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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 29800

FusionGeneSummary for QKI_ZNF214

check button Fusion gene summary
Fusion gene informationFusion gene name: QKI_ZNF214
Fusion gene ID: 29800
HgeneTgene
Gene symbol

QKI

ZNF214

Gene ID

9444

7761

Gene nameQKI, KH domain containing RNA bindingzinc finger protein 214
SynonymsHqk|QK|QK1|QK3|hqkIBAZ-1|BAZ1
Cytomap

6q26

11p15.4

Type of geneprotein-codingprotein-coding
Descriptionprotein quakingQKI/LOC100132735 fusionRNA binding protein HQKhomolog of mouse quaking QKI (KH domain RNA binding protein)quaking homolog, KH domain RNA bindingzinc finger protein 214BWSCR2-associated zinc finger protein 1
Modification date2018052220180523
UniProtAcc

Q96PU8

Q9UL59

Ensembl transtripts involved in fusion geneENST00000275262, ENST00000392127, 
ENST00000453779, ENST00000361752, 
ENST00000361195, ENST00000424802, 
ENST00000278314, ENST00000536068, 
ENST00000531083, 
Fusion gene scores* DoF score7 X 6 X 7=2941 X 1 X 1=1
# samples 131
** MAII scorelog2(13/294*10)=-1.17730453180791
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(1/1*10)=3.32192809488736
Context

PubMed: QKI [Title/Abstract] AND ZNF214 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-A2-A0CM-01AQKIchr6

163836367

+ZNF214chr11

7024086

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000275262ENST00000278314QKIchr6

163836367

+ZNF214chr11

7024086

-
5CDS-5UTRENST00000275262ENST00000536068QKIchr6

163836367

+ZNF214chr11

7024086

-
5CDS-5UTRENST00000275262ENST00000531083QKIchr6

163836367

+ZNF214chr11

7024086

-
5CDS-5UTRENST00000392127ENST00000278314QKIchr6

163836367

+ZNF214chr11

7024086

-
5CDS-5UTRENST00000392127ENST00000536068QKIchr6

163836367

+ZNF214chr11

7024086

-
5CDS-5UTRENST00000392127ENST00000531083QKIchr6

163836367

+ZNF214chr11

7024086

-
5CDS-5UTRENST00000453779ENST00000278314QKIchr6

163836367

+ZNF214chr11

7024086

-
5CDS-5UTRENST00000453779ENST00000536068QKIchr6

163836367

+ZNF214chr11

7024086

-
5CDS-5UTRENST00000453779ENST00000531083QKIchr6

163836367

+ZNF214chr11

7024086

-
5CDS-5UTRENST00000361752ENST00000278314QKIchr6

163836367

+ZNF214chr11

7024086

-
5CDS-5UTRENST00000361752ENST00000536068QKIchr6

163836367

+ZNF214chr11

7024086

-
5CDS-5UTRENST00000361752ENST00000531083QKIchr6

163836367

+ZNF214chr11

7024086

-
5CDS-5UTRENST00000361195ENST00000278314QKIchr6

163836367

+ZNF214chr11

7024086

-
5CDS-5UTRENST00000361195ENST00000536068QKIchr6

163836367

+ZNF214chr11

7024086

-
5CDS-5UTRENST00000361195ENST00000531083QKIchr6

163836367

+ZNF214chr11

7024086

-
5CDS-5UTRENST00000424802ENST00000278314QKIchr6

163836367

+ZNF214chr11

7024086

-
5CDS-5UTRENST00000424802ENST00000536068QKIchr6

163836367

+ZNF214chr11

7024086

-
5CDS-5UTRENST00000424802ENST00000531083QKIchr6

163836367

+ZNF214chr11

7024086

-

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FusionProtFeatures for QKI_ZNF214


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
QKI

Q96PU8

ZNF214

Q9UL59

May be involved in transcriptional regulation.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for QKI_ZNF214


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for QKI_ZNF214


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
QKIHNRNPK, USP30, MED12, MED13, MED25, MED16, MED17, MED1, MED24, MED23, MED4, MED29, MED31, MED15, MED14, MED26, MED10, POLR2A, MED27, ELAVL1, PSMF1, C10orf10, FUBP3, HCLS1, PCBP2, PTBP1, PTBP2, RBM14, RBFOX2, RBPMS, RNF138, SERF2, THAP1, USH1C, RBFOX1, PCBP1, PCBP4, APP, NDUFA7, CDV3, ATXN1, FN1, U2AF2, RBM23, RALY, WDR77, HNRNPH2, QKI, DAZ1, IL7R, CARM1, SNRPA, RBM11, NABP1, HNRNPLL, OIP5, RBMX, ZACN, CYP1A1, NTRK1, EWSR1, HYPK, DUSP22, DUSP4, ATE1, RBM42, FBXW11, SLC39A12, VAC14, TRIM11, SYNCRIP, SNRNP27ZNF214USP34, ANKS3, TOPORS, SOGA3, CENPB, SMARCAD1, NEK7, TRIM37, LRP4, TRIM39, ZC3H18, CBX6


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for QKI_ZNF214


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for QKI_ZNF214


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneQKIC0036341Schizophrenia5PSYGENET
HgeneQKIC0017638Glioma1CTD_human
HgeneQKIC0041696Unipolar Depression1PSYGENET
HgeneQKIC1269683Major Depressive Disorder1PSYGENET