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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 29818

FusionGeneSummary for QSOX1_LHX4

check button Fusion gene summary
Fusion gene informationFusion gene name: QSOX1_LHX4
Fusion gene ID: 29818
HgeneTgene
Gene symbol

QSOX1

LHX4

Gene ID

5768

89884

Gene namequiescin sulfhydryl oxidase 1LIM homeobox 4
SynonymsQ6|QSCN6CPHD4
Cytomap

1q25.2

1q25.2

Type of geneprotein-codingprotein-coding
Descriptionsulfhydryl oxidase 1quiescin Q6 sulfhydryl oxidase 1testis tissue sperm-binding protein Li 62nthiol oxidase 1LIM/homeobox protein Lhx4LIM homeobox protein 4
Modification date2018052320180522
UniProtAcc

O00391

Q969G2

Ensembl transtripts involved in fusion geneENST00000367602, ENST00000367600, 
ENST00000263726, 
Fusion gene scores* DoF score6 X 7 X 5=2103 X 2 X 3=18
# samples 73
** MAII scorelog2(7/210*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: QSOX1 [Title/Abstract] AND LHX4 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationOncogene involved fusion gene, in-frame and retained their domain.
Tumor suppressor gene involved fusion gene, in-frame but not retained their domain.
Tumor suppressor gene involved fusion gene, retained protein feature but frameshift.
DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain.
Transcription factor involved fusion gene, inframe and retained DNA-binding domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneLHX4

GO:0045944

positive regulation of transcription by RNA polymerase II

15998782


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDLUSCTCGA-34-A5IX-01AQSOX1chr1

180145169

+LHX4chr1

180235528

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000367602ENST00000263726QSOX1chr1

180145169

+LHX4chr1

180235528

+
In-frameENST00000367600ENST00000263726QSOX1chr1

180145169

+LHX4chr1

180235528

+

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FusionProtFeatures for QSOX1_LHX4


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
QSOX1

O00391

LHX4

Q969G2

Catalyzes the oxidation of sulfhydryl groups in peptideand protein thiols to disulfides with the reduction of oxygen tohydrogen peroxide. May contribute to disulfide bond formation in avariety of secreted proteins. In fibroblasts, it may have tumor-suppressing capabilities being involved in growth regulation.{ECO:0000269|PubMed:10542195, ECO:0000269|PubMed:10708601,ECO:0000269|PubMed:12176051, ECO:0000269|PubMed:16806532,ECO:0000269|PubMed:17331072, ECO:0000269|PubMed:18393449}. May play a critical role in the development ofrespiratory control mechanisms and in the normal growth andmaturation of the lung. Binds preferentially to methylated DNA(PubMed:28473536). {ECO:0000250, ECO:0000269|PubMed:28473536}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneQSOX1chr1:180145169chr1:180235528ENST00000367600+41336_156171605DomainThioredoxin
HgeneQSOX1chr1:180145169chr1:180235528ENST00000367602+41236_156171748DomainThioredoxin
TgeneLHX4chr1:180145169chr1:180235528ENST00000263726+16157_21682391DNA bindingHomeobox
TgeneLHX4chr1:180145169chr1:180235528ENST00000263726+1688_15082391DomainLIM zinc-binding 2

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneQSOX1chr1:180145169chr1:180235528ENST00000367600+413396_503171605DomainERV/ALR sulfhydryl oxidase
HgeneQSOX1chr1:180145169chr1:180235528ENST00000367602+412396_503171748DomainERV/ALR sulfhydryl oxidase
HgeneQSOX1chr1:180145169chr1:180235528ENST00000367600+413478_485171605Nucleotide bindingFAD
HgeneQSOX1chr1:180145169chr1:180235528ENST00000367602+412478_485171748Nucleotide bindingFAD
HgeneQSOX1chr1:180145169chr1:180235528ENST00000367600+413710_730171605TransmembraneHelical
HgeneQSOX1chr1:180145169chr1:180235528ENST00000367602+412710_730171748TransmembraneHelical
TgeneLHX4chr1:180145169chr1:180235528ENST00000263726+1628_8782391DomainLIM zinc-binding 1


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FusionGeneSequence for QSOX1_LHX4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for QSOX1_LHX4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
QSOX1UBE2D2, UBQLN4, BEGAIN, HLA-DPA1, GLT8D2, LYPD3, RP2, RBM24, MCM2, DDX31, IL1R2, CRP, ENSA, PVR, DEFA5, TRIM25LHX4IFT172, ISL1, SSX1, LDB2, SH2D1A, USP2, ORC6, CHCHD2, SNRNP25, TXNDC5, LONRF1, FDX1L, SSBP2, SSBP4, CEP97, ZNF574, CHMP1A, CYFIP2, CYFIP1, PRKRIR, ARID2, LDB1, ISL2, SMAD4, ABI2, ABI1, WASF2, C1orf52, DCAF5, TCAP, CETN1, TSC22D4


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneLHX4chr1:180145169chr1:180235528ENST00000263726+16199_211823915-mCpG DNA
TgeneLHX4chr1:180145169chr1:180235528ENST00000263726+16161_18182391DNA


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for QSOX1_LHX4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for QSOX1_LHX4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneQSOX1C0236969Substance-Related Disorders1CTD_human
TgeneLHX4C2678408PITUITARY HORMONE DEFICIENCY, COMBINED, 42CTD_human;ORPHANET;UNIPROT