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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 29971

FusionGeneSummary for RAB31_PSMA4

check button Fusion gene summary
Fusion gene informationFusion gene name: RAB31_PSMA4
Fusion gene ID: 29971
HgeneTgene
Gene symbol

RAB31

PSMA4

Gene ID

11031

5685

Gene nameRAB31, member RAS oncogene familyproteasome subunit alpha 4
SynonymsRab22BHC9|HsT17706|PSC9
Cytomap

18p11.22

15q25.1

Type of geneprotein-codingprotein-coding
Descriptionras-related protein Rab-31ras-related protein Rab-22Bproteasome subunit alpha type-4macropain subunit C9multicatalytic endopeptidase complex subunit C9proteasome (prosome, macropain) subunit, alpha type, 4proteasome component C9proteasome subunit HC9proteasome subunit L
Modification date2018052320180523
UniProtAcc

Q13636

P25789

Ensembl transtripts involved in fusion geneENST00000578921, ENST00000577284, 
ENST00000560217, ENST00000044462, 
ENST00000559082, ENST00000413382, 
ENST00000557929, ENST00000558281, 
ENST00000558341, ENST00000558094, 
Fusion gene scores* DoF score4 X 5 X 1=201 X 1 X 1=1
# samples 51
** MAII scorelog2(5/20*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(1/1*10)=3.32192809488736
Context

PubMed: RAB31 [Title/Abstract] AND PSMA4 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AW149658RAB31chr18

9862275

-PSMA4chr15

78841164

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000578921ENST00000560217RAB31chr18

9862275

-PSMA4chr15

78841164

+
3UTR-3CDSENST00000578921ENST00000044462RAB31chr18

9862275

-PSMA4chr15

78841164

+
3UTR-3CDSENST00000578921ENST00000559082RAB31chr18

9862275

-PSMA4chr15

78841164

+
3UTR-3CDSENST00000578921ENST00000413382RAB31chr18

9862275

-PSMA4chr15

78841164

+
3UTR-intronENST00000578921ENST00000557929RAB31chr18

9862275

-PSMA4chr15

78841164

+
3UTR-3UTRENST00000578921ENST00000558281RAB31chr18

9862275

-PSMA4chr15

78841164

+
3UTR-3UTRENST00000578921ENST00000558341RAB31chr18

9862275

-PSMA4chr15

78841164

+
3UTR-3UTRENST00000578921ENST00000558094RAB31chr18

9862275

-PSMA4chr15

78841164

+
intron-3CDSENST00000577284ENST00000560217RAB31chr18

9862275

-PSMA4chr15

78841164

+
intron-3CDSENST00000577284ENST00000044462RAB31chr18

9862275

-PSMA4chr15

78841164

+
intron-3CDSENST00000577284ENST00000559082RAB31chr18

9862275

-PSMA4chr15

78841164

+
intron-3CDSENST00000577284ENST00000413382RAB31chr18

9862275

-PSMA4chr15

78841164

+
intron-intronENST00000577284ENST00000557929RAB31chr18

9862275

-PSMA4chr15

78841164

+
intron-3UTRENST00000577284ENST00000558281RAB31chr18

9862275

-PSMA4chr15

78841164

+
intron-3UTRENST00000577284ENST00000558341RAB31chr18

9862275

-PSMA4chr15

78841164

+
intron-3UTRENST00000577284ENST00000558094RAB31chr18

9862275

-PSMA4chr15

78841164

+

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FusionProtFeatures for RAB31_PSMA4


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RAB31

Q13636

PSMA4

P25789

The small GTPases Rab are key regulators ofintracellular membrane trafficking, from the formation oftransport vesicles to their fusion with membranes. Rabs cyclebetween an inactive GDP-bound form and an active GTP-bound formthat is able to recruit to membranes different set of downstreameffectors directly responsible for vesicle formation, movement,tethering and fusion. Required for the integrity and for normalfunction of the Golgi apparatus and the trans-Golgi network. Playsa role in insulin-stimulated translocation of GLUT4 to the cellmembrane. Plays a role in M6PR transport from the trans-Golginetwork to endosomes. Plays a role in the internalization of EGFRfrom the cell membrane into endosomes. Plays a role in thematuration of phagosomes that engulf pathogens, such as S.aureusand M.tuberculosis. {ECO:0000269|PubMed:17189207,ECO:0000269|PubMed:17678623, ECO:0000269|PubMed:19725050,ECO:0000269|PubMed:21255211, ECO:0000269|PubMed:21586568}. Component of the 20S core proteasome complex involved inthe proteolytic degradation of most intracellular proteins. Thiscomplex plays numerous essential roles within the cell byassociating with different regulatory particles. Associated withtwo 19S regulatory particles, forms the 26S proteasome and thusparticipates in the ATP-dependent degradation of ubiquitinatedproteins. The 26S proteasome plays a key role in the maintenanceof protein homeostasis by removing misfolded or damaged proteinsthat could impair cellular functions, and by removing proteinswhose functions are no longer required. Associated with the PA200or PA28, the 20S proteasome mediates ubiquitin-independent proteindegradation. This type of proteolysis is required in severalpathways including spermatogenesis (20S-PA200 complex) orgeneration of a subset of MHC class I-presented antigenic peptides(20S-PA28 complex). {ECO:0000269|PubMed:15244466,ECO:0000269|PubMed:27176742, ECO:0000269|PubMed:8610016}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for RAB31_PSMA4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for RAB31_PSMA4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for RAB31_PSMA4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for RAB31_PSMA4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneRAB31C0023893Liver Cirrhosis, Experimental1CTD_human
TgenePSMA4C0019693HIV Infections1CTD_human
TgenePSMA4C0023903Liver neoplasms1CTD_human
TgenePSMA4C0024667Animal Mammary Neoplasms1CTD_human
TgenePSMA4C0024668Mammary Neoplasms, Experimental1CTD_human
TgenePSMA4C0035222Respiratory Distress Syndrome, Adult1CTD_human