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Fusion gene ID: 29818 |
FusionGeneSummary for QSOX1_LHX4 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: QSOX1_LHX4 | Fusion gene ID: 29818 | Hgene | Tgene | Gene symbol | QSOX1 | LHX4 | Gene ID | 5768 | 89884 |
| Gene name | quiescin sulfhydryl oxidase 1 | LIM homeobox 4 | |
| Synonyms | Q6|QSCN6 | CPHD4 | |
| Cytomap | 1q25.2 | 1q25.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | sulfhydryl oxidase 1quiescin Q6 sulfhydryl oxidase 1testis tissue sperm-binding protein Li 62nthiol oxidase 1 | LIM/homeobox protein Lhx4LIM homeobox protein 4 | |
| Modification date | 20180523 | 20180522 | |
| UniProtAcc | O00391 | Q969G2 | |
| Ensembl transtripts involved in fusion gene | ENST00000367602, ENST00000367600, | ENST00000263726, | |
| Fusion gene scores | * DoF score | 6 X 7 X 5=210 | 3 X 2 X 3=18 |
| # samples | 7 | 3 | |
| ** MAII score | log2(7/210*10)=-1.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: QSOX1 [Title/Abstract] AND LHX4 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Oncogene involved fusion gene, in-frame and retained their domain. Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. Tumor suppressor gene involved fusion gene, retained protein feature but frameshift. DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain. Transcription factor involved fusion gene, inframe and retained DNA-binding domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | LHX4 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 15998782 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | LUSC | TCGA-34-A5IX-01A | QSOX1 | chr1 | 180145169 | + | LHX4 | chr1 | 180235528 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000367602 | ENST00000263726 | QSOX1 | chr1 | 180145169 | + | LHX4 | chr1 | 180235528 | + |
| In-frame | ENST00000367600 | ENST00000263726 | QSOX1 | chr1 | 180145169 | + | LHX4 | chr1 | 180235528 | + |
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FusionProtFeatures for QSOX1_LHX4 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| QSOX1 | LHX4 |
| Catalyzes the oxidation of sulfhydryl groups in peptideand protein thiols to disulfides with the reduction of oxygen tohydrogen peroxide. May contribute to disulfide bond formation in avariety of secreted proteins. In fibroblasts, it may have tumor-suppressing capabilities being involved in growth regulation.{ECO:0000269|PubMed:10542195, ECO:0000269|PubMed:10708601,ECO:0000269|PubMed:12176051, ECO:0000269|PubMed:16806532,ECO:0000269|PubMed:17331072, ECO:0000269|PubMed:18393449}. | May play a critical role in the development ofrespiratory control mechanisms and in the normal growth andmaturation of the lung. Binds preferentially to methylated DNA(PubMed:28473536). {ECO:0000250, ECO:0000269|PubMed:28473536}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | QSOX1 | chr1:180145169 | chr1:180235528 | ENST00000367600 | + | 4 | 13 | 36_156 | 171 | 605 | Domain | Thioredoxin |
| Hgene | QSOX1 | chr1:180145169 | chr1:180235528 | ENST00000367602 | + | 4 | 12 | 36_156 | 171 | 748 | Domain | Thioredoxin |
| Tgene | >LHX4 | chr1:180145169 | chr1:180235528 | ENST00000263726 | + | 1 | 6 | 157_216 | 82 | 391 | DNA binding | Homeobox |
| Tgene | >LHX4 | chr1:180145169 | chr1:180235528 | ENST00000263726 | + | 1 | 6 | 88_150 | 82 | 391 | Domain | LIM zinc-binding 2 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >QSOX1 | chr1:180145169 | chr1:180235528 | ENST00000367600 | + | 4 | 13 | 396_503 | 171 | 605 | Domain | ERV/ALR sulfhydryl oxidase |
| Hgene | >QSOX1 | chr1:180145169 | chr1:180235528 | ENST00000367602 | + | 4 | 12 | 396_503 | 171 | 748 | Domain | ERV/ALR sulfhydryl oxidase |
| Hgene | >QSOX1 | chr1:180145169 | chr1:180235528 | ENST00000367600 | + | 4 | 13 | 478_485 | 171 | 605 | Nucleotide binding | FAD |
| Hgene | >QSOX1 | chr1:180145169 | chr1:180235528 | ENST00000367602 | + | 4 | 12 | 478_485 | 171 | 748 | Nucleotide binding | FAD |
| Hgene | >QSOX1 | chr1:180145169 | chr1:180235528 | ENST00000367600 | + | 4 | 13 | 710_730 | 171 | 605 | Transmembrane | Helical |
| Hgene | >QSOX1 | chr1:180145169 | chr1:180235528 | ENST00000367602 | + | 4 | 12 | 710_730 | 171 | 748 | Transmembrane | Helical |
| Tgene | LHX4 | chr1:180145169 | chr1:180235528 | ENST00000263726 | + | 1 | 6 | 28_87 | 82 | 391 | Domain | LIM zinc-binding 1 |
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FusionGeneSequence for QSOX1_LHX4 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for QSOX1_LHX4 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| QSOX1 | UBE2D2, UBQLN4, BEGAIN, HLA-DPA1, GLT8D2, LYPD3, RP2, RBM24, MCM2, DDX31, IL1R2, CRP, ENSA, PVR, DEFA5, TRIM25 | LHX4 | IFT172, ISL1, SSX1, LDB2, SH2D1A, USP2, ORC6, CHCHD2, SNRNP25, TXNDC5, LONRF1, FDX1L, SSBP2, SSBP4, CEP97, ZNF574, CHMP1A, CYFIP2, CYFIP1, PRKRIR, ARID2, LDB1, ISL2, SMAD4, ABI2, ABI1, WASF2, C1orf52, DCAF5, TCAP, CETN1, TSC22D4 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| Tgene | LHX4 | chr1:180145169 | chr1:180235528 | ENST00000263726 | + | 1 | 6 | 199_211 | 82 | 391 | 5-mCpG DNA |
| Tgene | LHX4 | chr1:180145169 | chr1:180235528 | ENST00000263726 | + | 1 | 6 | 161_181 | 82 | 391 | DNA |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for QSOX1_LHX4 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for QSOX1_LHX4 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | QSOX1 | C0236969 | Substance-Related Disorders | 1 | CTD_human |
| Tgene | LHX4 | C2678408 | PITUITARY HORMONE DEFICIENCY, COMBINED, 4 | 2 | CTD_human;ORPHANET;UNIPROT |
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