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Fusion gene ID: 29841 |
FusionGeneSummary for R3HDM2_LRIG3 |
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Fusion gene information | Fusion gene name: R3HDM2_LRIG3 | Fusion gene ID: 29841 | Hgene | Tgene | Gene symbol | R3HDM2 | LRIG3 | Gene ID | 22864 | 121227 |
Gene name | R3H domain containing 2 | leucine rich repeats and immunoglobulin like domains 3 | |
Synonyms | CAG6|PR01365 | LIG3 | |
Cytomap | 12q13.3 | 12q14.1 | |
Type of gene | protein-coding | protein-coding | |
Description | R3H domain-containing protein 2 | leucine-rich repeats and immunoglobulin-like domains protein 3LIG-3 | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | Q9Y2K5 | Q6UXM1 | |
Ensembl transtripts involved in fusion gene | ENST00000413953, ENST00000347140, ENST00000358907, ENST00000402412, ENST00000441731, ENST00000403821, ENST00000546843, | ENST00000379141, ENST00000320743, | |
Fusion gene scores | * DoF score | 29 X 12 X 9=3132 | 3 X 2 X 2=12 |
# samples | 28 | 3 | |
** MAII score | log2(28/3132*10)=-3.48358548034607 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/12*10)=1.32192809488736 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: R3HDM2 [Title/Abstract] AND LRIG3 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | SARC | TCGA-DX-A3LY-01B | R3HDM2 | chr12 | 57789532 | - | LRIG3 | chr12 | 59284578 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000413953 | ENST00000379141 | R3HDM2 | chr12 | 57789532 | - | LRIG3 | chr12 | 59284578 | - |
intron-3CDS | ENST00000413953 | ENST00000320743 | R3HDM2 | chr12 | 57789532 | - | LRIG3 | chr12 | 59284578 | - |
5UTR-3CDS | ENST00000347140 | ENST00000379141 | R3HDM2 | chr12 | 57789532 | - | LRIG3 | chr12 | 59284578 | - |
5UTR-3CDS | ENST00000347140 | ENST00000320743 | R3HDM2 | chr12 | 57789532 | - | LRIG3 | chr12 | 59284578 | - |
intron-3CDS | ENST00000358907 | ENST00000379141 | R3HDM2 | chr12 | 57789532 | - | LRIG3 | chr12 | 59284578 | - |
intron-3CDS | ENST00000358907 | ENST00000320743 | R3HDM2 | chr12 | 57789532 | - | LRIG3 | chr12 | 59284578 | - |
5UTR-3CDS | ENST00000402412 | ENST00000379141 | R3HDM2 | chr12 | 57789532 | - | LRIG3 | chr12 | 59284578 | - |
5UTR-3CDS | ENST00000402412 | ENST00000320743 | R3HDM2 | chr12 | 57789532 | - | LRIG3 | chr12 | 59284578 | - |
intron-3CDS | ENST00000441731 | ENST00000379141 | R3HDM2 | chr12 | 57789532 | - | LRIG3 | chr12 | 59284578 | - |
intron-3CDS | ENST00000441731 | ENST00000320743 | R3HDM2 | chr12 | 57789532 | - | LRIG3 | chr12 | 59284578 | - |
intron-3CDS | ENST00000403821 | ENST00000379141 | R3HDM2 | chr12 | 57789532 | - | LRIG3 | chr12 | 59284578 | - |
intron-3CDS | ENST00000403821 | ENST00000320743 | R3HDM2 | chr12 | 57789532 | - | LRIG3 | chr12 | 59284578 | - |
intron-3CDS | ENST00000546843 | ENST00000379141 | R3HDM2 | chr12 | 57789532 | - | LRIG3 | chr12 | 59284578 | - |
intron-3CDS | ENST00000546843 | ENST00000320743 | R3HDM2 | chr12 | 57789532 | - | LRIG3 | chr12 | 59284578 | - |
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FusionProtFeatures for R3HDM2_LRIG3 |
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Hgene | Tgene |
R3HDM2 | LRIG3 |
May play a role in craniofacial and inner earmorphogenesis during embryonic development. May act within theotic vesicle epithelium to control formation of the lateralsemicircular canal in the inner ear, possibly by restricting theexpression of NTN1 (By similarity). {ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for R3HDM2_LRIG3 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for R3HDM2_LRIG3 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
R3HDM2 | ELAVL1, ATXN1, YWHAB, REL, SPRY1, RBPMS, FAM168A, KRTAP3-2, C1orf94, KRTAP10-8, KRTAP10-3, NOTCH2NL, STAT5A | LRIG3 | CAND1, TAZ, TNFSF13B, PVRIG, GINM1, LPAR6, PTPRK, PTGER3, GAL3ST1, LRIG1, LRRN2, TMPRSS3 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for R3HDM2_LRIG3 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for R3HDM2_LRIG3 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | R3HDM2 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
Hgene | R3HDM2 | C3495559 | Juvenile arthritis | 1 | CTD_human |