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Fusion gene ID: 29976 |
FusionGeneSummary for RAB33B_RAB33B |
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Fusion gene information | Fusion gene name: RAB33B_RAB33B | Fusion gene ID: 29976 | Hgene | Tgene | Gene symbol | RAB33B | RAB33B | Gene ID | 83452 | 83452 |
Gene name | RAB33B, member RAS oncogene family | RAB33B, member RAS oncogene family | |
Synonyms | SMC2 | SMC2 | |
Cytomap | 4q31.1 | 4q31.1 | |
Type of gene | protein-coding | protein-coding | |
Description | ras-related protein Rab-33B | ras-related protein Rab-33B | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q9H082 | Q9H082 | |
Ensembl transtripts involved in fusion gene | ENST00000305626, ENST00000507271, | ENST00000305626, ENST00000507271, | |
Fusion gene scores | * DoF score | 3 X 2 X 3=18 | 1 X 1 X 1=1 |
# samples | 3 | 1 | |
** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(1/1*10)=3.32192809488736 | |
Context | PubMed: RAB33B [Title/Abstract] AND RAB33B [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | AA610417 | RAB33B | chr4 | 140397009 | + | RAB33B | chr4 | 140397072 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
3UTR-3UTR | ENST00000305626 | ENST00000305626 | RAB33B | chr4 | 140397009 | + | RAB33B | chr4 | 140397072 | - |
3UTR-intron | ENST00000305626 | ENST00000507271 | RAB33B | chr4 | 140397009 | + | RAB33B | chr4 | 140397072 | - |
intron-3UTR | ENST00000507271 | ENST00000305626 | RAB33B | chr4 | 140397009 | + | RAB33B | chr4 | 140397072 | - |
intron-intron | ENST00000507271 | ENST00000507271 | RAB33B | chr4 | 140397009 | + | RAB33B | chr4 | 140397072 | - |
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FusionProtFeatures for RAB33B_RAB33B |
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Hgene | Tgene |
RAB33B | RAB33B |
Protein transport. Acts, in coordination with RAB6A, toregulate intra-Golgi retrograde trafficking. It is involved inautophagy, acting as a modulator of autophagosome formation.{ECO:0000269|PubMed:20163571}. | Protein transport. Acts, in coordination with RAB6A, toregulate intra-Golgi retrograde trafficking. It is involved inautophagy, acting as a modulator of autophagosome formation.{ECO:0000269|PubMed:20163571}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for RAB33B_RAB33B |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for RAB33B_RAB33B |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for RAB33B_RAB33B |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for RAB33B_RAB33B |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | RAB33B | C3714896 | SMITH-MCCORT DYSPLASIA 2 | 2 | UNIPROT |
Tgene | RAB33B | C3714896 | SMITH-MCCORT DYSPLASIA 2 | 2 | UNIPROT |