK1, PDK1, AKT1, NCK2, PKN2, USP11, WDR20, HDAC5, PTEN, CCDC136, CHGB, MYO9B, FAM193B, EIF3G, EEF1A1, NEDD4, CEBPA, ELAVL1, VCP, HSP90AA1, HECW2, FRMPD2, TGFBR2, SKAP1, THBS3, CYP1A1, UNK, ACBD3, LSM2, LSM3, LSM4, LSM6, LSM7, CCT6A, PPM1B, RPE, PCM1, CEP162, CEP128, CEP44, CEP19, CETN2, CENPJ, ATP2A2, BTF3, DARS, EEF1D, EEF1G, EPRS, IARS, KARS, KTN1, MARS, RUFY1, RARS, SOAT1, VARS, SGPL1, VAPB, EEF1E1, ERLIN1, CKAP4, TRAM1, LARS, WDR74, MBOAT7, TRMT1L, TMUB1, RABL3, SNW1, CDC5L, AHSA1, CDH1, CETN1, CAMKV, GOPC, ZNF785, DFFB, DEF8, HAVCR2, PPIAL4G, LGALS7

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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RelatedDrugs for RAB3B_PKN2

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for RAB3B_PKN2

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source

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Statistics

Examples

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Fusion gene ID: 29991

FusionGeneSummary for RAB3B_PKN2

FusionProtFeatures for RAB3B_PKN2

FusionGeneSequence for RAB3B_PKN2

FusionGenePPI for RAB3B_PKN2

RelatedDrugs for RAB3B_PKN2

RelatedDiseases for RAB3B_PKN2