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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 29978

FusionGeneSummary for RAB34_EFCAB14

check button Fusion gene summary
Fusion gene informationFusion gene name: RAB34_EFCAB14
Fusion gene ID: 29978
HgeneTgene
Gene symbol

RAB34

EFCAB14

Gene ID

83871

9813

Gene nameRAB34, member RAS oncogene familyEF-hand calcium binding domain 14
SynonymsNARR|RAB39|RAHKIAA0494
Cytomap

17q11.2

1p33

Type of geneprotein-codingprotein-coding
Descriptionras-related protein Rab-34nine amino-acid residue-repeatsras-related protein Rab-39ras-related protein RahEF-hand calcium-binding domain-containing protein 14
Modification date2018052320180522
UniProtAcc

Q9BZG1

O75071

Ensembl transtripts involved in fusion geneENST00000447716, ENST00000395243, 
ENST00000453384, ENST00000301043, 
ENST00000450529, ENST00000415040, 
ENST00000395242, ENST00000395245, 
ENST00000436730, 
ENST00000544071, 
ENST00000371933, ENST00000484461, 
Fusion gene scores* DoF score3 X 4 X 2=245 X 5 X 2=50
# samples 45
** MAII scorelog2(4/24*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(5/50*10)=0
Context

PubMed: RAB34 [Title/Abstract] AND EFCAB14 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneRAB34

GO:0032418

lysosome localization

17881736

HgeneRAB34

GO:0043001

Golgi to plasma membrane protein transport

17881736

HgeneRAB34

GO:0044351

macropinocytosis

17881736

HgeneRAB34

GO:0072659

protein localization to plasma membrane

17881736


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1CB050469RAB34chr17

27044272

-EFCAB14chr1

47184753

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-5UTRENST00000447716ENST00000544071RAB34chr17

27044272

-EFCAB14chr1

47184753

-
intron-intronENST00000447716ENST00000371933RAB34chr17

27044272

-EFCAB14chr1

47184753

-
intron-intronENST00000447716ENST00000484461RAB34chr17

27044272

-EFCAB14chr1

47184753

-
intron-5UTRENST00000395243ENST00000544071RAB34chr17

27044272

-EFCAB14chr1

47184753

-
intron-intronENST00000395243ENST00000371933RAB34chr17

27044272

-EFCAB14chr1

47184753

-
intron-intronENST00000395243ENST00000484461RAB34chr17

27044272

-EFCAB14chr1

47184753

-
intron-5UTRENST00000453384ENST00000544071RAB34chr17

27044272

-EFCAB14chr1

47184753

-
intron-intronENST00000453384ENST00000371933RAB34chr17

27044272

-EFCAB14chr1

47184753

-
intron-intronENST00000453384ENST00000484461RAB34chr17

27044272

-EFCAB14chr1

47184753

-
intron-5UTRENST00000301043ENST00000544071RAB34chr17

27044272

-EFCAB14chr1

47184753

-
intron-intronENST00000301043ENST00000371933RAB34chr17

27044272

-EFCAB14chr1

47184753

-
intron-intronENST00000301043ENST00000484461RAB34chr17

27044272

-EFCAB14chr1

47184753

-
intron-5UTRENST00000450529ENST00000544071RAB34chr17

27044272

-EFCAB14chr1

47184753

-
intron-intronENST00000450529ENST00000371933RAB34chr17

27044272

-EFCAB14chr1

47184753

-
intron-intronENST00000450529ENST00000484461RAB34chr17

27044272

-EFCAB14chr1

47184753

-
intron-5UTRENST00000415040ENST00000544071RAB34chr17

27044272

-EFCAB14chr1

47184753

-
intron-intronENST00000415040ENST00000371933RAB34chr17

27044272

-EFCAB14chr1

47184753

-
intron-intronENST00000415040ENST00000484461RAB34chr17

27044272

-EFCAB14chr1

47184753

-
intron-5UTRENST00000395242ENST00000544071RAB34chr17

27044272

-EFCAB14chr1

47184753

-
intron-intronENST00000395242ENST00000371933RAB34chr17

27044272

-EFCAB14chr1

47184753

-
intron-intronENST00000395242ENST00000484461RAB34chr17

27044272

-EFCAB14chr1

47184753

-
intron-5UTRENST00000395245ENST00000544071RAB34chr17

27044272

-EFCAB14chr1

47184753

-
intron-intronENST00000395245ENST00000371933RAB34chr17

27044272

-EFCAB14chr1

47184753

-
intron-intronENST00000395245ENST00000484461RAB34chr17

27044272

-EFCAB14chr1

47184753

-
intron-5UTRENST00000436730ENST00000544071RAB34chr17

27044272

-EFCAB14chr1

47184753

-
intron-intronENST00000436730ENST00000371933RAB34chr17

27044272

-EFCAB14chr1

47184753

-
intron-intronENST00000436730ENST00000484461RAB34chr17

27044272

-EFCAB14chr1

47184753

-

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FusionProtFeatures for RAB34_EFCAB14


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RAB34

Q9BZG1

EFCAB14

O75071

Protein transport. Involved in the redistribution oflysosomes to the peri-Golgi region (By similarity). Plays a rolein the maturation of phagosomes that engulf pathogens, such asS.aureus and M.tuberculosis (PubMed:21255211). Plays a role in thefusion of phagosomes with lysosomes (PubMed:21255211). Acts alsoas a positive regulator of hedgehog signaling and regulatesciliary function (By similarity). {ECO:0000250|UniProtKB:Q64008,ECO:0000269|PubMed:21255211}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for RAB34_EFCAB14


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for RAB34_EFCAB14


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for RAB34_EFCAB14


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for RAB34_EFCAB14


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource