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Fusion gene ID: 29945 |
FusionGeneSummary for RAB25_PMF1 |
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Fusion gene information | Fusion gene name: RAB25_PMF1 | Fusion gene ID: 29945 | Hgene | Tgene | Gene symbol | RAB25 | PMF1 | Gene ID | 57111 | 100527963 |
Gene name | RAB25, member RAS oncogene family | PMF1-BGLAP readthrough | |
Synonyms | CATX-8|RAB11C | PMF1 | |
Cytomap | 1q22 | 1q22 | |
Type of gene | protein-coding | protein-coding | |
Description | ras-related protein Rab-25 | PMF1-BGLAP proteinpolyamine-modulated factor 1 | |
Modification date | 20180523 | 20180519 | |
UniProtAcc | P57735 | Q6P1K2 | |
Ensembl transtripts involved in fusion gene | ENST00000361084, ENST00000487325, | ENST00000368279, ENST00000368273, ENST00000368277, ENST00000565805, ENST00000567140, | |
Fusion gene scores | * DoF score | 2 X 1 X 2=4 | 3 X 3 X 3=27 |
# samples | 2 | 3 | |
** MAII score | log2(2/4*10)=2.32192809488736 | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: RAB25 [Title/Abstract] AND PMF1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation | Oncogene involved fusion gene, in-frame and retained their domain. Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. Tumor suppressor gene involved fusion gene, retained protein feature but frameshift. DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | RAB25 | GO:0008284 | positive regulation of cell proliferation | 15502842 |
Hgene | RAB25 | GO:0031268 | pseudopodium organization | 17925226 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | LUSC | TCGA-39-5037-01A | RAB25 | chr1 | 156031234 | + | PMF1 | chr1 | 156202111 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000361084 | ENST00000368279 | RAB25 | chr1 | 156031234 | + | PMF1 | chr1 | 156202111 | + |
5CDS-intron | ENST00000361084 | ENST00000368273 | RAB25 | chr1 | 156031234 | + | PMF1 | chr1 | 156202111 | + |
5CDS-intron | ENST00000361084 | ENST00000368277 | RAB25 | chr1 | 156031234 | + | PMF1 | chr1 | 156202111 | + |
5CDS-intron | ENST00000361084 | ENST00000565805 | RAB25 | chr1 | 156031234 | + | PMF1 | chr1 | 156202111 | + |
5CDS-intron | ENST00000361084 | ENST00000567140 | RAB25 | chr1 | 156031234 | + | PMF1 | chr1 | 156202111 | + |
3UTR-3CDS | ENST00000487325 | ENST00000368279 | RAB25 | chr1 | 156031234 | + | PMF1 | chr1 | 156202111 | + |
3UTR-intron | ENST00000487325 | ENST00000368273 | RAB25 | chr1 | 156031234 | + | PMF1 | chr1 | 156202111 | + |
3UTR-intron | ENST00000487325 | ENST00000368277 | RAB25 | chr1 | 156031234 | + | PMF1 | chr1 | 156202111 | + |
3UTR-intron | ENST00000487325 | ENST00000565805 | RAB25 | chr1 | 156031234 | + | PMF1 | chr1 | 156202111 | + |
3UTR-intron | ENST00000487325 | ENST00000567140 | RAB25 | chr1 | 156031234 | + | PMF1 | chr1 | 156202111 | + |
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FusionProtFeatures for RAB25_PMF1 |
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Hgene | Tgene |
RAB25 | PMF1 |
Involved in the regulation of cell survival. Promotesinvasive migration of cells in which it functions to localize andmaintain integrin alpha-V/beta-1 at the tips of extendingpseudopodia (PubMed:17925226). Involved in the regulation ofepithelial morphogenesis through the control of CLDN4 expressionand localization at tight junctions (By similarity). Mayselectively regulate the apical recycling pathway. Together withMYO5B regulates transcytosis (By similarity).{ECO:0000250|UniProtKB:E2RQ15, ECO:0000250|UniProtKB:P46629,ECO:0000250|UniProtKB:Q9WTL2, ECO:0000269|PubMed:17925226}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for RAB25_PMF1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for RAB25_PMF1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
RAB25 | PKIG, KPTN, AP2S1, RAB11FIP1, RAB11FIP2, RAB11FIP3, RAB11FIP5, ATP4A, MYO5B, OPTN, RAB11B, RAB11A, PDE4DIP, CDK15, FAM60A | PMF1 | NFE2L2, MIS12, DSN1, GDF9, KIAA1377, MED31, CRMP1, PTN, COPS6, GIT1, COPS7A, SUGT1, HSP90AA1, TCP10L, KDM1A, USHBP1, BUB1B, NSMCE1, NSL1, ZWINT, SGTB, SEC63, PGRMC2, ZRANB1, WDR45B, GNPAT, PPP1CC, ZMPSTE24, CMTM6, GFER, TALDO1, SPC24, SPC25, CASC5, NUF2, KIF21B, BICD2, RUFY2, GCC2, NDC80, ZC4H2, CEP89, FBXO28, RUFY1, TSNAX, ATG16L1, NRBF2, ALOX5, MLLT10, CENPC, RGPD8, STXBP4, MLF1, TRIM25, UBE2S |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for RAB25_PMF1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for RAB25_PMF1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |