![]() |
||||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Fusion gene ID: 29799 |
FusionGeneSummary for QKI_TAF12 |
![]() |
Fusion gene information | Fusion gene name: QKI_TAF12 | Fusion gene ID: 29799 | Hgene | Tgene | Gene symbol | QKI | TAF12 | Gene ID | 9444 | 6883 |
Gene name | QKI, KH domain containing RNA binding | TATA-box binding protein associated factor 12 | |
Synonyms | Hqk|QK|QK1|QK3|hqkI | TAF2J|TAFII20 | |
Cytomap | 6q26 | 1p35.3 | |
Type of gene | protein-coding | protein-coding | |
Description | protein quakingQKI/LOC100132735 fusionRNA binding protein HQKhomolog of mouse quaking QKI (KH domain RNA binding protein)quaking homolog, KH domain RNA binding | transcription initiation factor TFIID subunit 12TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 20kDaTAFII-20/TAFII-15TAFII20/TAFII15TATA box binding protein (TBP)-associated factor, RNA polymerase II, J, 20kDtranscription | |
Modification date | 20180522 | 20180523 | |
UniProtAcc | Q96PU8 | Q16514 | |
Ensembl transtripts involved in fusion gene | ENST00000275262, ENST00000392127, ENST00000453779, ENST00000361752, ENST00000361195, ENST00000424802, | ENST00000373824, ENST00000263974, ENST00000471683, | |
Fusion gene scores | * DoF score | 7 X 6 X 7=294 | 3 X 2 X 3=18 |
# samples | 13 | 3 | |
** MAII score | log2(13/294*10)=-1.17730453180791 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: QKI [Title/Abstract] AND TAF12 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
![]() |
Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | TAF12 | GO:0006352 | DNA-templated transcription, initiation | 9603525 |
Tgene | TAF12 | GO:0006367 | transcription initiation from RNA polymerase II promoter | 9603525 |
Tgene | TAF12 | GO:0043966 | histone H3 acetylation | 11564863 |
Tgene | TAF12 | GO:0051091 | positive regulation of DNA binding transcription factor activity | 15735663 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | BRCA | TCGA-E2-A1II-01A | QKI | chr6 | 163836367 | + | TAF12 | chr1 | 28948677 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-5UTR | ENST00000275262 | ENST00000373824 | QKI | chr6 | 163836367 | + | TAF12 | chr1 | 28948677 | - |
5CDS-5UTR | ENST00000275262 | ENST00000263974 | QKI | chr6 | 163836367 | + | TAF12 | chr1 | 28948677 | - |
5CDS-intron | ENST00000275262 | ENST00000471683 | QKI | chr6 | 163836367 | + | TAF12 | chr1 | 28948677 | - |
5CDS-5UTR | ENST00000392127 | ENST00000373824 | QKI | chr6 | 163836367 | + | TAF12 | chr1 | 28948677 | - |
5CDS-5UTR | ENST00000392127 | ENST00000263974 | QKI | chr6 | 163836367 | + | TAF12 | chr1 | 28948677 | - |
5CDS-intron | ENST00000392127 | ENST00000471683 | QKI | chr6 | 163836367 | + | TAF12 | chr1 | 28948677 | - |
5CDS-5UTR | ENST00000453779 | ENST00000373824 | QKI | chr6 | 163836367 | + | TAF12 | chr1 | 28948677 | - |
5CDS-5UTR | ENST00000453779 | ENST00000263974 | QKI | chr6 | 163836367 | + | TAF12 | chr1 | 28948677 | - |
5CDS-intron | ENST00000453779 | ENST00000471683 | QKI | chr6 | 163836367 | + | TAF12 | chr1 | 28948677 | - |
5CDS-5UTR | ENST00000361752 | ENST00000373824 | QKI | chr6 | 163836367 | + | TAF12 | chr1 | 28948677 | - |
5CDS-5UTR | ENST00000361752 | ENST00000263974 | QKI | chr6 | 163836367 | + | TAF12 | chr1 | 28948677 | - |
5CDS-intron | ENST00000361752 | ENST00000471683 | QKI | chr6 | 163836367 | + | TAF12 | chr1 | 28948677 | - |
5CDS-5UTR | ENST00000361195 | ENST00000373824 | QKI | chr6 | 163836367 | + | TAF12 | chr1 | 28948677 | - |
5CDS-5UTR | ENST00000361195 | ENST00000263974 | QKI | chr6 | 163836367 | + | TAF12 | chr1 | 28948677 | - |
5CDS-intron | ENST00000361195 | ENST00000471683 | QKI | chr6 | 163836367 | + | TAF12 | chr1 | 28948677 | - |
5CDS-5UTR | ENST00000424802 | ENST00000373824 | QKI | chr6 | 163836367 | + | TAF12 | chr1 | 28948677 | - |
5CDS-5UTR | ENST00000424802 | ENST00000263974 | QKI | chr6 | 163836367 | + | TAF12 | chr1 | 28948677 | - |
5CDS-intron | ENST00000424802 | ENST00000471683 | QKI | chr6 | 163836367 | + | TAF12 | chr1 | 28948677 | - |
Top |
FusionProtFeatures for QKI_TAF12 |
![]() |
Hgene | Tgene |
QKI | TAF12 |
TAFs are components of the transcription factor IID(TFIID) complex, PCAF histone acetylase complex and TBP-free TAFIIcomplex (TFTC). TAFs components-TIIFD are essential for mediatingregulation of RNA polymerase transcription. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for QKI_TAF12 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for QKI_TAF12 |
![]() |
![]() |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
QKI | HNRNPK, USP30, MED12, MED13, MED25, MED16, MED17, MED1, MED24, MED23, MED4, MED29, MED31, MED15, MED14, MED26, MED10, POLR2A, MED27, ELAVL1, PSMF1, C10orf10, FUBP3, HCLS1, PCBP2, PTBP1, PTBP2, RBM14, RBFOX2, RBPMS, RNF138, SERF2, THAP1, USH1C, RBFOX1, PCBP1, PCBP4, APP, NDUFA7, CDV3, ATXN1, FN1, U2AF2, RBM23, RALY, WDR77, HNRNPH2, QKI, DAZ1, IL7R, CARM1, SNRPA, RBM11, NABP1, HNRNPLL, OIP5, RBMX, ZACN, CYP1A1, NTRK1, EWSR1, HYPK, DUSP22, DUSP4, ATE1, RBM42, FBXW11, SLC39A12, VAC14, TRIM11, SYNCRIP, SNRNP27 | TAF12 | TAF4, TAF5, SUPT3H, TAF9, ATXN7, TAF6, TBP, ATF7, NFYB, NFYC, NFYA, TAF1A, TAF1C, TAF3, CPSF1, TAF10, ELAVL1, ERCC1, HIST3H3, KAT2B, TAF4B, UBE2I, PRKAR2B, CCDC101, TAF8, TADA1, PNKD, TADA2B, ATXN7L3, TADA3, MYC, FGFR1OP, XPO1, KIF22, RAB5A, TSNAX, ZWINT, KIF21B, CDKN2AIPNL, TAF7L, TAF6L, VASN, RFC4, TAF11, TAF7 |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for QKI_TAF12 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for QKI_TAF12 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | QKI | C0036341 | Schizophrenia | 5 | PSYGENET |
Hgene | QKI | C0017638 | Glioma | 1 | CTD_human |
Hgene | QKI | C0041696 | Unipolar Depression | 1 | PSYGENET |
Hgene | QKI | C1269683 | Major Depressive Disorder | 1 | PSYGENET |