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Fusion gene ID: 29932 |
FusionGeneSummary for RAB21_KSR1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: RAB21_KSR1 | Fusion gene ID: 29932 | Hgene | Tgene | Gene symbol | RAB21 | KSR1 | Gene ID | 23011 | 8844 |
| Gene name | RAB21, member RAS oncogene family | kinase suppressor of ras 1 | |
| Synonyms | - | KSR|RSU2 | |
| Cytomap | 12q21.1 | 17q11.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | ras-related protein Rab-21GTP-binding protein RAB21 | kinase suppressor of Ras 1 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q9UL25 | Q8IVT5 | |
| Ensembl transtripts involved in fusion gene | ENST00000261263, | ENST00000509603, ENST00000319524, ENST00000268763, ENST00000398988, ENST00000581975, ENST00000582410, ENST00000578981, | |
| Fusion gene scores | * DoF score | 8 X 4 X 2=64 | 10 X 7 X 5=350 |
| # samples | 6 | 9 | |
| ** MAII score | log2(6/64*10)=-0.0931094043914815 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(9/350*10)=-1.95935801550265 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: RAB21 [Title/Abstract] AND KSR1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Oncogene involved fusion gene, in-frame and retained their domain. Kinase involved fusion gene, inframe and retained kinase domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | RAB21 | GO:0017157 | regulation of exocytosis | 22705394 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-A8-A09Q-01A | RAB21 | chr12 | 72149068 | + | KSR1 | chr17 | 25877594 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000261263 | ENST00000509603 | RAB21 | chr12 | 72149068 | + | KSR1 | chr17 | 25877594 | + |
| In-frame | ENST00000261263 | ENST00000319524 | RAB21 | chr12 | 72149068 | + | KSR1 | chr17 | 25877594 | + |
| 5CDS-5UTR | ENST00000261263 | ENST00000268763 | RAB21 | chr12 | 72149068 | + | KSR1 | chr17 | 25877594 | + |
| 5CDS-5UTR | ENST00000261263 | ENST00000398988 | RAB21 | chr12 | 72149068 | + | KSR1 | chr17 | 25877594 | + |
| 5CDS-intron | ENST00000261263 | ENST00000581975 | RAB21 | chr12 | 72149068 | + | KSR1 | chr17 | 25877594 | + |
| 5CDS-intron | ENST00000261263 | ENST00000582410 | RAB21 | chr12 | 72149068 | + | KSR1 | chr17 | 25877594 | + |
| 5CDS-intron | ENST00000261263 | ENST00000578981 | RAB21 | chr12 | 72149068 | + | KSR1 | chr17 | 25877594 | + |
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FusionProtFeatures for RAB21_KSR1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| RAB21 | KSR1 |
| Regulates integrin internalization and recycling, butdoes not influence the traffic of endosomally translocatedreceptors in general. As a result, may regulate cell adhesion andmigration (By similarity). During the mitosis of adherent cells,controls the endosomal trafficking of integrins which is requiredfor the successful completion of cytokinesis. Involved in neuritegrowth (By similarity). {ECO:0000250,ECO:0000250|UniProtKB:Q6AXT5, ECO:0000269|PubMed:18804435}. | Scaffolding protein that is part of a multiproteinsignaling complex. Promotes phosphorylation of Raf family membersand activation of downstream MAP kinases. Promotes activation ofMAPK1 and/or MAPK3, both in response to EGF and to cAMP. Does nothave kinase activity by itself. {ECO:0000250|UniProtKB:Q61097}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | RAB21 | chr12:72149068 | chr17:25877594 | ENST00000261263 | + | 1 | 7 | 48_56 | 53 | 226 | Motif | Effector region |
| Hgene | RAB21 | chr12:72149068 | chr17:25877594 | ENST00000261263 | + | 1 | 7 | 26_34 | 53 | 226 | Nucleotide binding | Note=GTP |
| Tgene | >KSR1 | chr12:72149068 | chr17:25877594 | ENST00000268763 | + | 1 | 22 | 17_21 | -60 | 787 | Compositional bias | Note=Poly-Gly |
| Tgene | >KSR1 | chr12:72149068 | chr17:25877594 | ENST00000268763 | + | 1 | 22 | 289_292 | -60 | 787 | Compositional bias | Note=Poly-Pro |
| Tgene | >KSR1 | chr12:72149068 | chr17:25877594 | ENST00000268763 | + | 1 | 22 | 613_883 | -60 | 787 | Domain | Protein kinase |
| Tgene | >KSR1 | chr12:72149068 | chr17:25877594 | ENST00000268763 | + | 1 | 22 | 1_172 | -60 | 787 | Region | Mediates association with membranes |
| Tgene | >KSR1 | chr12:72149068 | chr17:25877594 | ENST00000268763 | + | 1 | 22 | 347_391 | -60 | 787 | Zinc finger | Phorbol-ester/DAG-type |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >RAB21 | chr12:72149068 | chr17:25877594 | ENST00000261263 | + | 1 | 7 | 132_135 | 53 | 226 | Nucleotide binding | Note=GTP |
| Hgene | >RAB21 | chr12:72149068 | chr17:25877594 | ENST00000261263 | + | 1 | 7 | 162_164 | 53 | 226 | Nucleotide binding | Note=GTP |
| Hgene | >RAB21 | chr12:72149068 | chr17:25877594 | ENST00000261263 | + | 1 | 7 | 74_78 | 53 | 226 | Nucleotide binding | GTP |
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FusionGeneSequence for RAB21_KSR1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_RAB21_ENST00000261263_chr12_72149068_+_KSR1_ENST00000509603_chr17_25877594_+_853aa MAAAGGGGGGAAAAGRAYSFKVVLLGEGCVGKTSLVLRYCENKFNDKHITTLQAKLVRYICKQRQCKLSVAPGERTPELNSYPRFSDWLY TFNVRPEVVQEIPRDLTLDALLEMNEAKVKETLRRCGASGDECGRLQYALTCLRKVTGLGGEHKEDSSWSSLDARRESGSGPSTDTLSAA SLPWPPGSSQLGRAGNSAQGPRSISVSALPASDSPTPSFSEGLSDTCIPLHASGRLTPRALHSFITPPTTPQLRRHTKLKPPRTPPPPSR KVFQLLPSFPTLTRSKSHESQLGNRIDDVSSMRFDLSHGSPQMVRRDIGLSVTHRFSTKSWLSQVCHVCQKSMIFGVKCKHCRLKCHNKC TKEAPACRISFLPLTRLRRTESVPSDINNPVDRAAEPHFGTLPKALTKKEHPPAMNHLDSSSNPSSTTSSTPSSPAPFPTSSNPSSATTP PNPSPGQRDSRFNFPAAYFIHHRQQFIFPDISAFAHAAPLPEAADGTRLDDQPKADVLEAHEAEAEEPEAGKSEAEDDEDEVDDLPSSRR PWRGPISRKASQTSVYLQEWDIPFEQVELGEPIGQGRWGRVHRGRWHGEVAIRLLEMDGHNQDHLKLFKKEVMNYRQTRHENVVLFMGAC MNPPHLAIITSFCKGRTLHSFVRDPKTSLDINKTRQIAQEIIKGMGYLHAKGIVHKDLKSKNVFYDNGKVVITDFGLFGISGVVREGRRE NQLKLSHDWLCYLAPEIVREMTPGKDEDQLPFSKAADVYAFGTVWYELQARDWPLKNQAAEASIWQIGSGEGMKRVLTSVSLGKEVSEIL >In-frame_RAB21_ENST00000261263_chr12_72149068_+_KSR1_ENST00000319524_chr17_25877594_+_900aa MAAAGGGGGGAAAAGRAYSFKVVLLGEGCVGKTSLVLRYCENKFNDKHITTLQAKLVRYICKQRQCKLSVAPGERTPELNSYPRFSDWLY TFNVRPEVVQEIPRDLTLDALLEMNEAKVKETLRRCGASGDECGRLQYALTCLRKVTGLGGEHKEDSSWSSLDARRESGSGPSTDTLSAA SLPWPPGSSQLGRAGNSAQGPRSISVSALPASDSPTPSFSEGLSDTCIPLHASGRLTPRALHSFITPPTTPQLRRHTKLKPPRTPPPPSR KVFQLLPSFPTLTRSKSHESQLGNRIDDVSSMRFDLSHGSPQMVRRDIGLSVTHRFSTKSWLSQVCHVCQKSMIFGVKCKHCRLKCHNKC TKEAPACRISFLPLTRLRRTESVPSDINNPVDRAAEPHFGTLPKALTKKEHPPAMNHLDSSSNPSSTTSSTPSSPAPFPTSSNPSSATTP PNPSPGQRDSRFNFPAAYFIHHRQQFIFPVPSAGHCWKCLLIAESLKENAFNISAFAHAAPLPEAADGTRLDDQPKADVLEAHEAEAEEP EAGKSEAEDDEDEVDDLPSSRRPWRGPISRKASQTSVYLQEWDIPFEQVELGEPIGQGRWGRVHRGRWHGEVAIRLLEMDGHNQDHLKLF KKEVMNYRQTRHENVVLFMGACMNPPHLAIITSFCKGRTLHSFVRDPKTSLDINKTRQIAQEIIKGMGYLHAKGIVHKDLKSKNVFYDNG KVVITDFGLFGISGVVREGRRENQLKLSHDWLCYLAPEIVREMTPGKDEDQLPFSKAADVYAFGTVWYELQARDWPLKNQAAEASIWQIG SGEGMKRVLTSVSLGKEVSEILSACWAFDLQERPSFSLLMDMLEKLPKLNRRLSHPGHFWKSADINSSKVVPRFERFGLGVLESSNPKMX |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_RAB21_ENST00000261263_chr12_72149068_+_KSR1_ENST00000509603_chr17_25877594_+_2559nt ATGGCTGCGGCCGGCGGCGGCGGCGGCGGGGCGGCGGCGGCGGGCCGAGCCTACTCGTTCAAGGTGGTGCTGCTGGGGGAAGGCTGCGTG GGGAAGACGTCGCTGGTGCTGCGCTACTGCGAGAACAAGTTTAACGACAAGCACATCACCACTCTGCAGGCGAAGCTGGTCCGTTACATT TGTAAGCAGAGGCAGTGCAAGCTGAGCGTGGCTCCCGGTGAGAGGACCCCAGAGCTCAACAGCTACCCCCGCTTCAGCGACTGGCTGTAC ACTTTCAACGTGAGGCCGGAGGTGGTGCAGGAGATCCCCCGAGACCTCACGCTGGATGCCCTGCTGGAGATGAATGAGGCCAAGGTGAAG GAGACGCTGCGGCGCTGTGGGGCCAGCGGGGATGAGTGTGGCCGTCTGCAGTATGCCCTCACCTGCCTGCGGAAGGTGACAGGCCTGGGA GGGGAGCACAAGGAGGACTCCAGTTGGAGTTCATTGGATGCGCGGCGGGAAAGTGGCTCAGGGCCTTCCACGGACACCCTCTCAGCAGCC AGCCTGCCCTGGCCCCCAGGGAGCTCCCAGCTGGGCAGAGCAGGCAACAGCGCCCAGGGCCCACGCTCCATCTCCGTGTCAGCTCTGCCC GCCTCAGACTCCCCCACCCCCAGCTTCAGTGAGGGCCTCTCAGACACCTGTATTCCCCTGCACGCCAGCGGCCGGCTGACCCCCCGTGCC CTGCACAGCTTCATCACCCCGCCCACCACACCCCAGCTGCGACGGCACACCAAGCTGAAGCCACCACGGACGCCCCCCCCACCCAGCCGC AAGGTCTTCCAGCTGCTGCCCAGCTTCCCCACACTCACCCGGAGCAAGTCCCATGAGTCTCAGCTGGGGAACCGCATTGATGACGTCTCC TCGATGAGGTTTGATCTCTCGCATGGATCCCCACAGATGGTACGGAGGGATATCGGGCTGTCGGTGACGCACAGGTTCTCCACCAAGTCC TGGCTGTCGCAGGTCTGCCACGTGTGCCAGAAGAGCATGATATTTGGAGTGAAGTGCAAGCATTGCAGGTTGAAGTGTCACAACAAATGT ACCAAAGAAGCCCCTGCCTGTAGAATATCCTTCCTGCCACTAACTCGGCTTCGGAGGACAGAATCTGTCCCCTCGGACATCAACAACCCG GTGGACAGAGCAGCCGAACCCCATTTTGGAACCCTCCCCAAAGCACTGACAAAGAAGGAGCACCCTCCGGCCATGAATCACCTGGACTCC AGCAGCAACCCTTCCTCCACCACCTCCTCCACACCCTCCTCACCGGCGCCCTTCCCGACATCATCCAACCCATCCAGCGCCACCACGCCC CCCAACCCCTCACCTGGCCAGCGGGACAGCAGGTTCAACTTCCCAGCTGCCTACTTCATTCATCATAGACAGCAGTTTATCTTTCCAGAC ATTTCAGCCTTTGCACACGCAGCCCCGCTCCCTGAAGCTGCCGACGGTACCCGGCTCGATGACCAGCCGAAAGCAGATGTGTTGGAAGCT CACGAAGCGGAGGCTGAGGAGCCAGAGGCTGGCAAGTCAGAGGCAGAAGACGATGAGGACGAGGTGGACGACTTGCCGAGCTCTCGCCGG CCCTGGCGGGGCCCCATCTCTCGCAAGGCCAGCCAGACCAGCGTGTACCTGCAGGAGTGGGACATCCCCTTCGAGCAGGTAGAGCTGGGC GAGCCCATCGGGCAGGGCCGCTGGGGCCGGGTGCACCGCGGCCGCTGGCATGGCGAGGTGGCCATTCGCCTGCTGGAGATGGACGGCCAC AACCAGGACCACCTGAAGCTCTTCAAGAAAGAGGTGATGAACTACCGGCAGACGCGGCATGAGAACGTGGTGCTCTTCATGGGGGCCTGC ATGAACCCGCCCCACCTGGCCATTATCACCAGCTTCTGCAAGGGGCGGACGTTGCACTCGTTTGTGAGGGACCCCAAGACGTCTCTGGAC ATCAACAAGACGAGGCAAATCGCTCAGGAGATCATCAAGGGCATGGGATATCTTCATGCCAAGGGCATCGTACACAAAGATCTCAAATCT AAGAACGTCTTCTATGACAACGGCAAGGTGGTCATCACAGACTTCGGGCTGTTTGGGATCTCAGGCGTGGTCCGAGAGGGACGGCGTGAG AACCAGCTAAAGCTGTCCCACGACTGGCTGTGCTATCTGGCCCCTGAGATTGTACGCGAGATGACCCCCGGGAAGGACGAGGATCAGCTG CCATTCTCCAAAGCTGCTGATGTCTATGCATTTGGGACTGTTTGGTATGAGCTGCAAGCAAGAGACTGGCCCTTGAAGAACCAGGCTGCA GAGGCATCCATCTGGCAGATTGGAAGCGGGGAAGGAATGAAGCGTGTCCTGACTTCTGTCAGCTTGGGGAAGGAAGTCAGTGAGATCCTG TCGGCCTGCTGGGCTTTCGACCTGCAGGAGAGACCCAGCTTCAGCCTGCTGATGGACATGCTGGAGAAACTTCCCAAGCTGAACCGGCGG >In-frame_RAB21_ENST00000261263_chr12_72149068_+_KSR1_ENST00000319524_chr17_25877594_+_2700nt ATGGCTGCGGCCGGCGGCGGCGGCGGCGGGGCGGCGGCGGCGGGCCGAGCCTACTCGTTCAAGGTGGTGCTGCTGGGGGAAGGCTGCGTG GGGAAGACGTCGCTGGTGCTGCGCTACTGCGAGAACAAGTTTAACGACAAGCACATCACCACTCTGCAGGCGAAGCTGGTCCGTTACATT TGTAAGCAGAGGCAGTGCAAGCTGAGCGTGGCTCCCGGTGAGAGGACCCCAGAGCTCAACAGCTACCCCCGCTTCAGCGACTGGCTGTAC ACTTTCAACGTGAGGCCGGAGGTGGTGCAGGAGATCCCCCGAGACCTCACGCTGGATGCCCTGCTGGAGATGAATGAGGCCAAGGTGAAG GAGACGCTGCGGCGCTGTGGGGCCAGCGGGGATGAGTGTGGCCGTCTGCAGTATGCCCTCACCTGCCTGCGGAAGGTGACAGGCCTGGGA GGGGAGCACAAGGAGGACTCCAGTTGGAGTTCATTGGATGCGCGGCGGGAAAGTGGCTCAGGGCCTTCCACGGACACCCTCTCAGCAGCC AGCCTGCCCTGGCCCCCAGGGAGCTCCCAGCTGGGCAGAGCAGGCAACAGCGCCCAGGGCCCACGCTCCATCTCCGTGTCAGCTCTGCCC GCCTCAGACTCCCCCACCCCCAGCTTCAGTGAGGGCCTCTCAGACACCTGTATTCCCCTGCACGCCAGCGGCCGGCTGACCCCCCGTGCC CTGCACAGCTTCATCACCCCGCCCACCACACCCCAGCTGCGACGGCACACCAAGCTGAAGCCACCACGGACGCCCCCCCCACCCAGCCGC AAGGTCTTCCAGCTGCTGCCCAGCTTCCCCACACTCACCCGGAGCAAGTCCCATGAGTCTCAGCTGGGGAACCGCATTGATGACGTCTCC TCGATGAGGTTTGATCTCTCGCATGGATCCCCACAGATGGTACGGAGGGATATCGGGCTGTCGGTGACGCACAGGTTCTCCACCAAGTCC TGGCTGTCGCAGGTCTGCCACGTGTGCCAGAAGAGCATGATATTTGGAGTGAAGTGCAAGCATTGCAGGTTGAAGTGTCACAACAAATGT ACCAAAGAAGCCCCTGCCTGTAGAATATCCTTCCTGCCACTAACTCGGCTTCGGAGGACAGAATCTGTCCCCTCGGACATCAACAACCCG GTGGACAGAGCAGCCGAACCCCATTTTGGAACCCTCCCCAAAGCACTGACAAAGAAGGAGCACCCTCCGGCCATGAATCACCTGGACTCC AGCAGCAACCCTTCCTCCACCACCTCCTCCACACCCTCCTCACCGGCGCCCTTCCCGACATCATCCAACCCATCCAGCGCCACCACGCCC CCCAACCCCTCACCTGGCCAGCGGGACAGCAGGTTCAACTTCCCAGCTGCCTACTTCATTCATCATAGACAGCAGTTTATCTTTCCAGTG CCATCTGCTGGCCATTGCTGGAAATGCCTCCTTATTGCAGAAAGTTTAAAGGAAAACGCTTTCAACATTTCAGCCTTTGCACACGCAGCC CCGCTCCCTGAAGCTGCCGACGGTACCCGGCTCGATGACCAGCCGAAAGCAGATGTGTTGGAAGCTCACGAAGCGGAGGCTGAGGAGCCA GAGGCTGGCAAGTCAGAGGCAGAAGACGATGAGGACGAGGTGGACGACTTGCCGAGCTCTCGCCGGCCCTGGCGGGGCCCCATCTCTCGC AAGGCCAGCCAGACCAGCGTGTACCTGCAGGAGTGGGACATCCCCTTCGAGCAGGTAGAGCTGGGCGAGCCCATCGGGCAGGGCCGCTGG GGCCGGGTGCACCGCGGCCGCTGGCATGGCGAGGTGGCCATTCGCCTGCTGGAGATGGACGGCCACAACCAGGACCACCTGAAGCTCTTC AAGAAAGAGGTGATGAACTACCGGCAGACGCGGCATGAGAACGTGGTGCTCTTCATGGGGGCCTGCATGAACCCGCCCCACCTGGCCATT ATCACCAGCTTCTGCAAGGGGCGGACGTTGCACTCGTTTGTGAGGGACCCCAAGACGTCTCTGGACATCAACAAGACGAGGCAAATCGCT CAGGAGATCATCAAGGGCATGGGATATCTTCATGCCAAGGGCATCGTACACAAAGATCTCAAATCTAAGAACGTCTTCTATGACAACGGC AAGGTGGTCATCACAGACTTCGGGCTGTTTGGGATCTCAGGCGTGGTCCGAGAGGGACGGCGTGAGAACCAGCTAAAGCTGTCCCACGAC TGGCTGTGCTATCTGGCCCCTGAGATTGTACGCGAGATGACCCCCGGGAAGGACGAGGATCAGCTGCCATTCTCCAAAGCTGCTGATGTC TATGCATTTGGGACTGTTTGGTATGAGCTGCAAGCAAGAGACTGGCCCTTGAAGAACCAGGCTGCAGAGGCATCCATCTGGCAGATTGGA AGCGGGGAAGGAATGAAGCGTGTCCTGACTTCTGTCAGCTTGGGGAAGGAAGTCAGTGAGATCCTGTCGGCCTGCTGGGCTTTCGACCTG CAGGAGAGACCCAGCTTCAGCCTGCTGATGGACATGCTGGAGAAACTTCCCAAGCTGAACCGGCGGCTCTCCCACCCTGGACACTTCTGG AAGTCAGCTGACATTAACAGCAGCAAAGTTGTACCCCGGTTTGAAAGGTTTGGCTTGGGCGTCCTGGAGTCCAGTAATCCAAAGATGTAG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_RAB21_ENST00000261263_chr12_72149068_+_KSR1_ENST00000509603_chr17_25877594_+_2815nt GAGACGCCATTAGAGGGAGGCAGAGAGGGATCGTTCTTCGCTTTTCCTCCGGTGCCTGACGTGGTGGGCTGGGGCCCTTCATTCTCGGAC TTTCCCTCAGCCCTTCCAGGCCTCGCCCGAGGAGGGCGTGGGGACAGCGCCCGGGTCGGCGGGGCCGGGGCGGTGGGGGCTGAGCCGGCC GTGGCTGTGAAGGCGCTGCCGCGGCTGTCGGGAGGGCGGCGCGACACTCGGGCTCGGGCGGCCGGGAAGCGACGGGATGGCTGCGGCCGG CGGCGGCGGCGGCGGGGCGGCGGCGGCGGGCCGAGCCTACTCGTTCAAGGTGGTGCTGCTGGGGGAAGGCTGCGTGGGGAAGACGTCGCT GGTGCTGCGCTACTGCGAGAACAAGTTTAACGACAAGCACATCACCACTCTGCAGGCGAAGCTGGTCCGTTACATTTGTAAGCAGAGGCA GTGCAAGCTGAGCGTGGCTCCCGGTGAGAGGACCCCAGAGCTCAACAGCTACCCCCGCTTCAGCGACTGGCTGTACACTTTCAACGTGAG GCCGGAGGTGGTGCAGGAGATCCCCCGAGACCTCACGCTGGATGCCCTGCTGGAGATGAATGAGGCCAAGGTGAAGGAGACGCTGCGGCG CTGTGGGGCCAGCGGGGATGAGTGTGGCCGTCTGCAGTATGCCCTCACCTGCCTGCGGAAGGTGACAGGCCTGGGAGGGGAGCACAAGGA GGACTCCAGTTGGAGTTCATTGGATGCGCGGCGGGAAAGTGGCTCAGGGCCTTCCACGGACACCCTCTCAGCAGCCAGCCTGCCCTGGCC CCCAGGGAGCTCCCAGCTGGGCAGAGCAGGCAACAGCGCCCAGGGCCCACGCTCCATCTCCGTGTCAGCTCTGCCCGCCTCAGACTCCCC CACCCCCAGCTTCAGTGAGGGCCTCTCAGACACCTGTATTCCCCTGCACGCCAGCGGCCGGCTGACCCCCCGTGCCCTGCACAGCTTCAT CACCCCGCCCACCACACCCCAGCTGCGACGGCACACCAAGCTGAAGCCACCACGGACGCCCCCCCCACCCAGCCGCAAGGTCTTCCAGCT GCTGCCCAGCTTCCCCACACTCACCCGGAGCAAGTCCCATGAGTCTCAGCTGGGGAACCGCATTGATGACGTCTCCTCGATGAGGTTTGA TCTCTCGCATGGATCCCCACAGATGGTACGGAGGGATATCGGGCTGTCGGTGACGCACAGGTTCTCCACCAAGTCCTGGCTGTCGCAGGT CTGCCACGTGTGCCAGAAGAGCATGATATTTGGAGTGAAGTGCAAGCATTGCAGGTTGAAGTGTCACAACAAATGTACCAAAGAAGCCCC TGCCTGTAGAATATCCTTCCTGCCACTAACTCGGCTTCGGAGGACAGAATCTGTCCCCTCGGACATCAACAACCCGGTGGACAGAGCAGC CGAACCCCATTTTGGAACCCTCCCCAAAGCACTGACAAAGAAGGAGCACCCTCCGGCCATGAATCACCTGGACTCCAGCAGCAACCCTTC CTCCACCACCTCCTCCACACCCTCCTCACCGGCGCCCTTCCCGACATCATCCAACCCATCCAGCGCCACCACGCCCCCCAACCCCTCACC TGGCCAGCGGGACAGCAGGTTCAACTTCCCAGCTGCCTACTTCATTCATCATAGACAGCAGTTTATCTTTCCAGACATTTCAGCCTTTGC ACACGCAGCCCCGCTCCCTGAAGCTGCCGACGGTACCCGGCTCGATGACCAGCCGAAAGCAGATGTGTTGGAAGCTCACGAAGCGGAGGC TGAGGAGCCAGAGGCTGGCAAGTCAGAGGCAGAAGACGATGAGGACGAGGTGGACGACTTGCCGAGCTCTCGCCGGCCCTGGCGGGGCCC CATCTCTCGCAAGGCCAGCCAGACCAGCGTGTACCTGCAGGAGTGGGACATCCCCTTCGAGCAGGTAGAGCTGGGCGAGCCCATCGGGCA GGGCCGCTGGGGCCGGGTGCACCGCGGCCGCTGGCATGGCGAGGTGGCCATTCGCCTGCTGGAGATGGACGGCCACAACCAGGACCACCT GAAGCTCTTCAAGAAAGAGGTGATGAACTACCGGCAGACGCGGCATGAGAACGTGGTGCTCTTCATGGGGGCCTGCATGAACCCGCCCCA CCTGGCCATTATCACCAGCTTCTGCAAGGGGCGGACGTTGCACTCGTTTGTGAGGGACCCCAAGACGTCTCTGGACATCAACAAGACGAG GCAAATCGCTCAGGAGATCATCAAGGGCATGGGATATCTTCATGCCAAGGGCATCGTACACAAAGATCTCAAATCTAAGAACGTCTTCTA TGACAACGGCAAGGTGGTCATCACAGACTTCGGGCTGTTTGGGATCTCAGGCGTGGTCCGAGAGGGACGGCGTGAGAACCAGCTAAAGCT GTCCCACGACTGGCTGTGCTATCTGGCCCCTGAGATTGTACGCGAGATGACCCCCGGGAAGGACGAGGATCAGCTGCCATTCTCCAAAGC TGCTGATGTCTATGCATTTGGGACTGTTTGGTATGAGCTGCAAGCAAGAGACTGGCCCTTGAAGAACCAGGCTGCAGAGGCATCCATCTG GCAGATTGGAAGCGGGGAAGGAATGAAGCGTGTCCTGACTTCTGTCAGCTTGGGGAAGGAAGTCAGTGAGATCCTGTCGGCCTGCTGGGC TTTCGACCTGCAGGAGAGACCCAGCTTCAGCCTGCTGATGGACATGCTGGAGAAACTTCCCAAGCTGAACCGGCGGCTCTCCCACCCTGG >In-frame_RAB21_ENST00000261263_chr12_72149068_+_KSR1_ENST00000319524_chr17_25877594_+_3255nt GAGACGCCATTAGAGGGAGGCAGAGAGGGATCGTTCTTCGCTTTTCCTCCGGTGCCTGACGTGGTGGGCTGGGGCCCTTCATTCTCGGAC TTTCCCTCAGCCCTTCCAGGCCTCGCCCGAGGAGGGCGTGGGGACAGCGCCCGGGTCGGCGGGGCCGGGGCGGTGGGGGCTGAGCCGGCC GTGGCTGTGAAGGCGCTGCCGCGGCTGTCGGGAGGGCGGCGCGACACTCGGGCTCGGGCGGCCGGGAAGCGACGGGATGGCTGCGGCCGG CGGCGGCGGCGGCGGGGCGGCGGCGGCGGGCCGAGCCTACTCGTTCAAGGTGGTGCTGCTGGGGGAAGGCTGCGTGGGGAAGACGTCGCT GGTGCTGCGCTACTGCGAGAACAAGTTTAACGACAAGCACATCACCACTCTGCAGGCGAAGCTGGTCCGTTACATTTGTAAGCAGAGGCA GTGCAAGCTGAGCGTGGCTCCCGGTGAGAGGACCCCAGAGCTCAACAGCTACCCCCGCTTCAGCGACTGGCTGTACACTTTCAACGTGAG GCCGGAGGTGGTGCAGGAGATCCCCCGAGACCTCACGCTGGATGCCCTGCTGGAGATGAATGAGGCCAAGGTGAAGGAGACGCTGCGGCG CTGTGGGGCCAGCGGGGATGAGTGTGGCCGTCTGCAGTATGCCCTCACCTGCCTGCGGAAGGTGACAGGCCTGGGAGGGGAGCACAAGGA GGACTCCAGTTGGAGTTCATTGGATGCGCGGCGGGAAAGTGGCTCAGGGCCTTCCACGGACACCCTCTCAGCAGCCAGCCTGCCCTGGCC CCCAGGGAGCTCCCAGCTGGGCAGAGCAGGCAACAGCGCCCAGGGCCCACGCTCCATCTCCGTGTCAGCTCTGCCCGCCTCAGACTCCCC CACCCCCAGCTTCAGTGAGGGCCTCTCAGACACCTGTATTCCCCTGCACGCCAGCGGCCGGCTGACCCCCCGTGCCCTGCACAGCTTCAT CACCCCGCCCACCACACCCCAGCTGCGACGGCACACCAAGCTGAAGCCACCACGGACGCCCCCCCCACCCAGCCGCAAGGTCTTCCAGCT GCTGCCCAGCTTCCCCACACTCACCCGGAGCAAGTCCCATGAGTCTCAGCTGGGGAACCGCATTGATGACGTCTCCTCGATGAGGTTTGA TCTCTCGCATGGATCCCCACAGATGGTACGGAGGGATATCGGGCTGTCGGTGACGCACAGGTTCTCCACCAAGTCCTGGCTGTCGCAGGT CTGCCACGTGTGCCAGAAGAGCATGATATTTGGAGTGAAGTGCAAGCATTGCAGGTTGAAGTGTCACAACAAATGTACCAAAGAAGCCCC TGCCTGTAGAATATCCTTCCTGCCACTAACTCGGCTTCGGAGGACAGAATCTGTCCCCTCGGACATCAACAACCCGGTGGACAGAGCAGC CGAACCCCATTTTGGAACCCTCCCCAAAGCACTGACAAAGAAGGAGCACCCTCCGGCCATGAATCACCTGGACTCCAGCAGCAACCCTTC CTCCACCACCTCCTCCACACCCTCCTCACCGGCGCCCTTCCCGACATCATCCAACCCATCCAGCGCCACCACGCCCCCCAACCCCTCACC TGGCCAGCGGGACAGCAGGTTCAACTTCCCAGCTGCCTACTTCATTCATCATAGACAGCAGTTTATCTTTCCAGTGCCATCTGCTGGCCA TTGCTGGAAATGCCTCCTTATTGCAGAAAGTTTAAAGGAAAACGCTTTCAACATTTCAGCCTTTGCACACGCAGCCCCGCTCCCTGAAGC TGCCGACGGTACCCGGCTCGATGACCAGCCGAAAGCAGATGTGTTGGAAGCTCACGAAGCGGAGGCTGAGGAGCCAGAGGCTGGCAAGTC AGAGGCAGAAGACGATGAGGACGAGGTGGACGACTTGCCGAGCTCTCGCCGGCCCTGGCGGGGCCCCATCTCTCGCAAGGCCAGCCAGAC CAGCGTGTACCTGCAGGAGTGGGACATCCCCTTCGAGCAGGTAGAGCTGGGCGAGCCCATCGGGCAGGGCCGCTGGGGCCGGGTGCACCG CGGCCGCTGGCATGGCGAGGTGGCCATTCGCCTGCTGGAGATGGACGGCCACAACCAGGACCACCTGAAGCTCTTCAAGAAAGAGGTGAT GAACTACCGGCAGACGCGGCATGAGAACGTGGTGCTCTTCATGGGGGCCTGCATGAACCCGCCCCACCTGGCCATTATCACCAGCTTCTG CAAGGGGCGGACGTTGCACTCGTTTGTGAGGGACCCCAAGACGTCTCTGGACATCAACAAGACGAGGCAAATCGCTCAGGAGATCATCAA GGGCATGGGATATCTTCATGCCAAGGGCATCGTACACAAAGATCTCAAATCTAAGAACGTCTTCTATGACAACGGCAAGGTGGTCATCAC AGACTTCGGGCTGTTTGGGATCTCAGGCGTGGTCCGAGAGGGACGGCGTGAGAACCAGCTAAAGCTGTCCCACGACTGGCTGTGCTATCT GGCCCCTGAGATTGTACGCGAGATGACCCCCGGGAAGGACGAGGATCAGCTGCCATTCTCCAAAGCTGCTGATGTCTATGCATTTGGGAC TGTTTGGTATGAGCTGCAAGCAAGAGACTGGCCCTTGAAGAACCAGGCTGCAGAGGCATCCATCTGGCAGATTGGAAGCGGGGAAGGAAT GAAGCGTGTCCTGACTTCTGTCAGCTTGGGGAAGGAAGTCAGTGAGATCCTGTCGGCCTGCTGGGCTTTCGACCTGCAGGAGAGACCCAG CTTCAGCCTGCTGATGGACATGCTGGAGAAACTTCCCAAGCTGAACCGGCGGCTCTCCCACCCTGGACACTTCTGGAAGTCAGCTGACAT TAACAGCAGCAAAGTTGTACCCCGGTTTGAAAGGTTTGGCTTGGGCGTCCTGGAGTCCAGTAATCCAAAGATGTAGCCAGCCATATGGTT TTTCGCTGCTGATCTCTTTCTTTTTAAAATGTGTTTCTGAAACATCCCAACAACCACCACGACAAAAAAACACTGCCTGCCCAGCGCTGC AAACCAGGAGCACACGTCCTAGATTCAGACTGTTGGCCATAAACCCCACTCGGGAGATGGAGCTGCACCTGCTATTTCTTAAAATGACAC CACCAACAACCAAACCTGTCATGACAGACAGCAAATGTTTACACGTATATTTCTCCTGAGTGAACCTGATGTTTTACAATAGGTAATAAT |
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FusionGenePPI for RAB21_KSR1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| RAB21 | ELAVL1, RABGEF1, LAMTOR3, HNRNPF, APPL1, CUL7, VSIG2, MCM2, GDI1, SLC22A16, FANCE, RAB2B, VAC14, VIPR2, DPAGT1, C16orf58, P2RX1, FUCA2, HCCS, GBA, SDHA, SOD1, TRIM25 | KSR1 | MAP2K1, BRAF, BRAP, KSR1, MARK3, RAF1, LSP1, HSP90AA1, YWHAE, YWHAB, SDF4, SKAP1, PRMT2, XPO1, VPRBP, NF2, PJA2, KCTD3, KIF13B, ZBTB21, GIGYF1, CGN, LRFN1, DENND1A, SH3PXD2A, RTKN, DENND4C, MAST3, SRGAP2, EIF4E2, SIPA1L1, PPM1H, LPIN3, LIMA1, MAGI1, TESK2, DCLK1, ZNF638, MAPKAP1, NF1, HDAC4, CBY1, SH3RF3, SRSF12, CDC25C, SYDE1, AGAP1, NADK, GIGYF2, CDC25B, CDK16, TANC2, CAMSAP2, PTPN13, RALGPS2, FAM110B, USP21, KIAA1804, RASAL2, TIAM1, ANKRD34A, FAM53C, PHLDB2, RPTOR, PLEKHA7, OSBPL6, KIF1C, MELK, NAV1, DENND4A, FAM110A, GAB2, STARD13, PTPN14, DEPDC1B, HDAC7, CWC25, INPP5E, LARP1, RAB11FIP2, PLEKHA5, MTFR1L, MLLT4, CHEK1, KIF1B, CSNK1A1, TBC1D25, EDC3, HDAC5, TBC1D1, DACT3, PANK2, REEP3, CRTC2, CRTC3, MICALL1, SH3BP4, BAIAP2, FGD6 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for RAB21_KSR1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for RAB21_KSR1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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