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Fusion gene ID: 29861 |
FusionGeneSummary for R3HDM4_JAK3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: R3HDM4_JAK3 | Fusion gene ID: 29861 | Hgene | Tgene | Gene symbol | R3HDM4 | JAK3 | Gene ID | 91300 | 3718 |
| Gene name | R3H domain containing 4 | Janus kinase 3 | |
| Synonyms | C19orf22 | JAK-3|JAK3_HUMAN|JAKL|L-JAK|LJAK | |
| Cytomap | 19p13.3 | 19p13.11 | |
| Type of gene | protein-coding | protein-coding | |
| Description | R3H domain-containing protein 4R3H domain-containing protein C19orf22 | tyrosine-protein kinase JAK3Janus kinase 3 (a protein tyrosine kinase, leukocyte)leukocyte Janus kinase | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q96D70 | P52333 | |
| Ensembl transtripts involved in fusion gene | ENST00000361574, ENST00000587975, | ENST00000458235, ENST00000534444, ENST00000526008, ENST00000527670, | |
| Fusion gene scores | * DoF score | 4 X 2 X 5=40 | 1 X 1 X 1=1 |
| # samples | 5 | 1 | |
| ** MAII score | log2(5/40*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: R3HDM4 [Title/Abstract] AND JAK3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Oncogene involved fusion gene, in-frame and retained their domain. Kinase involved fusion gene, inframe and retained kinase domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | JAK3 | GO:0035771 | interleukin-4-mediated signaling pathway | 7538655 |
| Tgene | JAK3 | GO:0070670 | response to interleukin-4 | 7538655|7594533 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | ESCA | TCGA-L5-A891-01A | R3HDM4 | chr19 | 913087 | - | JAK3 | chr19 | 17953981 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000361574 | ENST00000458235 | R3HDM4 | chr19 | 913087 | - | JAK3 | chr19 | 17953981 | - |
| In-frame | ENST00000361574 | ENST00000534444 | R3HDM4 | chr19 | 913087 | - | JAK3 | chr19 | 17953981 | - |
| 5CDS-5UTR | ENST00000361574 | ENST00000526008 | R3HDM4 | chr19 | 913087 | - | JAK3 | chr19 | 17953981 | - |
| 5CDS-5UTR | ENST00000361574 | ENST00000527670 | R3HDM4 | chr19 | 913087 | - | JAK3 | chr19 | 17953981 | - |
| In-frame | ENST00000587975 | ENST00000458235 | R3HDM4 | chr19 | 913087 | - | JAK3 | chr19 | 17953981 | - |
| In-frame | ENST00000587975 | ENST00000534444 | R3HDM4 | chr19 | 913087 | - | JAK3 | chr19 | 17953981 | - |
| 5CDS-5UTR | ENST00000587975 | ENST00000526008 | R3HDM4 | chr19 | 913087 | - | JAK3 | chr19 | 17953981 | - |
| 5CDS-5UTR | ENST00000587975 | ENST00000527670 | R3HDM4 | chr19 | 913087 | - | JAK3 | chr19 | 17953981 | - |
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FusionProtFeatures for R3HDM4_JAK3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| R3HDM4 | JAK3 |
| Non-receptor tyrosine kinase involved in variousprocesses such as cell growth, development, or differentiation.Mediates essential signaling events in both innate and adaptiveimmunity and plays a crucial role in hematopoiesis during T-cellsdevelopment. In the cytoplasm, plays a pivotal role in signaltransduction via its association with type I receptors sharing thecommon subunit gamma such as IL2R, IL4R, IL7R, IL9R, IL15R andIL21R. Following ligand binding to cell surface receptors,phosphorylates specific tyrosine residues on the cytoplasmic tailsof the receptor, creating docking sites for STATs proteins.Subsequently, phosphorylates the STATs proteins once they arerecruited to the receptor. Phosphorylated STATs then formhomodimer or heterodimers and translocate to the nucleus toactivate gene transcription. For example, upon IL2R activation byIL2, JAK1 and JAK3 molecules bind to IL2R beta (IL2RB) and gammachain (IL2RG) subunits inducing the tyrosine phosphorylation ofboth receptor subunits on their cytoplasmic domain. Then, STAT5AAND STAT5B are recruited, phosphorylated and activated by JAK1 andJAK3. Once activated, dimerized STAT5 translocates to the nucleusand promotes the transcription of specific target genes in acytokine-specific fashion. {ECO:0000269|PubMed:11909529,ECO:0000269|PubMed:20440074, ECO:0000269|PubMed:7662955,ECO:0000269|PubMed:8022485}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >JAK3 | chr19:913087 | chr19:17953981 | ENST00000458235 | - | 3 | 24 | 375_475 | 140 | 1125 | Domain | Note=SH2%3B atypical |
| Tgene | >JAK3 | chr19:913087 | chr19:17953981 | ENST00000458235 | - | 3 | 24 | 521_781 | 140 | 1125 | Domain | Protein kinase 1 |
| Tgene | >JAK3 | chr19:913087 | chr19:17953981 | ENST00000458235 | - | 3 | 24 | 822_1111 | 140 | 1125 | Domain | Protein kinase 2 |
| Tgene | >JAK3 | chr19:913087 | chr19:17953981 | ENST00000527670 | - | 2 | 23 | 375_475 | 140 | 1125 | Domain | Note=SH2%3B atypical |
| Tgene | >JAK3 | chr19:913087 | chr19:17953981 | ENST00000527670 | - | 2 | 23 | 521_781 | 140 | 1125 | Domain | Protein kinase 1 |
| Tgene | >JAK3 | chr19:913087 | chr19:17953981 | ENST00000527670 | - | 2 | 23 | 822_1111 | 140 | 1125 | Domain | Protein kinase 2 |
| Tgene | >JAK3 | chr19:913087 | chr19:17953981 | ENST00000534444 | - | 3 | 23 | 375_475 | 140 | 1095 | Domain | Note=SH2%3B atypical |
| Tgene | >JAK3 | chr19:913087 | chr19:17953981 | ENST00000534444 | - | 3 | 23 | 521_781 | 140 | 1095 | Domain | Protein kinase 1 |
| Tgene | >JAK3 | chr19:913087 | chr19:17953981 | ENST00000534444 | - | 3 | 23 | 822_1111 | 140 | 1095 | Domain | Protein kinase 2 |
| Tgene | >JAK3 | chr19:913087 | chr19:17953981 | ENST00000458235 | - | 3 | 24 | 828_836 | 140 | 1125 | Nucleotide binding | ATP |
| Tgene | >JAK3 | chr19:913087 | chr19:17953981 | ENST00000527670 | - | 2 | 23 | 828_836 | 140 | 1125 | Nucleotide binding | ATP |
| Tgene | >JAK3 | chr19:913087 | chr19:17953981 | ENST00000534444 | - | 3 | 23 | 828_836 | 140 | 1095 | Nucleotide binding | ATP |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >R3HDM4 | chr19:913087 | chr19:17953981 | ENST00000361574 | - | 1 | 8 | 132_184 | 23 | 269 | Compositional bias | Note=Arg-rich |
| Hgene | >R3HDM4 | chr19:913087 | chr19:17953981 | ENST00000361574 | - | 1 | 8 | 187_250 | 23 | 269 | Domain | R3H |
| Tgene | JAK3 | chr19:913087 | chr19:17953981 | ENST00000458235 | - | 3 | 24 | 24_356 | 140 | 1125 | Domain | FERM |
| Tgene | JAK3 | chr19:913087 | chr19:17953981 | ENST00000527670 | - | 2 | 23 | 24_356 | 140 | 1125 | Domain | FERM |
| Tgene | JAK3 | chr19:913087 | chr19:17953981 | ENST00000534444 | - | 3 | 23 | 24_356 | 140 | 1095 | Domain | FERM |
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FusionGeneSequence for R3HDM4_JAK3 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_R3HDM4_ENST00000361574_chr19_913087_-_JAK3_ENST00000458235_chr19_17953981_-_1008aa MVALENPECGPEAAEGTPGGRRLLTAVTWXVGASPWASVSRSRVSVSAWPCWTWPGWRESRPSGRESCXRLSATRPAYPQACATXSRAXA SXRGGVFGGRCAEPCAAWPPARQTGTRSWPSTSWTWSGWIQPGPPRPSTWASLGPLVATTGWGCSAWLVTAASPGPRENRRSSSPSATFQ KSXTLASSRPRALARPESTAWSLLPGQTTRFXRPSSQGCPRLCRSWRSWTATSGXPRTPSTSSARRWHRRGCWRKWPSSATAPSLWTLPS TSSRLGAHVLAPMFSAAAPRTLTASSSLSVSRTPLVLIIRAASSGAAPQEPSFWLASADPTAVFESSWQPAGMGGCTXMGWQXPSLPAVS PDPKKSPTXSWSREVTAHPHHPWFSPNPNTSXVRXHFTRSLLTAWSGMRTWAMGPSPRFTGAVAMRWWMGRPERQRCCXRSWMPSTRTAW SHSWKQRAXXAKCRTGISCCSTACAWLETAPWCRNLYTWGPXTCICENVATWCQPAGSCRWSNSWPTPSTIWRTKACPMAMSLPGRCSWL GRGLMGARPSSSXVTLGSAPLCXAWRCSPTGSPGWPPSVSGRRRHLAWKLTSGASAPRSGKCLVASPCPSVPWILLRNSNFMRTGSSCRP PSGQSWPCXFNSAWPMSRSRGPPSEPSFVTSIASSLQTMSSSQTPHLVPWHLVMGCGMVPSSMPAKTPRSSRRDTSSTSHSWARATLAAW SCAAMTRXATIQVPWWPXNSCSTAGQTSRGTFSGRFRSSKHCTVISLSSIVVSAMARAARACGWSWSTCPAAACATSCSGTARASMPAAS FSIPRRSARAWSTWAPAAACTATWPPETSSWRARHTSRSLTSAXLSCCRLTKTTTWSASQARAPFSGMPPNPSRTTSSLASQTSGASGSS CTSSSPTATKAAAPRPSSCGXWDVSGMSPPSAASWNCWRRARGCRRLLPALLRFTSSXSCAGPLAHRTGHHSAPWAPSWTCCGAEAGGVR >In-frame_R3HDM4_ENST00000361574_chr19_913087_-_JAK3_ENST00000534444_chr19_17953981_-_978aa MVALENPECGPEAAEGTPGGRRLLTAVTWXVGASPWASVSRSRVSVSAWPCWTWPGWRESRPSGRESCXRLSATRPAYPQACATXSRAXA SXRGGVFGGRCAEPCAAWPPARQTGTRSWPSTSWTWSGWIQPGPPRPSTWASLGPLVATTGWGCSAWLVTAASPGPRENRRSSSPSATFQ KSXTLASSRPRALARPESTAWSLLPGQTTRFXRPSSQGCPRLCRSWRSWTATSGXPRTPSTSSARRWHRRGCWRKWPSSATAPSLWTLPS TSSRLGAHVLAPMFSAAAPRTLTASSSLSVSRTPLVLIIRAASSGAAPQEPSFWLASADPTAVFESSWQPAGMGGCTXMGWQXPSLPAVS PDPKKSPTXSWSREVTAHPHHPWFSPNPNTSXVRXHFTRSLLTAWSGMRTWAMGPSPRFTGAVAMRWWMGRPERQRCCXRSWMPSTRTAW SHSWKQRAXXAKCRTGISCCSTACAWLETAPWCRNLYTWGPXTCICENVATWCQPAGSCRWSNSWPTPSTIWRTKACPMAMSLPGRCSWL GRGLMGARPSSSXVTLGSAPLCXAWRCSPTGSPGWPPSVSGRRRHLAWKLTSGASAPRSGKCLVASPCPSVPWILLRNSNFMRTGSSCRP PSGQSWPCXFNSAWPMSRSRGPPSEPSFVTSIASSLQTMSSSQTPHLVPWHLVMGCGMVPSSMPAKTPRSSRRDTSSTSHSWARATLAAW SCAAMTRXATIQVPWWPXNSCSTAGQTSRGTFSGRFRSSKHCTVISLSSIVVSAMARAARACGWSWSTCPAAACATSCSGTARASMPAAS FSIPRRSARAWSTWAPAAACTATWPPETSSWRARHTSRSLTSAXLSCCRLTKTTTWSASQARAPFSGMPPNPSRTTSSLASQTSGASGSS >In-frame_R3HDM4_ENST00000587975_chr19_913087_-_JAK3_ENST00000458235_chr19_17953981_-_1008aa MVALENPECGPEAAEGTPGGRRLLTAVTWXVGASPWASVSRSRVSVSAWPCWTWPGWRESRPSGRESCXRLSATRPAYPQACATXSRAXA SXRGGVFGGRCAEPCAAWPPARQTGTRSWPSTSWTWSGWIQPGPPRPSTWASLGPLVATTGWGCSAWLVTAASPGPRENRRSSSPSATFQ KSXTLASSRPRALARPESTAWSLLPGQTTRFXRPSSQGCPRLCRSWRSWTATSGXPRTPSTSSARRWHRRGCWRKWPSSATAPSLWTLPS TSSRLGAHVLAPMFSAAAPRTLTASSSLSVSRTPLVLIIRAASSGAAPQEPSFWLASADPTAVFESSWQPAGMGGCTXMGWQXPSLPAVS PDPKKSPTXSWSREVTAHPHHPWFSPNPNTSXVRXHFTRSLLTAWSGMRTWAMGPSPRFTGAVAMRWWMGRPERQRCCXRSWMPSTRTAW SHSWKQRAXXAKCRTGISCCSTACAWLETAPWCRNLYTWGPXTCICENVATWCQPAGSCRWSNSWPTPSTIWRTKACPMAMSLPGRCSWL GRGLMGARPSSSXVTLGSAPLCXAWRCSPTGSPGWPPSVSGRRRHLAWKLTSGASAPRSGKCLVASPCPSVPWILLRNSNFMRTGSSCRP PSGQSWPCXFNSAWPMSRSRGPPSEPSFVTSIASSLQTMSSSQTPHLVPWHLVMGCGMVPSSMPAKTPRSSRRDTSSTSHSWARATLAAW SCAAMTRXATIQVPWWPXNSCSTAGQTSRGTFSGRFRSSKHCTVISLSSIVVSAMARAARACGWSWSTCPAAACATSCSGTARASMPAAS FSIPRRSARAWSTWAPAAACTATWPPETSSWRARHTSRSLTSAXLSCCRLTKTTTWSASQARAPFSGMPPNPSRTTSSLASQTSGASGSS CTSSSPTATKAAAPRPSSCGXWDVSGMSPPSAASWNCWRRARGCRRLLPALLRFTSSXSCAGPLAHRTGHHSAPWAPSWTCCGAEAGGVR >In-frame_R3HDM4_ENST00000587975_chr19_913087_-_JAK3_ENST00000534444_chr19_17953981_-_978aa MVALENPECGPEAAEGTPGGRRLLTAVTWXVGASPWASVSRSRVSVSAWPCWTWPGWRESRPSGRESCXRLSATRPAYPQACATXSRAXA SXRGGVFGGRCAEPCAAWPPARQTGTRSWPSTSWTWSGWIQPGPPRPSTWASLGPLVATTGWGCSAWLVTAASPGPRENRRSSSPSATFQ KSXTLASSRPRALARPESTAWSLLPGQTTRFXRPSSQGCPRLCRSWRSWTATSGXPRTPSTSSARRWHRRGCWRKWPSSATAPSLWTLPS TSSRLGAHVLAPMFSAAAPRTLTASSSLSVSRTPLVLIIRAASSGAAPQEPSFWLASADPTAVFESSWQPAGMGGCTXMGWQXPSLPAVS PDPKKSPTXSWSREVTAHPHHPWFSPNPNTSXVRXHFTRSLLTAWSGMRTWAMGPSPRFTGAVAMRWWMGRPERQRCCXRSWMPSTRTAW SHSWKQRAXXAKCRTGISCCSTACAWLETAPWCRNLYTWGPXTCICENVATWCQPAGSCRWSNSWPTPSTIWRTKACPMAMSLPGRCSWL GRGLMGARPSSSXVTLGSAPLCXAWRCSPTGSPGWPPSVSGRRRHLAWKLTSGASAPRSGKCLVASPCPSVPWILLRNSNFMRTGSSCRP PSGQSWPCXFNSAWPMSRSRGPPSEPSFVTSIASSLQTMSSSQTPHLVPWHLVMGCGMVPSSMPAKTPRSSRRDTSSTSHSWARATLAAW SCAAMTRXATIQVPWWPXNSCSTAGQTSRGTFSGRFRSSKHCTVISLSSIVVSAMARAARACGWSWSTCPAAACATSCSGTARASMPAAS FSIPRRSARAWSTWAPAAACTATWPPETSSWRARHTSRSLTSAXLSCCRLTKTTTWSASQARAPFSGMPPNPSRTTSSLASQTSGASGSS |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_R3HDM4_ENST00000361574_chr19_913087_-_JAK3_ENST00000458235_chr19_17953981_-_3026nt ATGGTCGCGCTGGAGAACCCCGAGTGCGGCCCGGAGGCGGCGGAGGGCACCCCGGGCGGGCGGCGGCTGCTCACCGCAGTGACCTGGTGA GTGGGCGCCTCCCCGTGGGCCTCAGTCTCAAGGAGCAGGGTGAGTGTCTCAGCCTGGCCGTGTTGGACCTGGCCCGGATGGCGCGAGAGC AGGCCCAGCGGCCGGGAGAGCTGCTGAAGACTGTCAGCTACAAGGCCTGCCTACCCCCAAGCCTGCGCGACCTGATCCAGGGCCTGAGCT TCGTGACGCGGAGGCGTATTCGGAGGACGGTGCGCAGAGCCCTGCGCCGCGTGGCCGCCTGCCAGGCAGACCGGCACTCGCTCATGGCCA AGTACATCATGGACCTGGAGCGGCTGGATCCAGCCGGGGCCGCCGAGACCTTCCACGTGGGCCTCCCTGGGGCCCTTGGTGGCCACGACG GGCTGGGGCTGCTCCGCGTGGCTGGTGACGGCGGCATCGCCTGGACCCAGGGAGAACAGGAGGTCCTCCAGCCCTTCTGCGACTTTCCAG AAATCGTAGACATTAGCATCAAGCAGGCCCCGCGCGTTGGCCCGGCCGGAGAGCACCGCCTGGTCACTGTTACCAGGACAGACAACCAGA TTTTAGAGGCCGAGTTCCCAGGGCTGCCCGAGGCTCTGTCGTTCGTGGCGCTCGTGGACGGCTACTTCCGGCTGACCACGGACTCCCAGC ACTTCTTCTGCAAGGAGGTGGCACCGCCGAGGCTGCTGGAGGAAGTGGCCGAGCAGTGCCACGGCCCCATCACTCTGGACTTTGCCATCA ACAAGCTCAAGACTGGGGGCTCACGTCCTGGCTCCTATGTTCTCCGCCGCAGCCCCCAGGACTTTGACAGCTTCCTCCTCACTGTCTGTG TCCAGAACCCCCTTGGTCCTGATTATAAGGGCTGCCTCATCCGGCGCAGCCCCACAGGAACCTTCCTTCTGGTTGGCCTCAGCCGACCCC ACAGCAGTCTTCGAGAGCTCCTGGCAACCTGCTGGGATGGGGGGCTGCACGTAGATGGGGTGGCAGTGACCCTCACTTCCTGCTGTATCC CCAGACCCAAAGAAAAGTCCAACCTGATCGTGGTCCAGAGAGGTCACAGCCCACCCACATCATCCTTGGTTCAGCCCCAATCCCAATACC AGCTGAGTCAGATGACATTTCACAAGATCCCTGCTGACAGCCTGGAGTGGCATGAGAACCTGGGCCATGGGTCCTTCACCAAGATTTACC GGGGCTGTCGCCATGAGGTGGTGGATGGGGAGGCCCGAAAGACAGAGGTGCTGCTGAAGGTCATGGATGCCAAGCACAAGAACTGCATGG AGTCATTCCTGGAAGCAGCGAGCTTGATGAGCCAAGTGTCGTACCGGCATCTCGTGCTGCTCCACGGCGTGTGCATGGCTGGAGACAGCA CCATGGTGCAGGAATTTGTACACCTGGGGGCCATAGACATGTATCTGCGAAAACGTGGCCACCTGGTGCCAGCCAGCTGGAAGCTGCAGG TGGTCAAACAGCTGGCCTACGCCCTCAACTATCTGGAGGACAAAGGCCTGCCCCATGGCAATGTCTCTGCCCGGAAGGTGCTCCTGGCTC GGGAGGGGGCTGATGGGAGCCCGCCCTTCATCAAGCTGAGTGACCCTGGGGTCAGCCCCGCTGTGTTAAGCCTGGAGATGCTCACCGACA GGATCCCCTGGGTGGCCCCCGAGTGTCTCCGGGAGGCGCAGACACTTAGCTTGGAAGCTGACAAGTGGGGCTTCGGCGCCACGGTCTGGG AAGTGTTTAGTGGCGTCACCATGCCCATCAGTGCCCTGGATCCTGCTAAGAAACTCCAATTTTATGAGGACCGGCAGCAGCTGCCGGCCC CCAAGTGGACAGAGCTGGCCCTGCTGATTCAACAGTGCATGGCCTATGAGCCGGTCCAGAGGCCCTCCTTCCGAGCCGTCATTCGTGACC TCAATAGCCTCATCTCTTCAGACTATGAGCTCCTCTCAGACCCCACACCTGGTGCCCTGGCACCTCGTGATGGGCTGTGGAATGGTGCCC AGCTCTATGCCTGCCAAGACCCCACGATCTTCGAGGAGAGACACCTCAAGTACATCTCACAGCTGGGCAAGGGCAACTTTGGCAGCGTGG AGCTGTGCCGCTATGACCCGCTAGGCGACAATACAGGTGCCCTGGTGGCCGTGAAACAGCTGCAGCACAGCGGGCCAGACCAGCAGAGGG ACTTTCAGCGGGAGATTCAGATCCTCAAAGCACTGCACAGTGATTTCATTGTCAAGTATCGTGGTGTCAGCTATGGCCCGGGCCGCCAGA GCCTGCGGCTGGTCATGGAGTACCTGCCCAGCGGCTGCTTGCGCGACTTCCTGCAGCGGCACCGCGCGCGCCTCGATGCCAGCCGCCTCC TTCTCTATTCCTCGCAGATCTGCAAGGGCATGGAGTACCTGGGCTCCCGCCGCTGCGTGCACCGCGACCTGGCCGCCCGAAACATCCTCG TGGAGAGCGAGGCACACGTCAAGATCGCTGACTTCGGCCTAGCTAAGCTGCTGCCGCTTGACAAAGACTACTACGTGGTCCGCGAGCCAG GCCAGAGCCCCATTTTCTGGTATGCCCCCGAATCCCTCTCGGACAACATCTTCTCTCGCCAGTCAGACGTCTGGAGCTTCGGGGTCGTCC TGTACGAGCTCTTCACCTACTGCGACAAAAGCTGCAGCCCCTCGGCCGAGTTCCTGCGGATGATGGGATGTGAGCGGGATGTCCCCGCCC TCTGCCGCCTCTTGGAACTGCTGGAGGAGGGCCAGAGGCTGCCGGCGCCTCCTGCCTGCCCTGCTGAGGTTCACGAGCTCATGAAGCTGT GCTGGGCCCCTAGCCCACAGGACCGGCCATCATTCAGCGCCCTGGGCCCCCAGCTGGACATGCTGTGGAGCGGAAGCCGGGGGTGTGAGA >In-frame_R3HDM4_ENST00000361574_chr19_913087_-_JAK3_ENST00000534444_chr19_17953981_-_2936nt ATGGTCGCGCTGGAGAACCCCGAGTGCGGCCCGGAGGCGGCGGAGGGCACCCCGGGCGGGCGGCGGCTGCTCACCGCAGTGACCTGGTGA GTGGGCGCCTCCCCGTGGGCCTCAGTCTCAAGGAGCAGGGTGAGTGTCTCAGCCTGGCCGTGTTGGACCTGGCCCGGATGGCGCGAGAGC AGGCCCAGCGGCCGGGAGAGCTGCTGAAGACTGTCAGCTACAAGGCCTGCCTACCCCCAAGCCTGCGCGACCTGATCCAGGGCCTGAGCT TCGTGACGCGGAGGCGTATTCGGAGGACGGTGCGCAGAGCCCTGCGCCGCGTGGCCGCCTGCCAGGCAGACCGGCACTCGCTCATGGCCA AGTACATCATGGACCTGGAGCGGCTGGATCCAGCCGGGGCCGCCGAGACCTTCCACGTGGGCCTCCCTGGGGCCCTTGGTGGCCACGACG GGCTGGGGCTGCTCCGCGTGGCTGGTGACGGCGGCATCGCCTGGACCCAGGGAGAACAGGAGGTCCTCCAGCCCTTCTGCGACTTTCCAG AAATCGTAGACATTAGCATCAAGCAGGCCCCGCGCGTTGGCCCGGCCGGAGAGCACCGCCTGGTCACTGTTACCAGGACAGACAACCAGA TTTTAGAGGCCGAGTTCCCAGGGCTGCCCGAGGCTCTGTCGTTCGTGGCGCTCGTGGACGGCTACTTCCGGCTGACCACGGACTCCCAGC ACTTCTTCTGCAAGGAGGTGGCACCGCCGAGGCTGCTGGAGGAAGTGGCCGAGCAGTGCCACGGCCCCATCACTCTGGACTTTGCCATCA ACAAGCTCAAGACTGGGGGCTCACGTCCTGGCTCCTATGTTCTCCGCCGCAGCCCCCAGGACTTTGACAGCTTCCTCCTCACTGTCTGTG TCCAGAACCCCCTTGGTCCTGATTATAAGGGCTGCCTCATCCGGCGCAGCCCCACAGGAACCTTCCTTCTGGTTGGCCTCAGCCGACCCC ACAGCAGTCTTCGAGAGCTCCTGGCAACCTGCTGGGATGGGGGGCTGCACGTAGATGGGGTGGCAGTGACCCTCACTTCCTGCTGTATCC CCAGACCCAAAGAAAAGTCCAACCTGATCGTGGTCCAGAGAGGTCACAGCCCACCCACATCATCCTTGGTTCAGCCCCAATCCCAATACC AGCTGAGTCAGATGACATTTCACAAGATCCCTGCTGACAGCCTGGAGTGGCATGAGAACCTGGGCCATGGGTCCTTCACCAAGATTTACC GGGGCTGTCGCCATGAGGTGGTGGATGGGGAGGCCCGAAAGACAGAGGTGCTGCTGAAGGTCATGGATGCCAAGCACAAGAACTGCATGG AGTCATTCCTGGAAGCAGCGAGCTTGATGAGCCAAGTGTCGTACCGGCATCTCGTGCTGCTCCACGGCGTGTGCATGGCTGGAGACAGCA CCATGGTGCAGGAATTTGTACACCTGGGGGCCATAGACATGTATCTGCGAAAACGTGGCCACCTGGTGCCAGCCAGCTGGAAGCTGCAGG TGGTCAAACAGCTGGCCTACGCCCTCAACTATCTGGAGGACAAAGGCCTGCCCCATGGCAATGTCTCTGCCCGGAAGGTGCTCCTGGCTC GGGAGGGGGCTGATGGGAGCCCGCCCTTCATCAAGCTGAGTGACCCTGGGGTCAGCCCCGCTGTGTTAAGCCTGGAGATGCTCACCGACA GGATCCCCTGGGTGGCCCCCGAGTGTCTCCGGGAGGCGCAGACACTTAGCTTGGAAGCTGACAAGTGGGGCTTCGGCGCCACGGTCTGGG AAGTGTTTAGTGGCGTCACCATGCCCATCAGTGCCCTGGATCCTGCTAAGAAACTCCAATTTTATGAGGACCGGCAGCAGCTGCCGGCCC CCAAGTGGACAGAGCTGGCCCTGCTGATTCAACAGTGCATGGCCTATGAGCCGGTCCAGAGGCCCTCCTTCCGAGCCGTCATTCGTGACC TCAATAGCCTCATCTCTTCAGACTATGAGCTCCTCTCAGACCCCACACCTGGTGCCCTGGCACCTCGTGATGGGCTGTGGAATGGTGCCC AGCTCTATGCCTGCCAAGACCCCACGATCTTCGAGGAGAGACACCTCAAGTACATCTCACAGCTGGGCAAGGGCAACTTTGGCAGCGTGG AGCTGTGCCGCTATGACCCGCTAGGCGACAATACAGGTGCCCTGGTGGCCGTGAAACAGCTGCAGCACAGCGGGCCAGACCAGCAGAGGG ACTTTCAGCGGGAGATTCAGATCCTCAAAGCACTGCACAGTGATTTCATTGTCAAGTATCGTGGTGTCAGCTATGGCCCGGGCCGCCAGA GCCTGCGGCTGGTCATGGAGTACCTGCCCAGCGGCTGCTTGCGCGACTTCCTGCAGCGGCACCGCGCGCGCCTCGATGCCAGCCGCCTCC TTCTCTATTCCTCGCAGATCTGCAAGGGCATGGAGTACCTGGGCTCCCGCCGCTGCGTGCACCGCGACCTGGCCGCCCGAAACATCCTCG TGGAGAGCGAGGCACACGTCAAGATCGCTGACTTCGGCCTAGCTAAGCTGCTGCCGCTTGACAAAGACTACTACGTGGTCCGCGAGCCAG GCCAGAGCCCCATTTTCTGGTATGCCCCCGAATCCCTCTCGGACAACATCTTCTCTCGCCAGTCAGACGTCTGGAGCTTCGGGGTCGTCC TGTACGAGCTCTTCACCTACTGCGACAAAAGCTGCAGCCCCTCGGCCGAGTTCCTGCGGATGATGGGATGTGAGCGGGATGTCCCCGCCC TCTGCCGCCTCTTGGAACTGCTGGAGGAGGGCCAGAGGCTGCCGGCGCCTCCTGCCTGCCCTGCTGAGGTGAGCGCCGCAGGGCTAGCCT >In-frame_R3HDM4_ENST00000587975_chr19_913087_-_JAK3_ENST00000458235_chr19_17953981_-_3026nt ATGGTCGCGCTGGAGAACCCCGAGTGCGGCCCGGAGGCGGCGGAGGGCACCCCGGGCGGGCGGCGGCTGCTCACCGCAGTGACCTGGTGA GTGGGCGCCTCCCCGTGGGCCTCAGTCTCAAGGAGCAGGGTGAGTGTCTCAGCCTGGCCGTGTTGGACCTGGCCCGGATGGCGCGAGAGC AGGCCCAGCGGCCGGGAGAGCTGCTGAAGACTGTCAGCTACAAGGCCTGCCTACCCCCAAGCCTGCGCGACCTGATCCAGGGCCTGAGCT TCGTGACGCGGAGGCGTATTCGGAGGACGGTGCGCAGAGCCCTGCGCCGCGTGGCCGCCTGCCAGGCAGACCGGCACTCGCTCATGGCCA AGTACATCATGGACCTGGAGCGGCTGGATCCAGCCGGGGCCGCCGAGACCTTCCACGTGGGCCTCCCTGGGGCCCTTGGTGGCCACGACG GGCTGGGGCTGCTCCGCGTGGCTGGTGACGGCGGCATCGCCTGGACCCAGGGAGAACAGGAGGTCCTCCAGCCCTTCTGCGACTTTCCAG AAATCGTAGACATTAGCATCAAGCAGGCCCCGCGCGTTGGCCCGGCCGGAGAGCACCGCCTGGTCACTGTTACCAGGACAGACAACCAGA TTTTAGAGGCCGAGTTCCCAGGGCTGCCCGAGGCTCTGTCGTTCGTGGCGCTCGTGGACGGCTACTTCCGGCTGACCACGGACTCCCAGC ACTTCTTCTGCAAGGAGGTGGCACCGCCGAGGCTGCTGGAGGAAGTGGCCGAGCAGTGCCACGGCCCCATCACTCTGGACTTTGCCATCA ACAAGCTCAAGACTGGGGGCTCACGTCCTGGCTCCTATGTTCTCCGCCGCAGCCCCCAGGACTTTGACAGCTTCCTCCTCACTGTCTGTG TCCAGAACCCCCTTGGTCCTGATTATAAGGGCTGCCTCATCCGGCGCAGCCCCACAGGAACCTTCCTTCTGGTTGGCCTCAGCCGACCCC ACAGCAGTCTTCGAGAGCTCCTGGCAACCTGCTGGGATGGGGGGCTGCACGTAGATGGGGTGGCAGTGACCCTCACTTCCTGCTGTATCC CCAGACCCAAAGAAAAGTCCAACCTGATCGTGGTCCAGAGAGGTCACAGCCCACCCACATCATCCTTGGTTCAGCCCCAATCCCAATACC AGCTGAGTCAGATGACATTTCACAAGATCCCTGCTGACAGCCTGGAGTGGCATGAGAACCTGGGCCATGGGTCCTTCACCAAGATTTACC GGGGCTGTCGCCATGAGGTGGTGGATGGGGAGGCCCGAAAGACAGAGGTGCTGCTGAAGGTCATGGATGCCAAGCACAAGAACTGCATGG AGTCATTCCTGGAAGCAGCGAGCTTGATGAGCCAAGTGTCGTACCGGCATCTCGTGCTGCTCCACGGCGTGTGCATGGCTGGAGACAGCA CCATGGTGCAGGAATTTGTACACCTGGGGGCCATAGACATGTATCTGCGAAAACGTGGCCACCTGGTGCCAGCCAGCTGGAAGCTGCAGG TGGTCAAACAGCTGGCCTACGCCCTCAACTATCTGGAGGACAAAGGCCTGCCCCATGGCAATGTCTCTGCCCGGAAGGTGCTCCTGGCTC GGGAGGGGGCTGATGGGAGCCCGCCCTTCATCAAGCTGAGTGACCCTGGGGTCAGCCCCGCTGTGTTAAGCCTGGAGATGCTCACCGACA GGATCCCCTGGGTGGCCCCCGAGTGTCTCCGGGAGGCGCAGACACTTAGCTTGGAAGCTGACAAGTGGGGCTTCGGCGCCACGGTCTGGG AAGTGTTTAGTGGCGTCACCATGCCCATCAGTGCCCTGGATCCTGCTAAGAAACTCCAATTTTATGAGGACCGGCAGCAGCTGCCGGCCC CCAAGTGGACAGAGCTGGCCCTGCTGATTCAACAGTGCATGGCCTATGAGCCGGTCCAGAGGCCCTCCTTCCGAGCCGTCATTCGTGACC TCAATAGCCTCATCTCTTCAGACTATGAGCTCCTCTCAGACCCCACACCTGGTGCCCTGGCACCTCGTGATGGGCTGTGGAATGGTGCCC AGCTCTATGCCTGCCAAGACCCCACGATCTTCGAGGAGAGACACCTCAAGTACATCTCACAGCTGGGCAAGGGCAACTTTGGCAGCGTGG AGCTGTGCCGCTATGACCCGCTAGGCGACAATACAGGTGCCCTGGTGGCCGTGAAACAGCTGCAGCACAGCGGGCCAGACCAGCAGAGGG ACTTTCAGCGGGAGATTCAGATCCTCAAAGCACTGCACAGTGATTTCATTGTCAAGTATCGTGGTGTCAGCTATGGCCCGGGCCGCCAGA GCCTGCGGCTGGTCATGGAGTACCTGCCCAGCGGCTGCTTGCGCGACTTCCTGCAGCGGCACCGCGCGCGCCTCGATGCCAGCCGCCTCC TTCTCTATTCCTCGCAGATCTGCAAGGGCATGGAGTACCTGGGCTCCCGCCGCTGCGTGCACCGCGACCTGGCCGCCCGAAACATCCTCG TGGAGAGCGAGGCACACGTCAAGATCGCTGACTTCGGCCTAGCTAAGCTGCTGCCGCTTGACAAAGACTACTACGTGGTCCGCGAGCCAG GCCAGAGCCCCATTTTCTGGTATGCCCCCGAATCCCTCTCGGACAACATCTTCTCTCGCCAGTCAGACGTCTGGAGCTTCGGGGTCGTCC TGTACGAGCTCTTCACCTACTGCGACAAAAGCTGCAGCCCCTCGGCCGAGTTCCTGCGGATGATGGGATGTGAGCGGGATGTCCCCGCCC TCTGCCGCCTCTTGGAACTGCTGGAGGAGGGCCAGAGGCTGCCGGCGCCTCCTGCCTGCCCTGCTGAGGTTCACGAGCTCATGAAGCTGT GCTGGGCCCCTAGCCCACAGGACCGGCCATCATTCAGCGCCCTGGGCCCCCAGCTGGACATGCTGTGGAGCGGAAGCCGGGGGTGTGAGA >In-frame_R3HDM4_ENST00000587975_chr19_913087_-_JAK3_ENST00000534444_chr19_17953981_-_2936nt ATGGTCGCGCTGGAGAACCCCGAGTGCGGCCCGGAGGCGGCGGAGGGCACCCCGGGCGGGCGGCGGCTGCTCACCGCAGTGACCTGGTGA GTGGGCGCCTCCCCGTGGGCCTCAGTCTCAAGGAGCAGGGTGAGTGTCTCAGCCTGGCCGTGTTGGACCTGGCCCGGATGGCGCGAGAGC AGGCCCAGCGGCCGGGAGAGCTGCTGAAGACTGTCAGCTACAAGGCCTGCCTACCCCCAAGCCTGCGCGACCTGATCCAGGGCCTGAGCT TCGTGACGCGGAGGCGTATTCGGAGGACGGTGCGCAGAGCCCTGCGCCGCGTGGCCGCCTGCCAGGCAGACCGGCACTCGCTCATGGCCA AGTACATCATGGACCTGGAGCGGCTGGATCCAGCCGGGGCCGCCGAGACCTTCCACGTGGGCCTCCCTGGGGCCCTTGGTGGCCACGACG GGCTGGGGCTGCTCCGCGTGGCTGGTGACGGCGGCATCGCCTGGACCCAGGGAGAACAGGAGGTCCTCCAGCCCTTCTGCGACTTTCCAG AAATCGTAGACATTAGCATCAAGCAGGCCCCGCGCGTTGGCCCGGCCGGAGAGCACCGCCTGGTCACTGTTACCAGGACAGACAACCAGA TTTTAGAGGCCGAGTTCCCAGGGCTGCCCGAGGCTCTGTCGTTCGTGGCGCTCGTGGACGGCTACTTCCGGCTGACCACGGACTCCCAGC ACTTCTTCTGCAAGGAGGTGGCACCGCCGAGGCTGCTGGAGGAAGTGGCCGAGCAGTGCCACGGCCCCATCACTCTGGACTTTGCCATCA ACAAGCTCAAGACTGGGGGCTCACGTCCTGGCTCCTATGTTCTCCGCCGCAGCCCCCAGGACTTTGACAGCTTCCTCCTCACTGTCTGTG TCCAGAACCCCCTTGGTCCTGATTATAAGGGCTGCCTCATCCGGCGCAGCCCCACAGGAACCTTCCTTCTGGTTGGCCTCAGCCGACCCC ACAGCAGTCTTCGAGAGCTCCTGGCAACCTGCTGGGATGGGGGGCTGCACGTAGATGGGGTGGCAGTGACCCTCACTTCCTGCTGTATCC CCAGACCCAAAGAAAAGTCCAACCTGATCGTGGTCCAGAGAGGTCACAGCCCACCCACATCATCCTTGGTTCAGCCCCAATCCCAATACC AGCTGAGTCAGATGACATTTCACAAGATCCCTGCTGACAGCCTGGAGTGGCATGAGAACCTGGGCCATGGGTCCTTCACCAAGATTTACC GGGGCTGTCGCCATGAGGTGGTGGATGGGGAGGCCCGAAAGACAGAGGTGCTGCTGAAGGTCATGGATGCCAAGCACAAGAACTGCATGG AGTCATTCCTGGAAGCAGCGAGCTTGATGAGCCAAGTGTCGTACCGGCATCTCGTGCTGCTCCACGGCGTGTGCATGGCTGGAGACAGCA CCATGGTGCAGGAATTTGTACACCTGGGGGCCATAGACATGTATCTGCGAAAACGTGGCCACCTGGTGCCAGCCAGCTGGAAGCTGCAGG TGGTCAAACAGCTGGCCTACGCCCTCAACTATCTGGAGGACAAAGGCCTGCCCCATGGCAATGTCTCTGCCCGGAAGGTGCTCCTGGCTC GGGAGGGGGCTGATGGGAGCCCGCCCTTCATCAAGCTGAGTGACCCTGGGGTCAGCCCCGCTGTGTTAAGCCTGGAGATGCTCACCGACA GGATCCCCTGGGTGGCCCCCGAGTGTCTCCGGGAGGCGCAGACACTTAGCTTGGAAGCTGACAAGTGGGGCTTCGGCGCCACGGTCTGGG AAGTGTTTAGTGGCGTCACCATGCCCATCAGTGCCCTGGATCCTGCTAAGAAACTCCAATTTTATGAGGACCGGCAGCAGCTGCCGGCCC CCAAGTGGACAGAGCTGGCCCTGCTGATTCAACAGTGCATGGCCTATGAGCCGGTCCAGAGGCCCTCCTTCCGAGCCGTCATTCGTGACC TCAATAGCCTCATCTCTTCAGACTATGAGCTCCTCTCAGACCCCACACCTGGTGCCCTGGCACCTCGTGATGGGCTGTGGAATGGTGCCC AGCTCTATGCCTGCCAAGACCCCACGATCTTCGAGGAGAGACACCTCAAGTACATCTCACAGCTGGGCAAGGGCAACTTTGGCAGCGTGG AGCTGTGCCGCTATGACCCGCTAGGCGACAATACAGGTGCCCTGGTGGCCGTGAAACAGCTGCAGCACAGCGGGCCAGACCAGCAGAGGG ACTTTCAGCGGGAGATTCAGATCCTCAAAGCACTGCACAGTGATTTCATTGTCAAGTATCGTGGTGTCAGCTATGGCCCGGGCCGCCAGA GCCTGCGGCTGGTCATGGAGTACCTGCCCAGCGGCTGCTTGCGCGACTTCCTGCAGCGGCACCGCGCGCGCCTCGATGCCAGCCGCCTCC TTCTCTATTCCTCGCAGATCTGCAAGGGCATGGAGTACCTGGGCTCCCGCCGCTGCGTGCACCGCGACCTGGCCGCCCGAAACATCCTCG TGGAGAGCGAGGCACACGTCAAGATCGCTGACTTCGGCCTAGCTAAGCTGCTGCCGCTTGACAAAGACTACTACGTGGTCCGCGAGCCAG GCCAGAGCCCCATTTTCTGGTATGCCCCCGAATCCCTCTCGGACAACATCTTCTCTCGCCAGTCAGACGTCTGGAGCTTCGGGGTCGTCC TGTACGAGCTCTTCACCTACTGCGACAAAAGCTGCAGCCCCTCGGCCGAGTTCCTGCGGATGATGGGATGTGAGCGGGATGTCCCCGCCC TCTGCCGCCTCTTGGAACTGCTGGAGGAGGGCCAGAGGCTGCCGGCGCCTCCTGCCTGCCCTGCTGAGGTGAGCGCCGCAGGGCTAGCCT |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_R3HDM4_ENST00000361574_chr19_913087_-_JAK3_ENST00000458235_chr19_17953981_-_5057nt CGGGCGCCCGTCACTTCCTGCCCGGCCCGGTGAAGGCCCTGCCGGGCGGCGGCGGCGGCGACAGCGTGCGAGCCATGGTCGCGCTGGAGA ACCCCGAGTGCGGCCCGGAGGCGGCGGAGGGCACCCCGGGCGGGCGGCGGCTGCTCACCGCAGTGACCTGGTGAGTGGGCGCCTCCCCGT GGGCCTCAGTCTCAAGGAGCAGGGTGAGTGTCTCAGCCTGGCCGTGTTGGACCTGGCCCGGATGGCGCGAGAGCAGGCCCAGCGGCCGGG AGAGCTGCTGAAGACTGTCAGCTACAAGGCCTGCCTACCCCCAAGCCTGCGCGACCTGATCCAGGGCCTGAGCTTCGTGACGCGGAGGCG TATTCGGAGGACGGTGCGCAGAGCCCTGCGCCGCGTGGCCGCCTGCCAGGCAGACCGGCACTCGCTCATGGCCAAGTACATCATGGACCT GGAGCGGCTGGATCCAGCCGGGGCCGCCGAGACCTTCCACGTGGGCCTCCCTGGGGCCCTTGGTGGCCACGACGGGCTGGGGCTGCTCCG CGTGGCTGGTGACGGCGGCATCGCCTGGACCCAGGGAGAACAGGAGGTCCTCCAGCCCTTCTGCGACTTTCCAGAAATCGTAGACATTAG CATCAAGCAGGCCCCGCGCGTTGGCCCGGCCGGAGAGCACCGCCTGGTCACTGTTACCAGGACAGACAACCAGATTTTAGAGGCCGAGTT CCCAGGGCTGCCCGAGGCTCTGTCGTTCGTGGCGCTCGTGGACGGCTACTTCCGGCTGACCACGGACTCCCAGCACTTCTTCTGCAAGGA GGTGGCACCGCCGAGGCTGCTGGAGGAAGTGGCCGAGCAGTGCCACGGCCCCATCACTCTGGACTTTGCCATCAACAAGCTCAAGACTGG GGGCTCACGTCCTGGCTCCTATGTTCTCCGCCGCAGCCCCCAGGACTTTGACAGCTTCCTCCTCACTGTCTGTGTCCAGAACCCCCTTGG TCCTGATTATAAGGGCTGCCTCATCCGGCGCAGCCCCACAGGAACCTTCCTTCTGGTTGGCCTCAGCCGACCCCACAGCAGTCTTCGAGA GCTCCTGGCAACCTGCTGGGATGGGGGGCTGCACGTAGATGGGGTGGCAGTGACCCTCACTTCCTGCTGTATCCCCAGACCCAAAGAAAA GTCCAACCTGATCGTGGTCCAGAGAGGTCACAGCCCACCCACATCATCCTTGGTTCAGCCCCAATCCCAATACCAGCTGAGTCAGATGAC ATTTCACAAGATCCCTGCTGACAGCCTGGAGTGGCATGAGAACCTGGGCCATGGGTCCTTCACCAAGATTTACCGGGGCTGTCGCCATGA GGTGGTGGATGGGGAGGCCCGAAAGACAGAGGTGCTGCTGAAGGTCATGGATGCCAAGCACAAGAACTGCATGGAGTCATTCCTGGAAGC AGCGAGCTTGATGAGCCAAGTGTCGTACCGGCATCTCGTGCTGCTCCACGGCGTGTGCATGGCTGGAGACAGCACCATGGTGCAGGAATT TGTACACCTGGGGGCCATAGACATGTATCTGCGAAAACGTGGCCACCTGGTGCCAGCCAGCTGGAAGCTGCAGGTGGTCAAACAGCTGGC CTACGCCCTCAACTATCTGGAGGACAAAGGCCTGCCCCATGGCAATGTCTCTGCCCGGAAGGTGCTCCTGGCTCGGGAGGGGGCTGATGG GAGCCCGCCCTTCATCAAGCTGAGTGACCCTGGGGTCAGCCCCGCTGTGTTAAGCCTGGAGATGCTCACCGACAGGATCCCCTGGGTGGC CCCCGAGTGTCTCCGGGAGGCGCAGACACTTAGCTTGGAAGCTGACAAGTGGGGCTTCGGCGCCACGGTCTGGGAAGTGTTTAGTGGCGT CACCATGCCCATCAGTGCCCTGGATCCTGCTAAGAAACTCCAATTTTATGAGGACCGGCAGCAGCTGCCGGCCCCCAAGTGGACAGAGCT GGCCCTGCTGATTCAACAGTGCATGGCCTATGAGCCGGTCCAGAGGCCCTCCTTCCGAGCCGTCATTCGTGACCTCAATAGCCTCATCTC TTCAGACTATGAGCTCCTCTCAGACCCCACACCTGGTGCCCTGGCACCTCGTGATGGGCTGTGGAATGGTGCCCAGCTCTATGCCTGCCA AGACCCCACGATCTTCGAGGAGAGACACCTCAAGTACATCTCACAGCTGGGCAAGGGCAACTTTGGCAGCGTGGAGCTGTGCCGCTATGA CCCGCTAGGCGACAATACAGGTGCCCTGGTGGCCGTGAAACAGCTGCAGCACAGCGGGCCAGACCAGCAGAGGGACTTTCAGCGGGAGAT TCAGATCCTCAAAGCACTGCACAGTGATTTCATTGTCAAGTATCGTGGTGTCAGCTATGGCCCGGGCCGCCAGAGCCTGCGGCTGGTCAT GGAGTACCTGCCCAGCGGCTGCTTGCGCGACTTCCTGCAGCGGCACCGCGCGCGCCTCGATGCCAGCCGCCTCCTTCTCTATTCCTCGCA GATCTGCAAGGGCATGGAGTACCTGGGCTCCCGCCGCTGCGTGCACCGCGACCTGGCCGCCCGAAACATCCTCGTGGAGAGCGAGGCACA CGTCAAGATCGCTGACTTCGGCCTAGCTAAGCTGCTGCCGCTTGACAAAGACTACTACGTGGTCCGCGAGCCAGGCCAGAGCCCCATTTT CTGGTATGCCCCCGAATCCCTCTCGGACAACATCTTCTCTCGCCAGTCAGACGTCTGGAGCTTCGGGGTCGTCCTGTACGAGCTCTTCAC CTACTGCGACAAAAGCTGCAGCCCCTCGGCCGAGTTCCTGCGGATGATGGGATGTGAGCGGGATGTCCCCGCCCTCTGCCGCCTCTTGGA ACTGCTGGAGGAGGGCCAGAGGCTGCCGGCGCCTCCTGCCTGCCCTGCTGAGGTTCACGAGCTCATGAAGCTGTGCTGGGCCCCTAGCCC ACAGGACCGGCCATCATTCAGCGCCCTGGGCCCCCAGCTGGACATGCTGTGGAGCGGAAGCCGGGGGTGTGAGACTCATGCCTTCACTGC TCACCCAGAGGGCAAACACCACTCCCTGTCCTTTTCATAGCTCCTGCCCGCAGACCTCTGGATTAGGTCTCTGTTGACTGGCTGTGTGAC CTTAGGCCCGGAGCTGCCCCTCTCTGGGCCTCAGAGGCCTTATGAGGGTCCTCTACTTCAGGAACACCCCCATGACATTGCATTTGGGGG GGCTCCCGTGGCCTGTAGAATAGCCTGTGGCCTTTGCAATTTGTTAAGGTTCAAGACAGATGGGCATATGTGTCAGTGGGGCTCTCTGAG TCCTGGCCCAAAGAAGCAAGGAACCAAATTTAAGACTCTCGCATCTTCCCAACCCCTTAAGCCCTGGCCCCCTGAGTTTCCTTTTCTGTC TCTCTCTTTTTATTTTTTTTATTTTTATTTTTATTTTTGAGACAGAGCCTCGCTCTGTTACCCAGGGTGGAGTGCAGTGGTGCGATCTCG GCTCAGTGCAACCTCTGCTTCCCAGGTTCAAGCGATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGATTACAGGTGTGCACCACCACACC CGGCTAATTTTTTTTATTTTTAATAGAGATGAGGTTTCACCATGATGGCCAGGCTGATCTCGAACTCCTAACCTCAAGTGATCCTCCCAC CTCAGCCTCCCAAAGTGTTGGAATAATAGGCATGAGCCACTGCACCCAGGCTTTTTTTTTTTTAAATTTATTATTATTATTTTTAAGAGA CAGGATCTTGCTACGTTGCCCAGGCTGGTCTTGAACTCCTGGGCTACAGTGATCCTCCTGCCTTATCCTCCTAAATAGCTGGGACTACAG CACCTAGTTTTGAGTTTCCTGTCTTATTTCCAATGGGGACATTCATGTAGCTTTTTTTTTTTTTTTTTTTTTGAGACGGAGTCTCGCTCT GTCGCCCAGGCTGGAGTACAGTGGCGCAATCTAGGCTCACTGCAAGCTCCGCCTCCTGGGTTCACACCATTCTCTCGCCTCAGCCTCCCA AGTAGCTGGGACTACAGGCGCCCGCCACCACACCCGGCTAATTTTTTGTATTTTTAGTAGAGACGGGGTTTCACCTTGTTAGCCAGGATG GTTTCCATCTCCTGACCTCGTGATCTGCCCGTCTCGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACTGCGCCCGGCCCTCATGT AGCTTTAAATGTATGATCTGACTTCTGCTCCCCGATCTCTGTTTCTCTGGAGGAAGCCAAGGACAAGAGCAGTTGCTGTGGCTGGGACTC TGCCTTTTAGGGGAGCCCGTGTATCTCTTTGGGATCCTGAAAGGGGGCAGGAAAGGCTGGGGTCCCAGTCCACCCTAATGGTATCTGAGT GTCCTAGGGCTTCAGTTTTCCCACCTGTCCAATGGGACCCTTTCTGTCCTCACCCTACAAGGGGCACAAAGGGATGACACCAAACCTGGC AGGAACTTTTCACGCAATCAAGGGAAGGAAAGGCATTCCTGGCAGAGGGAACAGCATGCCAAGCGTGAGAAGGCTCAGAGTAAGGAGGTT AAGAGCCCAAGTATTGGAGCCTACAGTTTTGCCCCTTCCATGCAGTGTGACAGTGGGCAAGTTCCTTTCCCTCTCTGGGTCTCAGTTCTG TCCCCTGCAAAATGGTCAGAGCTTACCCCTTGGCTGTGCAGGGTCAACTTTCTGACTGGTGAGAGGGATTCTCATGCAGGTTAAGCTTCT GCTGCTCCTCCTCACCTGCAAAGCTTTTCTGCCACTTTTGCCTCCTTGGAAAACTCTTATCCATCTCTCAAAACTCCAGCTACCACATCC TTGCAGCCTTCCCTCATATACCCCCACTACTACTGTAGCCCTGTCCTTCCCTCCAGCCCCACTCTGGCCCTGGGGCTGGGGAAGTGTCTG TGTCCAGCTGTCTCCCCTGACCTCAGGGTTCCTTGGGGGCTGGGCTGAGGCCTCAGTACAGAGGGGGCTCTGGAAATGTTTGTTGACTGA >In-frame_R3HDM4_ENST00000361574_chr19_913087_-_JAK3_ENST00000534444_chr19_17953981_-_3252nt CGGGCGCCCGTCACTTCCTGCCCGGCCCGGTGAAGGCCCTGCCGGGCGGCGGCGGCGGCGACAGCGTGCGAGCCATGGTCGCGCTGGAGA ACCCCGAGTGCGGCCCGGAGGCGGCGGAGGGCACCCCGGGCGGGCGGCGGCTGCTCACCGCAGTGACCTGGTGAGTGGGCGCCTCCCCGT GGGCCTCAGTCTCAAGGAGCAGGGTGAGTGTCTCAGCCTGGCCGTGTTGGACCTGGCCCGGATGGCGCGAGAGCAGGCCCAGCGGCCGGG AGAGCTGCTGAAGACTGTCAGCTACAAGGCCTGCCTACCCCCAAGCCTGCGCGACCTGATCCAGGGCCTGAGCTTCGTGACGCGGAGGCG TATTCGGAGGACGGTGCGCAGAGCCCTGCGCCGCGTGGCCGCCTGCCAGGCAGACCGGCACTCGCTCATGGCCAAGTACATCATGGACCT GGAGCGGCTGGATCCAGCCGGGGCCGCCGAGACCTTCCACGTGGGCCTCCCTGGGGCCCTTGGTGGCCACGACGGGCTGGGGCTGCTCCG CGTGGCTGGTGACGGCGGCATCGCCTGGACCCAGGGAGAACAGGAGGTCCTCCAGCCCTTCTGCGACTTTCCAGAAATCGTAGACATTAG CATCAAGCAGGCCCCGCGCGTTGGCCCGGCCGGAGAGCACCGCCTGGTCACTGTTACCAGGACAGACAACCAGATTTTAGAGGCCGAGTT CCCAGGGCTGCCCGAGGCTCTGTCGTTCGTGGCGCTCGTGGACGGCTACTTCCGGCTGACCACGGACTCCCAGCACTTCTTCTGCAAGGA GGTGGCACCGCCGAGGCTGCTGGAGGAAGTGGCCGAGCAGTGCCACGGCCCCATCACTCTGGACTTTGCCATCAACAAGCTCAAGACTGG GGGCTCACGTCCTGGCTCCTATGTTCTCCGCCGCAGCCCCCAGGACTTTGACAGCTTCCTCCTCACTGTCTGTGTCCAGAACCCCCTTGG TCCTGATTATAAGGGCTGCCTCATCCGGCGCAGCCCCACAGGAACCTTCCTTCTGGTTGGCCTCAGCCGACCCCACAGCAGTCTTCGAGA GCTCCTGGCAACCTGCTGGGATGGGGGGCTGCACGTAGATGGGGTGGCAGTGACCCTCACTTCCTGCTGTATCCCCAGACCCAAAGAAAA GTCCAACCTGATCGTGGTCCAGAGAGGTCACAGCCCACCCACATCATCCTTGGTTCAGCCCCAATCCCAATACCAGCTGAGTCAGATGAC ATTTCACAAGATCCCTGCTGACAGCCTGGAGTGGCATGAGAACCTGGGCCATGGGTCCTTCACCAAGATTTACCGGGGCTGTCGCCATGA GGTGGTGGATGGGGAGGCCCGAAAGACAGAGGTGCTGCTGAAGGTCATGGATGCCAAGCACAAGAACTGCATGGAGTCATTCCTGGAAGC AGCGAGCTTGATGAGCCAAGTGTCGTACCGGCATCTCGTGCTGCTCCACGGCGTGTGCATGGCTGGAGACAGCACCATGGTGCAGGAATT TGTACACCTGGGGGCCATAGACATGTATCTGCGAAAACGTGGCCACCTGGTGCCAGCCAGCTGGAAGCTGCAGGTGGTCAAACAGCTGGC CTACGCCCTCAACTATCTGGAGGACAAAGGCCTGCCCCATGGCAATGTCTCTGCCCGGAAGGTGCTCCTGGCTCGGGAGGGGGCTGATGG GAGCCCGCCCTTCATCAAGCTGAGTGACCCTGGGGTCAGCCCCGCTGTGTTAAGCCTGGAGATGCTCACCGACAGGATCCCCTGGGTGGC CCCCGAGTGTCTCCGGGAGGCGCAGACACTTAGCTTGGAAGCTGACAAGTGGGGCTTCGGCGCCACGGTCTGGGAAGTGTTTAGTGGCGT CACCATGCCCATCAGTGCCCTGGATCCTGCTAAGAAACTCCAATTTTATGAGGACCGGCAGCAGCTGCCGGCCCCCAAGTGGACAGAGCT GGCCCTGCTGATTCAACAGTGCATGGCCTATGAGCCGGTCCAGAGGCCCTCCTTCCGAGCCGTCATTCGTGACCTCAATAGCCTCATCTC TTCAGACTATGAGCTCCTCTCAGACCCCACACCTGGTGCCCTGGCACCTCGTGATGGGCTGTGGAATGGTGCCCAGCTCTATGCCTGCCA AGACCCCACGATCTTCGAGGAGAGACACCTCAAGTACATCTCACAGCTGGGCAAGGGCAACTTTGGCAGCGTGGAGCTGTGCCGCTATGA CCCGCTAGGCGACAATACAGGTGCCCTGGTGGCCGTGAAACAGCTGCAGCACAGCGGGCCAGACCAGCAGAGGGACTTTCAGCGGGAGAT TCAGATCCTCAAAGCACTGCACAGTGATTTCATTGTCAAGTATCGTGGTGTCAGCTATGGCCCGGGCCGCCAGAGCCTGCGGCTGGTCAT GGAGTACCTGCCCAGCGGCTGCTTGCGCGACTTCCTGCAGCGGCACCGCGCGCGCCTCGATGCCAGCCGCCTCCTTCTCTATTCCTCGCA GATCTGCAAGGGCATGGAGTACCTGGGCTCCCGCCGCTGCGTGCACCGCGACCTGGCCGCCCGAAACATCCTCGTGGAGAGCGAGGCACA CGTCAAGATCGCTGACTTCGGCCTAGCTAAGCTGCTGCCGCTTGACAAAGACTACTACGTGGTCCGCGAGCCAGGCCAGAGCCCCATTTT CTGGTATGCCCCCGAATCCCTCTCGGACAACATCTTCTCTCGCCAGTCAGACGTCTGGAGCTTCGGGGTCGTCCTGTACGAGCTCTTCAC CTACTGCGACAAAAGCTGCAGCCCCTCGGCCGAGTTCCTGCGGATGATGGGATGTGAGCGGGATGTCCCCGCCCTCTGCCGCCTCTTGGA ACTGCTGGAGGAGGGCCAGAGGCTGCCGGCGCCTCCTGCCTGCCCTGCTGAGGTGAGCGCCGCAGGGCTAGCCTCAGTTTCCCAGTCTGT AGATTGGGCCGGGGTCTCGGGCAAGCCAGCTGGCGCCTGAGTCTCTGTACTGAGAAGAAAGGCTAGAGTGTGAGGCCGATGAGGATCCTG GCCCCCACTTGGCTACTCTCTCACTGTGTGGCAAGTCAGAGCACTTTCAGAGCCTCAGTTTACCCTTTTCCAAAATGAGAATAGTAATGC CTTATAGGGTGAGGGAAGATTAGACTCCTGAACACCTGTGCCTATGAGGGCTCAGCTCAAAGCCGAGCACACAGTCGATGCTCCATAAAT >In-frame_R3HDM4_ENST00000587975_chr19_913087_-_JAK3_ENST00000458235_chr19_17953981_-_5066nt GCCCGCCTCCGGGCGCCCGTCACTTCCTGCCCGGCCCGGTGAAGGCCCTGCCGGGCGGCGGCGGCGGCGACAGCGTGCGAGCCATGGTCG CGCTGGAGAACCCCGAGTGCGGCCCGGAGGCGGCGGAGGGCACCCCGGGCGGGCGGCGGCTGCTCACCGCAGTGACCTGGTGAGTGGGCG CCTCCCCGTGGGCCTCAGTCTCAAGGAGCAGGGTGAGTGTCTCAGCCTGGCCGTGTTGGACCTGGCCCGGATGGCGCGAGAGCAGGCCCA GCGGCCGGGAGAGCTGCTGAAGACTGTCAGCTACAAGGCCTGCCTACCCCCAAGCCTGCGCGACCTGATCCAGGGCCTGAGCTTCGTGAC GCGGAGGCGTATTCGGAGGACGGTGCGCAGAGCCCTGCGCCGCGTGGCCGCCTGCCAGGCAGACCGGCACTCGCTCATGGCCAAGTACAT CATGGACCTGGAGCGGCTGGATCCAGCCGGGGCCGCCGAGACCTTCCACGTGGGCCTCCCTGGGGCCCTTGGTGGCCACGACGGGCTGGG GCTGCTCCGCGTGGCTGGTGACGGCGGCATCGCCTGGACCCAGGGAGAACAGGAGGTCCTCCAGCCCTTCTGCGACTTTCCAGAAATCGT AGACATTAGCATCAAGCAGGCCCCGCGCGTTGGCCCGGCCGGAGAGCACCGCCTGGTCACTGTTACCAGGACAGACAACCAGATTTTAGA GGCCGAGTTCCCAGGGCTGCCCGAGGCTCTGTCGTTCGTGGCGCTCGTGGACGGCTACTTCCGGCTGACCACGGACTCCCAGCACTTCTT CTGCAAGGAGGTGGCACCGCCGAGGCTGCTGGAGGAAGTGGCCGAGCAGTGCCACGGCCCCATCACTCTGGACTTTGCCATCAACAAGCT CAAGACTGGGGGCTCACGTCCTGGCTCCTATGTTCTCCGCCGCAGCCCCCAGGACTTTGACAGCTTCCTCCTCACTGTCTGTGTCCAGAA CCCCCTTGGTCCTGATTATAAGGGCTGCCTCATCCGGCGCAGCCCCACAGGAACCTTCCTTCTGGTTGGCCTCAGCCGACCCCACAGCAG TCTTCGAGAGCTCCTGGCAACCTGCTGGGATGGGGGGCTGCACGTAGATGGGGTGGCAGTGACCCTCACTTCCTGCTGTATCCCCAGACC CAAAGAAAAGTCCAACCTGATCGTGGTCCAGAGAGGTCACAGCCCACCCACATCATCCTTGGTTCAGCCCCAATCCCAATACCAGCTGAG TCAGATGACATTTCACAAGATCCCTGCTGACAGCCTGGAGTGGCATGAGAACCTGGGCCATGGGTCCTTCACCAAGATTTACCGGGGCTG TCGCCATGAGGTGGTGGATGGGGAGGCCCGAAAGACAGAGGTGCTGCTGAAGGTCATGGATGCCAAGCACAAGAACTGCATGGAGTCATT CCTGGAAGCAGCGAGCTTGATGAGCCAAGTGTCGTACCGGCATCTCGTGCTGCTCCACGGCGTGTGCATGGCTGGAGACAGCACCATGGT GCAGGAATTTGTACACCTGGGGGCCATAGACATGTATCTGCGAAAACGTGGCCACCTGGTGCCAGCCAGCTGGAAGCTGCAGGTGGTCAA ACAGCTGGCCTACGCCCTCAACTATCTGGAGGACAAAGGCCTGCCCCATGGCAATGTCTCTGCCCGGAAGGTGCTCCTGGCTCGGGAGGG GGCTGATGGGAGCCCGCCCTTCATCAAGCTGAGTGACCCTGGGGTCAGCCCCGCTGTGTTAAGCCTGGAGATGCTCACCGACAGGATCCC CTGGGTGGCCCCCGAGTGTCTCCGGGAGGCGCAGACACTTAGCTTGGAAGCTGACAAGTGGGGCTTCGGCGCCACGGTCTGGGAAGTGTT TAGTGGCGTCACCATGCCCATCAGTGCCCTGGATCCTGCTAAGAAACTCCAATTTTATGAGGACCGGCAGCAGCTGCCGGCCCCCAAGTG GACAGAGCTGGCCCTGCTGATTCAACAGTGCATGGCCTATGAGCCGGTCCAGAGGCCCTCCTTCCGAGCCGTCATTCGTGACCTCAATAG CCTCATCTCTTCAGACTATGAGCTCCTCTCAGACCCCACACCTGGTGCCCTGGCACCTCGTGATGGGCTGTGGAATGGTGCCCAGCTCTA TGCCTGCCAAGACCCCACGATCTTCGAGGAGAGACACCTCAAGTACATCTCACAGCTGGGCAAGGGCAACTTTGGCAGCGTGGAGCTGTG CCGCTATGACCCGCTAGGCGACAATACAGGTGCCCTGGTGGCCGTGAAACAGCTGCAGCACAGCGGGCCAGACCAGCAGAGGGACTTTCA GCGGGAGATTCAGATCCTCAAAGCACTGCACAGTGATTTCATTGTCAAGTATCGTGGTGTCAGCTATGGCCCGGGCCGCCAGAGCCTGCG GCTGGTCATGGAGTACCTGCCCAGCGGCTGCTTGCGCGACTTCCTGCAGCGGCACCGCGCGCGCCTCGATGCCAGCCGCCTCCTTCTCTA TTCCTCGCAGATCTGCAAGGGCATGGAGTACCTGGGCTCCCGCCGCTGCGTGCACCGCGACCTGGCCGCCCGAAACATCCTCGTGGAGAG CGAGGCACACGTCAAGATCGCTGACTTCGGCCTAGCTAAGCTGCTGCCGCTTGACAAAGACTACTACGTGGTCCGCGAGCCAGGCCAGAG CCCCATTTTCTGGTATGCCCCCGAATCCCTCTCGGACAACATCTTCTCTCGCCAGTCAGACGTCTGGAGCTTCGGGGTCGTCCTGTACGA GCTCTTCACCTACTGCGACAAAAGCTGCAGCCCCTCGGCCGAGTTCCTGCGGATGATGGGATGTGAGCGGGATGTCCCCGCCCTCTGCCG CCTCTTGGAACTGCTGGAGGAGGGCCAGAGGCTGCCGGCGCCTCCTGCCTGCCCTGCTGAGGTTCACGAGCTCATGAAGCTGTGCTGGGC CCCTAGCCCACAGGACCGGCCATCATTCAGCGCCCTGGGCCCCCAGCTGGACATGCTGTGGAGCGGAAGCCGGGGGTGTGAGACTCATGC CTTCACTGCTCACCCAGAGGGCAAACACCACTCCCTGTCCTTTTCATAGCTCCTGCCCGCAGACCTCTGGATTAGGTCTCTGTTGACTGG CTGTGTGACCTTAGGCCCGGAGCTGCCCCTCTCTGGGCCTCAGAGGCCTTATGAGGGTCCTCTACTTCAGGAACACCCCCATGACATTGC ATTTGGGGGGGCTCCCGTGGCCTGTAGAATAGCCTGTGGCCTTTGCAATTTGTTAAGGTTCAAGACAGATGGGCATATGTGTCAGTGGGG CTCTCTGAGTCCTGGCCCAAAGAAGCAAGGAACCAAATTTAAGACTCTCGCATCTTCCCAACCCCTTAAGCCCTGGCCCCCTGAGTTTCC TTTTCTGTCTCTCTCTTTTTATTTTTTTTATTTTTATTTTTATTTTTGAGACAGAGCCTCGCTCTGTTACCCAGGGTGGAGTGCAGTGGT GCGATCTCGGCTCAGTGCAACCTCTGCTTCCCAGGTTCAAGCGATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGATTACAGGTGTGCAC CACCACACCCGGCTAATTTTTTTTATTTTTAATAGAGATGAGGTTTCACCATGATGGCCAGGCTGATCTCGAACTCCTAACCTCAAGTGA TCCTCCCACCTCAGCCTCCCAAAGTGTTGGAATAATAGGCATGAGCCACTGCACCCAGGCTTTTTTTTTTTTAAATTTATTATTATTATT TTTAAGAGACAGGATCTTGCTACGTTGCCCAGGCTGGTCTTGAACTCCTGGGCTACAGTGATCCTCCTGCCTTATCCTCCTAAATAGCTG GGACTACAGCACCTAGTTTTGAGTTTCCTGTCTTATTTCCAATGGGGACATTCATGTAGCTTTTTTTTTTTTTTTTTTTTTGAGACGGAG TCTCGCTCTGTCGCCCAGGCTGGAGTACAGTGGCGCAATCTAGGCTCACTGCAAGCTCCGCCTCCTGGGTTCACACCATTCTCTCGCCTC AGCCTCCCAAGTAGCTGGGACTACAGGCGCCCGCCACCACACCCGGCTAATTTTTTGTATTTTTAGTAGAGACGGGGTTTCACCTTGTTA GCCAGGATGGTTTCCATCTCCTGACCTCGTGATCTGCCCGTCTCGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACTGCGCCCGG CCCTCATGTAGCTTTAAATGTATGATCTGACTTCTGCTCCCCGATCTCTGTTTCTCTGGAGGAAGCCAAGGACAAGAGCAGTTGCTGTGG CTGGGACTCTGCCTTTTAGGGGAGCCCGTGTATCTCTTTGGGATCCTGAAAGGGGGCAGGAAAGGCTGGGGTCCCAGTCCACCCTAATGG TATCTGAGTGTCCTAGGGCTTCAGTTTTCCCACCTGTCCAATGGGACCCTTTCTGTCCTCACCCTACAAGGGGCACAAAGGGATGACACC AAACCTGGCAGGAACTTTTCACGCAATCAAGGGAAGGAAAGGCATTCCTGGCAGAGGGAACAGCATGCCAAGCGTGAGAAGGCTCAGAGT AAGGAGGTTAAGAGCCCAAGTATTGGAGCCTACAGTTTTGCCCCTTCCATGCAGTGTGACAGTGGGCAAGTTCCTTTCCCTCTCTGGGTC TCAGTTCTGTCCCCTGCAAAATGGTCAGAGCTTACCCCTTGGCTGTGCAGGGTCAACTTTCTGACTGGTGAGAGGGATTCTCATGCAGGT TAAGCTTCTGCTGCTCCTCCTCACCTGCAAAGCTTTTCTGCCACTTTTGCCTCCTTGGAAAACTCTTATCCATCTCTCAAAACTCCAGCT ACCACATCCTTGCAGCCTTCCCTCATATACCCCCACTACTACTGTAGCCCTGTCCTTCCCTCCAGCCCCACTCTGGCCCTGGGGCTGGGG AAGTGTCTGTGTCCAGCTGTCTCCCCTGACCTCAGGGTTCCTTGGGGGCTGGGCTGAGGCCTCAGTACAGAGGGGGCTCTGGAAATGTTT >In-frame_R3HDM4_ENST00000587975_chr19_913087_-_JAK3_ENST00000534444_chr19_17953981_-_3261nt GCCCGCCTCCGGGCGCCCGTCACTTCCTGCCCGGCCCGGTGAAGGCCCTGCCGGGCGGCGGCGGCGGCGACAGCGTGCGAGCCATGGTCG CGCTGGAGAACCCCGAGTGCGGCCCGGAGGCGGCGGAGGGCACCCCGGGCGGGCGGCGGCTGCTCACCGCAGTGACCTGGTGAGTGGGCG CCTCCCCGTGGGCCTCAGTCTCAAGGAGCAGGGTGAGTGTCTCAGCCTGGCCGTGTTGGACCTGGCCCGGATGGCGCGAGAGCAGGCCCA GCGGCCGGGAGAGCTGCTGAAGACTGTCAGCTACAAGGCCTGCCTACCCCCAAGCCTGCGCGACCTGATCCAGGGCCTGAGCTTCGTGAC GCGGAGGCGTATTCGGAGGACGGTGCGCAGAGCCCTGCGCCGCGTGGCCGCCTGCCAGGCAGACCGGCACTCGCTCATGGCCAAGTACAT CATGGACCTGGAGCGGCTGGATCCAGCCGGGGCCGCCGAGACCTTCCACGTGGGCCTCCCTGGGGCCCTTGGTGGCCACGACGGGCTGGG GCTGCTCCGCGTGGCTGGTGACGGCGGCATCGCCTGGACCCAGGGAGAACAGGAGGTCCTCCAGCCCTTCTGCGACTTTCCAGAAATCGT AGACATTAGCATCAAGCAGGCCCCGCGCGTTGGCCCGGCCGGAGAGCACCGCCTGGTCACTGTTACCAGGACAGACAACCAGATTTTAGA GGCCGAGTTCCCAGGGCTGCCCGAGGCTCTGTCGTTCGTGGCGCTCGTGGACGGCTACTTCCGGCTGACCACGGACTCCCAGCACTTCTT CTGCAAGGAGGTGGCACCGCCGAGGCTGCTGGAGGAAGTGGCCGAGCAGTGCCACGGCCCCATCACTCTGGACTTTGCCATCAACAAGCT CAAGACTGGGGGCTCACGTCCTGGCTCCTATGTTCTCCGCCGCAGCCCCCAGGACTTTGACAGCTTCCTCCTCACTGTCTGTGTCCAGAA CCCCCTTGGTCCTGATTATAAGGGCTGCCTCATCCGGCGCAGCCCCACAGGAACCTTCCTTCTGGTTGGCCTCAGCCGACCCCACAGCAG TCTTCGAGAGCTCCTGGCAACCTGCTGGGATGGGGGGCTGCACGTAGATGGGGTGGCAGTGACCCTCACTTCCTGCTGTATCCCCAGACC CAAAGAAAAGTCCAACCTGATCGTGGTCCAGAGAGGTCACAGCCCACCCACATCATCCTTGGTTCAGCCCCAATCCCAATACCAGCTGAG TCAGATGACATTTCACAAGATCCCTGCTGACAGCCTGGAGTGGCATGAGAACCTGGGCCATGGGTCCTTCACCAAGATTTACCGGGGCTG TCGCCATGAGGTGGTGGATGGGGAGGCCCGAAAGACAGAGGTGCTGCTGAAGGTCATGGATGCCAAGCACAAGAACTGCATGGAGTCATT CCTGGAAGCAGCGAGCTTGATGAGCCAAGTGTCGTACCGGCATCTCGTGCTGCTCCACGGCGTGTGCATGGCTGGAGACAGCACCATGGT GCAGGAATTTGTACACCTGGGGGCCATAGACATGTATCTGCGAAAACGTGGCCACCTGGTGCCAGCCAGCTGGAAGCTGCAGGTGGTCAA ACAGCTGGCCTACGCCCTCAACTATCTGGAGGACAAAGGCCTGCCCCATGGCAATGTCTCTGCCCGGAAGGTGCTCCTGGCTCGGGAGGG GGCTGATGGGAGCCCGCCCTTCATCAAGCTGAGTGACCCTGGGGTCAGCCCCGCTGTGTTAAGCCTGGAGATGCTCACCGACAGGATCCC CTGGGTGGCCCCCGAGTGTCTCCGGGAGGCGCAGACACTTAGCTTGGAAGCTGACAAGTGGGGCTTCGGCGCCACGGTCTGGGAAGTGTT TAGTGGCGTCACCATGCCCATCAGTGCCCTGGATCCTGCTAAGAAACTCCAATTTTATGAGGACCGGCAGCAGCTGCCGGCCCCCAAGTG GACAGAGCTGGCCCTGCTGATTCAACAGTGCATGGCCTATGAGCCGGTCCAGAGGCCCTCCTTCCGAGCCGTCATTCGTGACCTCAATAG CCTCATCTCTTCAGACTATGAGCTCCTCTCAGACCCCACACCTGGTGCCCTGGCACCTCGTGATGGGCTGTGGAATGGTGCCCAGCTCTA TGCCTGCCAAGACCCCACGATCTTCGAGGAGAGACACCTCAAGTACATCTCACAGCTGGGCAAGGGCAACTTTGGCAGCGTGGAGCTGTG CCGCTATGACCCGCTAGGCGACAATACAGGTGCCCTGGTGGCCGTGAAACAGCTGCAGCACAGCGGGCCAGACCAGCAGAGGGACTTTCA GCGGGAGATTCAGATCCTCAAAGCACTGCACAGTGATTTCATTGTCAAGTATCGTGGTGTCAGCTATGGCCCGGGCCGCCAGAGCCTGCG GCTGGTCATGGAGTACCTGCCCAGCGGCTGCTTGCGCGACTTCCTGCAGCGGCACCGCGCGCGCCTCGATGCCAGCCGCCTCCTTCTCTA TTCCTCGCAGATCTGCAAGGGCATGGAGTACCTGGGCTCCCGCCGCTGCGTGCACCGCGACCTGGCCGCCCGAAACATCCTCGTGGAGAG CGAGGCACACGTCAAGATCGCTGACTTCGGCCTAGCTAAGCTGCTGCCGCTTGACAAAGACTACTACGTGGTCCGCGAGCCAGGCCAGAG CCCCATTTTCTGGTATGCCCCCGAATCCCTCTCGGACAACATCTTCTCTCGCCAGTCAGACGTCTGGAGCTTCGGGGTCGTCCTGTACGA GCTCTTCACCTACTGCGACAAAAGCTGCAGCCCCTCGGCCGAGTTCCTGCGGATGATGGGATGTGAGCGGGATGTCCCCGCCCTCTGCCG CCTCTTGGAACTGCTGGAGGAGGGCCAGAGGCTGCCGGCGCCTCCTGCCTGCCCTGCTGAGGTGAGCGCCGCAGGGCTAGCCTCAGTTTC CCAGTCTGTAGATTGGGCCGGGGTCTCGGGCAAGCCAGCTGGCGCCTGAGTCTCTGTACTGAGAAGAAAGGCTAGAGTGTGAGGCCGATG AGGATCCTGGCCCCCACTTGGCTACTCTCTCACTGTGTGGCAAGTCAGAGCACTTTCAGAGCCTCAGTTTACCCTTTTCCAAAATGAGAA TAGTAATGCCTTATAGGGTGAGGGAAGATTAGACTCCTGAACACCTGTGCCTATGAGGGCTCAGCTCAAAGCCGAGCACACAGTCGATGC |
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FusionGenePPI for R3HDM4_JAK3 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| R3HDM4 | UBC | JAK3 | TIAF1, STAT5A, PRMT5, SHB, PTK2B, CXCR4, IL2RG, STAT5B, ALK, LEPR, IRS1, CD3E, CD247, STAM, STAM2, IKBKG, UHRF2, SOCS3, ERBB3, IL4R, JAK1, JAK2, TYK2, STAT3, STAT6, GTF2B, APOA1, CD81, CDK1, IL7R, KIT, BAG2, CCT2, CCT3, CCT4, CCT6A, CCT8, GNAS, GPATCH8, MAGED2, NAP1L1, NAP1L4, RNPS1, SRRM2, TCP1, TUBB1, CDK4, LNX1, ARAF, CAPN2, CENPC, COX4I1, CRY1, CSNK1E, DECR1, INPP5B, MRPL23, TAF1, TUBA4A, DHX16, RAB11A, NMI, WDR46, STUB1, SPTLC1, MTF2, RAB11FIP2, TNPO3, UBR5, GEMIN6, CCNL2, LYSMD2 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Tgene | JAK3 | chr19:913087 | chr19:17953981 | ENST00000458235 | - | 3 | 24 | 1_223 | 140 | 1125 | cytokine/interferon/growth hormone receptors |
| Tgene | JAK3 | chr19:913087 | chr19:17953981 | ENST00000527670 | - | 2 | 23 | 1_223 | 140 | 1125 | cytokine/interferon/growth hormone receptors |
| Tgene | JAK3 | chr19:913087 | chr19:17953981 | ENST00000534444 | - | 3 | 23 | 1_223 | 140 | 1095 | cytokine/interferon/growth hormone receptors |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for R3HDM4_JAK3 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Tgene | JAK3 | P52333 | DB08895 | Tofacitinib | Tyrosine-protein kinase JAK3 | small molecule | approved|investigational |
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RelatedDiseases for R3HDM4_JAK3 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | JAK3 | C0349639 | Juvenile Myelomonocytic Leukemia | 1 | CTD_human |
| Tgene | JAK3 | C1862939 | AMYOTROPHIC LATERAL SCLEROSIS 1 | 1 | CTD_human |
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