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Fusion gene ID: 29869 |
FusionGeneSummary for RAB10_SDC1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: RAB10_SDC1 | Fusion gene ID: 29869 | Hgene | Tgene | Gene symbol | RAB10 | SDC1 | Gene ID | 10890 | 6382 |
| Gene name | RAB10, member RAS oncogene family | syndecan 1 | |
| Synonyms | - | CD138|SDC|SYND1|syndecan | |
| Cytomap | 2p23.3 | 2p24.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | ras-related protein Rab-10GTP-binding protein RAB10ras-related GTP-binding protein | syndecan-1CD138 antigenheparan sulfate proteoglycan fibroblast growth factor receptorsyndecan proteoglycan 1 | |
| Modification date | 20180523 | 20180527 | |
| UniProtAcc | P61026 | P18827 | |
| Ensembl transtripts involved in fusion gene | ENST00000264710, ENST00000462003, | ENST00000254351, ENST00000381150, ENST00000403076, ENST00000482879, | |
| Fusion gene scores | * DoF score | 4 X 3 X 2=24 | 4 X 3 X 2=24 |
| # samples | 3 | 4 | |
| ** MAII score | log2(3/24*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(4/24*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: RAB10 [Title/Abstract] AND SDC1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Oncogene involved fusion gene, in-frame and retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BRCA | TCGA-BH-A5J0-01A | RAB10 | chr2 | 26350820 | + | SDC1 | chr2 | 20405185 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000264710 | ENST00000254351 | RAB10 | chr2 | 26350820 | + | SDC1 | chr2 | 20405185 | - |
| In-frame | ENST00000264710 | ENST00000381150 | RAB10 | chr2 | 26350820 | + | SDC1 | chr2 | 20405185 | - |
| In-frame | ENST00000264710 | ENST00000403076 | RAB10 | chr2 | 26350820 | + | SDC1 | chr2 | 20405185 | - |
| 5CDS-5UTR | ENST00000264710 | ENST00000482879 | RAB10 | chr2 | 26350820 | + | SDC1 | chr2 | 20405185 | - |
| 3UTR-3CDS | ENST00000462003 | ENST00000254351 | RAB10 | chr2 | 26350820 | + | SDC1 | chr2 | 20405185 | - |
| 3UTR-3CDS | ENST00000462003 | ENST00000381150 | RAB10 | chr2 | 26350820 | + | SDC1 | chr2 | 20405185 | - |
| 3UTR-3CDS | ENST00000462003 | ENST00000403076 | RAB10 | chr2 | 26350820 | + | SDC1 | chr2 | 20405185 | - |
| 3UTR-5UTR | ENST00000462003 | ENST00000482879 | RAB10 | chr2 | 26350820 | + | SDC1 | chr2 | 20405185 | - |
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FusionProtFeatures for RAB10_SDC1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| RAB10 | SDC1 |
| The small GTPases Rab are key regulators ofintracellular membrane trafficking, from the formation oftransport vesicles to their fusion with membranes. Rabs cyclebetween an inactive GDP-bound form and an active GTP-bound formthat is able to recruit to membranes different set of downstreameffectors directly responsible for vesicle formation, movement,tethering and fusion (By similarity). That Rab is mainly involvedin the biosynthetic transport of proteins from the Golgi to theplasma membrane. Regulates, for instance, SLC2A4/GLUT4 glucosetransporter-enriched vesicles delivery to the plasma membrane. Inparallel, it regulates the transport of TLR4, a toll-like receptorto the plasma membrane and therefore may be important for innateimmune response. Plays also a specific role in asymmetric proteintransport to the plasma membrane within the polarized neuron andepithelial cells. In neurons, it is involved in axonogenesisthrough regulation of vesicular membrane trafficking toward theaxonal plasma membrane while in epithelial cells, it regulatestransport from the Golgi to the basolateral membrane. Moreover,may play a role in the basolateral recycling pathway and inphagosome maturation. According to PubMed:23263280, may play arole in endoplasmic reticulum dynamics and morphology controllingtubulation along microtubules and tubules fusion. {ECO:0000250,ECO:0000269|PubMed:16641372, ECO:0000269|PubMed:21248164,ECO:0000269|PubMed:23263280}. | Cell surface proteoglycan that bears both heparansulfate and chondroitin sulfate and that links the cytoskeleton tothe interstitial matrix. Regulates exosome biogenesis in concertwith SDCBP and PDCD6IP (PubMed:22660413).{ECO:0000269|PubMed:22660413}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | RAB10 | chr2:26350820 | chr2:20405185 | ENST00000264710 | + | 5 | 6 | 38_46 | 173 | 201 | Motif | Effector region |
| Hgene | RAB10 | chr2:26350820 | chr2:20405185 | ENST00000264710 | + | 5 | 6 | 122_125 | 173 | 201 | Nucleotide binding | GTP |
| Hgene | RAB10 | chr2:26350820 | chr2:20405185 | ENST00000264710 | + | 5 | 6 | 152_154 | 173 | 201 | Nucleotide binding | GTP |
| Hgene | RAB10 | chr2:26350820 | chr2:20405185 | ENST00000264710 | + | 5 | 6 | 18_24 | 173 | 201 | Nucleotide binding | GTP |
| Hgene | RAB10 | chr2:26350820 | chr2:20405185 | ENST00000264710 | + | 5 | 6 | 35_41 | 173 | 201 | Nucleotide binding | GTP |
| Hgene | RAB10 | chr2:26350820 | chr2:20405185 | ENST00000264710 | + | 5 | 6 | 64_68 | 173 | 201 | Nucleotide binding | GTP |
| Tgene | >SDC1 | chr2:26350820 | chr2:20405185 | ENST00000254351 | - | 0 | 5 | 23_254 | 22 | 311 | Topological domain | Extracellular |
| Tgene | >SDC1 | chr2:26350820 | chr2:20405185 | ENST00000254351 | - | 0 | 5 | 276_310 | 22 | 311 | Topological domain | Cytoplasmic |
| Tgene | >SDC1 | chr2:26350820 | chr2:20405185 | ENST00000381150 | - | 1 | 6 | 23_254 | 22 | 311 | Topological domain | Extracellular |
| Tgene | >SDC1 | chr2:26350820 | chr2:20405185 | ENST00000381150 | - | 1 | 6 | 276_310 | 22 | 311 | Topological domain | Cytoplasmic |
| Tgene | >SDC1 | chr2:26350820 | chr2:20405185 | ENST00000254351 | - | 0 | 5 | 255_275 | 22 | 311 | Transmembrane | Helical |
| Tgene | >SDC1 | chr2:26350820 | chr2:20405185 | ENST00000381150 | - | 1 | 6 | 255_275 | 22 | 311 | Transmembrane | Helical |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for RAB10_SDC1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_RAB10_ENST00000264710_chr2_26350820_+_SDC1_ENST00000254351_chr2_20405185_-_462aa MAKKTYDLLFKLLLIGDSGVGKTCVLFRFSDDAFNTTFISTIGIDFKIKTVELQGKKIKLQIWDTAGQERFHTITTSYYRGAMGIMLVYD ITNGKSFENISKWLRNIDEHANEDVERMLLGNKCDMDDKRVVPKGKGEQIAREHGIRFFETSAKANINIEKAFLTLAEDILRKQIVATNL PPEDQDGSGDDSDNFSGSGAGALQDITLSQQTPSTWKDTQLLTAIPTSPEPTGLEATAASTSTLPAGEGPKEGEAVVLPEVEPGLTAREQ EATPRPRETTQLPTTHLASTTTATTAQEPATSHPHRDMQPGHHETSTPAGPSQADLHTPHTEDGGPSATERAAEDGASSQLPAAEGSGEQ DFTFETSGENTAVVAVEPDRRNQSPVDQGATGASQGLLDRKEVLGGVIAGGLVGLIFAVCLVGFMLYRMKKKDEGSYSLEEPKQANGGAY >In-frame_RAB10_ENST00000264710_chr2_26350820_+_SDC1_ENST00000381150_chr2_20405185_-_462aa MAKKTYDLLFKLLLIGDSGVGKTCVLFRFSDDAFNTTFISTIGIDFKIKTVELQGKKIKLQIWDTAGQERFHTITTSYYRGAMGIMLVYD ITNGKSFENISKWLRNIDEHANEDVERMLLGNKCDMDDKRVVPKGKGEQIAREHGIRFFETSAKANINIEKAFLTLAEDILRKQIVATNL PPEDQDGSGDDSDNFSGSGAGALQDITLSQQTPSTWKDTQLLTAIPTSPEPTGLEATAASTSTLPAGEGPKEGEAVVLPEVEPGLTAREQ EATPRPRETTQLPTTHLASTTTATTAQEPATSHPHRDMQPGHHETSTPAGPSQADLHTPHTEDGGPSATERAAEDGASSQLPAAEGSGEQ DFTFETSGENTAVVAVEPDRRNQSPVDQGATGASQGLLDRKEVLGGVIAGGLVGLIFAVCLVGFMLYRMKKKDEGSYSLEEPKQANGGAY >In-frame_RAB10_ENST00000264710_chr2_26350820_+_SDC1_ENST00000403076_chr2_20405185_-_321aa MAKKTYDLLFKLLLIGDSGVGKTCVLFRFSDDAFNTTFISTIGIDFKIKTVELQGKKIKLQIWDTAGQERFHTITTSYYRGAMGIMLVYD ITNGKSFENISKWLRNIDEHANEDVERMLLGNKCDMDDKRVVPKGKGEQIAREHGIRFFETSAKANINIEKAFLTLAEDILRKQIVATNL PPEDQDGSGDDSDNFSGSGAGALQDITLSQQTPSTWKDTQLLTAIPTSPEPTGLEATAASTSTLPAGEGPKEGEAVVLPEVEPGLTAREQ |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_RAB10_ENST00000264710_chr2_26350820_+_SDC1_ENST00000254351_chr2_20405185_-_1386nt ATGGCGAAGAAGACGTACGACCTGCTTTTCAAGCTGCTCCTGATCGGGGATTCCGGAGTGGGGAAGACCTGCGTCCTTTTTCGTTTTTCG GATGATGCCTTCAATACTACCTTTATTTCCACCATAGGAATAGACTTCAAGATCAAAACAGTTGAATTACAAGGAAAGAAGATCAAGCTA CAGATATGGGATACAGCAGGCCAGGAGCGATTTCACACCATCACAACCTCCTACTACAGAGGCGCAATGGGTATCATGCTAGTATATGAC ATCACCAATGGTAAAAGTTTTGAAAACATCAGCAAATGGCTTAGAAACATAGATGAGCATGCCAATGAAGATGTGGAAAGAATGTTACTA GGAAACAAGTGTGATATGGACGACAAAAGAGTTGTACCTAAAGGAAAAGGAGAACAGATTGCAAGGGAGCATGGTATTAGGTTTTTTGAG ACTAGTGCAAAAGCAAATATAAACATCGAAAAGGCGTTCCTCACGTTAGCTGAAGATATCCTTCGAAAGCAAATTGTGGCTACTAATTTG CCCCCTGAAGATCAAGATGGCTCTGGGGATGACTCTGACAACTTCTCCGGCTCAGGTGCAGGTGCTTTGCAAGATATCACCTTGTCACAG CAGACCCCCTCCACTTGGAAGGACACGCAGCTCCTGACGGCTATTCCCACGTCTCCAGAACCCACCGGCCTGGAGGCTACAGCTGCCTCC ACCTCCACCCTGCCGGCTGGAGAGGGGCCCAAGGAGGGAGAGGCTGTAGTCCTGCCAGAAGTGGAGCCTGGCCTCACCGCCCGGGAGCAG GAGGCCACCCCCCGACCCAGGGAGACCACACAGCTCCCGACCACTCATCTGGCCTCAACGACCACAGCCACCACGGCCCAGGAGCCCGCC ACCTCCCACCCCCACAGGGACATGCAGCCTGGCCACCATGAGACCTCAACCCCTGCAGGACCCAGCCAAGCTGACCTTCACACTCCCCAC ACAGAGGATGGAGGTCCTTCTGCCACCGAGAGGGCTGCTGAGGATGGAGCCTCCAGTCAGCTCCCAGCAGCAGAGGGCTCTGGGGAGCAG GACTTCACCTTTGAAACCTCGGGGGAGAATACGGCTGTAGTGGCCGTGGAGCCTGACCGCCGGAACCAGTCCCCAGTGGATCAGGGGGCC ACGGGGGCCTCACAGGGCCTCCTGGACAGGAAAGAGGTGCTGGGAGGGGTCATTGCCGGAGGCCTCGTGGGGCTCATCTTTGCTGTGTGC CTGGTGGGTTTCATGCTGTACCGCATGAAGAAGAAGGACGAAGGCAGCTACTCCTTGGAGGAGCCGAAACAAGCCAACGGCGGGGCCTAC >In-frame_RAB10_ENST00000264710_chr2_26350820_+_SDC1_ENST00000381150_chr2_20405185_-_1386nt ATGGCGAAGAAGACGTACGACCTGCTTTTCAAGCTGCTCCTGATCGGGGATTCCGGAGTGGGGAAGACCTGCGTCCTTTTTCGTTTTTCG GATGATGCCTTCAATACTACCTTTATTTCCACCATAGGAATAGACTTCAAGATCAAAACAGTTGAATTACAAGGAAAGAAGATCAAGCTA CAGATATGGGATACAGCAGGCCAGGAGCGATTTCACACCATCACAACCTCCTACTACAGAGGCGCAATGGGTATCATGCTAGTATATGAC ATCACCAATGGTAAAAGTTTTGAAAACATCAGCAAATGGCTTAGAAACATAGATGAGCATGCCAATGAAGATGTGGAAAGAATGTTACTA GGAAACAAGTGTGATATGGACGACAAAAGAGTTGTACCTAAAGGAAAAGGAGAACAGATTGCAAGGGAGCATGGTATTAGGTTTTTTGAG ACTAGTGCAAAAGCAAATATAAACATCGAAAAGGCGTTCCTCACGTTAGCTGAAGATATCCTTCGAAAGCAAATTGTGGCTACTAATTTG CCCCCTGAAGATCAAGATGGCTCTGGGGATGACTCTGACAACTTCTCCGGCTCAGGTGCAGGTGCTTTGCAAGATATCACCTTGTCACAG CAGACCCCCTCCACTTGGAAGGACACGCAGCTCCTGACGGCTATTCCCACGTCTCCAGAACCCACCGGCCTGGAGGCTACAGCTGCCTCC ACCTCCACCCTGCCGGCTGGAGAGGGGCCCAAGGAGGGAGAGGCTGTAGTCCTGCCAGAAGTGGAGCCTGGCCTCACCGCCCGGGAGCAG GAGGCCACCCCCCGACCCAGGGAGACCACACAGCTCCCGACCACTCATCTGGCCTCAACGACCACAGCCACCACGGCCCAGGAGCCCGCC ACCTCCCACCCCCACAGGGACATGCAGCCTGGCCACCATGAGACCTCAACCCCTGCAGGACCCAGCCAAGCTGACCTTCACACTCCCCAC ACAGAGGATGGAGGTCCTTCTGCCACCGAGAGGGCTGCTGAGGATGGAGCCTCCAGTCAGCTCCCAGCAGCAGAGGGCTCTGGGGAGCAG GACTTCACCTTTGAAACCTCGGGGGAGAATACGGCTGTAGTGGCCGTGGAGCCTGACCGCCGGAACCAGTCCCCAGTGGATCAGGGGGCC ACGGGGGCCTCACAGGGCCTCCTGGACAGGAAAGAGGTGCTGGGAGGGGTCATTGCCGGAGGCCTCGTGGGGCTCATCTTTGCTGTGTGC CTGGTGGGTTTCATGCTGTACCGCATGAAGAAGAAGGACGAAGGCAGCTACTCCTTGGAGGAGCCGAAACAAGCCAACGGCGGGGCCTAC >In-frame_RAB10_ENST00000264710_chr2_26350820_+_SDC1_ENST00000403076_chr2_20405185_-_963nt ATGGCGAAGAAGACGTACGACCTGCTTTTCAAGCTGCTCCTGATCGGGGATTCCGGAGTGGGGAAGACCTGCGTCCTTTTTCGTTTTTCG GATGATGCCTTCAATACTACCTTTATTTCCACCATAGGAATAGACTTCAAGATCAAAACAGTTGAATTACAAGGAAAGAAGATCAAGCTA CAGATATGGGATACAGCAGGCCAGGAGCGATTTCACACCATCACAACCTCCTACTACAGAGGCGCAATGGGTATCATGCTAGTATATGAC ATCACCAATGGTAAAAGTTTTGAAAACATCAGCAAATGGCTTAGAAACATAGATGAGCATGCCAATGAAGATGTGGAAAGAATGTTACTA GGAAACAAGTGTGATATGGACGACAAAAGAGTTGTACCTAAAGGAAAAGGAGAACAGATTGCAAGGGAGCATGGTATTAGGTTTTTTGAG ACTAGTGCAAAAGCAAATATAAACATCGAAAAGGCGTTCCTCACGTTAGCTGAAGATATCCTTCGAAAGCAAATTGTGGCTACTAATTTG CCCCCTGAAGATCAAGATGGCTCTGGGGATGACTCTGACAACTTCTCCGGCTCAGGTGCAGGTGCTTTGCAAGATATCACCTTGTCACAG CAGACCCCCTCCACTTGGAAGGACACGCAGCTCCTGACGGCTATTCCCACGTCTCCAGAACCCACCGGCCTGGAGGCTACAGCTGCCTCC ACCTCCACCCTGCCGGCTGGAGAGGGGCCCAAGGAGGGAGAGGCTGTAGTCCTGCCAGAAGTGGAGCCTGGCCTCACCGCCCGGGAGCAG GAGGCCACCCCCCGACCCAGGGAGACCACACAGCTCCCGACCACTCATCTGGCCTCAACGACCACAGCCACCACGGCCCAGGAGCCCGCC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_RAB10_ENST00000264710_chr2_26350820_+_SDC1_ENST00000254351_chr2_20405185_-_3854nt GAGAGGGCACGGGGAAAAGGTGGCTCTGGCCGGGGTGGCTCGGTTTCCTGGGGCTATGTAACTGAGCTCGTCGACTTAGGGGTCCTTCTT CGCTGCCCTCGCCGCGTGCTAGCAGGGAGTTTCCGCTCGGGAGAGAGACTGTCCTCACGCCCGCTGCGCCTCCTCGACGGCAGAGCAGGC TTGCTCGCCCGTGGGAGCGTCCCGGCCGAGAAGCCCTGAGGGGGGAGGGGAGGCCATTTTGTCCCGACCGACTCCCCGGAACCGGGCGGA CGGGCTGGGAGAGGCTGCGGAGCCGCGGTCGCCGCCCTCGGAGGCACTGGACGCCGCCACTGTCGGGGCTTCCTCAAAGCTGTTCGTAGG TCGCCCGCGCCGTCTCGAGCCTTTTTCCCACGCTTCCCCGGTCCTCCGGCCTGAGAACGCCCGAGTGAGGAGTTGGCCGTAGTGAGAGGG ACCGATCCCTTGGGGCCGCCGGCGGCGAGAGCCCGAGCCGCTCCTCCCAATGGCGAAGAAGACGTACGACCTGCTTTTCAAGCTGCTCCT GATCGGGGATTCCGGAGTGGGGAAGACCTGCGTCCTTTTTCGTTTTTCGGATGATGCCTTCAATACTACCTTTATTTCCACCATAGGAAT AGACTTCAAGATCAAAACAGTTGAATTACAAGGAAAGAAGATCAAGCTACAGATATGGGATACAGCAGGCCAGGAGCGATTTCACACCAT CACAACCTCCTACTACAGAGGCGCAATGGGTATCATGCTAGTATATGACATCACCAATGGTAAAAGTTTTGAAAACATCAGCAAATGGCT TAGAAACATAGATGAGCATGCCAATGAAGATGTGGAAAGAATGTTACTAGGAAACAAGTGTGATATGGACGACAAAAGAGTTGTACCTAA AGGAAAAGGAGAACAGATTGCAAGGGAGCATGGTATTAGGTTTTTTGAGACTAGTGCAAAAGCAAATATAAACATCGAAAAGGCGTTCCT CACGTTAGCTGAAGATATCCTTCGAAAGCAAATTGTGGCTACTAATTTGCCCCCTGAAGATCAAGATGGCTCTGGGGATGACTCTGACAA CTTCTCCGGCTCAGGTGCAGGTGCTTTGCAAGATATCACCTTGTCACAGCAGACCCCCTCCACTTGGAAGGACACGCAGCTCCTGACGGC TATTCCCACGTCTCCAGAACCCACCGGCCTGGAGGCTACAGCTGCCTCCACCTCCACCCTGCCGGCTGGAGAGGGGCCCAAGGAGGGAGA GGCTGTAGTCCTGCCAGAAGTGGAGCCTGGCCTCACCGCCCGGGAGCAGGAGGCCACCCCCCGACCCAGGGAGACCACACAGCTCCCGAC CACTCATCTGGCCTCAACGACCACAGCCACCACGGCCCAGGAGCCCGCCACCTCCCACCCCCACAGGGACATGCAGCCTGGCCACCATGA GACCTCAACCCCTGCAGGACCCAGCCAAGCTGACCTTCACACTCCCCACACAGAGGATGGAGGTCCTTCTGCCACCGAGAGGGCTGCTGA GGATGGAGCCTCCAGTCAGCTCCCAGCAGCAGAGGGCTCTGGGGAGCAGGACTTCACCTTTGAAACCTCGGGGGAGAATACGGCTGTAGT GGCCGTGGAGCCTGACCGCCGGAACCAGTCCCCAGTGGATCAGGGGGCCACGGGGGCCTCACAGGGCCTCCTGGACAGGAAAGAGGTGCT GGGAGGGGTCATTGCCGGAGGCCTCGTGGGGCTCATCTTTGCTGTGTGCCTGGTGGGTTTCATGCTGTACCGCATGAAGAAGAAGGACGA AGGCAGCTACTCCTTGGAGGAGCCGAAACAAGCCAACGGCGGGGCCTACCAGAAGCCCACCAAACAGGAGGAATTCTATGCCTGACGCGG GAGCCATGCGCCCCCTCCGCCCTGCCACTCACTAGGCCCCCACTTGCCTCTTCCTTGAAGAACTGCAGGCCCTGGCCTCCCCTGCCACCA GGCCACCTCCCCAGCATTCCAGCCCCTCTGGTCGCTCCTGCCCACGGAGTCGTGGGGTGTGCTGGGAGCTCCACTCTGCTTCTCTGACTT CTGCCTGGAGACTTAGGGCACCAGGGGTTTCTCGCATAGGACCTTTCCACCACAGCCAGCACCTGGCATCGCACCATTCTGACTCGGTTT CTCCAAACTGAAGCAGCCTCTCCCCAGGTCCAGCTCTGGAGGGGAGGGGGATCCGACTGCTTTGGACCTAAATGGCCTCATGTGGCTGGA AGATCCTGCGGGTGGGGCTTGGGGCTCACACACCTGTAGCACTTACTGGTAGGACCAAGCATCTTGGGGGGGTGGCCGCTGAGTGGCAGG GGACAGGAGTCCACTTTGTTTCGTGGGGAGGTCTAATCTAGATATCGACTTGTTTTTGCACATGTTTCCTCTAGTTCTTTGTTCATAGCC CAGTAGACCTTGTTACTTCTGAGGTAAGTTAAGTAAGTTGATTCGGTATCCCCCCATCTTGCTTCCCTAATCTATGGTCGGGAGACAGCA TCAGGGTTAAGAAGACTTTTTTTTTTTTTTTTTAAACTAGGAGAACCAAATCTGGAAGCCAAAATGTAGGCTTAGTTTGTGTGTTGTCTC TTGAGTTTGTCGCTCATGTGTGCAACAGGGTATGGACTATCTGTCTGGTGGCCCCGTTTCTGGTGGTCTGTTGGCAGGCTGGCCAGTCCA GGCTGCCGTGGGGCCGCCGCCTCTTTCAAGCAGTCGTGCCTGTGTCCATGCGCTCAGGGCCATGCTGAGGCCTGGGCCGCTGCCACGTTG GAGAAGCCCGTGTGAGAAGTGAATGCTGGGACTCAGCCTTCAGACAGAGAGGACTGTAGGGAGGGCGGCAGGGGCCTGGAGATCCTCCTG CAGACCACGCCCGTCCTGCCTGTGGCGCCGTCTCCAGGGGCTGCTTCCTCCTGGAAATTGACGAGGGGTGTCTTGGGCAGAGCTGGCTCT GAGCGCCTCCATCCAAGGCCAGGTTCTCCGTTAGCTCCTGTGGCCCCACCCTGGGCCCTGGGCTGGAATCAGGAATATTTTCCAAAGAGT GATAGTCTTTTGCTTTTGGCAAAACTCTACTTAATCCAATGGGTTTTTCCCTGTACAGTAGATTTTCCAAATGTAATAAACTTTAATATA AAGTAGTCCTGTGAATGCCACTGCCTTCGCTTCTTGCCTCTGTGCTGTGTGTGACGTGACCGGACTTTTCTGCAAACACCAACATGTTGG GAAACTTGGCTCGAATCTCTGTGCCTTCGTCTTTCCCATGGGGAGGGATTCTGGTTCCAGGGTCCCTCTGTGTATTTGCTTTTTTGTTTT GGCTGAAATTCTCCTGGAGGTCGGTAGGTTCAGCCAAGGTTTTATAAGGCTGATGTCAATTTCTGTGTTGCCAAGCTCCAAGCCCCATCT TCTAAATGGCAAAGGAAGGTGGATGGCCCCAGCACAGCTTGACCTGAGGCTGTGGTCACAGCGGAGGTGTGGAGCCGAGGCCTACCCCGC AGACACCTTGGACATCCTCCTCCCACCCGGCTGCAGAGGCCAGAGGCCCCCAGCCCAGGGCTCCTGCACTTACTTGCTTATTTGACAACG TTTCAGCGACTCCGTTGGCCACTCCGAGAGGTGGGCCAGTCTGTGGATCAGAGATGCACCACCAAGCCAAGGGAACCTGTGTCCGGTATT CGATACTGCGACTTTCTGCCTGGAGTGTATGACTGCACATGACTCGGGGGTGGGGAAAGGGGTCGGCTGACCATGCTCATCTGCTGGTCC >In-frame_RAB10_ENST00000264710_chr2_26350820_+_SDC1_ENST00000381150_chr2_20405185_-_3852nt GAGAGGGCACGGGGAAAAGGTGGCTCTGGCCGGGGTGGCTCGGTTTCCTGGGGCTATGTAACTGAGCTCGTCGACTTAGGGGTCCTTCTT CGCTGCCCTCGCCGCGTGCTAGCAGGGAGTTTCCGCTCGGGAGAGAGACTGTCCTCACGCCCGCTGCGCCTCCTCGACGGCAGAGCAGGC TTGCTCGCCCGTGGGAGCGTCCCGGCCGAGAAGCCCTGAGGGGGGAGGGGAGGCCATTTTGTCCCGACCGACTCCCCGGAACCGGGCGGA CGGGCTGGGAGAGGCTGCGGAGCCGCGGTCGCCGCCCTCGGAGGCACTGGACGCCGCCACTGTCGGGGCTTCCTCAAAGCTGTTCGTAGG TCGCCCGCGCCGTCTCGAGCCTTTTTCCCACGCTTCCCCGGTCCTCCGGCCTGAGAACGCCCGAGTGAGGAGTTGGCCGTAGTGAGAGGG ACCGATCCCTTGGGGCCGCCGGCGGCGAGAGCCCGAGCCGCTCCTCCCAATGGCGAAGAAGACGTACGACCTGCTTTTCAAGCTGCTCCT GATCGGGGATTCCGGAGTGGGGAAGACCTGCGTCCTTTTTCGTTTTTCGGATGATGCCTTCAATACTACCTTTATTTCCACCATAGGAAT AGACTTCAAGATCAAAACAGTTGAATTACAAGGAAAGAAGATCAAGCTACAGATATGGGATACAGCAGGCCAGGAGCGATTTCACACCAT CACAACCTCCTACTACAGAGGCGCAATGGGTATCATGCTAGTATATGACATCACCAATGGTAAAAGTTTTGAAAACATCAGCAAATGGCT TAGAAACATAGATGAGCATGCCAATGAAGATGTGGAAAGAATGTTACTAGGAAACAAGTGTGATATGGACGACAAAAGAGTTGTACCTAA AGGAAAAGGAGAACAGATTGCAAGGGAGCATGGTATTAGGTTTTTTGAGACTAGTGCAAAAGCAAATATAAACATCGAAAAGGCGTTCCT CACGTTAGCTGAAGATATCCTTCGAAAGCAAATTGTGGCTACTAATTTGCCCCCTGAAGATCAAGATGGCTCTGGGGATGACTCTGACAA CTTCTCCGGCTCAGGTGCAGGTGCTTTGCAAGATATCACCTTGTCACAGCAGACCCCCTCCACTTGGAAGGACACGCAGCTCCTGACGGC TATTCCCACGTCTCCAGAACCCACCGGCCTGGAGGCTACAGCTGCCTCCACCTCCACCCTGCCGGCTGGAGAGGGGCCCAAGGAGGGAGA GGCTGTAGTCCTGCCAGAAGTGGAGCCTGGCCTCACCGCCCGGGAGCAGGAGGCCACCCCCCGACCCAGGGAGACCACACAGCTCCCGAC CACTCATCTGGCCTCAACGACCACAGCCACCACGGCCCAGGAGCCCGCCACCTCCCACCCCCACAGGGACATGCAGCCTGGCCACCATGA GACCTCAACCCCTGCAGGACCCAGCCAAGCTGACCTTCACACTCCCCACACAGAGGATGGAGGTCCTTCTGCCACCGAGAGGGCTGCTGA GGATGGAGCCTCCAGTCAGCTCCCAGCAGCAGAGGGCTCTGGGGAGCAGGACTTCACCTTTGAAACCTCGGGGGAGAATACGGCTGTAGT GGCCGTGGAGCCTGACCGCCGGAACCAGTCCCCAGTGGATCAGGGGGCCACGGGGGCCTCACAGGGCCTCCTGGACAGGAAAGAGGTGCT GGGAGGGGTCATTGCCGGAGGCCTCGTGGGGCTCATCTTTGCTGTGTGCCTGGTGGGTTTCATGCTGTACCGCATGAAGAAGAAGGACGA AGGCAGCTACTCCTTGGAGGAGCCGAAACAAGCCAACGGCGGGGCCTACCAGAAGCCCACCAAACAGGAGGAATTCTATGCCTGACGCGG GAGCCATGCGCCCCCTCCGCCCTGCCACTCACTAGGCCCCCACTTGCCTCTTCCTTGAAGAACTGCAGGCCCTGGCCTCCCCTGCCACCA GGCCACCTCCCCAGCATTCCAGCCCCTCTGGTCGCTCCTGCCCACGGAGTCGTGGGGTGTGCTGGGAGCTCCACTCTGCTTCTCTGACTT CTGCCTGGAGACTTAGGGCACCAGGGGTTTCTCGCATAGGACCTTTCCACCACAGCCAGCACCTGGCATCGCACCATTCTGACTCGGTTT CTCCAAACTGAAGCAGCCTCTCCCCAGGTCCAGCTCTGGAGGGGAGGGGGATCCGACTGCTTTGGACCTAAATGGCCTCATGTGGCTGGA AGATCCTGCGGGTGGGGCTTGGGGCTCACACACCTGTAGCACTTACTGGTAGGACCAAGCATCTTGGGGGGGTGGCCGCTGAGTGGCAGG GGACAGGAGTCCACTTTGTTTCGTGGGGAGGTCTAATCTAGATATCGACTTGTTTTTGCACATGTTTCCTCTAGTTCTTTGTTCATAGCC CAGTAGACCTTGTTACTTCTGAGGTAAGTTAAGTAAGTTGATTCGGTATCCCCCCATCTTGCTTCCCTAATCTATGGTCGGGAGACAGCA TCAGGGTTAAGAAGACTTTTTTTTTTTTTTTTTAAACTAGGAGAACCAAATCTGGAAGCCAAAATGTAGGCTTAGTTTGTGTGTTGTCTC TTGAGTTTGTCGCTCATGTGTGCAACAGGGTATGGACTATCTGTCTGGTGGCCCCGTTTCTGGTGGTCTGTTGGCAGGCTGGCCAGTCCA GGCTGCCGTGGGGCCGCCGCCTCTTTCAAGCAGTCGTGCCTGTGTCCATGCGCTCAGGGCCATGCTGAGGCCTGGGCCGCTGCCACGTTG GAGAAGCCCGTGTGAGAAGTGAATGCTGGGACTCAGCCTTCAGACAGAGAGGACTGTAGGGAGGGCGGCAGGGGCCTGGAGATCCTCCTG CAGACCACGCCCGTCCTGCCTGTGGCGCCGTCTCCAGGGGCTGCTTCCTCCTGGAAATTGACGAGGGGTGTCTTGGGCAGAGCTGGCTCT GAGCGCCTCCATCCAAGGCCAGGTTCTCCGTTAGCTCCTGTGGCCCCACCCTGGGCCCTGGGCTGGAATCAGGAATATTTTCCAAAGAGT GATAGTCTTTTGCTTTTGGCAAAACTCTACTTAATCCAATGGGTTTTTCCCTGTACAGTAGATTTTCCAAATGTAATAAACTTTAATATA AAGTAGTCCTGTGAATGCCACTGCCTTCGCTTCTTGCCTCTGTGCTGTGTGTGACGTGACCGGACTTTTCTGCAAACACCAACATGTTGG GAAACTTGGCTCGAATCTCTGTGCCTTCGTCTTTCCCATGGGGAGGGATTCTGGTTCCAGGGTCCCTCTGTGTATTTGCTTTTTTGTTTT GGCTGAAATTCTCCTGGAGGTCGGTAGGTTCAGCCAAGGTTTTATAAGGCTGATGTCAATTTCTGTGTTGCCAAGCTCCAAGCCCCATCT TCTAAATGGCAAAGGAAGGTGGATGGCCCCAGCACAGCTTGACCTGAGGCTGTGGTCACAGCGGAGGTGTGGAGCCGAGGCCTACCCCGC AGACACCTTGGACATCCTCCTCCCACCCGGCTGCAGAGGCCAGAGGCCCCCAGCCCAGGGCTCCTGCACTTACTTGCTTATTTGACAACG TTTCAGCGACTCCGTTGGCCACTCCGAGAGGTGGGCCAGTCTGTGGATCAGAGATGCACCACCAAGCCAAGGGAACCTGTGTCCGGTATT CGATACTGCGACTTTCTGCCTGGAGTGTATGACTGCACATGACTCGGGGGTGGGGAAAGGGGTCGGCTGACCATGCTCATCTGCTGGTCC >In-frame_RAB10_ENST00000264710_chr2_26350820_+_SDC1_ENST00000403076_chr2_20405185_-_2246nt GAGAGGGCACGGGGAAAAGGTGGCTCTGGCCGGGGTGGCTCGGTTTCCTGGGGCTATGTAACTGAGCTCGTCGACTTAGGGGTCCTTCTT CGCTGCCCTCGCCGCGTGCTAGCAGGGAGTTTCCGCTCGGGAGAGAGACTGTCCTCACGCCCGCTGCGCCTCCTCGACGGCAGAGCAGGC TTGCTCGCCCGTGGGAGCGTCCCGGCCGAGAAGCCCTGAGGGGGGAGGGGAGGCCATTTTGTCCCGACCGACTCCCCGGAACCGGGCGGA CGGGCTGGGAGAGGCTGCGGAGCCGCGGTCGCCGCCCTCGGAGGCACTGGACGCCGCCACTGTCGGGGCTTCCTCAAAGCTGTTCGTAGG TCGCCCGCGCCGTCTCGAGCCTTTTTCCCACGCTTCCCCGGTCCTCCGGCCTGAGAACGCCCGAGTGAGGAGTTGGCCGTAGTGAGAGGG ACCGATCCCTTGGGGCCGCCGGCGGCGAGAGCCCGAGCCGCTCCTCCCAATGGCGAAGAAGACGTACGACCTGCTTTTCAAGCTGCTCCT GATCGGGGATTCCGGAGTGGGGAAGACCTGCGTCCTTTTTCGTTTTTCGGATGATGCCTTCAATACTACCTTTATTTCCACCATAGGAAT AGACTTCAAGATCAAAACAGTTGAATTACAAGGAAAGAAGATCAAGCTACAGATATGGGATACAGCAGGCCAGGAGCGATTTCACACCAT CACAACCTCCTACTACAGAGGCGCAATGGGTATCATGCTAGTATATGACATCACCAATGGTAAAAGTTTTGAAAACATCAGCAAATGGCT TAGAAACATAGATGAGCATGCCAATGAAGATGTGGAAAGAATGTTACTAGGAAACAAGTGTGATATGGACGACAAAAGAGTTGTACCTAA AGGAAAAGGAGAACAGATTGCAAGGGAGCATGGTATTAGGTTTTTTGAGACTAGTGCAAAAGCAAATATAAACATCGAAAAGGCGTTCCT CACGTTAGCTGAAGATATCCTTCGAAAGCAAATTGTGGCTACTAATTTGCCCCCTGAAGATCAAGATGGCTCTGGGGATGACTCTGACAA CTTCTCCGGCTCAGGTGCAGGTGCTTTGCAAGATATCACCTTGTCACAGCAGACCCCCTCCACTTGGAAGGACACGCAGCTCCTGACGGC TATTCCCACGTCTCCAGAACCCACCGGCCTGGAGGCTACAGCTGCCTCCACCTCCACCCTGCCGGCTGGAGAGGGGCCCAAGGAGGGAGA GGCTGTAGTCCTGCCAGAAGTGGAGCCTGGCCTCACCGCCCGGGAGCAGGAGGCCACCCCCCGACCCAGGGAGACCACACAGCTCCCGAC CACTCATCTGGCCTCAACGACCACAGCCACCACGGCCCAGGAGCCCGCCACCTCCCACCCCCACAGGGACATGCAGCCTGTCCACTTTGT TTCGTGGGGAGGTCTAATCTAGATATCGACTTGTTTTTGCACATGTTTCCTCTAGTTCTTTGTTCATAGCCCAGTAGACCTTGTTACTTC TGAGGTAAGTTAAGTAAGTTGATTCGGTATCCCCCCATCTTGCTTCCCTAATCTATGGTCGGGAGACAGCATCAGGGTTAAGAAGACTTT TTTTTTTTTTTTTTAAACTAGGAGAACCAAATCTGGAAGCCAAAATGTAGGCTTAGTTTGTGTGTTGTCTCTTGAGTTTGTCGCTCATGT GTGCAACAGGGTATGGACTATCTGTCTGGTGGCCCCGTTTCTGGTGGTCTGTTGGCAGGCTGGCCAGTCCAGGCTGCCGTGGGGCCGCCG CCTCTTTCAAGCAGTCGTGCCTGTGTCCATGCGCTCAGGGCCATGCTGAGGCCTGGGCCGCTGCCACGTTGGAGAAGCCCGTGTGAGAAG TGAATGCTGGGACTCAGCCTTCAGACAGAGAGGACTGTAGGGAGGGCGGCAGGGGCCTGGAGATCCTCCTGCAGACCACGCCCGTCCTGC CTGTGGCGCCGTCTCCAGGGGCTGCTTCCTCCTGGAAATTGACGAGGGGTGTCTTGGGCAGAGCTGGCTCTGAGCGCCTCCATCCAAGGC CAGGTTCTCCGTTAGCTCCTGTGGCCCCACCCTGGGCCCTGGGCTGGAATCAGGAATATTTTCCAAAGAGTGATAGTCTTTTGCTTTTGG |
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FusionGenePPI for RAB10_SDC1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| RAB10 | RAB8A, AP1S1, DOK2, AURKA, SYTL3, MLPH, ENOPH1, MICAL1, PPBP, ELAVL1, EVI5L, APP, ZMPSTE24, VCP, FN1, MTNR1A, UBL4A, ITGA4, ATP4A, RPA3, RPA2, RPA1, ASB17, STAU1, OPTN, CUL7, RNF2, CFL1, GDI2, GPI, LGALS1, PPIA, FKBP2, FUBP3, HNRNPA3, MAP3K15, MDH2, PKM, TAGLN2, TKT, UBE2L3, RAB5C, RAB7A, TIAL1, UQCRC2, MED20, TCTN2, GDI1, MIRLET7A1, TSSC1, CDC73, CDH1, MTMR14, DUSP22, TTC30B, SDHA, FOXA1, TRIM25 | SDC1 | LACRT, FGF2, CCL5, CXCL8, HGF, CASK, SDCBP, CTSG, APP, AHCY, ZNF593, BAG3, CD63, PTEN, EP300, FARP1, DHRS2, GMEB2, PRDM10, CYHR1, EPHA2, CSNK1G3, OCLN, HMGCS1, CCNY, EFR3A, PTPRG, ARVCF, AMPD2, RAP2A, RFTN1, PARP2, EEPD1, GNAZ, VANGL1, RRAS, GNB4, GMEB1, FBXO46, FTO, CSNK1G2, AHNAK, PRRC1, CTH, HRAS, NCAM1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for RAB10_SDC1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for RAB10_SDC1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | SDC1 | C0345967 | Malignant mesothelioma | 1 | CTD_human |
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