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Fusion gene ID: 29978 |
FusionGeneSummary for RAB34_EFCAB14 |
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Fusion gene information | Fusion gene name: RAB34_EFCAB14 | Fusion gene ID: 29978 | Hgene | Tgene | Gene symbol | RAB34 | EFCAB14 | Gene ID | 83871 | 9813 |
Gene name | RAB34, member RAS oncogene family | EF-hand calcium binding domain 14 | |
Synonyms | NARR|RAB39|RAH | KIAA0494 | |
Cytomap | 17q11.2 | 1p33 | |
Type of gene | protein-coding | protein-coding | |
Description | ras-related protein Rab-34nine amino-acid residue-repeatsras-related protein Rab-39ras-related protein Rah | EF-hand calcium-binding domain-containing protein 14 | |
Modification date | 20180523 | 20180522 | |
UniProtAcc | Q9BZG1 | O75071 | |
Ensembl transtripts involved in fusion gene | ENST00000447716, ENST00000395243, ENST00000453384, ENST00000301043, ENST00000450529, ENST00000415040, ENST00000395242, ENST00000395245, ENST00000436730, | ENST00000544071, ENST00000371933, ENST00000484461, | |
Fusion gene scores | * DoF score | 3 X 4 X 2=24 | 5 X 5 X 2=50 |
# samples | 4 | 5 | |
** MAII score | log2(4/24*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(5/50*10)=0 | |
Context | PubMed: RAB34 [Title/Abstract] AND EFCAB14 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | RAB34 | GO:0032418 | lysosome localization | 17881736 |
Hgene | RAB34 | GO:0043001 | Golgi to plasma membrane protein transport | 17881736 |
Hgene | RAB34 | GO:0044351 | macropinocytosis | 17881736 |
Hgene | RAB34 | GO:0072659 | protein localization to plasma membrane | 17881736 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | CB050469 | RAB34 | chr17 | 27044272 | - | EFCAB14 | chr1 | 47184753 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-5UTR | ENST00000447716 | ENST00000544071 | RAB34 | chr17 | 27044272 | - | EFCAB14 | chr1 | 47184753 | - |
intron-intron | ENST00000447716 | ENST00000371933 | RAB34 | chr17 | 27044272 | - | EFCAB14 | chr1 | 47184753 | - |
intron-intron | ENST00000447716 | ENST00000484461 | RAB34 | chr17 | 27044272 | - | EFCAB14 | chr1 | 47184753 | - |
intron-5UTR | ENST00000395243 | ENST00000544071 | RAB34 | chr17 | 27044272 | - | EFCAB14 | chr1 | 47184753 | - |
intron-intron | ENST00000395243 | ENST00000371933 | RAB34 | chr17 | 27044272 | - | EFCAB14 | chr1 | 47184753 | - |
intron-intron | ENST00000395243 | ENST00000484461 | RAB34 | chr17 | 27044272 | - | EFCAB14 | chr1 | 47184753 | - |
intron-5UTR | ENST00000453384 | ENST00000544071 | RAB34 | chr17 | 27044272 | - | EFCAB14 | chr1 | 47184753 | - |
intron-intron | ENST00000453384 | ENST00000371933 | RAB34 | chr17 | 27044272 | - | EFCAB14 | chr1 | 47184753 | - |
intron-intron | ENST00000453384 | ENST00000484461 | RAB34 | chr17 | 27044272 | - | EFCAB14 | chr1 | 47184753 | - |
intron-5UTR | ENST00000301043 | ENST00000544071 | RAB34 | chr17 | 27044272 | - | EFCAB14 | chr1 | 47184753 | - |
intron-intron | ENST00000301043 | ENST00000371933 | RAB34 | chr17 | 27044272 | - | EFCAB14 | chr1 | 47184753 | - |
intron-intron | ENST00000301043 | ENST00000484461 | RAB34 | chr17 | 27044272 | - | EFCAB14 | chr1 | 47184753 | - |
intron-5UTR | ENST00000450529 | ENST00000544071 | RAB34 | chr17 | 27044272 | - | EFCAB14 | chr1 | 47184753 | - |
intron-intron | ENST00000450529 | ENST00000371933 | RAB34 | chr17 | 27044272 | - | EFCAB14 | chr1 | 47184753 | - |
intron-intron | ENST00000450529 | ENST00000484461 | RAB34 | chr17 | 27044272 | - | EFCAB14 | chr1 | 47184753 | - |
intron-5UTR | ENST00000415040 | ENST00000544071 | RAB34 | chr17 | 27044272 | - | EFCAB14 | chr1 | 47184753 | - |
intron-intron | ENST00000415040 | ENST00000371933 | RAB34 | chr17 | 27044272 | - | EFCAB14 | chr1 | 47184753 | - |
intron-intron | ENST00000415040 | ENST00000484461 | RAB34 | chr17 | 27044272 | - | EFCAB14 | chr1 | 47184753 | - |
intron-5UTR | ENST00000395242 | ENST00000544071 | RAB34 | chr17 | 27044272 | - | EFCAB14 | chr1 | 47184753 | - |
intron-intron | ENST00000395242 | ENST00000371933 | RAB34 | chr17 | 27044272 | - | EFCAB14 | chr1 | 47184753 | - |
intron-intron | ENST00000395242 | ENST00000484461 | RAB34 | chr17 | 27044272 | - | EFCAB14 | chr1 | 47184753 | - |
intron-5UTR | ENST00000395245 | ENST00000544071 | RAB34 | chr17 | 27044272 | - | EFCAB14 | chr1 | 47184753 | - |
intron-intron | ENST00000395245 | ENST00000371933 | RAB34 | chr17 | 27044272 | - | EFCAB14 | chr1 | 47184753 | - |
intron-intron | ENST00000395245 | ENST00000484461 | RAB34 | chr17 | 27044272 | - | EFCAB14 | chr1 | 47184753 | - |
intron-5UTR | ENST00000436730 | ENST00000544071 | RAB34 | chr17 | 27044272 | - | EFCAB14 | chr1 | 47184753 | - |
intron-intron | ENST00000436730 | ENST00000371933 | RAB34 | chr17 | 27044272 | - | EFCAB14 | chr1 | 47184753 | - |
intron-intron | ENST00000436730 | ENST00000484461 | RAB34 | chr17 | 27044272 | - | EFCAB14 | chr1 | 47184753 | - |
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FusionProtFeatures for RAB34_EFCAB14 |
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Hgene | Tgene |
RAB34 | EFCAB14 |
Protein transport. Involved in the redistribution oflysosomes to the peri-Golgi region (By similarity). Plays a rolein the maturation of phagosomes that engulf pathogens, such asS.aureus and M.tuberculosis (PubMed:21255211). Plays a role in thefusion of phagosomes with lysosomes (PubMed:21255211). Acts alsoas a positive regulator of hedgehog signaling and regulatesciliary function (By similarity). {ECO:0000250|UniProtKB:Q64008,ECO:0000269|PubMed:21255211}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for RAB34_EFCAB14 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for RAB34_EFCAB14 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for RAB34_EFCAB14 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for RAB34_EFCAB14 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |