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Fusion gene ID: 29867 |
FusionGeneSummary for RAB10_DNAJC17 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: RAB10_DNAJC17 | Fusion gene ID: 29867 | Hgene | Tgene | Gene symbol | RAB10 | DNAJC17 | Gene ID | 10890 | 55192 |
| Gene name | RAB10, member RAS oncogene family | DnaJ heat shock protein family (Hsp40) member C17 | |
| Synonyms | - | - | |
| Cytomap | 2p23.3 | 15q15.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | ras-related protein Rab-10GTP-binding protein RAB10ras-related GTP-binding protein | dnaJ homolog subfamily C member 17DnaJ (Hsp40) homolog, subfamily C, member 17 | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | P61026 | Q9NVM6 | |
| Ensembl transtripts involved in fusion gene | ENST00000264710, ENST00000462003, | ENST00000220496, ENST00000558727, | |
| Fusion gene scores | * DoF score | 4 X 3 X 2=24 | 2 X 2 X 2=8 |
| # samples | 3 | 2 | |
| ** MAII score | log2(3/24*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: RAB10 [Title/Abstract] AND DNAJC17 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Oncogene involved fusion gene, in-frame and retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | OV | TCGA-13-0906-01A | RAB10 | chr2 | 26332775 | + | DNAJC17 | chr15 | 41072195 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000264710 | ENST00000220496 | RAB10 | chr2 | 26332775 | + | DNAJC17 | chr15 | 41072195 | - |
| 5CDS-intron | ENST00000264710 | ENST00000558727 | RAB10 | chr2 | 26332775 | + | DNAJC17 | chr15 | 41072195 | - |
| 3UTR-3CDS | ENST00000462003 | ENST00000220496 | RAB10 | chr2 | 26332775 | + | DNAJC17 | chr15 | 41072195 | - |
| 3UTR-intron | ENST00000462003 | ENST00000558727 | RAB10 | chr2 | 26332775 | + | DNAJC17 | chr15 | 41072195 | - |
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FusionProtFeatures for RAB10_DNAJC17 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| RAB10 | DNAJC17 |
| The small GTPases Rab are key regulators ofintracellular membrane trafficking, from the formation oftransport vesicles to their fusion with membranes. Rabs cyclebetween an inactive GDP-bound form and an active GTP-bound formthat is able to recruit to membranes different set of downstreameffectors directly responsible for vesicle formation, movement,tethering and fusion (By similarity). That Rab is mainly involvedin the biosynthetic transport of proteins from the Golgi to theplasma membrane. Regulates, for instance, SLC2A4/GLUT4 glucosetransporter-enriched vesicles delivery to the plasma membrane. Inparallel, it regulates the transport of TLR4, a toll-like receptorto the plasma membrane and therefore may be important for innateimmune response. Plays also a specific role in asymmetric proteintransport to the plasma membrane within the polarized neuron andepithelial cells. In neurons, it is involved in axonogenesisthrough regulation of vesicular membrane trafficking toward theaxonal plasma membrane while in epithelial cells, it regulatestransport from the Golgi to the basolateral membrane. Moreover,may play a role in the basolateral recycling pathway and inphagosome maturation. According to PubMed:23263280, may play arole in endoplasmic reticulum dynamics and morphology controllingtubulation along microtubules and tubules fusion. {ECO:0000250,ECO:0000269|PubMed:16641372, ECO:0000269|PubMed:21248164,ECO:0000269|PubMed:23263280}. | May negatively affect PAX8-induced thyroglobulin/TGtranscription. {ECO:0000250|UniProtKB:Q91WT4}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | RAB10 | chr2:26332775 | chr15:41072195 | ENST00000264710 | + | 3 | 6 | 38_46 | 109 | 201 | Motif | Effector region |
| Hgene | RAB10 | chr2:26332775 | chr15:41072195 | ENST00000264710 | + | 3 | 6 | 18_24 | 109 | 201 | Nucleotide binding | GTP |
| Hgene | RAB10 | chr2:26332775 | chr15:41072195 | ENST00000264710 | + | 3 | 6 | 35_41 | 109 | 201 | Nucleotide binding | GTP |
| Hgene | RAB10 | chr2:26332775 | chr15:41072195 | ENST00000264710 | + | 3 | 6 | 64_68 | 109 | 201 | Nucleotide binding | GTP |
| Tgene | >DNAJC17 | chr2:26332775 | chr15:41072195 | ENST00000220496 | - | 0 | 11 | 111_117 | 26 | 305 | Compositional bias | Note=Poly-Glu |
| Tgene | >DNAJC17 | chr2:26332775 | chr15:41072195 | ENST00000220496 | - | 0 | 11 | 178_249 | 26 | 305 | Domain | Note=RRM |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >RAB10 | chr2:26332775 | chr15:41072195 | ENST00000264710 | + | 3 | 6 | 122_125 | 109 | 201 | Nucleotide binding | GTP |
| Hgene | >RAB10 | chr2:26332775 | chr15:41072195 | ENST00000264710 | + | 3 | 6 | 152_154 | 109 | 201 | Nucleotide binding | GTP |
| Tgene | DNAJC17 | chr2:26332775 | chr15:41072195 | ENST00000220496 | - | 0 | 11 | 11_76 | 26 | 305 | Domain | J |
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FusionGeneSequence for RAB10_DNAJC17 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_RAB10_ENST00000264710_chr2_26332775_+_DNAJC17_ENST00000220496_chr15_41072195_-_388aa MAKKTYDLLFKLLLIGDSGVGKTCVLFRFSDDAFNTTFISTIGIDFKIKTVELQGKKIKLQIWDTAGQERFHTITTSYYRGAMGIMLVYD ITNGKSFENISKWLRNIDEVKKAYRQKALSCHPDKNPDNPRAAELFHQLSQALEVLTDAAARAAYDKVRKAKKQAAERTQKLDEKRKKVK LDLEARERQAQAQESEEEEESRSTRTLEQEIERLREEGSRQLEEQQRLIREQIRQERDQRLRGKAENTEGQGTPKLKLKWKCKKEDESKG GYSKDVLLRLLQKYGEVLNLVLSSKKPGTAVVEFATVKAAELAVQNEVGLVDNPLKISWLEGQPQDAVGRSHSGLSKGSVLSERDYESLV |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_RAB10_ENST00000264710_chr2_26332775_+_DNAJC17_ENST00000220496_chr15_41072195_-_1164nt ATGGCGAAGAAGACGTACGACCTGCTTTTCAAGCTGCTCCTGATCGGGGATTCCGGAGTGGGGAAGACCTGCGTCCTTTTTCGTTTTTCG GATGATGCCTTCAATACTACCTTTATTTCCACCATAGGAATAGACTTCAAGATCAAAACAGTTGAATTACAAGGAAAGAAGATCAAGCTA CAGATATGGGATACAGCAGGCCAGGAGCGATTTCACACCATCACAACCTCCTACTACAGAGGCGCAATGGGTATCATGCTAGTATATGAC ATCACCAATGGTAAAAGTTTTGAAAACATCAGCAAATGGCTTAGAAACATAGATGAGGTAAAGAAGGCGTATAGGCAGAAGGCCCTCTCC TGCCACCCAGACAAAAATCCAGATAATCCCAGAGCAGCTGAACTCTTCCACCAGCTTTCTCAGGCCTTGGAGGTGCTGACCGATGCTGCA GCCAGGGCTGCATATGACAAGGTCAGGAAAGCCAAGAAGCAAGCAGCAGAGAGGACCCAGAAACTTGATGAGAAAAGGAAGAAAGTGAAG CTTGACCTGGAGGCCCGGGAGCGGCAGGCCCAGGCCCAGGAGAGTGAGGAGGAAGAGGAGAGCCGGAGCACCAGGACACTAGAGCAAGAG ATCGAACGCCTGAGAGAAGAGGGTTCCCGGCAGCTGGAGGAACAGCAGAGGCTCATCCGGGAGCAGATACGCCAGGAGCGTGACCAGAGG TTGAGAGGAAAGGCAGAAAATACTGAAGGCCAAGGAACCCCCAAACTAAAGCTAAAATGGAAGTGCAAGAAGGAGGATGAGTCAAAAGGT GGCTACTCCAAAGACGTCCTCCTACGGCTTTTGCAGAAGTATGGTGAGGTTCTCAACCTGGTGCTTTCCAGTAAGAAGCCAGGCACTGCT GTGGTGGAGTTTGCAACCGTCAAGGCAGCGGAGCTGGCTGTCCAGAATGAAGTTGGCCTGGTGGATAACCCTCTGAAGATTTCCTGGTTG GAGGGACAGCCCCAGGATGCCGTGGGCCGCAGCCACTCAGGACTGTCAAAGGGCTCAGTGCTGTCAGAGAGGGACTACGAGAGCCTCGTC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_RAB10_ENST00000264710_chr2_26332775_+_DNAJC17_ENST00000220496_chr15_41072195_-_1734nt GAGAGGGCACGGGGAAAAGGTGGCTCTGGCCGGGGTGGCTCGGTTTCCTGGGGCTATGTAACTGAGCTCGTCGACTTAGGGGTCCTTCTT CGCTGCCCTCGCCGCGTGCTAGCAGGGAGTTTCCGCTCGGGAGAGAGACTGTCCTCACGCCCGCTGCGCCTCCTCGACGGCAGAGCAGGC TTGCTCGCCCGTGGGAGCGTCCCGGCCGAGAAGCCCTGAGGGGGGAGGGGAGGCCATTTTGTCCCGACCGACTCCCCGGAACCGGGCGGA CGGGCTGGGAGAGGCTGCGGAGCCGCGGTCGCCGCCCTCGGAGGCACTGGACGCCGCCACTGTCGGGGCTTCCTCAAAGCTGTTCGTAGG TCGCCCGCGCCGTCTCGAGCCTTTTTCCCACGCTTCCCCGGTCCTCCGGCCTGAGAACGCCCGAGTGAGGAGTTGGCCGTAGTGAGAGGG ACCGATCCCTTGGGGCCGCCGGCGGCGAGAGCCCGAGCCGCTCCTCCCAATGGCGAAGAAGACGTACGACCTGCTTTTCAAGCTGCTCCT GATCGGGGATTCCGGAGTGGGGAAGACCTGCGTCCTTTTTCGTTTTTCGGATGATGCCTTCAATACTACCTTTATTTCCACCATAGGAAT AGACTTCAAGATCAAAACAGTTGAATTACAAGGAAAGAAGATCAAGCTACAGATATGGGATACAGCAGGCCAGGAGCGATTTCACACCAT CACAACCTCCTACTACAGAGGCGCAATGGGTATCATGCTAGTATATGACATCACCAATGGTAAAAGTTTTGAAAACATCAGCAAATGGCT TAGAAACATAGATGAGGTAAAGAAGGCGTATAGGCAGAAGGCCCTCTCCTGCCACCCAGACAAAAATCCAGATAATCCCAGAGCAGCTGA ACTCTTCCACCAGCTTTCTCAGGCCTTGGAGGTGCTGACCGATGCTGCAGCCAGGGCTGCATATGACAAGGTCAGGAAAGCCAAGAAGCA AGCAGCAGAGAGGACCCAGAAACTTGATGAGAAAAGGAAGAAAGTGAAGCTTGACCTGGAGGCCCGGGAGCGGCAGGCCCAGGCCCAGGA GAGTGAGGAGGAAGAGGAGAGCCGGAGCACCAGGACACTAGAGCAAGAGATCGAACGCCTGAGAGAAGAGGGTTCCCGGCAGCTGGAGGA ACAGCAGAGGCTCATCCGGGAGCAGATACGCCAGGAGCGTGACCAGAGGTTGAGAGGAAAGGCAGAAAATACTGAAGGCCAAGGAACCCC CAAACTAAAGCTAAAATGGAAGTGCAAGAAGGAGGATGAGTCAAAAGGTGGCTACTCCAAAGACGTCCTCCTACGGCTTTTGCAGAAGTA TGGTGAGGTTCTCAACCTGGTGCTTTCCAGTAAGAAGCCAGGCACTGCTGTGGTGGAGTTTGCAACCGTCAAGGCAGCGGAGCTGGCTGT CCAGAATGAAGTTGGCCTGGTGGATAACCCTCTGAAGATTTCCTGGTTGGAGGGACAGCCCCAGGATGCCGTGGGCCGCAGCCACTCAGG ACTGTCAAAGGGCTCAGTGCTGTCAGAGAGGGACTACGAGAGCCTCGTCATGATGCGCATGCGCCAGGCGGCCGAGCGGCAACAGCTGAT CGCACGGATGCAGCAGGAAGACCAGGAGGGGCCGCCTACGTAGCCCCAGCTCCAGCCATCCACCCCTCAGCCCTTTTCTTCAACGTCACC |
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FusionGenePPI for RAB10_DNAJC17 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| RAB10 | RAB8A, AP1S1, DOK2, AURKA, SYTL3, MLPH, ENOPH1, MICAL1, PPBP, ELAVL1, EVI5L, APP, ZMPSTE24, VCP, FN1, MTNR1A, UBL4A, ITGA4, ATP4A, RPA3, RPA2, RPA1, ASB17, STAU1, OPTN, CUL7, RNF2, CFL1, GDI2, GPI, LGALS1, PPIA, FKBP2, FUBP3, HNRNPA3, MAP3K15, MDH2, PKM, TAGLN2, TKT, UBE2L3, RAB5C, RAB7A, TIAL1, UQCRC2, MED20, TCTN2, GDI1, MIRLET7A1, TSSC1, CDC73, CDH1, MTMR14, DUSP22, TTC30B, SDHA, FOXA1, TRIM25 | DNAJC17 | PTH1R, C1orf123, C12orf10, DHX29, ELAC2, HSPA5, KIN, TRMT6, HSPA14, HSPA9, HSPH1, HYOU1, HIST1H2BG |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for RAB10_DNAJC17 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for RAB10_DNAJC17 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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