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Fusion gene ID: 29796 |
FusionGeneSummary for QKI_MRPL14 |
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Fusion gene information | Fusion gene name: QKI_MRPL14 | Fusion gene ID: 29796 | Hgene | Tgene | Gene symbol | QKI | MRPL14 | Gene ID | 9444 | 64928 |
Gene name | QKI, KH domain containing RNA binding | mitochondrial ribosomal protein L14 | |
Synonyms | Hqk|QK|QK1|QK3|hqkI | L14mt|L32mt|MRP-L14|MRP-L32|MRPL32|RMPL32|RPML32 | |
Cytomap | 6q26 | 6p21.1 | |
Type of gene | protein-coding | protein-coding | |
Description | protein quakingQKI/LOC100132735 fusionRNA binding protein HQKhomolog of mouse quaking QKI (KH domain RNA binding protein)quaking homolog, KH domain RNA binding | 39S ribosomal protein L14, mitochondrial39S ribosomal protein L32, mitochondrialmitochondrial large ribosomal subunit protein uL14m | |
Modification date | 20180522 | 20180523 | |
UniProtAcc | Q96PU8 | Q6P1L8 | |
Ensembl transtripts involved in fusion gene | ENST00000275262, ENST00000392127, ENST00000453779, ENST00000361752, ENST00000361195, ENST00000424802, | ENST00000372014, | |
Fusion gene scores | * DoF score | 7 X 6 X 7=294 | 11 X 6 X 7=462 |
# samples | 13 | 13 | |
** MAII score | log2(13/294*10)=-1.17730453180791 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(13/462*10)=-1.8293812283876 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: QKI [Title/Abstract] AND MRPL14 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | OV | TCGA-13-0897-01A | QKI | chr6 | 163899928 | + | MRPL14 | chr6 | 44084366 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-5UTR | ENST00000275262 | ENST00000372014 | QKI | chr6 | 163899928 | + | MRPL14 | chr6 | 44084366 | - |
5CDS-5UTR | ENST00000392127 | ENST00000372014 | QKI | chr6 | 163899928 | + | MRPL14 | chr6 | 44084366 | - |
5CDS-5UTR | ENST00000453779 | ENST00000372014 | QKI | chr6 | 163899928 | + | MRPL14 | chr6 | 44084366 | - |
5CDS-5UTR | ENST00000361752 | ENST00000372014 | QKI | chr6 | 163899928 | + | MRPL14 | chr6 | 44084366 | - |
5CDS-5UTR | ENST00000361195 | ENST00000372014 | QKI | chr6 | 163899928 | + | MRPL14 | chr6 | 44084366 | - |
5CDS-5UTR | ENST00000424802 | ENST00000372014 | QKI | chr6 | 163899928 | + | MRPL14 | chr6 | 44084366 | - |
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FusionProtFeatures for QKI_MRPL14 |
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Hgene | Tgene |
QKI | MRPL14 |
Forms part of 2 intersubunit bridges in the assembledribosome. Upon binding to MALSU1 intersubunit bridge formation isblocked, preventing ribosome formation and repressing translation(Probable). {ECO:0000305|PubMed:22829778}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for QKI_MRPL14 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for QKI_MRPL14 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
QKI | HNRNPK, USP30, MED12, MED13, MED25, MED16, MED17, MED1, MED24, MED23, MED4, MED29, MED31, MED15, MED14, MED26, MED10, POLR2A, MED27, ELAVL1, PSMF1, C10orf10, FUBP3, HCLS1, PCBP2, PTBP1, PTBP2, RBM14, RBFOX2, RBPMS, RNF138, SERF2, THAP1, USH1C, RBFOX1, PCBP1, PCBP4, APP, NDUFA7, CDV3, ATXN1, FN1, U2AF2, RBM23, RALY, WDR77, HNRNPH2, QKI, DAZ1, IL7R, CARM1, SNRPA, RBM11, NABP1, HNRNPLL, OIP5, RBMX, ZACN, CYP1A1, NTRK1, EWSR1, HYPK, DUSP22, DUSP4, ATE1, RBM42, FBXW11, SLC39A12, VAC14, TRIM11, SYNCRIP, SNRNP27 | MRPL14 | ICT1, CUL3, MRPL40, MRPL19, MRPL39, MRPL38, MRPL13, MRPL53, MRPS14, MRPS10, MRPL15, MRPL2, MRPL4, MRPL22, MRPL16, SARNP, CDV3, TUFM, PPIF, HNRNPR, NDUFA7, DUT, SRPRB, GADD45GIP1, RPS20, EEF1A1, MRPL28, HNRNPDL, ZC3H3, MRPL37, MRPS30, MRPL47, RPS15, RPS15A, ETS2, GOLT1B, MRPL50, WRAP53, MRPL9, MRPL1, NDUFA4, C6orf203, RC3H1, ZNF746, MRPL10, MRPL41, PDHA1 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for QKI_MRPL14 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for QKI_MRPL14 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | QKI | C0036341 | Schizophrenia | 5 | PSYGENET |
Hgene | QKI | C0017638 | Glioma | 1 | CTD_human |
Hgene | QKI | C0041696 | Unipolar Depression | 1 | PSYGENET |
Hgene | QKI | C1269683 | Major Depressive Disorder | 1 | PSYGENET |