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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 29821

FusionGeneSummary for QSOX1_SMR3B

check button Fusion gene summary
Fusion gene informationFusion gene name: QSOX1_SMR3B
Fusion gene ID: 29821
HgeneTgene
Gene symbol

QSOX1

SMR3B

Gene ID

5768

10879

Gene namequiescin sulfhydryl oxidase 1submaxillary gland androgen regulated protein 3B
SynonymsQ6|QSCN6P-B|PBII|PRL3|PROL3|SMR1B
Cytomap

1q25.2

4q13.3

Type of geneprotein-codingprotein-coding
Descriptionsulfhydryl oxidase 1quiescin Q6 sulfhydryl oxidase 1testis tissue sperm-binding protein Li 62nthiol oxidase 1submaxillary gland androgen-regulated protein 3Bproline rich 3proline-rich peptide P-Bproline-rich protein 3salivary proline-rich proteinsubmaxillary gland androgen regulated protein 3 homolog B
Modification date2018052320180523
UniProtAcc

O00391

P02814

Ensembl transtripts involved in fusion geneENST00000367602, ENST00000367600, 
ENST00000504825, ENST00000304915, 
Fusion gene scores* DoF score6 X 7 X 5=2109 X 8 X 2=144
# samples 73
** MAII scorelog2(7/210*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/144*10)=-2.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: QSOX1 [Title/Abstract] AND SMR3B [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-AN-A0FL-01AQSOX1chr1

180165703

+SMR3Bchr4

71255724

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000367602ENST00000504825QSOX1chr1

180165703

+SMR3Bchr4

71255724

+
5CDS-3UTRENST00000367602ENST00000304915QSOX1chr1

180165703

+SMR3Bchr4

71255724

+
5CDS-intronENST00000367600ENST00000504825QSOX1chr1

180165703

+SMR3Bchr4

71255724

+
5CDS-3UTRENST00000367600ENST00000304915QSOX1chr1

180165703

+SMR3Bchr4

71255724

+

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FusionProtFeatures for QSOX1_SMR3B


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
QSOX1

O00391

SMR3B

P02814

Catalyzes the oxidation of sulfhydryl groups in peptideand protein thiols to disulfides with the reduction of oxygen tohydrogen peroxide. May contribute to disulfide bond formation in avariety of secreted proteins. In fibroblasts, it may have tumor-suppressing capabilities being involved in growth regulation.{ECO:0000269|PubMed:10542195, ECO:0000269|PubMed:10708601,ECO:0000269|PubMed:12176051, ECO:0000269|PubMed:16806532,ECO:0000269|PubMed:17331072, ECO:0000269|PubMed:18393449}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for QSOX1_SMR3B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for QSOX1_SMR3B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
QSOX1UBE2D2, UBQLN4, BEGAIN, HLA-DPA1, GLT8D2, LYPD3, RP2, RBM24, MCM2, DDX31, IL1R2, CRP, ENSA, PVR, DEFA5, TRIM25SMR3BRAD21, UBQLN1, UBTD2, RASSF10, BCHE, TNFRSF19, SNRPF


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for QSOX1_SMR3B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for QSOX1_SMR3B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneQSOX1C0236969Substance-Related Disorders1CTD_human