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Fusion gene ID: 29954 |
FusionGeneSummary for RAB28_C14orf37 |
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Fusion gene information | Fusion gene name: RAB28_C14orf37 | Fusion gene ID: 29954 | Hgene | Tgene | Gene symbol | RAB28 | C14orf37 | Gene ID | 9364 |
Gene name | RAB28, member RAS oncogene family | ||
Synonyms | CORD18 | ||
Cytomap | 4p15.33 | ||
Type of gene | protein-coding | ||
Description | ras-related protein Rab-28 | ||
Modification date | 20180526 | ||
UniProtAcc | P51157 | ||
Ensembl transtripts involved in fusion gene | ENST00000330852, ENST00000288723, ENST00000338176, | ENST00000267485, ENST00000334342, | |
Fusion gene scores | * DoF score | 3 X 2 X 3=18 | 11 X 10 X 3=330 |
# samples | 3 | 12 | |
** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(12/330*10)=-1.4594316186373 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: RAB28 [Title/Abstract] AND C14orf37 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BM721428 | RAB28 | chr4 | 13405276 | - | C14orf37 | chr14 | 58719167 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000330852 | ENST00000267485 | RAB28 | chr4 | 13405276 | - | C14orf37 | chr14 | 58719167 | + |
intron-intron | ENST00000330852 | ENST00000334342 | RAB28 | chr4 | 13405276 | - | C14orf37 | chr14 | 58719167 | + |
intron-intron | ENST00000288723 | ENST00000267485 | RAB28 | chr4 | 13405276 | - | C14orf37 | chr14 | 58719167 | + |
intron-intron | ENST00000288723 | ENST00000334342 | RAB28 | chr4 | 13405276 | - | C14orf37 | chr14 | 58719167 | + |
intron-intron | ENST00000338176 | ENST00000267485 | RAB28 | chr4 | 13405276 | - | C14orf37 | chr14 | 58719167 | + |
intron-intron | ENST00000338176 | ENST00000334342 | RAB28 | chr4 | 13405276 | - | C14orf37 | chr14 | 58719167 | + |
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FusionProtFeatures for RAB28_C14orf37 |
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Hgene | Tgene |
RAB28 | C14orf37 |
Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for RAB28_C14orf37 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for RAB28_C14orf37 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for RAB28_C14orf37 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for RAB28_C14orf37 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |