	FusionGeneSummary
	FusionProtFeature
	FusionGeneSequence
	FusionGenePPI
	RelatedDrugs
	RelatedDiseases

Fusion gene ID: 29798

FusionGeneSummary for QKI_QKI

Fusion gene summary

Fusion gene information	Fusion gene name: QKI_QKI
	Fusion gene ID: 29798
		Hgene	Tgene
	Gene symbol	QKI	QKI
	Gene ID	9444	9444
	Gene name	QKI, KH domain containing RNA binding	QKI, KH domain containing RNA binding
	Synonyms	Hqk\|QK\|QK1\|QK3\|hqkI	Hqk\|QK\|QK1\|QK3\|hqkI
	Cytomap	6q26	6q26
	Type of gene	protein-coding	protein-coding
	Description	protein quakingQKI/LOC100132735 fusionRNA binding protein HQKhomolog of mouse quaking QKI (KH domain RNA binding protein)quaking homolog, KH domain RNA binding	protein quakingQKI/LOC100132735 fusionRNA binding protein HQKhomolog of mouse quaking QKI (KH domain RNA binding protein)quaking homolog, KH domain RNA binding
	Modification date	20180522	20180522
	UniProtAcc	Q96PU8	Q96PU8
	Ensembl transtripts involved in fusion gene	ENST00000275262, ENST00000392127, ENST00000453779, ENST00000361752, ENST00000361195, ENST00000424802,	ENST00000275262, ENST00000392127, ENST00000453779, ENST00000361752, ENST00000361195, ENST00000424802,
Fusion gene scores	* DoF score	7 X 6 X 7=294	13 X 14 X 6=1092
	# samples	13	18
	** MAII score	log2(13/294*10)=-1.17730453180791 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(18/1092*10)=-2.60090404459018 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: QKI [Title/Abstract] AND QKI [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS3.1			DW433368	QKI	chr6	163870852	+	QKI	chr6	163869132	+
ChiTaRS3.1			CD109394	QKI	chr6	163835830	+	QKI	chr6	163835666	+
ChiTaRS3.1			BF348123	QKI	chr6	163992063	-	QKI	chr6	163992110	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-intron	ENST00000275262	ENST00000275262	QKI	chr6	163870852	+	QKI	chr6	163869132	+
intron-intron	ENST00000275262	ENST00000392127	QKI	chr6	163870852	+	QKI	chr6	163869132	+
intron-intron	ENST00000275262	ENST00000453779	QKI	chr6	163870852	+	QKI	chr6	163869132	+
intron-intron	ENST00000275262	ENST00000361752	QKI	chr6	163870852	+	QKI	chr6	163869132	+
intron-intron	ENST00000275262	ENST00000361195	QKI	chr6	163870852	+	QKI	chr6	163869132	+
intron-intron	ENST00000275262	ENST00000424802	QKI	chr6	163870852	+	QKI	chr6	163869132	+
intron-intron	ENST00000392127	ENST00000275262	QKI	chr6	163870852	+	QKI	chr6	163869132	+
intron-intron	ENST00000392127	ENST00000392127	QKI	chr6	163870852	+	QKI	chr6	163869132	+
intron-intron	ENST00000392127	ENST00000453779	QKI	chr6	163870852	+	QKI	chr6	163869132	+
intron-intron	ENST00000392127	ENST00000361752	QKI	chr6	163870852	+	QKI	chr6	163869132	+
intron-intron	ENST00000392127	ENST00000361195	QKI	chr6	163870852	+	QKI	chr6	163869132	+
intron-intron	ENST00000392127	ENST00000424802	QKI	chr6	163870852	+	QKI	chr6	163869132	+
intron-intron	ENST00000453779	ENST00000275262	QKI	chr6	163870852	+	QKI	chr6	163869132	+
intron-intron	ENST00000453779	ENST00000392127	QKI	chr6	163870852	+	QKI	chr6	163869132	+
intron-intron	ENST00000453779	ENST00000453779	QKI	chr6	163870852	+	QKI	chr6	163869132	+
intron-intron	ENST00000453779	ENST00000361752	QKI	chr6	163870852	+	QKI	chr6	163869132	+
intron-intron	ENST00000453779	ENST00000361195	QKI	chr6	163870852	+	QKI	chr6	163869132	+
intron-intron	ENST00000453779	ENST00000424802	QKI	chr6	163870852	+	QKI	chr6	163869132	+
intron-intron	ENST00000361752	ENST00000275262	QKI	chr6	163870852	+	QKI	chr6	163869132	+
intron-intron	ENST00000361752	ENST00000392127	QKI	chr6	163870852	+	QKI	chr6	163869132	+
intron-intron	ENST00000361752	ENST00000453779	QKI	chr6	163870852	+	QKI	chr6	163869132	+
intron-intron	ENST00000361752	ENST00000361752	QKI	chr6	163870852	+	QKI	chr6	163869132	+
intron-intron	ENST00000361752	ENST00000361195	QKI	chr6	163870852	+	QKI	chr6	163869132	+
intron-intron	ENST00000361752	ENST00000424802	QKI	chr6	163870852	+	QKI	chr6	163869132	+
intron-intron	ENST00000361195	ENST00000275262	QKI	chr6	163870852	+	QKI	chr6	163869132	+
intron-intron	ENST00000361195	ENST00000392127	QKI	chr6	163870852	+	QKI	chr6	163869132	+
intron-intron	ENST00000361195	ENST00000453779	QKI	chr6	163870852	+	QKI	chr6	163869132	+
intron-intron	ENST00000361195	ENST00000361752	QKI	chr6	163870852	+	QKI	chr6	163869132	+
intron-intron	ENST00000361195	ENST00000361195	QKI	chr6	163870852	+	QKI	chr6	163869132	+
intron-intron	ENST00000361195	ENST00000424802	QKI	chr6	163870852	+	QKI	chr6	163869132	+
intron-intron	ENST00000424802	ENST00000275262	QKI	chr6	163870852	+	QKI	chr6	163869132	+
intron-intron	ENST00000424802	ENST00000392127	QKI	chr6	163870852	+	QKI	chr6	163869132	+
intron-intron	ENST00000424802	ENST00000453779	QKI	chr6	163870852	+	QKI	chr6	163869132	+
intron-intron	ENST00000424802	ENST00000361752	QKI	chr6	163870852	+	QKI	chr6	163869132	+
intron-intron	ENST00000424802	ENST00000361195	QKI	chr6	163870852	+	QKI	chr6	163869132	+
intron-intron	ENST00000424802	ENST00000424802	QKI	chr6	163870852	+	QKI	chr6	163869132	+
5UTR-intron	ENST00000275262	ENST00000275262	QKI	chr6	163835830	+	QKI	chr6	163835666	+
5UTR-intron	ENST00000275262	ENST00000392127	QKI	chr6	163835830	+	QKI	chr6	163835666	+
5UTR-intron	ENST00000275262	ENST00000453779	QKI	chr6	163835830	+	QKI	chr6	163835666	+
5UTR-intron	ENST00000275262	ENST00000361752	QKI	chr6	163835830	+	QKI	chr6	163835666	+
5UTR-intron	ENST00000275262	ENST00000361195	QKI	chr6	163835830	+	QKI	chr6	163835666	+
5UTR-intron	ENST00000275262	ENST00000424802	QKI	chr6	163835830	+	QKI	chr6	163835666	+
5UTR-intron	ENST00000392127	ENST00000275262	QKI	chr6	163835830	+	QKI	chr6	163835666	+
5UTR-intron	ENST00000392127	ENST00000392127	QKI	chr6	163835830	+	QKI	chr6	163835666	+
5UTR-intron	ENST00000392127	ENST00000453779	QKI	chr6	163835830	+	QKI	chr6	163835666	+
5UTR-intron	ENST00000392127	ENST00000361752	QKI	chr6	163835830	+	QKI	chr6	163835666	+
5UTR-intron	ENST00000392127	ENST00000361195	QKI	chr6	163835830	+	QKI	chr6	163835666	+
5UTR-intron	ENST00000392127	ENST00000424802	QKI	chr6	163835830	+	QKI	chr6	163835666	+
5UTR-intron	ENST00000453779	ENST00000275262	QKI	chr6	163835830	+	QKI	chr6	163835666	+
5UTR-intron	ENST00000453779	ENST00000392127	QKI	chr6	163835830	+	QKI	chr6	163835666	+
5UTR-intron	ENST00000453779	ENST00000453779	QKI	chr6	163835830	+	QKI	chr6	163835666	+
5UTR-intron	ENST00000453779	ENST00000361752	QKI	chr6	163835830	+	QKI	chr6	163835666	+
5UTR-intron	ENST00000453779	ENST00000361195	QKI	chr6	163835830	+	QKI	chr6	163835666	+
5UTR-intron	ENST00000453779	ENST00000424802	QKI	chr6	163835830	+	QKI	chr6	163835666	+
5UTR-intron	ENST00000361752	ENST00000275262	QKI	chr6	163835830	+	QKI	chr6	163835666	+
5UTR-intron	ENST00000361752	ENST00000392127	QKI	chr6	163835830	+	QKI	chr6	163835666	+
5UTR-intron	ENST00000361752	ENST00000453779	QKI	chr6	163835830	+	QKI	chr6	163835666	+
5UTR-intron	ENST00000361752	ENST00000361752	QKI	chr6	163835830	+	QKI	chr6	163835666	+
5UTR-intron	ENST00000361752	ENST00000361195	QKI	chr6	163835830	+	QKI	chr6	163835666	+
5UTR-intron	ENST00000361752	ENST00000424802	QKI	chr6	163835830	+	QKI	chr6	163835666	+
intron-intron	ENST00000361195	ENST00000275262	QKI	chr6	163835830	+	QKI	chr6	163835666	+
intron-intron	ENST00000361195	ENST00000392127	QKI	chr6	163835830	+	QKI	chr6	163835666	+
intron-intron	ENST00000361195	ENST00000453779	QKI	chr6	163835830	+	QKI	chr6	163835666	+
intron-intron	ENST00000361195	ENST00000361752	QKI	chr6	163835830	+	QKI	chr6	163835666	+
intron-intron	ENST00000361195	ENST00000361195	QKI	chr6	163835830	+	QKI	chr6	163835666	+
intron-intron	ENST00000361195	ENST00000424802	QKI	chr6	163835830	+	QKI	chr6	163835666	+
intron-intron	ENST00000424802	ENST00000275262	QKI	chr6	163835830	+	QKI	chr6	163835666	+
intron-intron	ENST00000424802	ENST00000392127	QKI	chr6	163835830	+	QKI	chr6	163835666	+
intron-intron	ENST00000424802	ENST00000453779	QKI	chr6	163835830	+	QKI	chr6	163835666	+
intron-intron	ENST00000424802	ENST00000361752	QKI	chr6	163835830	+	QKI	chr6	163835666	+
intron-intron	ENST00000424802	ENST00000361195	QKI	chr6	163835830	+	QKI	chr6	163835666	+
intron-intron	ENST00000424802	ENST00000424802	QKI	chr6	163835830	+	QKI	chr6	163835666	+
intron-intron	ENST00000275262	ENST00000275262	QKI	chr6	163992063	-	QKI	chr6	163992110	+
intron-intron	ENST00000275262	ENST00000392127	QKI	chr6	163992063	-	QKI	chr6	163992110	+
intron-intron	ENST00000275262	ENST00000453779	QKI	chr6	163992063	-	QKI	chr6	163992110	+
intron-3UTR	ENST00000275262	ENST00000361752	QKI	chr6	163992063	-	QKI	chr6	163992110	+
intron-intron	ENST00000275262	ENST00000361195	QKI	chr6	163992063	-	QKI	chr6	163992110	+
intron-intron	ENST00000275262	ENST00000424802	QKI	chr6	163992063	-	QKI	chr6	163992110	+
intron-intron	ENST00000392127	ENST00000275262	QKI	chr6	163992063	-	QKI	chr6	163992110	+
intron-intron	ENST00000392127	ENST00000392127	QKI	chr6	163992063	-	QKI	chr6	163992110	+
intron-intron	ENST00000392127	ENST00000453779	QKI	chr6	163992063	-	QKI	chr6	163992110	+
intron-3UTR	ENST00000392127	ENST00000361752	QKI	chr6	163992063	-	QKI	chr6	163992110	+
intron-intron	ENST00000392127	ENST00000361195	QKI	chr6	163992063	-	QKI	chr6	163992110	+
intron-intron	ENST00000392127	ENST00000424802	QKI	chr6	163992063	-	QKI	chr6	163992110	+
intron-intron	ENST00000453779	ENST00000275262	QKI	chr6	163992063	-	QKI	chr6	163992110	+
intron-intron	ENST00000453779	ENST00000392127	QKI	chr6	163992063	-	QKI	chr6	163992110	+
intron-intron	ENST00000453779	ENST00000453779	QKI	chr6	163992063	-	QKI	chr6	163992110	+
intron-3UTR	ENST00000453779	ENST00000361752	QKI	chr6	163992063	-	QKI	chr6	163992110	+
intron-intron	ENST00000453779	ENST00000361195	QKI	chr6	163992063	-	QKI	chr6	163992110	+
intron-intron	ENST00000453779	ENST00000424802	QKI	chr6	163992063	-	QKI	chr6	163992110	+
3UTR-intron	ENST00000361752	ENST00000275262	QKI	chr6	163992063	-	QKI	chr6	163992110	+
3UTR-intron	ENST00000361752	ENST00000392127	QKI	chr6	163992063	-	QKI	chr6	163992110	+
3UTR-intron	ENST00000361752	ENST00000453779	QKI	chr6	163992063	-	QKI	chr6	163992110	+
3UTR-3UTR	ENST00000361752	ENST00000361752	QKI	chr6	163992063	-	QKI	chr6	163992110	+
3UTR-intron	ENST00000361752	ENST00000361195	QKI	chr6	163992063	-	QKI	chr6	163992110	+
3UTR-intron	ENST00000361752	ENST00000424802	QKI	chr6	163992063	-	QKI	chr6	163992110	+
intron-intron	ENST00000361195	ENST00000275262	QKI	chr6	163992063	-	QKI	chr6	163992110	+
intron-intron	ENST00000361195	ENST00000392127	QKI	chr6	163992063	-	QKI	chr6	163992110	+
intron-intron	ENST00000361195	ENST00000453779	QKI	chr6	163992063	-	QKI	chr6	163992110	+
intron-3UTR	ENST00000361195	ENST00000361752	QKI	chr6	163992063	-	QKI	chr6	163992110	+
intron-intron	ENST00000361195	ENST00000361195	QKI	chr6	163992063	-	QKI	chr6	163992110	+
intron-intron	ENST00000361195	ENST00000424802	QKI	chr6	163992063	-	QKI	chr6	163992110	+
intron-intron	ENST00000424802	ENST00000275262	QKI	chr6	163992063	-	QKI	chr6	163992110	+
intron-intron	ENST00000424802	ENST00000392127	QKI	chr6	163992063	-	QKI	chr6	163992110	+
intron-intron	ENST00000424802	ENST00000453779	QKI	chr6	163992063	-	QKI	chr6	163992110	+
intron-3UTR	ENST00000424802	ENST00000361752	QKI	chr6	163992063	-	QKI	chr6	163992110	+
intron-intron	ENST00000424802	ENST00000361195	QKI	chr6	163992063	-	QKI	chr6	163992110	+
intron-intron	ENST00000424802	ENST00000424802	QKI	chr6	163992063	-	QKI	chr6	163992110	+

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FusionProtFeatures for QKI_QKI

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
QKI Q96PU8	QKI Q96PU8

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
.

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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FusionGeneSequence for QKI_QKI

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for QKI_QKI

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page
.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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RelatedDrugs for QKI_QKI

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for QKI_QKI

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	QKI	C0036341	Schizophrenia	5	PSYGENET
Hgene	QKI	C0017638	Glioma	1	CTD_human
Hgene	QKI	C0041696	Unipolar Depression	1	PSYGENET
Hgene	QKI	C1269683	Major Depressive Disorder	1	PSYGENET
Tgene	QKI	C0036341	Schizophrenia	5	PSYGENET
Tgene	QKI	C0017638	Glioma	1	CTD_human
Tgene	QKI	C0041696	Unipolar Depression	1	PSYGENET
Tgene	QKI	C1269683	Major Depressive Disorder	1	PSYGENET

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Fusion gene ID: 29798

FusionGeneSummary for QKI_QKI

FusionProtFeatures for QKI_QKI

FusionGeneSequence for QKI_QKI

FusionGenePPI for QKI_QKI

RelatedDrugs for QKI_QKI

RelatedDiseases for QKI_QKI