FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 2988

FusionGeneSummary for ASH2L_ZFYVE28

check button Fusion gene summary
Fusion gene informationFusion gene name: ASH2L_ZFYVE28
Fusion gene ID: 2988
HgeneTgene
Gene symbol

ASH2L

ZFYVE28

Gene ID

9070

57732

Gene nameASH2 like, histone lysine methyltransferase complex subunitzinc finger FYVE-type containing 28
SynonymsASH2|ASH2L1|ASH2L2|Bre2LST2|LYST2
Cytomap

8p11.23

4p16.3

Type of geneprotein-codingprotein-coding
Descriptionset1/Ash2 histone methyltransferase complex subunit ASH2ASH2-like proteinash2 (absent, small, or homeotic)-likelateral signaling target protein 2 homologhLst2zinc finger FYVE domain-containing protein 28zinc finger, FYVE domain containing 28
Modification date2018052320180523
UniProtAcc

Q9UBL3

Q9HCC9

Ensembl transtripts involved in fusion geneENST00000343823, ENST00000250635, 
ENST00000545394, ENST00000428278, 
ENST00000521652, ENST00000524263, 
ENST00000290974, ENST00000511071, 
ENST00000515312, ENST00000515169, 
ENST00000509171, ENST00000503000, 
ENST00000508471, ENST00000505421, 
Fusion gene scores* DoF score8 X 6 X 5=2408 X 6 X 7=336
# samples 88
** MAII scorelog2(8/240*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/336*10)=-2.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ASH2L [Title/Abstract] AND ZFYVE28 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneASH2L

GO:0006974

cellular response to DNA damage stimulus

17500065

HgeneASH2L

GO:0043627

response to estrogen

16603732

HgeneASH2L

GO:0051568

histone H3-K4 methylation

17355966|19556245


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-LL-A7T0-01AASH2Lchr8

37976881

+ZFYVE28chr4

2343342

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000343823ENST00000290974ASH2Lchr8

37976881

+ZFYVE28chr4

2343342

-
Frame-shiftENST00000343823ENST00000511071ASH2Lchr8

37976881

+ZFYVE28chr4

2343342

-
5CDS-5UTRENST00000343823ENST00000515312ASH2Lchr8

37976881

+ZFYVE28chr4

2343342

-
5CDS-5UTRENST00000343823ENST00000515169ASH2Lchr8

37976881

+ZFYVE28chr4

2343342

-
5CDS-5UTRENST00000343823ENST00000509171ASH2Lchr8

37976881

+ZFYVE28chr4

2343342

-
5CDS-5UTRENST00000343823ENST00000503000ASH2Lchr8

37976881

+ZFYVE28chr4

2343342

-
5CDS-intronENST00000343823ENST00000508471ASH2Lchr8

37976881

+ZFYVE28chr4

2343342

-
5CDS-intronENST00000343823ENST00000505421ASH2Lchr8

37976881

+ZFYVE28chr4

2343342

-
Frame-shiftENST00000250635ENST00000290974ASH2Lchr8

37976881

+ZFYVE28chr4

2343342

-
Frame-shiftENST00000250635ENST00000511071ASH2Lchr8

37976881

+ZFYVE28chr4

2343342

-
5CDS-5UTRENST00000250635ENST00000515312ASH2Lchr8

37976881

+ZFYVE28chr4

2343342

-
5CDS-5UTRENST00000250635ENST00000515169ASH2Lchr8

37976881

+ZFYVE28chr4

2343342

-
5CDS-5UTRENST00000250635ENST00000509171ASH2Lchr8

37976881

+ZFYVE28chr4

2343342

-
5CDS-5UTRENST00000250635ENST00000503000ASH2Lchr8

37976881

+ZFYVE28chr4

2343342

-
5CDS-intronENST00000250635ENST00000508471ASH2Lchr8

37976881

+ZFYVE28chr4

2343342

-
5CDS-intronENST00000250635ENST00000505421ASH2Lchr8

37976881

+ZFYVE28chr4

2343342

-
Frame-shiftENST00000545394ENST00000290974ASH2Lchr8

37976881

+ZFYVE28chr4

2343342

-
Frame-shiftENST00000545394ENST00000511071ASH2Lchr8

37976881

+ZFYVE28chr4

2343342

-
5CDS-5UTRENST00000545394ENST00000515312ASH2Lchr8

37976881

+ZFYVE28chr4

2343342

-
5CDS-5UTRENST00000545394ENST00000515169ASH2Lchr8

37976881

+ZFYVE28chr4

2343342

-
5CDS-5UTRENST00000545394ENST00000509171ASH2Lchr8

37976881

+ZFYVE28chr4

2343342

-
5CDS-5UTRENST00000545394ENST00000503000ASH2Lchr8

37976881

+ZFYVE28chr4

2343342

-
5CDS-intronENST00000545394ENST00000508471ASH2Lchr8

37976881

+ZFYVE28chr4

2343342

-
5CDS-intronENST00000545394ENST00000505421ASH2Lchr8

37976881

+ZFYVE28chr4

2343342

-
Frame-shiftENST00000428278ENST00000290974ASH2Lchr8

37976881

+ZFYVE28chr4

2343342

-
Frame-shiftENST00000428278ENST00000511071ASH2Lchr8

37976881

+ZFYVE28chr4

2343342

-
5CDS-5UTRENST00000428278ENST00000515312ASH2Lchr8

37976881

+ZFYVE28chr4

2343342

-
5CDS-5UTRENST00000428278ENST00000515169ASH2Lchr8

37976881

+ZFYVE28chr4

2343342

-
5CDS-5UTRENST00000428278ENST00000509171ASH2Lchr8

37976881

+ZFYVE28chr4

2343342

-
5CDS-5UTRENST00000428278ENST00000503000ASH2Lchr8

37976881

+ZFYVE28chr4

2343342

-
5CDS-intronENST00000428278ENST00000508471ASH2Lchr8

37976881

+ZFYVE28chr4

2343342

-
5CDS-intronENST00000428278ENST00000505421ASH2Lchr8

37976881

+ZFYVE28chr4

2343342

-
Frame-shiftENST00000521652ENST00000290974ASH2Lchr8

37976881

+ZFYVE28chr4

2343342

-
Frame-shiftENST00000521652ENST00000511071ASH2Lchr8

37976881

+ZFYVE28chr4

2343342

-
5CDS-5UTRENST00000521652ENST00000515312ASH2Lchr8

37976881

+ZFYVE28chr4

2343342

-
5CDS-5UTRENST00000521652ENST00000515169ASH2Lchr8

37976881

+ZFYVE28chr4

2343342

-
5CDS-5UTRENST00000521652ENST00000509171ASH2Lchr8

37976881

+ZFYVE28chr4

2343342

-
5CDS-5UTRENST00000521652ENST00000503000ASH2Lchr8

37976881

+ZFYVE28chr4

2343342

-
5CDS-intronENST00000521652ENST00000508471ASH2Lchr8

37976881

+ZFYVE28chr4

2343342

-
5CDS-intronENST00000521652ENST00000505421ASH2Lchr8

37976881

+ZFYVE28chr4

2343342

-
intron-3CDSENST00000524263ENST00000290974ASH2Lchr8

37976881

+ZFYVE28chr4

2343342

-
intron-3CDSENST00000524263ENST00000511071ASH2Lchr8

37976881

+ZFYVE28chr4

2343342

-
intron-5UTRENST00000524263ENST00000515312ASH2Lchr8

37976881

+ZFYVE28chr4

2343342

-
intron-5UTRENST00000524263ENST00000515169ASH2Lchr8

37976881

+ZFYVE28chr4

2343342

-
intron-5UTRENST00000524263ENST00000509171ASH2Lchr8

37976881

+ZFYVE28chr4

2343342

-
intron-5UTRENST00000524263ENST00000503000ASH2Lchr8

37976881

+ZFYVE28chr4

2343342

-
intron-intronENST00000524263ENST00000508471ASH2Lchr8

37976881

+ZFYVE28chr4

2343342

-
intron-intronENST00000524263ENST00000505421ASH2Lchr8

37976881

+ZFYVE28chr4

2343342

-

Top

FusionProtFeatures for ASH2L_ZFYVE28


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ASH2L

Q9UBL3

ZFYVE28

Q9HCC9

Component of the Set1/Ash2 histone methyltransferase(HMT) complex, a complex that specifically methylates 'Lys-4' ofhistone H3, but not if the neighboring 'Lys-9' residue is alreadymethylated. As part of the MLL1/MLL complex it is involved inmethylation and dimethylation at 'Lys-4' of histone H3. Mayfunction as a transcriptional regulator. May play a role inhematopoiesis. {ECO:0000269|PubMed:12670868,ECO:0000269|PubMed:19556245}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for ASH2L_ZFYVE28


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for ASH2L_ZFYVE28


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ASH2LDPY30, KMT2A, ASH2L, MEN1, RBBP5, WDR5, HCFC1, HCFC2, KMT2C, HIST3H3, UNC119, CXXC1, SETD1A, WDR82P1, KDM6A, PHF8, MYB, CHD8, CTNNB1, ZNF335, CCAR2, C11orf30, NCOA6, ZSCAN1, HIST1H3A, SRRM1, PAX7, MEF2D, SETD1B, PAXIP1, KMT2D, USF1, PAGR1, KMT2B, E2F1, E2F4, PRMT1, WDR82, PSMC5, PYGO2, CDC73, ESR1, KDM4B, BARD1, BRCA1, PPP1CC, KDM6B, SMAD9, WWP1, SENP3, PPARG, PKN1, EP300, TP53, MICU2, XPO1, FOXQ1, DNMT3L, CHD7, KMT2E, CCDC69, EPB41L5, FOXA1ZFYVE28EGF, RAB5A, RAB4A, RAB7A, EGFR, PRNP


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for ASH2L_ZFYVE28


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for ASH2L_ZFYVE28


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource