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Fusion gene ID: 29956 |
FusionGeneSummary for RAB28_STAP1 |
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Fusion gene information | Fusion gene name: RAB28_STAP1 | Fusion gene ID: 29956 | Hgene | Tgene | Gene symbol | RAB28 | STAP1 | Gene ID | 9364 | 26228 |
Gene name | RAB28, member RAS oncogene family | signal transducing adaptor family member 1 | |
Synonyms | CORD18 | BRDG1|STAP-1 | |
Cytomap | 4p15.33 | 4q13.2 | |
Type of gene | protein-coding | protein-coding | |
Description | ras-related protein Rab-28 | signal-transducing adaptor protein 1BCR downstream-signaling protein 1docking protein BRDG1stem cell adaptor protein 1 | |
Modification date | 20180526 | 20180519 | |
UniProtAcc | P51157 | Q9ULZ2 | |
Ensembl transtripts involved in fusion gene | ENST00000330852, ENST00000288723, ENST00000338176, | ENST00000265404, ENST00000396225, | |
Fusion gene scores | * DoF score | 3 X 2 X 3=18 | 4 X 4 X 3=48 |
# samples | 3 | 4 | |
** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: RAB28 [Title/Abstract] AND STAP1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | STAP1 | GO:0050861 | positive regulation of B cell receptor signaling pathway | 10518561 |
Tgene | STAP1 | GO:1903997 | positive regulation of non-membrane spanning protein tyrosine kinase activity | 10518561 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | HNSC | TCGA-QK-A8Z8-01A | RAB28 | chr4 | 13462323 | - | STAP1 | chr4 | 68456602 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000330852 | ENST00000265404 | RAB28 | chr4 | 13462323 | - | STAP1 | chr4 | 68456602 | + |
Frame-shift | ENST00000330852 | ENST00000396225 | RAB28 | chr4 | 13462323 | - | STAP1 | chr4 | 68456602 | + |
Frame-shift | ENST00000288723 | ENST00000265404 | RAB28 | chr4 | 13462323 | - | STAP1 | chr4 | 68456602 | + |
Frame-shift | ENST00000288723 | ENST00000396225 | RAB28 | chr4 | 13462323 | - | STAP1 | chr4 | 68456602 | + |
Frame-shift | ENST00000338176 | ENST00000265404 | RAB28 | chr4 | 13462323 | - | STAP1 | chr4 | 68456602 | + |
Frame-shift | ENST00000338176 | ENST00000396225 | RAB28 | chr4 | 13462323 | - | STAP1 | chr4 | 68456602 | + |
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FusionProtFeatures for RAB28_STAP1 |
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Hgene | Tgene |
RAB28 | STAP1 |
In BCR signaling, appears to function as a dockingprotein acting downstream of TEC and participates in a positivefeedback loop by increasing the activity of TEC.{ECO:0000269|PubMed:10518561}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for RAB28_STAP1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for RAB28_STAP1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
RAB28 | APP, DUSP12, DUSP23, FBXO42, PDE6D, NCOA3, CTSV, CCDC144A, HMMR, KIF7, HSF1, MNS1 | STAP1 | SH3KBP1, FAM134C, CD2AP, SULT1A1, CAPZA2, CAPZB, CCND3 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for RAB28_STAP1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for RAB28_STAP1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |