FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 29816

FusionGeneSummary for QSER1_QSER1

check button Fusion gene summary
Fusion gene informationFusion gene name: QSER1_QSER1
Fusion gene ID: 29816
HgeneTgene
Gene symbol

QSER1

QSER1

Gene ID

79832

79832

Gene nameglutamine and serine rich 1glutamine and serine rich 1
Synonyms--
Cytomap

11p13

11p13

Type of geneprotein-codingprotein-coding
Descriptionglutamine and serine-rich protein 1glutamine and serine-rich protein 1
Modification date2018051920180519
UniProtAcc

Q2KHR3

Q2KHR3

Ensembl transtripts involved in fusion geneENST00000399302, ENST00000527250, 
ENST00000527788, 		ENST00000399302, 
ENST00000527250, ENST00000527788, 
Fusion gene scores* DoF score5 X 4 X 4=804 X 5 X 3=60
# samples 65
** MAII scorelog2(6/80*10)=-0.415037499278844
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/60*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: QSER1 [Title/Abstract] AND QSER1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BG029448QSER1chr11

32999163

-QSER1chr11

32999215

+
ChiTaRS3.1AA053856QSER1chr11

32956981

+QSER1chr11

32948701

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3UTRENST00000399302ENST00000399302QSER1chr11

32999163

-QSER1chr11

32999215

+
3UTR-intronENST00000399302ENST00000527250QSER1chr11

32999163

-QSER1chr11

32999215

+
3UTR-intronENST00000399302ENST00000527788QSER1chr11

32999163

-QSER1chr11

32999215

+
intron-3UTRENST00000527250ENST00000399302QSER1chr11

32999163

-QSER1chr11

32999215

+
intron-intronENST00000527250ENST00000527250QSER1chr11

32999163

-QSER1chr11

32999215

+
intron-intronENST00000527250ENST00000527788QSER1chr11

32999163

-QSER1chr11

32999215

+
intron-3UTRENST00000527788ENST00000399302QSER1chr11

32999163

-QSER1chr11

32999215

+
intron-intronENST00000527788ENST00000527250QSER1chr11

32999163

-QSER1chr11

32999215

+
intron-intronENST00000527788ENST00000527788QSER1chr11

32999163

-QSER1chr11

32999215

+
5CDS-5UTRENST00000399302ENST00000399302QSER1chr11

32956981

+QSER1chr11

32948701

+
5CDS-3UTRENST00000399302ENST00000527250QSER1chr11

32956981

+QSER1chr11

32948701

+
5CDS-5UTRENST00000399302ENST00000527788QSER1chr11

32956981

+QSER1chr11

32948701

+
intron-5UTRENST00000527250ENST00000399302QSER1chr11

32956981

+QSER1chr11

32948701

+
intron-3UTRENST00000527250ENST00000527250QSER1chr11

32956981

+QSER1chr11

32948701

+
intron-5UTRENST00000527250ENST00000527788QSER1chr11

32956981

+QSER1chr11

32948701

+
5CDS-5UTRENST00000527788ENST00000399302QSER1chr11

32956981

+QSER1chr11

32948701

+
5CDS-3UTRENST00000527788ENST00000527250QSER1chr11

32956981

+QSER1chr11

32948701

+
5CDS-5UTRENST00000527788ENST00000527788QSER1chr11

32956981

+QSER1chr11

32948701

+

Top

FusionProtFeatures for QSER1_QSER1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
QSER1

Q2KHR3

QSER1

Q2KHR3


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for QSER1_QSER1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for QSER1_QSER1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
QSER1SOX2, MAGEA10, FHL3, FAM170A, HNRNPH2, PDLIM7, FBXO31, FOXJ2, FOXP1, C11orf30, PHF12, GATAD1, COMMD8, HSPBP1, PLEC, AAK1, SEC24B, CCDC88A, EYA4, UBE2D2, BRD1QSER1SOX2, MAGEA10, FHL3, FAM170A, HNRNPH2, PDLIM7, FBXO31, FOXJ2, FOXP1, C11orf30, PHF12, GATAD1, COMMD8, HSPBP1, PLEC, AAK1, SEC24B, CCDC88A, EYA4, UBE2D2, BRD1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for QSER1_QSER1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for QSER1_QSER1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource