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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 29928

FusionGeneSummary for RAB20_MYO16

check button Fusion gene summary
Fusion gene informationFusion gene name: RAB20_MYO16
Fusion gene ID: 29928
HgeneTgene
Gene symbol

RAB20

MYO16

Gene ID

55647

23026

Gene nameRAB20, member RAS oncogene familymyosin XVI
Synonyms-MYAP3|MYR8|Myo16b|NYAP3|PPP1R107
Cytomap

13q34

13q33.3

Type of geneprotein-codingprotein-coding
Descriptionras-related protein Rab-20unconventional myosin-XVIMYO16 variant proteinmyosin heavy chain Myr 8neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 3neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 3protein phosphatase 1, regulatory subunit 10
Modification date2018052320180519
UniProtAcc

Q9NX57

Q9Y6X6

Ensembl transtripts involved in fusion geneENST00000267328, ENST00000356711, 
ENST00000251041, ENST00000357550, 
ENST00000457511, ENST00000467639, 
Fusion gene scores* DoF score1 X 1 X 1=110 X 8 X 9=720
# samples 110
** MAII scorelog2(1/1*10)=3.32192809488736log2(10/720*10)=-2.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RAB20 [Title/Abstract] AND MYO16 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDSTADTCGA-D7-6518-01ARAB20chr13

111213695

-MYO16chr13

109610036

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000267328ENST00000356711RAB20chr13

111213695

-MYO16chr13

109610036

+
Frame-shitENST00000267328ENST00000251041RAB20chr13

111213695

-MYO16chr13

109610036

+
Frame-shitENST00000267328ENST00000357550RAB20chr13

111213695

-MYO16chr13

109610036

+
Frame-shitENST00000267328ENST00000457511RAB20chr13

111213695

-MYO16chr13

109610036

+
5CDS-intronENST00000267328ENST00000467639RAB20chr13

111213695

-MYO16chr13

109610036

+

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FusionProtFeatures for RAB20_MYO16


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RAB20

Q9NX57

MYO16

Q9Y6X6

Plays a role in apical endocytosis/recycling. Plays arole in the maturation and acidification of phagosomes that engulfpathogens, such as S.aureus and M.tuberculosis. Plays a role inthe fusion of phagosomes with lysosomes.{ECO:0000269|PubMed:21255211}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for RAB20_MYO16


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for RAB20_MYO16


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
RAB20NXF1MYO16NRXN1, NCKAP1, CYFIP2, CYFIP1, PIK3R1, ARHGAP26, ACOT9


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for RAB20_MYO16


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for RAB20_MYO16


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneMYO16C0036341Schizophrenia1PSYGENET