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Fusion gene ID: 29821 |
FusionGeneSummary for QSOX1_SMR3B |
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Fusion gene information | Fusion gene name: QSOX1_SMR3B | Fusion gene ID: 29821 | Hgene | Tgene | Gene symbol | QSOX1 | SMR3B | Gene ID | 5768 | 10879 |
Gene name | quiescin sulfhydryl oxidase 1 | submaxillary gland androgen regulated protein 3B | |
Synonyms | Q6|QSCN6 | P-B|PBII|PRL3|PROL3|SMR1B | |
Cytomap | 1q25.2 | 4q13.3 | |
Type of gene | protein-coding | protein-coding | |
Description | sulfhydryl oxidase 1quiescin Q6 sulfhydryl oxidase 1testis tissue sperm-binding protein Li 62nthiol oxidase 1 | submaxillary gland androgen-regulated protein 3Bproline rich 3proline-rich peptide P-Bproline-rich protein 3salivary proline-rich proteinsubmaxillary gland androgen regulated protein 3 homolog B | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | O00391 | P02814 | |
Ensembl transtripts involved in fusion gene | ENST00000367602, ENST00000367600, | ENST00000504825, ENST00000304915, | |
Fusion gene scores | * DoF score | 6 X 7 X 5=210 | 9 X 8 X 2=144 |
# samples | 7 | 3 | |
** MAII score | log2(7/210*10)=-1.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/144*10)=-2.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: QSOX1 [Title/Abstract] AND SMR3B [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | BRCA | TCGA-AN-A0FL-01A | QSOX1 | chr1 | 180165703 | + | SMR3B | chr4 | 71255724 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-intron | ENST00000367602 | ENST00000504825 | QSOX1 | chr1 | 180165703 | + | SMR3B | chr4 | 71255724 | + |
5CDS-3UTR | ENST00000367602 | ENST00000304915 | QSOX1 | chr1 | 180165703 | + | SMR3B | chr4 | 71255724 | + |
5CDS-intron | ENST00000367600 | ENST00000504825 | QSOX1 | chr1 | 180165703 | + | SMR3B | chr4 | 71255724 | + |
5CDS-3UTR | ENST00000367600 | ENST00000304915 | QSOX1 | chr1 | 180165703 | + | SMR3B | chr4 | 71255724 | + |
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FusionProtFeatures for QSOX1_SMR3B |
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Hgene | Tgene |
QSOX1 | SMR3B |
Catalyzes the oxidation of sulfhydryl groups in peptideand protein thiols to disulfides with the reduction of oxygen tohydrogen peroxide. May contribute to disulfide bond formation in avariety of secreted proteins. In fibroblasts, it may have tumor-suppressing capabilities being involved in growth regulation.{ECO:0000269|PubMed:10542195, ECO:0000269|PubMed:10708601,ECO:0000269|PubMed:12176051, ECO:0000269|PubMed:16806532,ECO:0000269|PubMed:17331072, ECO:0000269|PubMed:18393449}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for QSOX1_SMR3B |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for QSOX1_SMR3B |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
QSOX1 | UBE2D2, UBQLN4, BEGAIN, HLA-DPA1, GLT8D2, LYPD3, RP2, RBM24, MCM2, DDX31, IL1R2, CRP, ENSA, PVR, DEFA5, TRIM25 | SMR3B | RAD21, UBQLN1, UBTD2, RASSF10, BCHE, TNFRSF19, SNRPF |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for QSOX1_SMR3B |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for QSOX1_SMR3B |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | QSOX1 | C0236969 | Substance-Related Disorders | 1 | CTD_human |