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Fusion gene ID: 29807 |
FusionGeneSummary for QRICH1_TRAIP |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: QRICH1_TRAIP | Fusion gene ID: 29807 | Hgene | Tgene | Gene symbol | QRICH1 | TRAIP | Gene ID | 54870 | 10293 |
| Gene name | glutamine rich 1 | TRAF interacting protein | |
| Synonyms | VERBRAS | RNF206|SCKL9|TRIP | |
| Cytomap | 3p21.31 | 3p21.31 | |
| Type of gene | protein-coding | protein-coding | |
| Description | glutamine-rich protein 1 | E3 ubiquitin-protein ligase TRAIPRING-type E3 ubiquitin transferase TRAIPring finger protein 206 | |
| Modification date | 20180525 | 20180519 | |
| UniProtAcc | Q2TAL8 | Q9BWF2 | |
| Ensembl transtripts involved in fusion gene | ENST00000395443, ENST00000357496, ENST00000424300, ENST00000479449, | ENST00000331456, ENST00000469027, ENST00000473863, | |
| Fusion gene scores | * DoF score | 7 X 5 X 6=210 | 4 X 4 X 5=80 |
| # samples | 7 | 5 | |
| ** MAII score | log2(7/210*10)=-1.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/80*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: QRICH1 [Title/Abstract] AND TRAIP [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | TRAIP | GO:0010804 | negative regulation of tumor necrosis factor-mediated signaling pathway | 19151749 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LIHC | TCGA-DD-AAD0-01A | QRICH1 | chr3 | 49114142 | - | TRAIP | chr3 | 49869501 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000395443 | ENST00000331456 | QRICH1 | chr3 | 49114142 | - | TRAIP | chr3 | 49869501 | - |
| In-frame | ENST00000395443 | ENST00000469027 | QRICH1 | chr3 | 49114142 | - | TRAIP | chr3 | 49869501 | - |
| 5CDS-intron | ENST00000395443 | ENST00000473863 | QRICH1 | chr3 | 49114142 | - | TRAIP | chr3 | 49869501 | - |
| In-frame | ENST00000357496 | ENST00000331456 | QRICH1 | chr3 | 49114142 | - | TRAIP | chr3 | 49869501 | - |
| In-frame | ENST00000357496 | ENST00000469027 | QRICH1 | chr3 | 49114142 | - | TRAIP | chr3 | 49869501 | - |
| 5CDS-intron | ENST00000357496 | ENST00000473863 | QRICH1 | chr3 | 49114142 | - | TRAIP | chr3 | 49869501 | - |
| In-frame | ENST00000424300 | ENST00000331456 | QRICH1 | chr3 | 49114142 | - | TRAIP | chr3 | 49869501 | - |
| In-frame | ENST00000424300 | ENST00000469027 | QRICH1 | chr3 | 49114142 | - | TRAIP | chr3 | 49869501 | - |
| 5CDS-intron | ENST00000424300 | ENST00000473863 | QRICH1 | chr3 | 49114142 | - | TRAIP | chr3 | 49869501 | - |
| intron-3CDS | ENST00000479449 | ENST00000331456 | QRICH1 | chr3 | 49114142 | - | TRAIP | chr3 | 49869501 | - |
| intron-3CDS | ENST00000479449 | ENST00000469027 | QRICH1 | chr3 | 49114142 | - | TRAIP | chr3 | 49869501 | - |
| intron-intron | ENST00000479449 | ENST00000473863 | QRICH1 | chr3 | 49114142 | - | TRAIP | chr3 | 49869501 | - |
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FusionProtFeatures for QRICH1_TRAIP |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| QRICH1 | TRAIP |
| E3 ubiquitin ligase acting as a negative regulator ofinnate immune signaling. Inhibits activation of NF-kappa-Bmediated by TNF. Negatively regulates TLR3/4- and RIG-I-mediatedIRF3 activation and subsequent IFNB1 production and cellularantiviral response by promoting 'Lys-48'-linked polyubiquitinationof TNK1 leading to its proteasomal degradation (By similarity)(PubMed:22945920). Involved in response to genotoxic lesionsduring genome replication. Promotes H2AX and RPA2 phosphorylationafter replication-associated DNA damage and assists forkprogression at UV-induced replication-blocking lesions during Sphase (PubMed:26595769). Has also been proposed to play a role inpromoting translesion synthesis by mediating the assembly of 'Lys-63'-linked poly-ubiquitin chains on the Y-family polymerase POLNin order to facilitate bypass of DNA lesions and preserve genomicintegrity (PubMed:24553286). The function in translesion synthesisis controversial (PubMed:26595769). {ECO:0000250|UniProtKB:Q8VIG6,ECO:0000269|PubMed:22945920, ECO:0000269|PubMed:24553286,ECO:0000269|PubMed:26595769, ECO:0000303|PubMed:26595769}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | QRICH1 | chr3:49114142 | chr3:49869501 | ENST00000357496 | - | 3 | 11 | 1_64 | 103 | 777 | Domain | Note=CARD |
| Hgene | QRICH1 | chr3:49114142 | chr3:49869501 | ENST00000395443 | - | 2 | 10 | 1_64 | 103 | 777 | Domain | Note=CARD |
| Hgene | QRICH1 | chr3:49114142 | chr3:49869501 | ENST00000424300 | - | 3 | 11 | 1_64 | 103 | 777 | Domain | Note=CARD |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >QRICH1 | chr3:49114142 | chr3:49869501 | ENST00000357496 | - | 3 | 11 | 85_462 | 103 | 777 | Compositional bias | Note=Gln-rich |
| Hgene | >QRICH1 | chr3:49114142 | chr3:49869501 | ENST00000395443 | - | 2 | 10 | 85_462 | 103 | 777 | Compositional bias | Note=Gln-rich |
| Hgene | >QRICH1 | chr3:49114142 | chr3:49869501 | ENST00000424300 | - | 3 | 11 | 85_462 | 103 | 777 | Compositional bias | Note=Gln-rich |
| Tgene | TRAIP | chr3:49114142 | chr3:49869501 | ENST00000331456 | - | 9 | 15 | 201_280 | 294 | 470 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | TRAIP | chr3:49114142 | chr3:49869501 | ENST00000331456 | - | 9 | 15 | 70_177 | 294 | 470 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | TRAIP | chr3:49114142 | chr3:49869501 | ENST00000331456 | - | 9 | 15 | 7_50 | 294 | 470 | Zinc finger | RING-type |
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FusionGeneSequence for QRICH1_TRAIP |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_QRICH1_ENST00000395443_chr3_49114142_-_TRAIP_ENST00000331456_chr3_49869501_-_278aa MNNSLENTISFEEYIRVKARSVPQHRMKEFLDSLASKGPEALQEFQQTATTTMVYQQGGNCIYTDSTEVAGSLLELACPVTTSVQPQTQQ EQQIQVQQPQQVQPSPCGGESEAPPAILPXXYXSQCYLXCGYSPSPALQLPAWLLRKTLPREVTLPNSGCPQEDMQRPQEGVPALTGWPE LCRRARXGTGWCLPYFCPECHPRPETAQEAQVRVLLQQRCGKDRLRWARWPDKIHPAYXHSHDPPIACXAQDQGXAEGEGEDSAFSLPGQ >In-frame_QRICH1_ENST00000395443_chr3_49114142_-_TRAIP_ENST00000469027_chr3_49869501_-_248aa MNNSLENTISFEEYIRVKARSVPQHRMKEFLDSLASKGPEALQEFQQTATTTMVYQQGGNCIYTDSTEVAGSLLELACPVTTSVQPQTQQ EQQIQVQQPQQVQPSPCGGESEAPPAILPXXYXSQCYLXCGYSPSPALQLPAWLLRKTLPREVTLPNSGCPQEDMQRPQEGVPALTGWPE >In-frame_QRICH1_ENST00000357496_chr3_49114142_-_TRAIP_ENST00000331456_chr3_49869501_-_278aa MNNSLENTISFEEYIRVKARSVPQHRMKEFLDSLASKGPEALQEFQQTATTTMVYQQGGNCIYTDSTEVAGSLLELACPVTTSVQPQTQQ EQQIQVQQPQQVQPSPCGGESEAPPAILPXXYXSQCYLXCGYSPSPALQLPAWLLRKTLPREVTLPNSGCPQEDMQRPQEGVPALTGWPE LCRRARXGTGWCLPYFCPECHPRPETAQEAQVRVLLQQRCGKDRLRWARWPDKIHPAYXHSHDPPIACXAQDQGXAEGEGEDSAFSLPGQ >In-frame_QRICH1_ENST00000357496_chr3_49114142_-_TRAIP_ENST00000469027_chr3_49869501_-_248aa MNNSLENTISFEEYIRVKARSVPQHRMKEFLDSLASKGPEALQEFQQTATTTMVYQQGGNCIYTDSTEVAGSLLELACPVTTSVQPQTQQ EQQIQVQQPQQVQPSPCGGESEAPPAILPXXYXSQCYLXCGYSPSPALQLPAWLLRKTLPREVTLPNSGCPQEDMQRPQEGVPALTGWPE >In-frame_QRICH1_ENST00000424300_chr3_49114142_-_TRAIP_ENST00000331456_chr3_49869501_-_278aa MNNSLENTISFEEYIRVKARSVPQHRMKEFLDSLASKGPEALQEFQQTATTTMVYQQGGNCIYTDSTEVAGSLLELACPVTTSVQPQTQQ EQQIQVQQPQQVQPSPCGGESEAPPAILPXXYXSQCYLXCGYSPSPALQLPAWLLRKTLPREVTLPNSGCPQEDMQRPQEGVPALTGWPE LCRRARXGTGWCLPYFCPECHPRPETAQEAQVRVLLQQRCGKDRLRWARWPDKIHPAYXHSHDPPIACXAQDQGXAEGEGEDSAFSLPGQ >In-frame_QRICH1_ENST00000424300_chr3_49114142_-_TRAIP_ENST00000469027_chr3_49869501_-_248aa MNNSLENTISFEEYIRVKARSVPQHRMKEFLDSLASKGPEALQEFQQTATTTMVYQQGGNCIYTDSTEVAGSLLELACPVTTSVQPQTQQ EQQIQVQQPQQVQPSPCGGESEAPPAILPXXYXSQCYLXCGYSPSPALQLPAWLLRKTLPREVTLPNSGCPQEDMQRPQEGVPALTGWPE |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_QRICH1_ENST00000395443_chr3_49114142_-_TRAIP_ENST00000331456_chr3_49869501_-_835nt ATGAATAATTCCCTAGAGAACACCATCTCCTTTGAAGAGTACATCCGAGTAAAGGCACGGTCTGTCCCGCAACACAGGATGAAGGAATTT CTGGACTCACTGGCCTCTAAGGGGCCAGAAGCCCTTCAGGAGTTCCAGCAGACAGCCACCACTACCATGGTGTACCAACAGGGTGGGAAC TGCATATACACAGACAGCACTGAAGTGGCTGGGTCTTTGCTTGAACTTGCCTGTCCAGTCACCACCAGTGTTCAGCCACAAACCCAGCAA GAACAGCAGATCCAGGTTCAGCAGCCGCAGCAGGTTCAGCCCAGCCCCTGTGGAGGTGAATCTGAAGCTCCGCCGGCCATCCTTCCGTGA TGATATTGATCTCAATGCTACCTTTGATGTGGATACTCCCCCAGCCCGGCCCTCCAGCTCCCAGCATGGTTACTACGAAAAACTTTGCCT AGAGAAGTCACACTCCCCAATTCAGGATGTCCCCAAGAAGATATGCAAAGGCCCCAGGAAGGAGTCCCAGCTCTCACTGGGTGGCCAGAG CTGTGCAGGAGAGCCAGATGAGGAACTGGTTGGTGCCTTCCCTATTTTTGTCCGGAATGCCATCCTAGGCCAGAAACAGCCCAAGAGGCC CAGGTCAGAGTCCTCTTGCAGCAAAGATGTGGTAAGGACAGGCTTCGATGGGCTCGGTGGCCGGACAAAATTCATCCAGCCTACTGACAC AGTCATGATCCGCCCATTGCCTGTTAAGCCCAAGACCAAGGTTAAGCAGAGGGTGAGGGTGAAGACAGTGCCTTCTCTCTTCCAGGCCAA >In-frame_QRICH1_ENST00000395443_chr3_49114142_-_TRAIP_ENST00000469027_chr3_49869501_-_745nt ATGAATAATTCCCTAGAGAACACCATCTCCTTTGAAGAGTACATCCGAGTAAAGGCACGGTCTGTCCCGCAACACAGGATGAAGGAATTT CTGGACTCACTGGCCTCTAAGGGGCCAGAAGCCCTTCAGGAGTTCCAGCAGACAGCCACCACTACCATGGTGTACCAACAGGGTGGGAAC TGCATATACACAGACAGCACTGAAGTGGCTGGGTCTTTGCTTGAACTTGCCTGTCCAGTCACCACCAGTGTTCAGCCACAAACCCAGCAA GAACAGCAGATCCAGGTTCAGCAGCCGCAGCAGGTTCAGCCCAGCCCCTGTGGAGGTGAATCTGAAGCTCCGCCGGCCATCCTTCCGTGA TGATATTGATCTCAATGCTACCTTTGATGTGGATACTCCCCCAGCCCGGCCCTCCAGCTCCCAGCATGGTTACTACGAAAAACTTTGCCT AGAGAAGTCACACTCCCCAATTCAGGATGTCCCCAAGAAGATATGCAAAGGCCCCAGGAAGGAGTCCCAGCTCTCACTGGGTGGCCAGAG CTGTGCAGGAGAGCCAGATGAGGAACTGGTTGGTGCCTTCCCTATTTTTGTCCGGAATGCCATCCTAGGCCAGAAACAGCCCAAGAGGCC CAGGTCAGAGTCCTCTTGCAGCAAAGATGTGGTAAGGACAGGCTTCGATGGGCTCGGTGGCCGGACAAAATTCATCCAGCCTGTATCCTT >In-frame_QRICH1_ENST00000357496_chr3_49114142_-_TRAIP_ENST00000331456_chr3_49869501_-_835nt ATGAATAATTCCCTAGAGAACACCATCTCCTTTGAAGAGTACATCCGAGTAAAGGCACGGTCTGTCCCGCAACACAGGATGAAGGAATTT CTGGACTCACTGGCCTCTAAGGGGCCAGAAGCCCTTCAGGAGTTCCAGCAGACAGCCACCACTACCATGGTGTACCAACAGGGTGGGAAC TGCATATACACAGACAGCACTGAAGTGGCTGGGTCTTTGCTTGAACTTGCCTGTCCAGTCACCACCAGTGTTCAGCCACAAACCCAGCAA GAACAGCAGATCCAGGTTCAGCAGCCGCAGCAGGTTCAGCCCAGCCCCTGTGGAGGTGAATCTGAAGCTCCGCCGGCCATCCTTCCGTGA TGATATTGATCTCAATGCTACCTTTGATGTGGATACTCCCCCAGCCCGGCCCTCCAGCTCCCAGCATGGTTACTACGAAAAACTTTGCCT AGAGAAGTCACACTCCCCAATTCAGGATGTCCCCAAGAAGATATGCAAAGGCCCCAGGAAGGAGTCCCAGCTCTCACTGGGTGGCCAGAG CTGTGCAGGAGAGCCAGATGAGGAACTGGTTGGTGCCTTCCCTATTTTTGTCCGGAATGCCATCCTAGGCCAGAAACAGCCCAAGAGGCC CAGGTCAGAGTCCTCTTGCAGCAAAGATGTGGTAAGGACAGGCTTCGATGGGCTCGGTGGCCGGACAAAATTCATCCAGCCTACTGACAC AGTCATGATCCGCCCATTGCCTGTTAAGCCCAAGACCAAGGTTAAGCAGAGGGTGAGGGTGAAGACAGTGCCTTCTCTCTTCCAGGCCAA >In-frame_QRICH1_ENST00000357496_chr3_49114142_-_TRAIP_ENST00000469027_chr3_49869501_-_745nt ATGAATAATTCCCTAGAGAACACCATCTCCTTTGAAGAGTACATCCGAGTAAAGGCACGGTCTGTCCCGCAACACAGGATGAAGGAATTT CTGGACTCACTGGCCTCTAAGGGGCCAGAAGCCCTTCAGGAGTTCCAGCAGACAGCCACCACTACCATGGTGTACCAACAGGGTGGGAAC TGCATATACACAGACAGCACTGAAGTGGCTGGGTCTTTGCTTGAACTTGCCTGTCCAGTCACCACCAGTGTTCAGCCACAAACCCAGCAA GAACAGCAGATCCAGGTTCAGCAGCCGCAGCAGGTTCAGCCCAGCCCCTGTGGAGGTGAATCTGAAGCTCCGCCGGCCATCCTTCCGTGA TGATATTGATCTCAATGCTACCTTTGATGTGGATACTCCCCCAGCCCGGCCCTCCAGCTCCCAGCATGGTTACTACGAAAAACTTTGCCT AGAGAAGTCACACTCCCCAATTCAGGATGTCCCCAAGAAGATATGCAAAGGCCCCAGGAAGGAGTCCCAGCTCTCACTGGGTGGCCAGAG CTGTGCAGGAGAGCCAGATGAGGAACTGGTTGGTGCCTTCCCTATTTTTGTCCGGAATGCCATCCTAGGCCAGAAACAGCCCAAGAGGCC CAGGTCAGAGTCCTCTTGCAGCAAAGATGTGGTAAGGACAGGCTTCGATGGGCTCGGTGGCCGGACAAAATTCATCCAGCCTGTATCCTT >In-frame_QRICH1_ENST00000424300_chr3_49114142_-_TRAIP_ENST00000331456_chr3_49869501_-_835nt ATGAATAATTCCCTAGAGAACACCATCTCCTTTGAAGAGTACATCCGAGTAAAGGCACGGTCTGTCCCGCAACACAGGATGAAGGAATTT CTGGACTCACTGGCCTCTAAGGGGCCAGAAGCCCTTCAGGAGTTCCAGCAGACAGCCACCACTACCATGGTGTACCAACAGGGTGGGAAC TGCATATACACAGACAGCACTGAAGTGGCTGGGTCTTTGCTTGAACTTGCCTGTCCAGTCACCACCAGTGTTCAGCCACAAACCCAGCAA GAACAGCAGATCCAGGTTCAGCAGCCGCAGCAGGTTCAGCCCAGCCCCTGTGGAGGTGAATCTGAAGCTCCGCCGGCCATCCTTCCGTGA TGATATTGATCTCAATGCTACCTTTGATGTGGATACTCCCCCAGCCCGGCCCTCCAGCTCCCAGCATGGTTACTACGAAAAACTTTGCCT AGAGAAGTCACACTCCCCAATTCAGGATGTCCCCAAGAAGATATGCAAAGGCCCCAGGAAGGAGTCCCAGCTCTCACTGGGTGGCCAGAG CTGTGCAGGAGAGCCAGATGAGGAACTGGTTGGTGCCTTCCCTATTTTTGTCCGGAATGCCATCCTAGGCCAGAAACAGCCCAAGAGGCC CAGGTCAGAGTCCTCTTGCAGCAAAGATGTGGTAAGGACAGGCTTCGATGGGCTCGGTGGCCGGACAAAATTCATCCAGCCTACTGACAC AGTCATGATCCGCCCATTGCCTGTTAAGCCCAAGACCAAGGTTAAGCAGAGGGTGAGGGTGAAGACAGTGCCTTCTCTCTTCCAGGCCAA >In-frame_QRICH1_ENST00000424300_chr3_49114142_-_TRAIP_ENST00000469027_chr3_49869501_-_745nt ATGAATAATTCCCTAGAGAACACCATCTCCTTTGAAGAGTACATCCGAGTAAAGGCACGGTCTGTCCCGCAACACAGGATGAAGGAATTT CTGGACTCACTGGCCTCTAAGGGGCCAGAAGCCCTTCAGGAGTTCCAGCAGACAGCCACCACTACCATGGTGTACCAACAGGGTGGGAAC TGCATATACACAGACAGCACTGAAGTGGCTGGGTCTTTGCTTGAACTTGCCTGTCCAGTCACCACCAGTGTTCAGCCACAAACCCAGCAA GAACAGCAGATCCAGGTTCAGCAGCCGCAGCAGGTTCAGCCCAGCCCCTGTGGAGGTGAATCTGAAGCTCCGCCGGCCATCCTTCCGTGA TGATATTGATCTCAATGCTACCTTTGATGTGGATACTCCCCCAGCCCGGCCCTCCAGCTCCCAGCATGGTTACTACGAAAAACTTTGCCT AGAGAAGTCACACTCCCCAATTCAGGATGTCCCCAAGAAGATATGCAAAGGCCCCAGGAAGGAGTCCCAGCTCTCACTGGGTGGCCAGAG CTGTGCAGGAGAGCCAGATGAGGAACTGGTTGGTGCCTTCCCTATTTTTGTCCGGAATGCCATCCTAGGCCAGAAACAGCCCAAGAGGCC CAGGTCAGAGTCCTCTTGCAGCAAAGATGTGGTAAGGACAGGCTTCGATGGGCTCGGTGGCCGGACAAAATTCATCCAGCCTGTATCCTT |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_QRICH1_ENST00000395443_chr3_49114142_-_TRAIP_ENST00000331456_chr3_49869501_-_1810nt AAAGGAGGCTCTGGCGGGCGACGGAAGGTGGGTCCAAAGAGCTAGCTTGGAGCCCTAGCCTTCCGAGACTCCACTACTAGGCCAAGCCAC GGCCCTAGCTCCGCCCCACATGGAGAGGCGTCCATGGGCGGAGCGAGCCGCTCCATACCCTAGGATCCACTATCCGCTCTAGCGGCCAGA AGCGCGGCCACCTTCCCCTGCTGAAGCGTTCACTTTAATTTTGGCCGGTAGGCAGTCCCAGATCTCGCGGGATCCGACGCCCCGATTATC GCGAGAGGAGCAATCGGCTCCTATTGGCTGTGAGGGTTGAATGTAAGATGGCGCCCAGGGAGCTGTGAGGAGAAAACCCTGTCGGTCTTG GAGCGACGACGGCAGAACCAGGGTCCCTGGCGGTGCGGCGGGGCCGGCGGGTGCAGCGGAGGCGGCGGCGGCGGCGGCAGTGACGTCGCC GGGAACCCTAAGGACTCTGCAATATGAATAATTCCCTAGAGAACACCATCTCCTTTGAAGAGTACATCCGAGTAAAGGCACGGTCTGTCC CGCAACACAGGATGAAGGAATTTCTGGACTCACTGGCCTCTAAGGGGCCAGAAGCCCTTCAGGAGTTCCAGCAGACAGCCACCACTACCA TGGTGTACCAACAGGGTGGGAACTGCATATACACAGACAGCACTGAAGTGGCTGGGTCTTTGCTTGAACTTGCCTGTCCAGTCACCACCA GTGTTCAGCCACAAACCCAGCAAGAACAGCAGATCCAGGTTCAGCAGCCGCAGCAGGTTCAGCCCAGCCCCTGTGGAGGTGAATCTGAAG CTCCGCCGGCCATCCTTCCGTGATGATATTGATCTCAATGCTACCTTTGATGTGGATACTCCCCCAGCCCGGCCCTCCAGCTCCCAGCAT GGTTACTACGAAAAACTTTGCCTAGAGAAGTCACACTCCCCAATTCAGGATGTCCCCAAGAAGATATGCAAAGGCCCCAGGAAGGAGTCC CAGCTCTCACTGGGTGGCCAGAGCTGTGCAGGAGAGCCAGATGAGGAACTGGTTGGTGCCTTCCCTATTTTTGTCCGGAATGCCATCCTA GGCCAGAAACAGCCCAAGAGGCCCAGGTCAGAGTCCTCTTGCAGCAAAGATGTGGTAAGGACAGGCTTCGATGGGCTCGGTGGCCGGACA AAATTCATCCAGCCTACTGACACAGTCATGATCCGCCCATTGCCTGTTAAGCCCAAGACCAAGGTTAAGCAGAGGGTGAGGGTGAAGACA GTGCCTTCTCTCTTCCAGGCCAAGCTGGACACCTTCCTGTGGTCGTGAGAACAGTGAGTCTGACCAATGGCCAGACACATGCCTGCAACT TGTAGGTCAAGGACTGTCCAGGCAGGGGTTTTGTGGACAGAGCCCCACTTTCGGGACCAGCCTGAGGTGTAAGGGCAGACAAACAGGTGA GGGTGAGTGTGGCACCCAGAGACTGCTCTTCCTGCCCTCACCCTGCCCCACTCCTACGACTGGGAGCTGACATGACCAGCCCACTGATCC TGTCAGCAGGTCCTGCTCCTGTTGCCAGGCTCCTGTTTATAGCCATGATCAGATGTGGTCAGACTCTTTCTGGGCCTGGAGACCACGGTC ACTTGTTGACTGTCTCTGTGGACCAGAGTGCTTGAGGCATCTCAGGCAGCCTCAGCCCAAGCTTCTACCTGCCTTTGACTTGCTTCTAGG CATAGCCTGGGCCAAGCAGGGTGGGGAATGGAGGATAGCATGGGATGTATGGAGAGGATGGAAGATTTTCATGTAAAATAAAATTAAAAA >In-frame_QRICH1_ENST00000395443_chr3_49114142_-_TRAIP_ENST00000469027_chr3_49869501_-_1387nt AAAGGAGGCTCTGGCGGGCGACGGAAGGTGGGTCCAAAGAGCTAGCTTGGAGCCCTAGCCTTCCGAGACTCCACTACTAGGCCAAGCCAC GGCCCTAGCTCCGCCCCACATGGAGAGGCGTCCATGGGCGGAGCGAGCCGCTCCATACCCTAGGATCCACTATCCGCTCTAGCGGCCAGA AGCGCGGCCACCTTCCCCTGCTGAAGCGTTCACTTTAATTTTGGCCGGTAGGCAGTCCCAGATCTCGCGGGATCCGACGCCCCGATTATC GCGAGAGGAGCAATCGGCTCCTATTGGCTGTGAGGGTTGAATGTAAGATGGCGCCCAGGGAGCTGTGAGGAGAAAACCCTGTCGGTCTTG GAGCGACGACGGCAGAACCAGGGTCCCTGGCGGTGCGGCGGGGCCGGCGGGTGCAGCGGAGGCGGCGGCGGCGGCGGCAGTGACGTCGCC GGGAACCCTAAGGACTCTGCAATATGAATAATTCCCTAGAGAACACCATCTCCTTTGAAGAGTACATCCGAGTAAAGGCACGGTCTGTCC CGCAACACAGGATGAAGGAATTTCTGGACTCACTGGCCTCTAAGGGGCCAGAAGCCCTTCAGGAGTTCCAGCAGACAGCCACCACTACCA TGGTGTACCAACAGGGTGGGAACTGCATATACACAGACAGCACTGAAGTGGCTGGGTCTTTGCTTGAACTTGCCTGTCCAGTCACCACCA GTGTTCAGCCACAAACCCAGCAAGAACAGCAGATCCAGGTTCAGCAGCCGCAGCAGGTTCAGCCCAGCCCCTGTGGAGGTGAATCTGAAG CTCCGCCGGCCATCCTTCCGTGATGATATTGATCTCAATGCTACCTTTGATGTGGATACTCCCCCAGCCCGGCCCTCCAGCTCCCAGCAT GGTTACTACGAAAAACTTTGCCTAGAGAAGTCACACTCCCCAATTCAGGATGTCCCCAAGAAGATATGCAAAGGCCCCAGGAAGGAGTCC CAGCTCTCACTGGGTGGCCAGAGCTGTGCAGGAGAGCCAGATGAGGAACTGGTTGGTGCCTTCCCTATTTTTGTCCGGAATGCCATCCTA GGCCAGAAACAGCCCAAGAGGCCCAGGTCAGAGTCCTCTTGCAGCAAAGATGTGGTAAGGACAGGCTTCGATGGGCTCGGTGGCCGGACA AAATTCATCCAGCCTGTATCCTTTTCCTGTGATGTTGAGCTGAGCTGAACTGTGGAGCCCATACTATGCCTCACCTATACCCCCAGCCTG CCAGTGCCAACAGCCTCAGGTGTGCAGTGCTGGGCCTCATTCTGTGTATCAGCGCCGCCCACCCCCGGCTCTGAGCCTTTCTTGCCCTGC >In-frame_QRICH1_ENST00000357496_chr3_49114142_-_TRAIP_ENST00000331456_chr3_49869501_-_1569nt GAGGGTTGAATGTAAGATGGCGCCCAGGGAGCTGTGAGGAGAAAACCCTGTCGGTCTTGGAGCGACGACGGCAGAACCAGGGTCCCTGGC GGTGCGGCGGGGCCGGCGGGTGCAGCGGAGGCGGCGGCGGCGGCGGCAGTGACGTCGCCGGAATATTAGAAGTCTTAAGAACTCAGGACA AGCAGCAGAAATACATGCAACATGGTGACTGGAACCCTAAGGACTCTGCAATATGAATAATTCCCTAGAGAACACCATCTCCTTTGAAGA GTACATCCGAGTAAAGGCACGGTCTGTCCCGCAACACAGGATGAAGGAATTTCTGGACTCACTGGCCTCTAAGGGGCCAGAAGCCCTTCA GGAGTTCCAGCAGACAGCCACCACTACCATGGTGTACCAACAGGGTGGGAACTGCATATACACAGACAGCACTGAAGTGGCTGGGTCTTT GCTTGAACTTGCCTGTCCAGTCACCACCAGTGTTCAGCCACAAACCCAGCAAGAACAGCAGATCCAGGTTCAGCAGCCGCAGCAGGTTCA GCCCAGCCCCTGTGGAGGTGAATCTGAAGCTCCGCCGGCCATCCTTCCGTGATGATATTGATCTCAATGCTACCTTTGATGTGGATACTC CCCCAGCCCGGCCCTCCAGCTCCCAGCATGGTTACTACGAAAAACTTTGCCTAGAGAAGTCACACTCCCCAATTCAGGATGTCCCCAAGA AGATATGCAAAGGCCCCAGGAAGGAGTCCCAGCTCTCACTGGGTGGCCAGAGCTGTGCAGGAGAGCCAGATGAGGAACTGGTTGGTGCCT TCCCTATTTTTGTCCGGAATGCCATCCTAGGCCAGAAACAGCCCAAGAGGCCCAGGTCAGAGTCCTCTTGCAGCAAAGATGTGGTAAGGA CAGGCTTCGATGGGCTCGGTGGCCGGACAAAATTCATCCAGCCTACTGACACAGTCATGATCCGCCCATTGCCTGTTAAGCCCAAGACCA AGGTTAAGCAGAGGGTGAGGGTGAAGACAGTGCCTTCTCTCTTCCAGGCCAAGCTGGACACCTTCCTGTGGTCGTGAGAACAGTGAGTCT GACCAATGGCCAGACACATGCCTGCAACTTGTAGGTCAAGGACTGTCCAGGCAGGGGTTTTGTGGACAGAGCCCCACTTTCGGGACCAGC CTGAGGTGTAAGGGCAGACAAACAGGTGAGGGTGAGTGTGGCACCCAGAGACTGCTCTTCCTGCCCTCACCCTGCCCCACTCCTACGACT GGGAGCTGACATGACCAGCCCACTGATCCTGTCAGCAGGTCCTGCTCCTGTTGCCAGGCTCCTGTTTATAGCCATGATCAGATGTGGTCA GACTCTTTCTGGGCCTGGAGACCACGGTCACTTGTTGACTGTCTCTGTGGACCAGAGTGCTTGAGGCATCTCAGGCAGCCTCAGCCCAAG CTTCTACCTGCCTTTGACTTGCTTCTAGGCATAGCCTGGGCCAAGCAGGGTGGGGAATGGAGGATAGCATGGGATGTATGGAGAGGATGG >In-frame_QRICH1_ENST00000357496_chr3_49114142_-_TRAIP_ENST00000469027_chr3_49869501_-_1146nt GAGGGTTGAATGTAAGATGGCGCCCAGGGAGCTGTGAGGAGAAAACCCTGTCGGTCTTGGAGCGACGACGGCAGAACCAGGGTCCCTGGC GGTGCGGCGGGGCCGGCGGGTGCAGCGGAGGCGGCGGCGGCGGCGGCAGTGACGTCGCCGGAATATTAGAAGTCTTAAGAACTCAGGACA AGCAGCAGAAATACATGCAACATGGTGACTGGAACCCTAAGGACTCTGCAATATGAATAATTCCCTAGAGAACACCATCTCCTTTGAAGA GTACATCCGAGTAAAGGCACGGTCTGTCCCGCAACACAGGATGAAGGAATTTCTGGACTCACTGGCCTCTAAGGGGCCAGAAGCCCTTCA GGAGTTCCAGCAGACAGCCACCACTACCATGGTGTACCAACAGGGTGGGAACTGCATATACACAGACAGCACTGAAGTGGCTGGGTCTTT GCTTGAACTTGCCTGTCCAGTCACCACCAGTGTTCAGCCACAAACCCAGCAAGAACAGCAGATCCAGGTTCAGCAGCCGCAGCAGGTTCA GCCCAGCCCCTGTGGAGGTGAATCTGAAGCTCCGCCGGCCATCCTTCCGTGATGATATTGATCTCAATGCTACCTTTGATGTGGATACTC CCCCAGCCCGGCCCTCCAGCTCCCAGCATGGTTACTACGAAAAACTTTGCCTAGAGAAGTCACACTCCCCAATTCAGGATGTCCCCAAGA AGATATGCAAAGGCCCCAGGAAGGAGTCCCAGCTCTCACTGGGTGGCCAGAGCTGTGCAGGAGAGCCAGATGAGGAACTGGTTGGTGCCT TCCCTATTTTTGTCCGGAATGCCATCCTAGGCCAGAAACAGCCCAAGAGGCCCAGGTCAGAGTCCTCTTGCAGCAAAGATGTGGTAAGGA CAGGCTTCGATGGGCTCGGTGGCCGGACAAAATTCATCCAGCCTGTATCCTTTTCCTGTGATGTTGAGCTGAGCTGAACTGTGGAGCCCA TACTATGCCTCACCTATACCCCCAGCCTGCCAGTGCCAACAGCCTCAGGTGTGCAGTGCTGGGCCTCATTCTGTGTATCAGCGCCGCCCA >In-frame_QRICH1_ENST00000424300_chr3_49114142_-_TRAIP_ENST00000331456_chr3_49869501_-_1775nt CGCGTTCCCGGCCCGGATATCTCTGCTCTAGGAGCTGTGGCCCGTGGGCAACCGCGGCTTTCTGGAGCGCGCGCCCGTGACGACCCCCAG TTTTGGGGCGCGCGCTCTGATATCGGGTGGCGGTGCTGCCTCGAGAGCGCGCAGGAGGCTTCTGCTGAGCAGAGGGCCGGCCGCGGCTCG TTGCGCTGGGAAGGTTGAGGATTGGGTCCTTTCTGGTCTGGTGACGTTCCCGGGCATCCGTGGCCTCGGCCTGGAGAGAAACCAACCAGC TTTGCTGTCTGGCTTGCGGTTCCGCTCCTCTGTGAGGGGGGCGAGATTGCCCGTTCTCCTCGAAGAATGCCGTTACTTGAGGCCCAAAAT ATTAGAAGTCTTAAGAACTCAGGACAAGCAGCAGAAATACATGCAACATGGTGACTGGAACCCTAAGGACTCTGCAATATGAATAATTCC CTAGAGAACACCATCTCCTTTGAAGAGTACATCCGAGTAAAGGCACGGTCTGTCCCGCAACACAGGATGAAGGAATTTCTGGACTCACTG GCCTCTAAGGGGCCAGAAGCCCTTCAGGAGTTCCAGCAGACAGCCACCACTACCATGGTGTACCAACAGGGTGGGAACTGCATATACACA GACAGCACTGAAGTGGCTGGGTCTTTGCTTGAACTTGCCTGTCCAGTCACCACCAGTGTTCAGCCACAAACCCAGCAAGAACAGCAGATC CAGGTTCAGCAGCCGCAGCAGGTTCAGCCCAGCCCCTGTGGAGGTGAATCTGAAGCTCCGCCGGCCATCCTTCCGTGATGATATTGATCT CAATGCTACCTTTGATGTGGATACTCCCCCAGCCCGGCCCTCCAGCTCCCAGCATGGTTACTACGAAAAACTTTGCCTAGAGAAGTCACA CTCCCCAATTCAGGATGTCCCCAAGAAGATATGCAAAGGCCCCAGGAAGGAGTCCCAGCTCTCACTGGGTGGCCAGAGCTGTGCAGGAGA GCCAGATGAGGAACTGGTTGGTGCCTTCCCTATTTTTGTCCGGAATGCCATCCTAGGCCAGAAACAGCCCAAGAGGCCCAGGTCAGAGTC CTCTTGCAGCAAAGATGTGGTAAGGACAGGCTTCGATGGGCTCGGTGGCCGGACAAAATTCATCCAGCCTACTGACACAGTCATGATCCG CCCATTGCCTGTTAAGCCCAAGACCAAGGTTAAGCAGAGGGTGAGGGTGAAGACAGTGCCTTCTCTCTTCCAGGCCAAGCTGGACACCTT CCTGTGGTCGTGAGAACAGTGAGTCTGACCAATGGCCAGACACATGCCTGCAACTTGTAGGTCAAGGACTGTCCAGGCAGGGGTTTTGTG GACAGAGCCCCACTTTCGGGACCAGCCTGAGGTGTAAGGGCAGACAAACAGGTGAGGGTGAGTGTGGCACCCAGAGACTGCTCTTCCTGC CCTCACCCTGCCCCACTCCTACGACTGGGAGCTGACATGACCAGCCCACTGATCCTGTCAGCAGGTCCTGCTCCTGTTGCCAGGCTCCTG TTTATAGCCATGATCAGATGTGGTCAGACTCTTTCTGGGCCTGGAGACCACGGTCACTTGTTGACTGTCTCTGTGGACCAGAGTGCTTGA GGCATCTCAGGCAGCCTCAGCCCAAGCTTCTACCTGCCTTTGACTTGCTTCTAGGCATAGCCTGGGCCAAGCAGGGTGGGGAATGGAGGA >In-frame_QRICH1_ENST00000424300_chr3_49114142_-_TRAIP_ENST00000469027_chr3_49869501_-_1352nt CGCGTTCCCGGCCCGGATATCTCTGCTCTAGGAGCTGTGGCCCGTGGGCAACCGCGGCTTTCTGGAGCGCGCGCCCGTGACGACCCCCAG TTTTGGGGCGCGCGCTCTGATATCGGGTGGCGGTGCTGCCTCGAGAGCGCGCAGGAGGCTTCTGCTGAGCAGAGGGCCGGCCGCGGCTCG TTGCGCTGGGAAGGTTGAGGATTGGGTCCTTTCTGGTCTGGTGACGTTCCCGGGCATCCGTGGCCTCGGCCTGGAGAGAAACCAACCAGC TTTGCTGTCTGGCTTGCGGTTCCGCTCCTCTGTGAGGGGGGCGAGATTGCCCGTTCTCCTCGAAGAATGCCGTTACTTGAGGCCCAAAAT ATTAGAAGTCTTAAGAACTCAGGACAAGCAGCAGAAATACATGCAACATGGTGACTGGAACCCTAAGGACTCTGCAATATGAATAATTCC CTAGAGAACACCATCTCCTTTGAAGAGTACATCCGAGTAAAGGCACGGTCTGTCCCGCAACACAGGATGAAGGAATTTCTGGACTCACTG GCCTCTAAGGGGCCAGAAGCCCTTCAGGAGTTCCAGCAGACAGCCACCACTACCATGGTGTACCAACAGGGTGGGAACTGCATATACACA GACAGCACTGAAGTGGCTGGGTCTTTGCTTGAACTTGCCTGTCCAGTCACCACCAGTGTTCAGCCACAAACCCAGCAAGAACAGCAGATC CAGGTTCAGCAGCCGCAGCAGGTTCAGCCCAGCCCCTGTGGAGGTGAATCTGAAGCTCCGCCGGCCATCCTTCCGTGATGATATTGATCT CAATGCTACCTTTGATGTGGATACTCCCCCAGCCCGGCCCTCCAGCTCCCAGCATGGTTACTACGAAAAACTTTGCCTAGAGAAGTCACA CTCCCCAATTCAGGATGTCCCCAAGAAGATATGCAAAGGCCCCAGGAAGGAGTCCCAGCTCTCACTGGGTGGCCAGAGCTGTGCAGGAGA GCCAGATGAGGAACTGGTTGGTGCCTTCCCTATTTTTGTCCGGAATGCCATCCTAGGCCAGAAACAGCCCAAGAGGCCCAGGTCAGAGTC CTCTTGCAGCAAAGATGTGGTAAGGACAGGCTTCGATGGGCTCGGTGGCCGGACAAAATTCATCCAGCCTGTATCCTTTTCCTGTGATGT TGAGCTGAGCTGAACTGTGGAGCCCATACTATGCCTCACCTATACCCCCAGCCTGCCAGTGCCAACAGCCTCAGGTGTGCAGTGCTGGGC CTCATTCTGTGTATCAGCGCCGCCCACCCCCGGCTCTGAGCCTTTCTTGCCCTGCATTGCAGTCCTTTCTCGCCCTGCATTGCAGTCCTT 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FusionGenePPI for QRICH1_TRAIP |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| QRICH1 | ATXN1, NUDCD3, PRKCSH, PAICS, RPL11, SUPT16H, CRX, FHL3, MEOX1, NFIX, SIAH1, TRAF1, PUF60, SEPHS1, HSPB8, NLK, QRICH1, GMCL1, RBM17, HSFY1, ENO1, MOV10, NXF1, ZDHHC17, APP, PHF19, PMM1, RFPL4B, SEC13, LHX6, WRAP73, NTRK1, FOXJ2, HSPA8, FSCN2, GAN, WDYHV1, SNRNP27, BAG4, HSPBP1, LPXN | TRAIP | FLII, TRAF1, TRAF2, TNFRSF1B, TNFRSF8, UBE2U, TSG101, UBE2H, UBE2K, UBE2Z, CYLD, TRAIP, TRAF3, TRAF5, TRAF6, RAD21, TBK1, SYK, UBE2D1, UBE2D2, UBE2D3, APP, USP2, RNF4, TRIM23, RNF114, TRIM41, UBOX5, POLH, POLK, MAPRE2, PCNA, MAGEF1, MAP3K7, UIMC1, RNF20, RNF40 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Tgene | TRAIP | chr3:49114142 | chr3:49869501 | ENST00000331456 | - | 9 | 15 | 211_469 | 294 | 470 | CYLD |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for QRICH1_TRAIP |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for QRICH1_TRAIP |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | TRAIP | C0013336 | Dwarfism | 1 | CTD_human |
| Tgene | TRAIP | C0025958 | Microcephaly | 1 | CTD_human |
| Tgene | TRAIP | C4225212 | SECKEL SYNDROME 9 | 1 | UNIPROT |
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