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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 29814

FusionGeneSummary for QSER1_KIAA1328

check button Fusion gene summary
Fusion gene informationFusion gene name: QSER1_KIAA1328
Fusion gene ID: 29814
HgeneTgene
Gene symbol

QSER1

KIAA1328

Gene ID

79832

57536

Gene nameglutamine and serine rich 1KIAA1328
Synonyms--
Cytomap

11p13

18q12.2

Type of geneprotein-codingprotein-coding
Descriptionglutamine and serine-rich protein 1protein hinderinhinderin
Modification date2018051920180519
UniProtAcc

Q2KHR3

Q86T90

Ensembl transtripts involved in fusion geneENST00000399302, ENST00000527250, 
ENST00000527788, 
ENST00000543923, 
ENST00000435985, ENST00000280020, 
ENST00000591619, ENST00000586135, 
ENST00000592521, ENST00000586501, 
ENST00000601437, 
Fusion gene scores* DoF score5 X 4 X 4=803 X 3 X 3=27
# samples 63
** MAII scorelog2(6/80*10)=-0.415037499278844
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: QSER1 [Title/Abstract] AND KIAA1328 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDLUADTCGA-44-3917-01AQSER1chr11

32979632

+KIAA1328chr18

34504875

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000399302ENST00000543923QSER1chr11

32979632

+KIAA1328chr18

34504875

+
5CDS-intronENST00000399302ENST00000435985QSER1chr11

32979632

+KIAA1328chr18

34504875

+
5CDS-intronENST00000399302ENST00000280020QSER1chr11

32979632

+KIAA1328chr18

34504875

+
5CDS-intronENST00000399302ENST00000591619QSER1chr11

32979632

+KIAA1328chr18

34504875

+
5CDS-5UTRENST00000399302ENST00000586135QSER1chr11

32979632

+KIAA1328chr18

34504875

+
5CDS-intronENST00000399302ENST00000592521QSER1chr11

32979632

+KIAA1328chr18

34504875

+
5CDS-intronENST00000399302ENST00000586501QSER1chr11

32979632

+KIAA1328chr18

34504875

+
5CDS-intronENST00000399302ENST00000601437QSER1chr11

32979632

+KIAA1328chr18

34504875

+
intron-intronENST00000527250ENST00000543923QSER1chr11

32979632

+KIAA1328chr18

34504875

+
intron-intronENST00000527250ENST00000435985QSER1chr11

32979632

+KIAA1328chr18

34504875

+
intron-intronENST00000527250ENST00000280020QSER1chr11

32979632

+KIAA1328chr18

34504875

+
intron-intronENST00000527250ENST00000591619QSER1chr11

32979632

+KIAA1328chr18

34504875

+
intron-5UTRENST00000527250ENST00000586135QSER1chr11

32979632

+KIAA1328chr18

34504875

+
intron-intronENST00000527250ENST00000592521QSER1chr11

32979632

+KIAA1328chr18

34504875

+
intron-intronENST00000527250ENST00000586501QSER1chr11

32979632

+KIAA1328chr18

34504875

+
intron-intronENST00000527250ENST00000601437QSER1chr11

32979632

+KIAA1328chr18

34504875

+
5CDS-intronENST00000527788ENST00000543923QSER1chr11

32979632

+KIAA1328chr18

34504875

+
5CDS-intronENST00000527788ENST00000435985QSER1chr11

32979632

+KIAA1328chr18

34504875

+
5CDS-intronENST00000527788ENST00000280020QSER1chr11

32979632

+KIAA1328chr18

34504875

+
5CDS-intronENST00000527788ENST00000591619QSER1chr11

32979632

+KIAA1328chr18

34504875

+
5CDS-5UTRENST00000527788ENST00000586135QSER1chr11

32979632

+KIAA1328chr18

34504875

+
5CDS-intronENST00000527788ENST00000592521QSER1chr11

32979632

+KIAA1328chr18

34504875

+
5CDS-intronENST00000527788ENST00000586501QSER1chr11

32979632

+KIAA1328chr18

34504875

+
5CDS-intronENST00000527788ENST00000601437QSER1chr11

32979632

+KIAA1328chr18

34504875

+

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FusionProtFeatures for QSER1_KIAA1328


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
QSER1

Q2KHR3

KIAA1328

Q86T90

Competes with SMC1 for binding to SMC3. May affect theavailability of SMC3 to engage in the formation of multimericprotein complexes. {ECO:0000269|PubMed:15656913}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for QSER1_KIAA1328


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for QSER1_KIAA1328


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
QSER1SOX2, MAGEA10, FHL3, FAM170A, HNRNPH2, PDLIM7, FBXO31, FOXJ2, FOXP1, C11orf30, PHF12, GATAD1, COMMD8, HSPBP1, PLEC, AAK1, SEC24B, CCDC88A, EYA4, UBE2D2, BRD1KIAA1328APC, PCM1, OFD1, CEP135, FGFR1OP, CCDC14, CDC14A


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for QSER1_KIAA1328


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for QSER1_KIAA1328


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource